Reinforcement Learning Outperforms Supervised Fine-Tuning: A Case Study on Audio Question Answering

Recently, reinforcement learning (RL) has been shown to greatly enhance the reasoning capabilities of large language models (LLMs), and RL-based approaches have been progressively applied to visual multimodal tasks. However, the audio modality has largely been overlooked in these developments. Thus, we conduct a series of RL explorations in audio understanding and reasoning, specifically focusing on the audio question answering (AQA) task. We leverage the group relative policy optimization (GRPO) algorithm to Qwen2-Audio-7B-Instruct, and our experiments demonstrated state-of-the-art performance on the MMAU Test-mini benchmark, achieving an accuracy rate of 64.5%. The main findings in this technical report are as follows: 1) The GRPO algorithm can be effectively applied to large audio language models (LALMs), even when the model has only 8.2B parameters; 2) With only 38k post-training samples, RL significantly outperforms supervised fine-tuning (SFT), indicating that RL-based approaches can be effective without large datasets; 3) The explicit reasoning process has not shown significant benefits for AQA tasks, and how to efficiently utilize deep thinking remains an open question for further research; 4) LALMs still lag far behind humans auditory-language reasoning, suggesting that the RL-based approaches warrant further exploration. Our project is available at https://github.com/xiaomi-research/r1-aqa and https://huggingface.co/mispeech/r1-aqa.

FlowAgent: Achieving Compliance and Flexibility for Workflow Agents

The integration of workflows with large language models (LLMs) enables LLM-based agents to execute predefined procedures, enhancing automation in real-world applications. Traditional rule-based methods tend to limit the inherent flexibility of LLMs, as their predefined execution paths restrict the models' action space, particularly when the unexpected, out-of-workflow (OOW) queries are encountered. Conversely, prompt-based methods allow LLMs to fully control the flow, which can lead to diminished enforcement of procedural compliance. To address these challenges, we introduce FlowAgent, a novel agent framework designed to maintain both compliance and flexibility. We propose the Procedure Description Language (PDL), which combines the adaptability of natural language with the precision of code to formulate workflows. Building on PDL, we develop a comprehensive framework that empowers LLMs to manage OOW queries effectively, while keeping the execution path under the supervision of a set of controllers. Additionally, we present a new evaluation methodology to rigorously assess an LLM agent's ability to handle OOW scenarios, going beyond routine flow compliance tested in existing benchmarks. Experiments on three datasets demonstrate that FlowAgent not only adheres to workflows but also effectively manages OOW queries, highlighting its dual strengths in compliance and flexibility. The code is available at https://github.com/Lightblues/FlowAgent.

CAMP in the Odyssey: Provably Robust Reinforcement Learning with Certified Radius Maximization

Deep reinforcement learning (DRL) has gained widespread adoption in control and decision-making tasks due to its strong performance in dynamic environments. However, DRL agents are vulnerable to noisy observations and adversarial attacks, and concerns about the adversarial robustness of DRL systems have emerged. Recent efforts have focused on addressing these robustness issues by establishing rigorous theoretical guarantees for the returns achieved by DRL agents in adversarial settings. Among these approaches, policy smoothing has proven to be an effective and scalable method for certifying the robustness of DRL agents. Nevertheless, existing certifiably robust DRL relies on policies trained with simple Gaussian augmentations, resulting in a suboptimal trade-off between certified robustness and certified return. To address this issue, we introduce a novel paradigm dubbed \texttt{C}ertified-r\texttt{A}dius-\texttt{M}aximizing \texttt{P}olicy (\texttt{CAMP}) training. \texttt{CAMP} is designed to enhance DRL policies, achieving better utility without compromising provable robustness. By leveraging the insight that the global certified radius can be derived from local certified radii based on training-time statistics, \texttt{CAMP} formulates a surrogate loss related to the local certified radius and optimizes the policy guided by this surrogate loss. We also introduce \textit{policy imitation} as a novel technique to stabilize \texttt{CAMP} training. Experimental results demonstrate that \texttt{CAMP} significantly improves the robustness-return trade-off across various tasks. Based on the results, \texttt{CAMP} can achieve up to twice the certified expected return compared to that of baselines. Our code is available at https://github.com/NeuralSec/camp-robust-rl.

Fusion of Millimeter-wave Radar and Pulse Oximeter Data for Low-burden Diagnosis of Obstructive Sleep Apnea-Hypopnea Syndrome

Objective: The aim of the study is to develop a novel method for improved diagnosis of obstructive sleep apnea-hypopnea syndrome (OSAHS) in clinical or home settings, with the focus on achieving diagnostic performance comparable to the gold-standard polysomnography (PSG) with significantly reduced monitoring burden. Methods: We propose a method using millimeter-wave radar and pulse oximeter for OSAHS diagnosis (ROSA). It contains a sleep apnea-hypopnea events (SAE) detection network, which directly predicts the temporal localization of SAE, and a sleep staging network, which predicts the sleep stages throughout the night, based on radar signals. It also fuses oxygen saturation (SpO2) information from the pulse oximeter to adjust the score of SAE detected by radar. Results: Experimental results on a real-world dataset (>800 hours of overnight recordings, 100 subjects) demonstrated high agreement (ICC=0.9870) on apnea-hypopnea index (AHI) between ROSA and PSG. ROSA also exhibited excellent diagnostic performance, exceeding 90% in accuracy across AHI diagnostic thresholds of 5, 15 and 30 events/h. Conclusion: ROSA improves diagnostic accuracy by fusing millimeter-wave radar and pulse oximeter data. It provides a reliable and low-burden solution for OSAHS diagnosis. Significance: ROSA addresses the limitations of high complexity and monitoring burden associated with traditional PSG. The high accuracy and low burden of ROSA show its potential to improve the accessibility of OSAHS diagnosis among population.

A Semiparametric Bayesian Method for Instrumental Variable Analysis with Partly Interval-Censored Time-to-Event Outcome

This paper develops a semiparametric Bayesian instrumental variable analysis method for estimating the causal effect of an endogenous variable when dealing with unobserved confounders and measurement errors with partly interval-censored time-to-event data, where event times are observed exactly for some subjects but left-censored, right-censored, or interval-censored for others. Our method is based on a two-stage Dirichlet process mixture instrumental variable (DPMIV) model which simultaneously models the first-stage random error term for the exposure variable and the second-stage random error term for the time-to-event outcome using a bivariate Gaussian mixture of the Dirichlet process (DPM) model. The DPM model can be broadly understood as a mixture model with an unspecified number of Gaussian components, which relaxes the normal error assumptions and allows the number of mixture components to be determined by the data. We develop an MCMC algorithm for the DPMIV model tailored for partly interval-censored data and conduct extensive simulations to assess the performance of our DPMIV method in comparison with some competing methods. Our simulations revealed that our proposed method is robust under different error distributions and can have superior performance over its parametric counterpart under various scenarios. We further demonstrate the effectiveness of our approach on an UK Biobank data to investigate the causal effect of systolic blood pressure on time-to-development of cardiovascular disease from the onset of diabetes mellitus.

Focus-N-Fix: Region-Aware Fine-Tuning for Text-to-Image Generation

Text-to-image (T2I) generation has made significant advances in recent years, but challenges still remain in the generation of perceptual artifacts, misalignment with complex prompts, and safety. The prevailing approach to address these issues involves collecting human feedback on generated images, training reward models to estimate human feedback, and then fine-tuning T2I models based on the reward models to align them with human preferences. However, while existing reward fine-tuning methods can produce images with higher rewards, they may change model behavior in unexpected ways. For example, fine-tuning for one quality aspect (e.g., safety) may degrade other aspects (e.g., prompt alignment), or may lead to reward hacking (e.g., finding a way to increase rewards without having the intended effect). In this paper, we propose Focus-N-Fix, a region-aware fine-tuning method that trains models to correct only previously problematic image regions. The resulting fine-tuned model generates images with the same high-level structure as the original model but shows significant improvements in regions where the original model was deficient in safety (over-sexualization and violence), plausibility, or other criteria. Our experiments demonstrate that Focus-N-Fix improves these localized quality aspects with little or no degradation to others and typically imperceptible changes in the rest of the image. Disclaimer: This paper contains images that may be overly sexual, violent, offensive, or harmful.

Large Language Models for Bioinformatics

With the rapid advancements in large language model (LLM) technology and the emergence of bioinformatics-specific language models (BioLMs), there is a growing need for a comprehensive analysis of the current landscape, computational characteristics, and diverse applications. This survey aims to address this need by providing a thorough review of BioLMs, focusing on their evolution, classification, and distinguishing features, alongside a detailed examination of training methodologies, datasets, and evaluation frameworks. We explore the wide-ranging applications of BioLMs in critical areas such as disease diagnosis, drug discovery, and vaccine development, highlighting their impact and transformative potential in bioinformatics. We identify key challenges and limitations inherent in BioLMs, including data privacy and security concerns, interpretability issues, biases in training data and model outputs, and domain adaptation complexities. Finally, we highlight emerging trends and future directions, offering valuable insights to guide researchers and clinicians toward advancing BioLMs for increasingly sophisticated biological and clinical applications.

Adaptable and Precise: Enterprise-Scenario LLM Function-Calling Capability Training Pipeline

Enterprises possess a vast array of API assets scattered across various functions, forming the backbone of existing business processes. By leveraging these APIs as functional tools, enterprises can design diverse, scenario-specific agent applications, driven by on-premise function-calling models as the core engine. However, generic models often fail to meet enterprise requirements in terms of computational efficiency, output accuracy, and stability, necessitating scenario-specific adaptation. In this paper, we propose a training pipeline for function-calling capabilities tailored to real-world business scenarios. This pipeline includes the synthesis and augmentation of scenario-specific function-calling data, model fine-tuning, and performance evaluation and analysis. Using this pipeline, we generated 1,260 fully AI-generated samples and 1,035 augmented manually-labeled samples in digital HR agent scenario. The Qwen2.5-Coder-7B-Instruct model was employed as the base model and fine-tuned using the LoRA method on four GPUs with 24GB VRAM. Our fine-tuned model demonstrated outstanding performance in evaluations and practical applications, surpassing GPT-4 and GPT-4o in accuracy on the test set. These results validate the reliability of the proposed pipeline for training scenario-specific function-calling models.

Can video generation replace cinematographers? Research on the cinematic language of generated video

Recent advancements in text-to-video (T2V) generation have leveraged diffusion models to enhance the visual coherence of videos generated from textual descriptions. However, most research has primarily focused on object motion, with limited attention given to cinematic language in videos, which is crucial for cinematographers to convey emotion and narrative pacing. To address this limitation, we propose a threefold approach to enhance the ability of T2V models to generate controllable cinematic language. Specifically, we introduce a cinematic language dataset that encompasses shot framing, angle, and camera movement, enabling models to learn diverse cinematic styles. Building on this, to facilitate robust cinematic alignment evaluation, we present CameraCLIP, a model fine-tuned on the proposed dataset that excels in understanding complex cinematic language in generated videos and can further provide valuable guidance in the multi-shot composition process. Finally, we propose CLIPLoRA, a cost-guided dynamic LoRA composition method that facilitates smooth transitions and realistic blending of cinematic language by dynamically fusing multiple pre-trained cinematic LoRAs within a single video. Our experiments demonstrate that CameraCLIP outperforms existing models in assessing the alignment between cinematic language and video, achieving an R@1 score of 0.81. Additionally, CLIPLoRA improves the ability for multi-shot composition, potentially bridging the gap between automatically generated videos and those shot by professional cinematographers.

3D Distance-color-coded Assessment of PCI Stent Apposition via Deep-learning-based Three-dimensional Multi-object Segmentation

Coronary artery disease poses a significant global health challenge, often necessitating percutaneous coronary intervention (PCI) with stent implantation. Assessing stent apposition holds pivotal importance in averting and identifying PCI complications that lead to in-stent restenosis. Here we proposed a novel three-dimensional (3D) distance-color-coded assessment (DccA)for PCI stent apposition via deep-learning-based 3D multi-object segmentation in intravascular optical coherence tomography (IV-OCT). Our proposed 3D DccA accurately segments 3D vessel lumens and stents in IV-OCT images, using a spatial matching network and dual-layer training with style transfer. It quantifies and maps stent-lumen distances into a 3D color space, facilitating 3D visual assessment of PCI stent apposition. Achieving over 95% segmentation precision, our proposed DccA enhances clinical evaluation of PCI stent deployment and supports personalized treatment planning.