3D Distance-color-coded Assessment of PCI Stent Apposition via Deep-learning-based Three-dimensional Multi-object Segmentation

Coronary artery disease poses a significant global health challenge, often necessitating percutaneous coronary intervention (PCI) with stent implantation. Assessing stent apposition holds pivotal importance in averting and identifying PCI complications that lead to in-stent restenosis. Here we proposed a novel three-dimensional (3D) distance-color-coded assessment (DccA)for PCI stent apposition via deep-learning-based 3D multi-object segmentation in intravascular optical coherence tomography (IV-OCT). Our proposed 3D DccA accurately segments 3D vessel lumens and stents in IV-OCT images, using a spatial matching network and dual-layer training with style transfer. It quantifies and maps stent-lumen distances into a 3D color space, facilitating 3D visual assessment of PCI stent apposition. Achieving over 95% segmentation precision, our proposed DccA enhances clinical evaluation of PCI stent deployment and supports personalized treatment planning.

Model Developmental Safety: A Safety-Centric Method and Applications in Vision-Language Models

In the real world, a learning-enabled system usually undergoes multiple cycles of model development to enhance the system's ability to handle difficult or emerging tasks. This continual model development process raises a significant issue that the model development for acquiring new or improving existing capabilities may inadvertently lose capabilities of the old model, also known as catastrophic forgetting. Existing continual learning studies focus on mitigating catastrophic forgetting by trading off performance on previous tasks and new tasks to ensure good average performance. However, they are inadequate for many applications especially in safety-critical domains, as failure to strictly preserve the performance of the old model not only introduces safety risks and uncertainties but also imposes substantial expenses in the re-improving and re-validation of existing properties. To address this issue, we introduce model developmental safety as a guarantee of a learning system such that in the model development process the new model should strictly preserve the existing protected capabilities of the old model while improving its performance on target tasks. To ensure the model developmental safety, we present a safety-centric framework by formulating the model developmental safety as data-dependent constraints. Under this framework, we study how to develop a pretrained vision-language model (aka the CLIP model) for acquiring new capabilities or improving existing capabilities of image classification. We propose an efficient constrained optimization algorithm with theoretical guarantee and use its insights to finetune a CLIP model with task-dependent heads for promoting the model developmental safety. Our experiments on improving vision perception capabilities on autonomous driving and scene recognition datasets demonstrate the efficacy of the proposed approach.

GLRT-Based Metric Learning for Remote Sensing Object Retrieval

With the improvement in the quantity and quality of remote sensing images, content-based remote sensing object retrieval (CBRSOR) has become an increasingly important topic. However, existing CBRSOR methods neglect the utilization of global statistical information during both training and test stages, which leads to the overfitting of neural networks to simple sample pairs of samples during training and suboptimal metric performance. Inspired by the Neyman-Pearson theorem, we propose a generalized likelihood ratio test-based metric learning (GLRTML) approach, which can estimate the relative difficulty of sample pairs by incorporating global data distribution information during training and test phases. This guides the network to focus more on difficult samples during the training process, thereby encourages the network to learn more discriminative feature embeddings. In addition, GLRT is a more effective than traditional metric space due to the utilization of global data distribution information. Accurately estimating the distribution of embeddings is critical for GLRTML. However, in real-world applications, there is often a distribution shift between the training and target domains, which diminishes the effectiveness of directly using the distribution estimated on training data. To address this issue, we propose the clustering pseudo-labels-based fast parameter adaptation (CPLFPA) method. CPLFPA efficiently estimates the distribution of embeddings in the target domain by clustering target domain instances and re-estimating the distribution parameters for GLRTML. We reorganize datasets for CBRSOR tasks based on fine-grained ship remote sensing image slices (FGSRSI-23) and military aircraft recognition (MAR20) datasets. Extensive experiments on these datasets demonstrate the effectiveness of our proposed GLRTML and CPLFPA.

Detection of Sleep Apnea-Hypopnea Events Using Millimeter-wave Radar and Pulse Oximeter

Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a sleep-related breathing disorder associated with significant morbidity and mortality worldwide. The gold standard for OSAHS diagnosis, polysomnography (PSG), faces challenges in popularization due to its high cost and complexity. Recently, radar has shown potential in detecting sleep apnea-hypopnea events (SAE) with the advantages of low cost and non-contact monitoring. However, existing studies, especially those using deep learning, employ segment-based classification approach for SAE detection, making the task of event quantity estimation difficult. Additionally, radar-based SAE detection is susceptible to interference from body movements and the environment. Oxygen saturation (SpO2) can offer valuable information about OSAHS, but it also has certain limitations and cannot be used alone for diagnosis. In this study, we propose a method using millimeter-wave radar and pulse oximeter to detect SAE, called ROSA. It fuses information from both sensors, and directly predicts the temporal localization of SAE. Experimental results demonstrate a high degree of consistency (ICC=0.9864) between AHI from ROSA and PSG. This study presents an effective method with low-load device for the diagnosis of OSAHS.

Deep Learning-based Automated Diagnosis of Obstructive Sleep Apnea and Sleep Stage Classification in Children Using Millimeter-wave Radar and Pulse Oximeter

Study Objectives: To evaluate the agreement between the millimeter-wave radar-based device and polysomnography (PSG) in diagnosis of obstructive sleep apnea (OSA) and classification of sleep stage in children. Methods: 281 children, aged 1 to 18 years, who underwent sleep monitoring between September and November 2023 at the Sleep Center of Beijing Children's Hospital, Capital Medical University, were recruited in the study. All enrolled children underwent sleep monitoring by PSG and the millimeter-wave radar-based device, QSA600, simultaneously. QSA600 recordings were automatically analyzed using a deep learning model meanwhile the PSG data was manually scored. Results: The Obstructive Apnea-Hypopnea Index (OAHI) obtained from QSA600 and PSG demonstrates a high level of agreement with an intraclass correlation coefficient of 0.945 (95% CI: 0.93 to 0.96). Bland-Altman analysis indicates that the mean difference of OAHI between QSA600 and PSG is -0.10 events/h (95% CI: -11.15 to 10.96). The deep learning model evaluated through cross-validation showed good sensitivity (81.8%, 84.3% and 89.7%) and specificity (90.5%, 95.3% and 97.1%) values for diagnosing children with OAHI>1, OAHI>5 and OAHI>10. The area under the receiver operating characteristic curve is 0.923, 0.955 and 0.988, respectively. For sleep stage classification, the model achieved Kappa coefficients of 0.854, 0.781, and 0.734, with corresponding overall accuracies of 95.0%, 84.8%, and 79.7% for Wake-sleep classification, Wake-REM-Light-Deep classification, and Wake-REM-N1-N2 N3 classification, respectively. Conclusions: QSA600 has demonstrated high agreement with PSG in diagnosing OSA and performing sleep staging in children. The device is portable, low-load and suitable for follow up and long-term pediatric sleep assessment.

Evaluation of OpenAI o1: Opportunities and Challenges of AGI

This comprehensive study evaluates the performance of OpenAI's o1-preview large language model across a diverse array of complex reasoning tasks, spanning multiple domains, including computer science, mathematics, natural sciences, medicine, linguistics, and social sciences. Through rigorous testing, o1-preview demonstrated remarkable capabilities, often achieving human-level or superior performance in areas ranging from coding challenges to scientific reasoning and from language processing to creative problem-solving. Key findings include: -83.3% success rate in solving complex competitive programming problems, surpassing many human experts. -Superior ability in generating coherent and accurate radiology reports, outperforming other evaluated models. -100% accuracy in high school-level mathematical reasoning tasks, providing detailed step-by-step solutions. -Advanced natural language inference capabilities across general and specialized domains like medicine. -Impressive performance in chip design tasks, outperforming specialized models in areas such as EDA script generation and bug analysis. -Remarkable proficiency in anthropology and geology, demonstrating deep understanding and reasoning in these specialized fields. -Strong capabilities in quantitative investing. O1 has comprehensive financial knowledge and statistical modeling skills. -Effective performance in social media analysis, including sentiment analysis and emotion recognition. The model excelled particularly in tasks requiring intricate reasoning and knowledge integration across various fields. While some limitations were observed, including occasional errors on simpler problems and challenges with certain highly specialized concepts, the overall results indicate significant progress towards artificial general intelligence.

Multi-Output Distributional Fairness via Post-Processing

The post-processing approaches are becoming prominent techniques to enhance machine learning models' fairness because of their intuitiveness, low computational cost, and excellent scalability. However, most existing post-processing methods are designed for task-specific fairness measures and are limited to single-output models. In this paper, we introduce a post-processing method for multi-output models, such as the ones used for multi-task/multi-class classification and representation learning, to enhance a model's distributional parity, a task-agnostic fairness measure. Existing techniques to achieve distributional parity are based on the (inverse) cumulative density function of a model's output, which is limited to single-output models. Extending previous works, our method employs an optimal transport mapping to move a model's outputs across different groups towards their empirical Wasserstein barycenter. An approximation technique is applied to reduce the complexity of computing the exact barycenter and a kernel regression method is proposed for extending this process to out-of-sample data. Our empirical studies, which compare our method to current existing post-processing baselines on multi-task/multi-class classification and representation learning tasks, demonstrate the effectiveness of the proposed approach.

Leveraging Open Knowledge for Advancing Task Expertise in Large Language Models

The cultivation of expertise for large language models (LLMs) to solve tasks of specific areas often requires special-purpose tuning with calibrated behaviors on the expected stable outputs. To avoid huge cost brought by manual preparation of instruction datasets and training resources up to hundreds of hours, the exploitation of open knowledge including a wealth of low rank adaptation (LoRA) models and instruction datasets serves as a good starting point. However, existing methods on model and data selection focus on the performance of general-purpose capabilities while neglecting the knowledge gap exposed in domain-specific deployment. In the present study, we propose to bridge such gap by introducing few human-annotated samples (i.e., K-shot) for advancing task expertise of LLMs with open knowledge. Specifically, we develop an efficient and scalable pipeline to cost-efficiently produce task experts where K-shot data intervene in selecting the most promising expert candidates and the task-relevant instructions. A mixture-of-expert (MoE) system is built to make the best use of individual-yet-complementary knowledge between multiple experts. We unveil the two keys to the success of a MoE system, 1) the abidance by K-shot, and 2) the insistence on diversity. For the former, we ensure that models that truly possess problem-solving abilities on K-shot are selected rather than those blind guessers. Besides, during data selection, instructions that share task-relevant contexts with K-shot are prioritized. For the latter, we highlight the diversity of constituting experts and that of the fine-tuning instructions throughout the model and data selection process. Extensive experimental results confirm the superiority of our approach over existing methods on utilization of open knowledge across various tasks. Codes and models will be released later.

GLIMMER: Incorporating Graph and Lexical Features in Unsupervised Multi-Document Summarization

Pre-trained language models are increasingly being used in multi-document summarization tasks. However, these models need large-scale corpora for pre-training and are domain-dependent. Other non-neural unsupervised summarization approaches mostly rely on key sentence extraction, which can lead to information loss. To address these challenges, we propose a lightweight yet effective unsupervised approach called GLIMMER: a Graph and LexIcal features based unsupervised Multi-docuMEnt summaRization approach. It first constructs a sentence graph from the source documents, then automatically identifies semantic clusters by mining low-level features from raw texts, thereby improving intra-cluster correlation and the fluency of generated sentences. Finally, it summarizes clusters into natural sentences. Experiments conducted on Multi-News, Multi-XScience and DUC-2004 demonstrate that our approach outperforms existing unsupervised approaches. Furthermore, it surpasses state-of-the-art pre-trained multi-document summarization models (e.g. PEGASUS and PRIMERA) under zero-shot settings in terms of ROUGE scores. Additionally, human evaluations indicate that summaries generated by GLIMMER achieve high readability and informativeness scores. Our code is available at https://github.com/Oswald1997/GLIMMER.

Unleashing the Power of Data Tsunami: A Comprehensive Survey on Data Assessment and Selection for Instruction Tuning of Language Models

Instruction tuning plays a critical role in aligning large language models (LLMs) with human preference. Despite the vast amount of open instruction datasets, naively training a LLM on all existing instructions may not be optimal and practical. To pinpoint the most beneficial datapoints, data assessment and selection methods have been proposed in the fields of natural language processing (NLP) and deep learning. However, under the context of instruction tuning, there still exists a gap in knowledge on what kind of data evaluation metrics can be employed and how they can be integrated into the selection mechanism. To bridge this gap, we present a comprehensive review on existing literature of data assessment and selection especially for instruction tuning of LLMs. We systematically categorize all applicable methods into quality-based, diversity-based, and importance-based ones where a unified, fine-grained taxonomy is structured. For each category, representative methods are elaborated to describe the landscape of relevant research. In addition, comparison between latest methods is conducted on their officially reported results to provide in-depth discussions on their limitations. Finally, we summarize the open challenges and propose the promosing avenues for future studies. All related contents are available at https://github.com/yuleiqin/fantastic-data-engineering.