Resolving the bias-precision paradox with stochastic causal representation learning for personalized medicine

Estimating individualized treatment effects from longitudinal observational data is central to data-driven medicine, yet existing methods face a fundamental limitation: reducing confounding bias often suppresses clinically informative heterogeneity, degrading patient-specific predictions. Here, we identify this tension as a bias-precision paradox in causal representation learning and introduce sampling-based maximum mean discrepancy (sMMD), a stochastic alignment strategy that replaces global adversarial balancing with subset-level matching. We instantiate this approach in a framework for counterfactual outcome prediction with attribution-grounded interpretability. Across two large-scale ICU cohorts (n = 27,783), our framework improves accuracy under distribution shift, reducing error by up to 11.5% and substantially increasing recall in high-risk tasks. Mechanistic analyses show that sMMD selectively preserves clinically decisive variables. In human-AI evaluation, our method outperforms clinicians-in-training and large language models, and improves clinician accuracy by 14.7% while reducing decision time, enabling interpretable, real-time clinical decision support.

RCLRec: Reverse Curriculum Learning for Modeling Sparse Conversions in Generative Recommendation

Conversion objectives in large-scale recommender systems are sparse, making them difficult to optimize. Generative recommendation (GR) partially alleviates data sparsity by organizing multi-type behaviors into a unified token sequence with shared representations, but conversion signals remain insufficiently modeled. While recent behavior-aware GR models encode behavior types and employ behavior-aware attention to highlight decision-related intermediate behaviors, they still rely on standard attention over the full history and provide no additional supervision for conversions, leaving conversion sparsity largely unresolved. To address these challenges, we propose RCLRec, a reverse curriculum learning-based GR framework for sparse conversion supervision. For each conversion target, RCLRec constructs a short curriculum by selecting a subsequence of conversion-related items from the history in reverse. Their semantic tokens are fed to the decoder as a prefix, together with the target conversion tokens, under a joint generation objective. This design provides additional instance-specific intermediate supervision, alleviating conversion sparsity and focusing the model on the user's critical decision process. We further introduce a curriculum quality-aware loss to ensure that the selected curricula are informative for conversion prediction. Experiments on offline datasets and an online A/B test show that RCLRec achieves superior performance, with +2.09% advertising revenue and +1.86% orders in online deployment.

AgenticRS-Architecture: System Design for Agentic Recommender Systems

AutoModel is an agent based architecture for the full lifecycle of industrial recommender systems. Instead of a fixed recall and ranking pipeline, AutoModel organizes recommendation as a set of interacting evolution agents with long term memory and self improvement capability. We instantiate three core agents along the axes of models, features, and resources: AutoTrain for model design and training, AutoFeature for data analysis and feature evolution, and AutoPerf for performance, deployment, and online experimentation. A shared coordination and knowledge layer connects these agents and records decisions, configurations, and outcomes. Through a case study of a module called paper autotrain, we show how AutoTrain automates paper driven model reproduction by closing the loop from method parsing to code generation, large scale training, and offline comparison, reducing manual effort for method transfer. AutoModel enables locally automated yet globally aligned evolution of large scale recommender systems and can be generalized to other AI systems such as search and advertising.

Rethinking Recommendation Paradigms: From Pipelines to Agentic Recommender Systems

Large-scale industrial recommenders typically use a fixed multi-stage pipeline (recall, ranking, re-ranking) and have progressed from collaborative filtering to deep and large pre-trained models. However, both multi-stage and so-called One Model designs remain essentially static: models are black boxes, and system improvement relies on manual hypotheses and engineering, which is hard to scale under heterogeneous data and multi-objective business constraints. We propose an Agentic Recommender System (AgenticRS) that reorganizes key modules as agents. Modules are promoted to agents only when they form a functionally closed loop, can be independently evaluated, and possess an evolvable decision space. For model agents, we outline two self-evolution mechanisms: reinforcement learning style optimization in well-defined action spaces, and large language model based generation and selection of new architectures and training schemes in open-ended design spaces. We further distinguish individual evolution of single agents from compositional evolution over how multiple agents are selected and connected, and use a layered inner and outer reward design to couple local optimization with global objectives. This provides a concise blueprint for turning static pipelines into self-evolving agentic recommender systems.

SiMO: Single-Modality-Operable Multimodal Collaborative Perception

Collaborative perception integrates multi-agent perspectives to enhance the sensing range and overcome occlusion issues. While existing multimodal approaches leverage complementary sensors to improve performance, they are highly prone to failure--especially when a key sensor like LiDAR is unavailable. The root cause is that feature fusion leads to semantic mismatches between single-modality features and the downstream modules. This paper addresses this challenge for the first time in the field of collaborative perception, introducing Single-Modality-Operable Multimodal Collaborative Perception (SiMO). By adopting the proposed Length-Adaptive Multi-Modal Fusion (LAMMA), SiMO can adaptively handle remaining modal features during modal failures while maintaining consistency of the semantic space. Additionally, leveraging the innovative "Pretrain-Align-Fuse-RD" training strategy, SiMO addresses the issue of modality competition--generally overlooked by existing methods--ensuring the independence of each individual modality branch. Experiments demonstrate that SiMO effectively aligns multimodal features while simultaneously preserving modality-specific features, enabling it to maintain optimal performance across all individual modalities. The implementation details can be found in https://github.com/dempsey-wen/SiMO.

Learning to Reflect and Correct: Towards Better Decoding Trajectories for Large-Scale Generative Recommendation

Generative Recommendation (GR) has become a promising paradigm for large-scale recommendation systems. However, existing GR models typically perform single-pass decoding without explicit refinement, causing early deviations to accumulate and ultimately degrade recommendation quality. To tackle this problem, we propose GRC, which is, to our knowledge, the first structured reflection-correction framework for GR that extends standard decoding into a Generation-Reflection-Correction (GRC) process. Concretely, GRC introduces a supervised reflection-correction template that decomposes the decoding process into initial draft generation, multi-granular reflection, and reflection-guided correction, thereby enabling structured reflection and correction in the semantic token space. To further explore the enlarged refinement space introduced by the GRC process, we optimize the entire GRC trajectory with GRPO-based reinforcement learning, under a carefully designed reward function with token-level and trajectory-level signals. For efficient online serving, we propose an Entropy-Guided Reflection Scheduling (EGRS) strategy that dynamically allocates more correction budget to high-uncertainty decoding trajectories during beam search. Extensive experiments on real-world datasets show that GRC consistently outperforms six state-of-the-art baselines by up to 15.74%, and online A/B tests demonstrate its substantial practical value in large-scale industrial recommendation, delivering a 1.79% lift in advertising revenue with only modest latency overhead.

Masked Diffusion Generative Recommendation

Generative recommendation (GR) typically first quantizes continuous item embeddings into multi-level semantic IDs (SIDs), and then generates the next item via autoregressive decoding. Although existing methods are already competitive in terms of recommendation performance, directly inheriting the autoregressive decoding paradigm from language models still suffers from three key limitations: (1) autoregressive decoding struggles to jointly capture global dependencies among the multi-dimensional features associated with different positions of SID; (2) using a unified, fixed decoding path for the same item implicitly assumes that all users attend to item attributes in the same order; (3) autoregressive decoding is inefficient at inference time and struggles to meet real-time requirements. To tackle these challenges, we propose MDGR, a Masked Diffusion Generative Recommendation framework that reshapes the GR pipeline from three perspectives: codebook, training, and inference. (1) We adopt a parallel codebook to provide a structural foundation for diffusion-based GR. (2) During training, we adaptively construct masking supervision signals along both the temporal and sample dimensions. (3) During inference, we develop a warm-up-based two-stage parallel decoding strategy for efficient generation of SIDs. Extensive experiments on multiple public and industrial-scale datasets show that MDGR outperforms ten state-of-the-art baselines by up to 10.78%. Furthermore, by deploying MDGR on a large-scale online advertising platform, we achieve a 1.20% increase in revenue, demonstrating its practical value. The code will be released upon acceptance.

AI-generated data contamination erodes pathological variability and diagnostic reliability

Generative artificial intelligence (AI) is rapidly populating medical records with synthetic content, creating a feedback loop where future models are increasingly at risk of training on uncurated AI-generated data. However, the clinical consequences of this AI-generated data contamination remain unexplored. Here, we show that in the absence of mandatory human verification, this self-referential cycle drives a rapid erosion of pathological variability and diagnostic reliability. By analysing more than 800,000 synthetic data points across clinical text generation, vision-language reporting, and medical image synthesis, we find that models progressively converge toward generic phenotypes regardless of the model architecture. Specifically, rare but critical findings, including pneumothorax and effusions, vanish from the synthetic content generated by AI models, while demographic representations skew heavily toward middle-aged male phenotypes. Crucially, this degradation is masked by false diagnostic confidence; models continue to issue reassuring reports while failing to detect life-threatening pathology, with false reassurance rates tripling to 40%. Blinded physician evaluation confirms that this decoupling of confidence and accuracy renders AI-generated documentation clinically useless after just two generations. We systematically evaluate three mitigation strategies, finding that while synthetic volume scaling fails to prevent collapse, mixing real data with quality-aware filtering effectively preserves diversity. Ultimately, our results suggest that without policy-mandated human oversight, the deployment of generative AI threatens to degrade the very healthcare data ecosystems it relies upon.

GADPN: Graph Adaptive Denoising and Perturbation Networks via Singular Value Decomposition

While Graph Neural Networks (GNNs) excel on graph-structured data, their performance is fundamentally limited by the quality of the observed graph, which often contains noise, missing links, or structural properties misaligned with GNNs' underlying assumptions. To address this, graph structure learning aims to infer a more optimal topology. Existing methods, however, often incur high computational costs due to complex generative models and iterative joint optimization, limiting their practical utility. In this paper, we propose GADPN, a simple yet effective graph structure learning framework that adaptively refines graph topology via low-rank denoising and generalized structural perturbation. Our approach makes two key contributions: (1) we introduce Bayesian optimization to adaptively determine the optimal denoising strength, tailoring the process to each graph's homophily level; and (2) we extend the structural perturbation method to arbitrary graphs via Singular Value Decomposition (SVD), overcoming its original limitation to symmetric structures. Extensive experiments on benchmark datasets demonstrate that GADPN achieves state-of-the-art performance while significantly improving efficiency. It shows particularly strong gains on challenging disassortative graphs, validating its ability to robustly learn enhanced graph structures across diverse network types.

Synergistic Integration and Discrepancy Resolution of Contextualized Knowledge for Personalized Recommendation

The integration of large language models (LLMs) into recommendation systems has revealed promising potential through their capacity to extract world knowledge for enhanced reasoning capabilities. However, current methodologies that adopt static schema-based prompting mechanisms encounter significant limitations: (1) they employ universal template structures that neglect the multi-faceted nature of user preference diversity; (2) they implement superficial alignment between semantic knowledge representations and behavioral feature spaces without achieving comprehensive latent space integration. To address these challenges, we introduce CoCo, an end-to-end framework that dynamically constructs user-specific contextual knowledge embeddings through a dual-mechanism approach. Our method realizes profound integration of semantic and behavioral latent dimensions via adaptive knowledge fusion and contradiction resolution modules. Experimental evaluations across diverse benchmark datasets and an enterprise-level e-commerce platform demonstrate CoCo's superiority, achieving a maximum 8.58% improvement over seven cutting-edge methods in recommendation accuracy. The framework's deployment on a production advertising system resulted in a 1.91% sales growth, validating its practical effectiveness. With its modular design and model-agnostic architecture, CoCo provides a versatile solution for next-generation recommendation systems requiring both knowledge-enhanced reasoning and personalized adaptation.