Multiple instance learning is a machine learning paradigm where training data is organized into bags of instances.
Generalized planning studies the construction of solution strategies that generalize across families of planning problems sharing a common domain model, formally defined by a transition function $γ: S \times A \rightarrow S$. Classical approaches achieve such generalization through symbolic abstractions and explicit reasoning over $γ$. In contrast, recent Transformer-based planners, such as PlanGPT and Plansformer, largely cast generalized planning as direct action-sequence prediction, bypassing explicit transition modeling. While effective on in-distribution instances, these approaches typically require large datasets and model sizes, and often suffer from state drift in long-horizon settings due to the absence of explicit world-state evolution. In this work, we formulate generalized planning as a transition-model learning problem, in which a neural model explicitly approximates the successor-state function $\hatγ \approx γ$ and generates plans by rolling out symbolic state trajectories. Instead of predicting actions directly, the model autoregressively predicts intermediate world states, thereby learning the domain dynamics as an implicit world model. To study size-invariant generalization and sample efficiency, we systematically evaluate multiple state representations and neural architectures, including relational graph encodings. Our results show that learning explicit transition models yields higher out-of-distribution satisficing-plan success than direct action-sequence prediction in multiple domains, while achieving these gains with significantly fewer training instances and smaller models. This is an extended version of a short paper accepted at ICAPS 2026 under the same title.
Single-point annotation is increasingly prominent in visual tasks for labeling cost reduction. However, it challenges tasks requiring high precision, such as the point-prompted instance segmentation (PPIS) task, which aims to estimate precise masks using single-point prompts to train a segmentation network. Due to the constraints of point annotations, granularity ambiguity and boundary uncertainty arise the difficulty distinguishing between different levels of detail (eg. whole object vs. parts) and the challenge of precisely delineating object boundaries. Previous works have usually inherited the paradigm of mask generation along with proposal selection to achieve PPIS. However, proposal selection relies solely on category information, failing to resolve the ambiguity of different granularity. Furthermore, mask generators offer only finite discrete solutions that often deviate from actual masks, particularly at boundaries. To address these issues, we propose the Semantic-Aware Point-Prompted Instance Segmentation Network (SAPNet). It integrates Point Distance Guidance and Box Mining Strategy to tackle group and local issues caused by the point's granularity ambiguity. Additionally, we incorporate completeness scores within proposals to add spatial granularity awareness, enhancing multiple instance learning (MIL) in proposal selection termed S-MIL. The Multi-level Affinity Refinement conveys pixel and semantic clues, narrowing boundary uncertainty during mask refinement. These modules culminate in SAPNet++, mitigating point prompt's granularity ambiguity and boundary uncertainty and significantly improving segmentation performance. Extensive experiments on four challenging datasets validate the effectiveness of our methods, highlighting the potential to advance PPIS.
Supervised causal learning has shown promise in causal discovery, yet it often struggles with generalization across diverse interventional settings, particularly when intervention targets are unknown. To address this, we propose TICL (Test-time Interventional Causal Learning), a novel method that synergizes Test-Time Training with Joint Causal Inference. Specifically, we design a self-augmentation strategy to generate instance-specific training data at test time, effectively avoiding distribution shifts. Furthermore, by integrating joint causal inference, we developed a PC-inspired two-phase supervised learning scheme, which effectively leverages self-augmented training data while ensuring theoretical identifiability. Extensive experiments on bnlearn benchmarks demonstrate TICL's superiority in multiple aspects of causal discovery and intervention target detection.
On-the-fly Directed Controller Synthesis (OTF-DCS) mitigates state-space explosion by incrementally exploring the system and relies critically on an exploration policy to guide search efficiently. Recent reinforcement learning (RL) approaches learn such policies and achieve promising zero-shot generalization from small training instances to larger unseen ones. However, a fundamental limitation is anisotropic generalization, where an RL policy exhibits strong performance only in a specific region of the domain-parameter space while remaining fragile elsewhere due to training stochasticity and trajectory-dependent bias. To address this, we propose a Soft Mixture-of-Experts framework that combines multiple RL experts via a prior-confidence gating mechanism and treats these anisotropic behaviors as complementary specializations. The evaluation on the Air Traffic benchmark shows that Soft-MoE substantially expands the solvable parameter space and improves robustness compared to any single expert.
Whole slide images (WSIs) are the gold standard for pathological diagnosis and sub-typing. Current main-stream two-step frameworks employ offline feature encoders trained without domain-specific knowledge. Among them, attention-based multiple instance learning (MIL) methods are outcome-oriented and offer limited interpretability. Clustering-based approaches can provide explainable decision-making process but suffer from high dimension features and semantically ambiguous centroids. To this end, we propose an end-to-end MIL framework that integrates Grassmann re-embedding and manifold adaptive clustering, where the manifold geometric structure facilitates robust clustering results. Furthermore, we design a prior knowledge guiding proxy instance labeling and aggregation strategy to approximate patch labels and focus on pathologically relevant tumor regions. Experiments on multicentre WSI datasets demonstrate that: 1) our cluster-incorporated model achieves superior performance in both grading accuracy and interpretability; 2) end-to-end learning refines better feature representations and it requires acceptable computation resources.
Normalization and scaling are fundamental preprocessing steps in time series modeling, yet their role in Transformer-based models remains underexplored from a theoretical perspective. In this work, we present the first formal analysis of how different normalization strategies, specifically instance-based and global scaling, impact the expressivity of Transformer-based architectures for time series representation learning. We propose a novel expressivity framework tailored to time series, which quantifies a model's ability to distinguish between similar and dissimilar inputs in the representation space. Using this framework, we derive theoretical bounds for two widely used normalization methods: Standard and Min-Max scaling. Our analysis reveals that the choice of normalization strategy can significantly influence the model's representational capacity, depending on the task and data characteristics. We complement our theory with empirical validation on classification and forecasting benchmarks using multiple Transformer-based models. Our results show that no single normalization method consistently outperforms others, and in some cases, omitting normalization entirely leads to superior performance. These findings highlight the critical role of preprocessing in time series learning and motivate the need for more principled normalization strategies tailored to specific tasks and datasets.
Despite the recent success of Multimodal Large Language Models (MLLMs), existing approaches predominantly assume the availability of multiple modalities during training and inference. In practice, multimodal data is often incomplete because modalities may be missing, collected asynchronously, or available only for a subset of examples. In this work, we propose PRIMO, a supervised latent-variable imputation model that quantifies the predictive impact of any missing modality within the multimodal learning setting. PRIMO enables the use of all available training examples, whether modalities are complete or partial. Specifically, it models the missing modality through a latent variable that captures its relationship with the observed modality in the context of prediction. During inference, we draw many samples from the learned distribution over the missing modality to both obtain the marginal predictive distribution (for the purpose of prediction) and analyze the impact of the missing modalities on the prediction for each instance. We evaluate PRIMO on a synthetic XOR dataset, Audio-Vision MNIST, and MIMIC-III for mortality and ICD-9 prediction. Across all datasets, PRIMO obtains performance comparable to unimodal baselines when a modality is fully missing and to multimodal baselines when all modalities are available. PRIMO quantifies the predictive impact of a modality at the instance level using a variance-based metric computed from predictions across latent completions. We visually demonstrate how varying completions of the missing modality result in a set of plausible labels.
Whole slide images (WSIs) enable weakly supervised prognostic modeling via multiple instance learning (MIL). Spatial transcriptomics (ST) preserves in situ gene expression, providing a spatial molecular context that complements morphology. As paired WSI-ST cohorts scale to population level, leveraging their complementary spatial signals for prognosis becomes crucial; however, principled cross-modal fusion strategies remain limited for this paradigm. To this end, we introduce PathoSpatial, an interpretable end-to-end framework integrating co-registered WSIs and ST to learn spatially informed prognostic representations. PathoSpatial uses task-guided prototype learning within a multi-level experts architecture, adaptively orchestrating unsupervised within-modality discovery with supervised cross-modal aggregation. By design, PathoSpatial substantially strengthens interpretability while maintaining discriminative ability. We evaluate PathoSpatial on a triple-negative breast cancer cohort with paired ST and WSIs. PathoSpatial delivers strong and consistent performance across five survival endpoints, achieving superior or comparable performance to leading unimodal and multimodal methods. PathoSpatial inherently enables post-hoc prototype interpretation and molecular risk decomposition, providing quantitative, biologically grounded explanations, highlighting candidate prognostic factors. We present PathoSpatial as a proof-of-concept for scalable and interpretable multimodal learning for spatial omics-pathology fusion.
Camera virtualization -- an emerging solution to novel view synthesis -- holds transformative potential for visual entertainment, live performances, and sports broadcasting by enabling the generation of photorealistic images from novel viewpoints using images from a limited set of calibrated multiple static physical cameras. Despite recent advances, achieving spatially and temporally coherent and photorealistic rendering of dynamic scenes with efficient time-archival capabilities, particularly in fast-paced sports and stage performances, remains challenging for existing approaches. Recent methods based on 3D Gaussian Splatting (3DGS) for dynamic scenes could offer real-time view-synthesis results. Yet, they are hindered by their dependence on accurate 3D point clouds from the structure-from-motion method and their inability to handle large, non-rigid, rapid motions of different subjects (e.g., flips, jumps, articulations, sudden player-to-player transitions). Moreover, independent motions of multiple subjects can break the Gaussian-tracking assumptions commonly used in 4DGS, ST-GS, and other dynamic splatting variants. This paper advocates reconsidering a neural volume rendering formulation for camera virtualization and efficient time-archival capabilities, making it useful for sports broadcasting and related applications. By modeling a dynamic scene as rigid transformations across multiple synchronized camera views at a given time, our method performs neural representation learning, providing enhanced visual rendering quality at test time. A key contribution of our approach is its support for time-archival, i.e., users can revisit any past temporal instance of a dynamic scene and can perform novel view synthesis, enabling retrospective rendering for replay, analysis, and archival of live events, a functionality absent in existing neural rendering approaches and novel view synthesis...
Building agentic systems that can autonomously self-improve from experience is a longstanding goal of AI. Large language models (LLMs) today primarily self-improve via two mechanisms: self-reflection for context updates, and reinforcement learning (RL) for weight updates. In this work, we propose Evolutionary System Prompt Learning (E-SPL), a method for jointly improving model contexts and model weights. In each RL iteration, E-SPL selects multiple system prompts and runs rollouts with each in parallel. It applies RL updates to model weights conditioned on each system prompt, and evolutionary updates to the system prompt population via LLM-driven mutation and crossover. Each system prompt has a TrueSkill rating for evolutionary selection, updated from relative performance within each RL iteration batch. E-SPL encourages a natural division between declarative knowledge encoded in prompts and procedural knowledge encoded in weights, resulting in improved performance across reasoning and agentic tasks. For instance, in an easy-to-hard (AIME $\rightarrow$ BeyondAIME) generalization setting, E-SPL improves RL success rate from 38.8% $\rightarrow$ 45.1% while also outperforming reflective prompt evolution (40.0%). Overall, our results show that coupling reinforcement learning with system prompt evolution yields consistent gains in sample efficiency and generalization. Code: https://github.com/LunjunZhang/E-SPL