Thinking in Scales: Accelerating Gigapixel Pathology Image Analysis via Adaptive Continuous Reasoning

Traditional whole slide image (WSI) analysis methods typically rely on the multiple instance learning (MIL) paradigm, which extracts patch-level features at high magnification and aggregates them for slide-level prediction. However, such exhaustive patch-level processing is computationally expensive, severely limiting the efficiency and scalability of WSI analysis. To address this challenge, we propose PathCTM (a Pathology-oriented Continuous Thought Model) that enables token-efficient scale-space continuous reasoning for gigapixel WSIs. PathCTM formulates diagnostic inference as a dynamic sequential information pursuit. It progressively transitions from low-magnification global to high-magnification local inspection, and adaptively terminates inference when sufficient evidence is gathered to effectively bound decision uncertainty. Specifically, it uses conditional computation for dynamic scale switching with attention-guided region pruning, coupled with confidence-aware early stopping. Extensive experiments demonstrate that, compared with standard MIL-based methods, PathCTM reduces the number of required image patches by 95.95% and shortens inference time by approximately 95.62%, while maintaining AUC without degradation. Code is available at https://github.com/JSGe-AI/PathCTM.

Beyond Numerical Features: CNN-Driven Algorithm Selection via Contour Plots for Continuous Black-Box Optimization

The present paper introduces a new representation-driven approach to per-instance algorithm selection, applied to black-box optimization, for automatically choosing the most promising solver from a fixed portfolio. Prior work in continuous optimization largely relies on numerical descriptors, including Exploratory Landscape Analysis features and learned embeddings such as Deep-ELA. This work studies a complementary representation: contour-map visualizations of probed landscapes. A CNN regressor takes multiple instance-specific contour views (stacked or encoded per view and aggregated) and predicts per-solver performance, enabling selection by the predicted best value. On the standard BBOB 2009 single-objective protocol, the resulting selectors significantly outperform the single best solver (SBS) and are competitive with feature-based baselines. A subsequent bi-objective evaluation under the DeepELA setting further indicates that the same image-based principle can be competitive when using windowed contour views. Overall, the results suggest that simple vision models can exploit spatial structure in probed landscapes for algorithm selection without handcrafted ELA features.

Robust Recommendation from Noisy Implicit Feedback: A GMM-Weighted Bayes-label Transition Matrix Framework

Learning from implicit feedback in recommender systems is fundamentally challenged by pervasive label noise. While conventional denoising approaches often discard noisy instances to ensure robustness, this strategy inevitably suffers from low data utilization. Alternative methods that employ a Bayes-label transition matrix (BLTM) can leverage all available data, but their estimates tend to be biased in practical recommendation scenarios. To address these limitations, this paper proposes a Robust GMM-weighted Bayes-label Transition Matrix framework (RGBT). Our solution utilizes a Gaussian Mixture Model (GMM) to derive instance-specific reliability scores, which systematically calibrate the BLTM estimation to mitigate bias. Theoretical analysis confirms that our approach, by leveraging the BLTM framework with GMM calibration, simultaneously ensures full sample utilization, delivers consistent estimation, and critically, achieves a significant reduction in estimation variance. Extensive experiments on multiple real-world and synthetically flipped datasets demonstrate that RGBT not only utilizes noisy samples more effectively than mainstream reliable sample-based denoising methods, but also achieves significantly superior calibration capability of the transition matrix compared to state-of-the-art transition matrix-based denoising approaches.

Projecting Latent RL Actions: Towards Generalizable and Scalable Graph Combinatorial Optimization

Graph combinatorial optimization (GCO) has attracted growing interest, as many NP-hard problems naturally admit graph formulations, yet their combinatorial explosion renders exact methods computationally intractable. Recent advances in Reinforcement Learning (RL) combined with Graph Neural Networks (GNNs) have significantly improved learning-based GCO solvers. However, existing approaches face limitations in both generalization across diverse graph instances and computational scalability as action spaces grow. To address both challenges, we introduce projection agents, a novel RL-GCO approach that operates directly in a continuous GNN-based action embedding space, predicting a desired latent action in a single forward pass and subsequently decoding it into a valid discrete action. Additionally, we enable fair comparison across RL methods through a shared embedding space for both observations and actions. Across diverse benchmarks, our approach achieves up to 16.2x faster inference and up to 40% better generalization than existing solutions using only simple nearest-neighbor decoding, while opening the door to strong RL performance in super-linear decision spaces with multiple interdependent variables. Finally, we release LaGCO-RL, a Python library that automates latent action-space construction and supports existing RL-GCO solutions, promoting reproducibility and adaptation to new GCO benchmarks.

Dual-Prompt CLIP with Hybrid Visual Encoders for Occluded Person Re-Identification

Occluded person re-identification focuses on matching partially visible pedestrians across multiple camera views. However, occlusions disrupt body-region cues, thereby complicating cross-view matching. Most person ReID methods built on pretrained vision-language models only focus on enhancing prompt-based feature learning while ignoring the semantic information of occluders. Based on the success of CLIP-ReID, we propose a novel Dual Prompt Learning ReID (DPL-ReID) model for occluded person ReID. It incorporates a Dual Prompt Learning (Dual-PL) strategy, which can utilize textual cues to capture complete pedestrian semantics and keep robustness against occlusion, and a Real-World Occlusion Augmentation (RWOA) method that realistically simulates occlusion scenarios encountered in real word to enrich occluded samples. In addition, we also design a Weighted Gated Feature Fusion (WGFF) method, which in corporates LSNet to capture global information and act as a feature-gating mechanism. This mechanism can effectively guide the CLIP visual encoder toward generating more comprehensive feature representations. Extensive experiments on several benchmark occluded ReID datasets show that our proposed DPL-ReID achieves the state-of-the art performance. The occlusion instance library are available at https://github.com/stone-qiao/DPL-ReID.

Efficient Lookahead Encoding and Abstracted Width for Learning General Policies in Classical Planning

Generalized planning aims to learn policies that generalize across collections of instances within a classical planning domain. Recent Graph Neural Network (GNN) approaches have learned nearly perfect policies for several domains. This work improves on the recently published idea of Iterated Width (IW) policies. Therein, the policy broadens its successor scope through an IW-lookahead search that can "jump" over multiple transitions, simplifying the problem structure. Yet, each transition is evaluated individually, leading to unscalable compute costs and expressivity limitations. Furthermore, although IW(1) is attractive because it scales linearly with the number of atoms, it becomes inefficient once thousands of objects are considered, as in the International Planning Competition (IPC) 2023 benchmark. We address both limitations. First, we introduce a vastly more efficient holistic encoding of the entire search tree. It jointly represents IW(1)-reachable states only by their relational differences to the current state, enabling Relational GNNs (R-GNNs) to score all transitions in a single forward pass. Second, we define Abstracted IW(1) to improve scaling through relational abstraction during novelty checks. Rather than testing fully instantiated atoms, it abstracts each atom by replacing all but one argument with its type. The original atom is novel if any of its abstracted forms is novel. This structural compression shifts novelty search scaling from atoms to objects, while preserving meaningful subgoal structure. We evaluate our contributions on the hyperscaling IPC 2023 benchmark and across diverse domains, including domains requiring features beyond the $C_2$ logic fragment. Our policies achieve new state-of-the-art performance, significantly surpassing prior work, including the classical planner LAMA.

Collision-Resistant Single-Pass Method for Unsupervised Fine-Grained Image Hashing

Unsupervised fine-grained image hashing aims to learn compact binary codes that preserve subtle visual differences among highly similar instances without manual annotations. However, most existing methods neglect collision resistance, leading to identical hash codes for slightly semantically different samples. In this paper, we propose Collision-Resistant Single-Pass Self-Supervised Semantic Hashing (CS3H), a collision-resistant framework that directly optimizes Hamming-space similarity via a single-pass normalized Hamming distance loss to produce well-separated binary representations. We further introduce a collision-sensitive attention module to emphasize rare and discriminative local patterns, reducing hash collisions and improving fine-grained discrimination. Experiments on multiple benchmarks show that CS3H consistently outperforms state-of-the-art methods in retrieval accuracy while achieving superior collision resistance with minimal computational overhead.

Collaborating in Multi-Armed Bandits with Strategic Agents

We study collaborative learning in multi-agent Bayesian bandit problems, where strategic agents collectively solve the same bandit instance. While multiple agents can accelerate learning by sharing information, strategic agents might prefer to free-ride and avoid exploration. We consider a setting with persistent agents that participate in multiple time periods. This is in contrast to most previous works on incentives in multi-agent MAB, which assume short-lived agents, namely each agent has a single decision to make and optimizes their expected reward in that single decision. As in the multi-agent MAB model with incentives, our model does not have monetary transfers, and the only incentives are through information sharing. We propose \texttt{CAOS}, a mechanism that sustains collaboration as a Nash equilibrium while achieving strong regret guarantees. Our results demonstrate that collaborative exploration can be sustained purely through information sharing, achieving performance close to that of fully cooperative systems despite strategic behavior.

Are Compact Rationales Free? Measuring Tile Selection Headroom in Frozen WSI-MIL

Whole-slide image (WSI) multiple instance learning (MIL) classifiers can achieve strong slide-level AUC while leaving the full-bag prediction opaque. Attention scores are widely reused as post-hoc explanations, but high attention can reflect aggregation preference rather than a compact, model-sufficient rationale. We study post-hoc rationale highlighting for frozen WSI-MIL: given a trained classifier, can its slide-level prediction be recovered from a compact, output-consistent tile subset without retraining the backbone? We instantiate this with Finding Optimal Contextual Instances (FOCI), a lightweight rationale-readout layer over a frozen MIL backbone. FOCI is trained with model-output sufficiency and exclusion objectives over keep/drop tile subsets, evaluated with an insertion-style Sequential Reveal Protocol (SRP) adapted to WSI-MIL, and summarized by the Selection Headroom Index (SHI). Across three WSI benchmarks and seven MIL backbones, FOCI reveals that compact rationales are selection-headroom dependent: transformer and multi-branch attention aggregators can admit compact rationales, near-minimal attention-pooling baselines enter a selection-saturation regime, and hard-selection backbones can conflict with an external readout. For TransMIL, relative to its documented CLS-proxy ranking, FOCI reduces the Minimum Sufficient K (MSK) tile count by 32-56% across benchmarks, while ACMIL+FOCI attains the highest mean SHI (+0.465). Deletion-based perturbation and selected-only downstream evaluation provide complementary checks. These results position FOCI as a model-level interpretability and audit layer: selected tiles are not claims of clinical or pathologist-level diagnostic sufficiency, but candidate rationales that offer a compact, reviewable view of when a frozen MIL prediction can be localized to a small output-consistent subset.

CellDX AI Autopilot: Agent-Guided Training and Deployment of Pathology Classifiers

Training AI models for computational pathology currently requires access to expensive whole-slide-image datasets, GPU infrastructure, deep expertise in machine learning, and substantial engineering effort. We present CellDX AI Autopilot, a platform that lets users -- from pathologists with no ML background to ML practitioners running many parallel experiments -- train, evaluate, and deploy whole-slide image classifiers through natural language interaction with an AI agent. The platform provides a structured set of agent skills that guide the user through dataset curation, automated hyperparameter tuning, multi-strategy model comparison, and human-in-the-loop deployment, all on a pre-built dataset of over 32,000 cases and 66,000 H&E-stained whole-slide images with pre-extracted features. We describe the agent skill architecture, the underlying Multiple Instance Learning (MIL) training framework supporting four classification strategies, and an iterative pairwise hyperparameter search (grid or seeded random) that reduces tuning cost by over 30x compared to exhaustive search. CellDX AI Autopilot is, to our knowledge, the first system to expose pathology-specialized agent skills and a pathology-specialized training platform to general-purpose AI agents (e.g. any LLM-based agent runtime), delivering end-to-end automated model training without requiring the agent itself to be domain-specific. The platform addresses both the ML-expertise bottleneck that limits adoption in diagnostic pathology and the engineering bottleneck that limits how many experiments a researcher can run cost-effectively.