TopoTxR: A topology-guided deep convolutional network for breast parenchyma learning on DCE-MRIs

Characterization of breast parenchyma in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a challenging task owing to the complexity of underlying tissue structures. Existing quantitative approaches, like radiomics and deep learning models, lack explicit quantification of intricate and subtle parenchymal structures, including fibroglandular tissue. To address this, we propose a novel topological approach that explicitly extracts multi-scale topological structures to better approximate breast parenchymal structures, and then incorporates these structures into a deep-learning-based prediction model via an attention mechanism. Our topology-informed deep learning model, \emph{TopoTxR}, leverages topology to provide enhanced insights into tissues critical for disease pathophysiology and treatment response. We empirically validate \emph{TopoTxR} using the VICTRE phantom breast dataset, showing that the topological structures extracted by our model effectively approximate the breast parenchymal structures. We further demonstrate \emph{TopoTxR}'s efficacy in predicting response to neoadjuvant chemotherapy. Our qualitative and quantitative analyses suggest differential topological behavior of breast tissue in treatment-na\"ive imaging, in patients who respond favorably to therapy as achieving pathological complete response (pCR) versus those who do not. In a comparative analysis with several baselines on the publicly available I-SPY 1 dataset (N=161, including 47 patients with pCR and 114 without) and the Rutgers proprietary dataset (N=120, with 69 patients achieving pCR and 51 not), \emph{TopoTxR} demonstrates a notable improvement, achieving a 2.6\% increase in accuracy and a 4.6\% enhancement in AUC compared to the state-of-the-art method.

VQ-Map: Bird's-Eye-View Map Layout Estimation in Tokenized Discrete Space via Vector Quantization

Bird's-eye-view (BEV) map layout estimation requires an accurate and full understanding of the semantics for the environmental elements around the ego car to make the results coherent and realistic. Due to the challenges posed by occlusion, unfavourable imaging conditions and low resolution, \emph{generating} the BEV semantic maps corresponding to corrupted or invalid areas in the perspective view (PV) is appealing very recently. \emph{The question is how to align the PV features with the generative models to facilitate the map estimation}. In this paper, we propose to utilize a generative model similar to the Vector Quantized-Variational AutoEncoder (VQ-VAE) to acquire prior knowledge for the high-level BEV semantics in the tokenized discrete space. Thanks to the obtained BEV tokens accompanied with a codebook embedding encapsulating the semantics for different BEV elements in the groundtruth maps, we are able to directly align the sparse backbone image features with the obtained BEV tokens from the discrete representation learning based on a specialized token decoder module, and finally generate high-quality BEV maps with the BEV codebook embedding serving as a bridge between PV and BEV. We evaluate the BEV map layout estimation performance of our model, termed VQ-Map, on both the nuScenes and Argoverse benchmarks, achieving 62.2/47.6 mean IoU for surround-view/monocular evaluation on nuScenes, as well as 73.4 IoU for monocular evaluation on Argoverse, which all set a new record for this map layout estimation task. The code and models are available on \url{https://github.com/Z1zyw/VQ-Map}.

Data Augmentation for Automated Adaptive Rodent Training

Fully optimized automation of behavioral training protocols for lab animals like rodents has long been a coveted goal for researchers. It is an otherwise labor-intensive and time-consuming process that demands close interaction between the animal and the researcher. In this work, we used a data-driven approach to optimize the way rodents are trained in labs. In pursuit of our goal, we looked at data augmentation, a technique that scales well in data-poor environments. Using data augmentation, we built several artificial rodent models, which in turn would be used to build an efficient and automatic trainer. Then we developed a novel similarity metric based on the action probability distribution to measure the behavioral resemblance of our models to that of real rodents.

Long-Tailed Backdoor Attack Using Dynamic Data Augmentation Operations

Recently, backdoor attack has become an increasing security threat to deep neural networks and drawn the attention of researchers. Backdoor attacks exploit vulnerabilities in third-party pretrained models during the training phase, enabling them to behave normally for clean samples and mispredict for samples with specific triggers. Existing backdoor attacks mainly focus on balanced datasets. However, real-world datasets often follow long-tailed distributions. In this paper, for the first time, we explore backdoor attack on such datasets. Specifically, we first analyze the influence of data imbalance on backdoor attack. Based on our analysis, we propose an effective backdoor attack named Dynamic Data Augmentation Operation (D$^2$AO). We design D$^2$AO selectors to select operations depending jointly on the class, sample type (clean vs. backdoored) and sample features. Meanwhile, we develop a trigger generator to generate sample-specific triggers. Through simultaneous optimization of the backdoored model and trigger generator, guided by dynamic data augmentation operation selectors, we achieve significant advancements. Extensive experiments demonstrate that our method can achieve the state-of-the-art attack performance while preserving the clean accuracy.

Generative Edge Detection with Stable Diffusion

Edge detection is typically viewed as a pixel-level classification problem mainly addressed by discriminative methods. Recently, generative edge detection methods, especially diffusion model based solutions, are initialized in the edge detection task. Despite great potential, the retraining of task-specific designed modules and multi-step denoising inference limits their broader applications. Upon closer investigation, we speculate that part of the reason is the under-exploration of the rich discriminative information encoded in extensively pre-trained large models (\eg, stable diffusion models). Thus motivated, we propose a novel approach, named Generative Edge Detector (GED), by fully utilizing the potential of the pre-trained stable diffusion model. Our model can be trained and inferred efficiently without specific network design due to the rich high-level and low-level prior knowledge empowered by the pre-trained stable diffusion. Specifically, we propose to finetune the denoising U-Net and predict latent edge maps directly, by taking the latent image feature maps as input. Additionally, due to the subjectivity and ambiguity of the edges, we also incorporate the granularity of the edges into the denoising U-Net model as one of the conditions to achieve controllable and diverse predictions. Furthermore, we devise a granularity regularization to ensure the relative granularity relationship of the multiple predictions. We conduct extensive experiments on multiple datasets and achieve competitive performance (\eg, 0.870 and 0.880 in terms of ODS and OIS on the BSDS test dataset).

Backdooring Vision-Language Models with Out-Of-Distribution Data

The emergence of Vision-Language Models (VLMs) represents a significant advancement in integrating computer vision with Large Language Models (LLMs) to generate detailed text descriptions from visual inputs. Despite their growing importance, the security of VLMs, particularly against backdoor attacks, is under explored. Moreover, prior works often assume attackers have access to the original training data, which is often unrealistic. In this paper, we address a more practical and challenging scenario where attackers must rely solely on Out-Of-Distribution (OOD) data. We introduce VLOOD (Backdooring Vision-Language Models with Out-of-Distribution Data), a novel approach with two key contributions: (1) demonstrating backdoor attacks on VLMs in complex image-to-text tasks while minimizing degradation of the original semantics under poisoned inputs, and (2) proposing innovative techniques for backdoor injection without requiring any access to the original training data. Our evaluation on image captioning and visual question answering (VQA) tasks confirms the effectiveness of VLOOD, revealing a critical security vulnerability in VLMs and laying the foundation for future research on securing multimodal models against sophisticated threats.

TrojVLM: Backdoor Attack Against Vision Language Models

The emergence of Vision Language Models (VLMs) is a significant advancement in integrating computer vision with Large Language Models (LLMs) to produce detailed text descriptions based on visual inputs, yet it introduces new security vulnerabilities. Unlike prior work that centered on single modalities or classification tasks, this study introduces TrojVLM, the first exploration of backdoor attacks aimed at VLMs engaged in complex image-to-text generation. Specifically, TrojVLM inserts predetermined target text into output text when encountering poisoned images. Moreover, a novel semantic preserving loss is proposed to ensure the semantic integrity of the original image content. Our evaluation on image captioning and visual question answering (VQA) tasks confirms the effectiveness of TrojVLM in maintaining original semantic content while triggering specific target text outputs. This study not only uncovers a critical security risk in VLMs and image-to-text generation but also sets a foundation for future research on securing multimodal models against such sophisticated threats.

NAS-BNN: Neural Architecture Search for Binary Neural Networks

Binary Neural Networks (BNNs) have gained extensive attention for their superior inferencing efficiency and compression ratio compared to traditional full-precision networks. However, due to the unique characteristics of BNNs, designing a powerful binary architecture is challenging and often requires significant manpower. A promising solution is to utilize Neural Architecture Search (NAS) to assist in designing BNNs, but current NAS methods for BNNs are relatively straightforward and leave a performance gap between the searched models and manually designed ones. To address this gap, we propose a novel neural architecture search scheme for binary neural networks, named NAS-BNN. We first carefully design a search space based on the unique characteristics of BNNs. Then, we present three training strategies, which significantly enhance the training of supernet and boost the performance of all subnets. Our discovered binary model family outperforms previous BNNs for a wide range of operations (OPs) from 20M to 200M. For instance, we achieve 68.20% top-1 accuracy on ImageNet with only 57M OPs. In addition, we validate the transferability of these searched BNNs on the object detection task, and our binary detectors with the searched BNNs achieve a novel state-of-the-art result, e.g., 31.6% mAP with 370M OPs, on MS COCO dataset. The source code and models will be released at https://github.com/VDIGPKU/NAS-BNN.

GrassNet: State Space Model Meets Graph Neural Network

Designing spectral convolutional networks is a formidable task in graph learning. In traditional spectral graph neural networks (GNNs), polynomial-based methods are commonly used to design filters via the Laplacian matrix. In practical applications, however, these polynomial methods encounter inherent limitations, which primarily arise from the the low-order truncation of polynomial filters and the lack of overall modeling of the graph spectrum. This leads to poor performance of existing spectral approaches on real-world graph data, especially when the spectrum is highly concentrated or contains many numerically identical values, as they tend to apply the exact same modulation to signals with the same frequencies. To overcome these issues, in this paper, we propose Graph State Space Network (GrassNet), a novel graph neural network with theoretical support that provides a simple yet effective scheme for designing and learning arbitrary graph spectral filters. In particular, our GrassNet introduces structured state space models (SSMs) to model the correlations of graph signals at different frequencies and derives a unique rectification for each frequency in the graph spectrum. To the best of our knowledge, our work is the first to employ SSMs for the design of GNN spectral filters, and it theoretically offers greater expressive power compared with polynomial filters. Extensive experiments on nine public benchmarks reveal that GrassNet achieves superior performance in real-world graph modeling tasks.

DFA-GNN: Forward Learning of Graph Neural Networks by Direct Feedback Alignment

Graph neural networks are recognized for their strong performance across various applications, with the backpropagation algorithm playing a central role in the development of most GNN models. However, despite its effectiveness, BP has limitations that challenge its biological plausibility and affect the efficiency, scalability and parallelism of training neural networks for graph-based tasks. While several non-BP training algorithms, such as the direct feedback alignment, have been successfully applied to fully-connected and convolutional network components for handling Euclidean data, directly adapting these non-BP frameworks to manage non-Euclidean graph data in GNN models presents significant challenges. These challenges primarily arise from the violation of the i.i.d. assumption in graph data and the difficulty in accessing prediction errors for all samples (nodes) within the graph. To overcome these obstacles, in this paper we propose DFA-GNN, a novel forward learning framework tailored for GNNs with a case study of semi-supervised learning. The proposed method breaks the limitations of BP by using a dedicated forward training mechanism. Specifically, DFA-GNN extends the principles of DFA to adapt to graph data and unique architecture of GNNs, which incorporates the information of graph topology into the feedback links to accommodate the non-Euclidean characteristics of graph data. Additionally, for semi-supervised graph learning tasks, we developed a pseudo error generator that spreads residual errors from training data to create a pseudo error for each unlabeled node. These pseudo errors are then utilized to train GNNs using DFA. Extensive experiments on 10 public benchmarks reveal that our learning framework outperforms not only previous non-BP methods but also the standard BP methods, and it exhibits excellent robustness against various types of noise and attacks.