MME-CoT: Benchmarking Chain-of-Thought in Large Multimodal Models for Reasoning Quality, Robustness, and Efficiency

Answering questions with Chain-of-Thought (CoT) has significantly enhanced the reasoning capabilities of Large Language Models (LLMs), yet its impact on Large Multimodal Models (LMMs) still lacks a systematic assessment and in-depth investigation. In this paper, we introduce MME-CoT, a specialized benchmark evaluating the CoT reasoning performance of LMMs, spanning six domains: math, science, OCR, logic, space-time, and general scenes. As the first comprehensive study in this area, we propose a thorough evaluation suite incorporating three novel metrics that assess the reasoning quality, robustness, and efficiency at a fine-grained level. Leveraging curated high-quality data and a unique evaluation strategy, we conduct an in-depth analysis of state-of-the-art LMMs, uncovering several key insights: 1) Models with reflection mechanism demonstrate a superior CoT quality, with Kimi k1.5 outperforming GPT-4o and demonstrating the highest quality results; 2) CoT prompting often degrades LMM performance on perception-heavy tasks, suggesting a potentially harmful overthinking behavior; and 3) Although the CoT quality is high, LMMs with reflection exhibit significant inefficiency in both normal response and self-correction phases. We hope MME-CoT serves as a foundation for advancing multimodal reasoning in LMMs. Project Page: https://mmecot.github.io/

IMAGINE-E: Image Generation Intelligence Evaluation of State-of-the-art Text-to-Image Models

With the rapid development of diffusion models, text-to-image(T2I) models have made significant progress, showcasing impressive abilities in prompt following and image generation. Recently launched models such as FLUX.1 and Ideogram2.0, along with others like Dall-E3 and Stable Diffusion 3, have demonstrated exceptional performance across various complex tasks, raising questions about whether T2I models are moving towards general-purpose applicability. Beyond traditional image generation, these models exhibit capabilities across a range of fields, including controllable generation, image editing, video, audio, 3D, and motion generation, as well as computer vision tasks like semantic segmentation and depth estimation. However, current evaluation frameworks are insufficient to comprehensively assess these models' performance across expanding domains. To thoroughly evaluate these models, we developed the IMAGINE-E and tested six prominent models: FLUX.1, Ideogram2.0, Midjourney, Dall-E3, Stable Diffusion 3, and Jimeng. Our evaluation is divided into five key domains: structured output generation, realism, and physical consistency, specific domain generation, challenging scenario generation, and multi-style creation tasks. This comprehensive assessment highlights each model's strengths and limitations, particularly the outstanding performance of FLUX.1 and Ideogram2.0 in structured and specific domain tasks, underscoring the expanding applications and potential of T2I models as foundational AI tools. This study provides valuable insights into the current state and future trajectory of T2I models as they evolve towards general-purpose usability. Evaluation scripts will be released at https://github.com/jylei16/Imagine-e.

Can We Generate Images with CoT? Let's Verify and Reinforce Image Generation Step by Step

Chain-of-Thought (CoT) reasoning has been extensively explored in large models to tackle complex understanding tasks. However, it still remains an open question whether such strategies can be applied to verifying and reinforcing image generation scenarios. In this paper, we provide the first comprehensive investigation of the potential of CoT reasoning to enhance autoregressive image generation. We focus on three techniques: scaling test-time computation for verification, aligning model preferences with Direct Preference Optimization (DPO), and integrating these techniques for complementary effects. Our results demonstrate that these approaches can be effectively adapted and combined to significantly improve image generation performance. Furthermore, given the pivotal role of reward models in our findings, we propose the Potential Assessment Reward Model (PARM) and PARM++, specialized for autoregressive image generation. PARM adaptively assesses each generation step through a potential assessment approach, merging the strengths of existing reward models, and PARM++ further introduces a reflection mechanism to self-correct the generated unsatisfactory image. Using our investigated reasoning strategies, we enhance a baseline model, Show-o, to achieve superior results, with a significant +24% improvement on the GenEval benchmark, surpassing Stable Diffusion 3 by +15%. We hope our study provides unique insights and paves a new path for integrating CoT reasoning with autoregressive image generation. Code and models are released at https://github.com/ZiyuGuo99/Image-Generation-CoT

Aligning Knowledge Concepts to Whole Slide Images for Precise Histopathology Image Analysis

Due to the large size and lack of fine-grained annotation, Whole Slide Images (WSIs) analysis is commonly approached as a Multiple Instance Learning (MIL) problem. However, previous studies only learn from training data, posing a stark contrast to how human clinicians teach each other and reason about histopathologic entities and factors. Here we present a novel knowledge concept-based MIL framework, named ConcepPath to fill this gap. Specifically, ConcepPath utilizes GPT-4 to induce reliable diseasespecific human expert concepts from medical literature, and incorporate them with a group of purely learnable concepts to extract complementary knowledge from training data. In ConcepPath, WSIs are aligned to these linguistic knowledge concepts by utilizing pathology vision-language model as the basic building component. In the application of lung cancer subtyping, breast cancer HER2 scoring, and gastric cancer immunotherapy-sensitive subtyping task, ConcepPath significantly outperformed previous SOTA methods which lack the guidance of human expert knowledge.

Point Cloud Understanding via Attention-Driven Contrastive Learning

Recently Transformer-based models have advanced point cloud understanding by leveraging self-attention mechanisms, however, these methods often overlook latent information in less prominent regions, leading to increased sensitivity to perturbations and limited global comprehension. To solve this issue, we introduce PointACL, an attention-driven contrastive learning framework designed to address these limitations. Our method employs an attention-driven dynamic masking strategy that guides the model to focus on under-attended regions, enhancing the understanding of global structures within the point cloud. Then we combine the original pre-training loss with a contrastive learning loss, improving feature discrimination and generalization. Extensive experiments validate the effectiveness of PointACL, as it achieves state-of-the-art performance across a variety of 3D understanding tasks, including object classification, part segmentation, and few-shot learning. Specifically, when integrated with different Transformer backbones like Point-MAE and PointGPT, PointACL demonstrates improved performance on datasets such as ScanObjectNN, ModelNet40, and ShapeNetPart. This highlights its superior capability in capturing both global and local features, as well as its enhanced robustness against perturbations and incomplete data.

SmoothCache: A Universal Inference Acceleration Technique for Diffusion Transformers

Diffusion Transformers (DiT) have emerged as powerful generative models for various tasks, including image, video, and speech synthesis. However, their inference process remains computationally expensive due to the repeated evaluation of resource-intensive attention and feed-forward modules. To address this, we introduce SmoothCache, a model-agnostic inference acceleration technique for DiT architectures. SmoothCache leverages the observed high similarity between layer outputs across adjacent diffusion timesteps. By analyzing layer-wise representation errors from a small calibration set, SmoothCache adaptively caches and reuses key features during inference. Our experiments demonstrate that SmoothCache achieves 8% to 71% speed up while maintaining or even improving generation quality across diverse modalities. We showcase its effectiveness on DiT-XL for image generation, Open-Sora for text-to-video, and Stable Audio Open for text-to-audio, highlighting its potential to enable real-time applications and broaden the accessibility of powerful DiT models.

Artificial Intelligence for Biomedical Video Generation

As a prominent subfield of Artificial Intelligence Generated Content (AIGC), video generation has achieved notable advancements in recent years. The introduction of Sora-alike models represents a pivotal breakthrough in video generation technologies, significantly enhancing the quality of synthesized videos. Particularly in the realm of biomedicine, video generation technology has shown immense potential such as medical concept explanation, disease simulation, and biomedical data augmentation. In this article, we thoroughly examine the latest developments in video generation models and explore their applications, challenges, and future opportunities in the biomedical sector. We have conducted an extensive review and compiled a comprehensive list of datasets from various sources to facilitate the development and evaluation of video generative models in biomedicine. Given the rapid progress in this field, we have also created a github repository to regularly update the advances of biomedical video generation at: https://github.com/Lee728243228/Biomedical-Video-Generation

SAM2Point: Segment Any 3D as Videos in Zero-shot and Promptable Manners

We introduce SAM2Point, a preliminary exploration adapting Segment Anything Model 2 (SAM 2) for zero-shot and promptable 3D segmentation. SAM2Point interprets any 3D data as a series of multi-directional videos, and leverages SAM 2 for 3D-space segmentation, without further training or 2D-3D projection. Our framework supports various prompt types, including 3D points, boxes, and masks, and can generalize across diverse scenarios, such as 3D objects, indoor scenes, outdoor environments, and raw sparse LiDAR. Demonstrations on multiple 3D datasets, e.g., Objaverse, S3DIS, ScanNet, Semantic3D, and KITTI, highlight the robust generalization capabilities of SAM2Point. To our best knowledge, we present the most faithful implementation of SAM in 3D, which may serve as a starting point for future research in promptable 3D segmentation. Online Demo: https://huggingface.co/spaces/ZiyuG/SAM2Point . Code: https://github.com/ZiyuGuo99/SAM2Point .

MAVIS: Mathematical Visual Instruction Tuning

Multi-modal Large Language Models (MLLMs) have recently emerged as a significant focus in academia and industry. Despite their proficiency in general multi-modal scenarios, the mathematical problem-solving capabilities in visual contexts remain insufficiently explored. We identify three key areas within MLLMs that need to be improved: visual encoding of math diagrams, diagram-language alignment, and mathematical reasoning skills. This draws forth an urgent demand for large-scale, high-quality data and training pipelines in visual mathematics. In this paper, we propose MAVIS, the first MAthematical VISual instruction tuning paradigm for MLLMs, involving a series of mathematical visual datasets and specialized MLLMs. Targeting the three issues, MAVIS contains three progressive training stages from scratch. First, we curate MAVIS-Caption, consisting of 558K diagram-caption pairs, to fine-tune a math-specific vision encoder (CLIP-Math) through contrastive learning, tailored for improved diagram visual encoding. Second, we utilize MAVIS-Caption to align the CLIP-Math with a large language model (LLM) by a projection layer, enhancing vision-language alignment in mathematical domains. Third, we introduce MAVIS-Instruct, including 900K meticulously collected and annotated visual math problems, which is adopted to finally instruct-tune the MLLM for robust mathematical reasoning skills. In MAVIS-Instruct, we incorporate complete chain-of-thought (CoT) rationales for each problem, and minimize textual redundancy, thereby concentrating the model towards the visual elements. Data and Models are released at https://github.com/ZrrSkywalker/MAVIS

TripletMix: Triplet Data Augmentation for 3D Understanding

Data augmentation has proven to be a vital tool for enhancing the generalization capabilities of deep learning models, especially in the context of 3D vision where traditional datasets are often limited. Despite previous advancements, existing methods primarily cater to unimodal data scenarios, leaving a gap in the augmentation of multimodal triplet data, which integrates text, images, and point clouds. Simultaneously augmenting all three modalities enhances diversity and improves alignment across modalities, resulting in more comprehensive and robust 3D representations. To address this gap, we propose TripletMix, a novel approach to address the previously unexplored issue of multimodal data augmentation in 3D understanding. TripletMix innovatively applies the principles of mixed-based augmentation to multimodal triplet data, allowing for the preservation and optimization of cross-modal connections. Our proposed TripletMix combines feature-level and input-level augmentations to achieve dual enhancement between raw data and latent features, significantly improving the model's cross-modal understanding and generalization capabilities by ensuring feature consistency and providing diverse and realistic training samples. We demonstrate that TripletMix not only improves the baseline performance of models in various learning scenarios including zero-shot and linear probing classification but also significantly enhances model generalizability. Notably, we improved the zero-shot classification accuracy on ScanObjectNN from 51.3 percent to 61.9 percent, and on Objaverse-LVIS from 46.8 percent to 51.4 percent. Our findings highlight the potential of multimodal data augmentation to significantly advance 3D object recognition and understanding.