DexSinGrasp: Learning a Unified Policy for Dexterous Object Singulation and Grasping in Cluttered Environments

Grasping objects in cluttered environments remains a fundamental yet challenging problem in robotic manipulation. While prior works have explored learning-based synergies between pushing and grasping for two-fingered grippers, few have leveraged the high degrees of freedom (DoF) in dexterous hands to perform efficient singulation for grasping in cluttered settings. In this work, we introduce DexSinGrasp, a unified policy for dexterous object singulation and grasping. DexSinGrasp enables high-dexterity object singulation to facilitate grasping, significantly improving efficiency and effectiveness in cluttered environments. We incorporate clutter arrangement curriculum learning to enhance success rates and generalization across diverse clutter conditions, while policy distillation enables a deployable vision-based grasping strategy. To evaluate our approach, we introduce a set of cluttered grasping tasks with varying object arrangements and occlusion levels. Experimental results show that our method outperforms baselines in both efficiency and grasping success rate, particularly in dense clutter. Codes, appendix, and videos are available on our project website https://nus-lins-lab.github.io/dexsingweb/.

BADGR: Bundle Adjustment Diffusion Conditioned by GRadients for Wide-Baseline Floor Plan Reconstruction

Reconstructing precise camera poses and floor plan layouts from wide-baseline RGB panoramas is a difficult and unsolved problem. We introduce BADGR, a novel diffusion model that jointly performs reconstruction and bundle adjustment (BA) to refine poses and layouts from a coarse state, using 1D floor boundary predictions from dozens of images of varying input densities. Unlike a guided diffusion model, BADGR is conditioned on dense per-entity outputs from a single-step Levenberg Marquardt (LM) optimizer and is trained to predict camera and wall positions while minimizing reprojection errors for view-consistency. The objective of layout generation from denoising diffusion process complements BA optimization by providing additional learned layout-structural constraints on top of the co-visible features across images. These constraints help BADGR to make plausible guesses on spatial relations which help constrain pose graph, such as wall adjacency, collinearity, and learn to mitigate errors from dense boundary observations with global contexts. BADGR trains exclusively on 2D floor plans, simplifying data acquisition, enabling robust augmentation, and supporting variety of input densities. Our experiments and analysis validate our method, which significantly outperforms the state-of-the-art pose and floor plan layout reconstruction with different input densities.

Offline Model-Based Optimization: Comprehensive Review

Offline optimization is a fundamental challenge in science and engineering, where the goal is to optimize black-box functions using only offline datasets. This setting is particularly relevant when querying the objective function is prohibitively expensive or infeasible, with applications spanning protein engineering, material discovery, neural architecture search, and beyond. The main difficulty lies in accurately estimating the objective landscape beyond the available data, where extrapolations are fraught with significant epistemic uncertainty. This uncertainty can lead to objective hacking(reward hacking), exploiting model inaccuracies in unseen regions, or other spurious optimizations that yield misleadingly high performance estimates outside the training distribution. Recent advances in model-based optimization(MBO) have harnessed the generalization capabilities of deep neural networks to develop offline-specific surrogate and generative models. Trained with carefully designed strategies, these models are more robust against out-of-distribution issues, facilitating the discovery of improved designs. Despite its growing impact in accelerating scientific discovery, the field lacks a comprehensive review. To bridge this gap, we present the first thorough review of offline MBO. We begin by formalizing the problem for both single-objective and multi-objective settings and by reviewing recent benchmarks and evaluation metrics. We then categorize existing approaches into two key areas: surrogate modeling, which emphasizes accurate function approximation in out-of-distribution regions, and generative modeling, which explores high-dimensional design spaces to identify high-performing designs. Finally, we examine the key challenges and propose promising directions for advancement in this rapidly evolving field including safe control of superintelligent systems.

Deformable Registration Framework for Augmented Reality-based Surgical Guidance in Head and Neck Tumor Resection

Head and neck squamous cell carcinoma (HNSCC) has one of the highest rates of recurrence cases among solid malignancies. Recurrence rates can be reduced by improving positive margins localization. Frozen section analysis (FSA) of resected specimens is the gold standard for intraoperative margin assessment. However, because of the complex 3D anatomy and the significant shrinkage of resected specimens, accurate margin relocation from specimen back onto the resection site based on FSA results remains challenging. We propose a novel deformable registration framework that uses both the pre-resection upper surface and the post-resection site of the specimen to incorporate thickness information into the registration process. The proposed method significantly improves target registration error (TRE), demonstrating enhanced adaptability to thicker specimens. In tongue specimens, the proposed framework improved TRE by up to 33% as compared to prior deformable registration. Notably, tongue specimens exhibit complex 3D anatomies and hold the highest clinical significance compared to other head and neck specimens from the buccal and skin. We analyzed distinct deformation behaviors in different specimens, highlighting the need for tailored deformation strategies. To further aid intraoperative visualization, we also integrated this framework with an augmented reality-based auto-alignment system. The combined system can accurately and automatically overlay the deformed 3D specimen mesh with positive margin annotation onto the resection site. With a pilot study of the AR guided framework involving two surgeons, the integrated system improved the surgeons' average target relocation error from 9.8 cm to 4.8 cm.

GrInAdapt: Scaling Retinal Vessel Structural Map Segmentation Through Grounding, Integrating and Adapting Multi-device, Multi-site, and Multi-modal Fundus Domains

Retinal vessel segmentation is critical for diagnosing ocular conditions, yet current deep learning methods are limited by modality-specific challenges and significant distribution shifts across imaging devices, resolutions, and anatomical regions. In this paper, we propose GrInAdapt, a novel framework for source-free multi-target domain adaptation that leverages multi-view images to refine segmentation labels and enhance model generalizability for optical coherence tomography angiography (OCTA) of the fundus of the eye. GrInAdapt follows an intuitive three-step approach: (i) grounding images to a common anchor space via registration, (ii) integrating predictions from multiple views to achieve improved label consensus, and (iii) adapting the source model to diverse target domains. Furthermore, GrInAdapt is flexible enough to incorporate auxiliary modalities such as color fundus photography, to provide complementary cues for robust vessel segmentation. Extensive experiments on a multi-device, multi-site, and multi-modal retinal dataset demonstrate that GrInAdapt significantly outperforms existing domain adaptation methods, achieving higher segmentation accuracy and robustness across multiple domains. These results highlight the potential of GrInAdapt to advance automated retinal vessel analysis and support robust clinical decision-making.

Synthetic imagery for fuzzy object detection: A comparative study

The fuzzy object detection is a challenging field of research in computer vision (CV). Distinguishing between fuzzy and non-fuzzy object detection in CV is important. Fuzzy objects such as fire, smoke, mist, and steam present significantly greater complexities in terms of visual features, blurred edges, varying shapes, opacity, and volume compared to non-fuzzy objects such as trees and cars. Collection of a balanced and diverse dataset and accurate annotation is crucial to achieve better ML models for fuzzy objects, however, the task of collection and annotation is still highly manual. In this research, we propose and leverage an alternative method of generating and automatically annotating fully synthetic fire images based on 3D models for training an object detection model. Moreover, the performance, and efficiency of the trained ML models on synthetic images is compared with ML models trained on real imagery and mixed imagery. Findings proved the effectiveness of the synthetic data for fire detection, while the performance improves as the test dataset covers a broader spectrum of real fires. Our findings illustrates that when synthetic imagery and real imagery is utilized in a mixed training set the resulting ML model outperforms models trained on real imagery as well as models trained on synthetic imagery for detection of a broad spectrum of fires. The proposed method for automating the annotation of synthetic fuzzy objects imagery carries substantial implications for reducing both time and cost in creating computer vision models specifically tailored for detecting fuzzy objects.

Robust Guided Diffusion for Offline Black-Box Optimization

Offline black-box optimization aims to maximize a black-box function using an offline dataset of designs and their measured properties. Two main approaches have emerged: the forward approach, which learns a mapping from input to its value, thereby acting as a proxy to guide optimization, and the inverse approach, which learns a mapping from value to input for conditional generation. (a) Although proxy-free~(classifier-free) diffusion shows promise in robustly modeling the inverse mapping, it lacks explicit guidance from proxies, essential for generating high-performance samples beyond the training distribution. Therefore, we propose \textit{proxy-enhanced sampling} which utilizes the explicit guidance from a trained proxy to bolster proxy-free diffusion with enhanced sampling control. (b) Yet, the trained proxy is susceptible to out-of-distribution issues. To address this, we devise the module \textit{diffusion-based proxy refinement}, which seamlessly integrates insights from proxy-free diffusion back into the proxy for refinement. To sum up, we propose \textit{\textbf{R}obust \textbf{G}uided \textbf{D}iffusion for Offline Black-box Optimization}~(\textbf{RGD}), combining the advantages of proxy~(explicit guidance) and proxy-free diffusion~(robustness) for effective conditional generation. RGD achieves state-of-the-art results on various design-bench tasks, underscoring its efficacy. Our code is at https://anonymous.4open.science/r/RGD-27A5/README.md.

OCTCube: A 3D foundation model for optical coherence tomography that improves cross-dataset, cross-disease, cross-device and cross-modality analysis

Optical coherence tomography (OCT) has become critical for diagnosing retinal diseases as it enables 3D images of the retina and optic nerve. OCT acquisition is fast, non-invasive, affordable, and scalable. Due to its broad applicability, massive numbers of OCT images have been accumulated in routine exams, making it possible to train large-scale foundation models that can generalize to various diagnostic tasks using OCT images. Nevertheless, existing foundation models for OCT only consider 2D image slices, overlooking the rich 3D structure. Here, we present OCTCube, a 3D foundation model pre-trained on 26,605 3D OCT volumes encompassing 1.62 million 2D OCT images. OCTCube is developed based on 3D masked autoencoders and exploits FlashAttention to reduce the larger GPU memory usage caused by modeling 3D volumes. OCTCube outperforms 2D models when predicting 8 retinal diseases in both inductive and cross-dataset settings, indicating that utilizing the 3D structure in the model instead of 2D data results in significant improvement. OCTCube further shows superior performance on cross-device prediction and when predicting systemic diseases, such as diabetes and hypertension, further demonstrating its strong generalizability. Finally, we propose a contrastive-self-supervised-learning-based OCT-IR pre-training framework (COIP) for cross-modality analysis on OCT and infrared retinal (IR) images, where the OCT volumes are embedded using OCTCube. We demonstrate that COIP enables accurate alignment between OCT and IR en face images. Collectively, OCTCube, a 3D OCT foundation model, demonstrates significantly better performance against 2D models on 27 out of 29 tasks and comparable performance on the other two tasks, paving the way for AI-based retinal disease diagnosis.

ManiFoundation Model for General-Purpose Robotic Manipulation of Contact Synthesis with Arbitrary Objects and Robots

To substantially enhance robot intelligence, there is a pressing need to develop a large model that enables general-purpose robots to proficiently undertake a broad spectrum of manipulation tasks, akin to the versatile task-planning ability exhibited by LLMs. The vast diversity in objects, robots, and manipulation tasks presents huge challenges. Our work introduces a comprehensive framework to develop a foundation model for general robotic manipulation that formalizes a manipulation task as contact synthesis. Specifically, our model takes as input object and robot manipulator point clouds, object physical attributes, target motions, and manipulation region masks. It outputs contact points on the object and associated contact forces or post-contact motions for robots to achieve the desired manipulation task. We perform extensive experiments both in the simulation and real-world settings, manipulating articulated rigid objects, rigid objects, and deformable objects that vary in dimensionality, ranging from one-dimensional objects like ropes to two-dimensional objects like cloth and extending to three-dimensional objects such as plasticine. Our model achieves average success rates of around 90\%. Supplementary materials and videos are available on our project website at https://manifoundationmodel.github.io/.

Enhancing LLM Safety via Constrained Direct Preference Optimization

The rapidly increasing capabilities of large language models (LLMs) raise an urgent need to align AI systems with diverse human preferences to simultaneously enhance their usefulness and safety, despite the often conflicting nature of these goals. To address this important problem, a promising approach is to enforce a safety constraint at the fine-tuning stage through a constrained Reinforcement Learning from Human Feedback (RLHF) framework. This approach, however, is computationally expensive and often unstable. In this work, we introduce Constrained DPO (C-DPO), a novel extension of the recently proposed Direct Preference Optimization (DPO) approach for fine-tuning LLMs that is both efficient and lightweight. By integrating dual gradient descent and DPO, our method identifies a nearly optimal trade-off between helpfulness and harmlessness without using reinforcement learning. Empirically, our approach provides a safety guarantee to LLMs that is missing in DPO while achieving significantly higher rewards under the same safety constraint compared to a recently proposed safe RLHF approach. Warning: This paper contains example data that may be offensive or harmful.