EvoMaster: A Foundational Evolving Agent Framework for Agentic Science at Scale

The convergence of large language models and agents is catalyzing a new era of scientific discovery: Agentic Science. While the scientific method is inherently iterative, existing agent frameworks are predominantly static, narrowly scoped, and lack the capacity to learn from trial and error. To bridge this gap, we present EvoMaster, a foundational evolving agent framework engineered specifically for Agentic Science at Scale. Driven by the core principle of continuous self-evolution, EvoMaster empowers agents to iteratively refine hypotheses, self-critique, and progressively accumulate knowledge across experimental cycles, faithfully mirroring human scientific inquiry. Crucially, as a domain-agnostic base harness, EvoMaster is exceptionally easy to scale up -- enabling developers to build and deploy highly capable, self-evolving scientific agents for arbitrary disciplines in approximately 100 lines of code. Built upon EvoMaster, we incubated the SciMaster ecosystem across domains such as machine learning, physics, and general science. Evaluations on four authoritative benchmarks (Humanity's Last Exam, MLE-Bench Lite, BrowseComp, and FrontierScience) demonstrate that EvoMaster achieves state-of-the-art scores of 41.1%, 75.8%, 73.3%, and 53.3%, respectively. It comprehensively outperforms the general-purpose baseline OpenClaw with relative improvements ranging from +159% to +316%, robustly validating its efficacy and generality as the premier foundational framework for the next generation of autonomous scientific discovery. EvoMaster is available at https://github.com/sjtu-sai-agents/EvoMaster.

POINTS-Seeker: Towards Training a Multimodal Agentic Search Model from Scratch

While Large Multimodal Models (LMMs) demonstrate impressive visual perception, they remain epistemically constrained by their static parametric knowledge. To transcend these boundaries, multimodal search models have been adopted to actively interact with the external environment for evidence retrieval. Diverging from prevailing paradigms that merely retrofit general LMMs with search tools as modular extensions, we explore the potential of building a multimodal agentic search model from scratch. Specifically, we make the following contributions: (i) we introduce Agentic Seeding, a dedicated phase designed to weave the foundational precursors necessary for eliciting agentic behaviors; (ii) we uncover a performance bottleneck in long-horizon interactions, where the increasing volume of interaction history overwhelms the model's ability to locate ground-truth evidence. To mitigate this, we propose V-Fold, an adaptive history-aware compression scheme that preserves recent dialogue turns in high fidelity while folding historical context into the visual space via rendering; and (iii) we develop POINTS-Seeker-8B, a state-of-the-art multimodal agentic search model that consistently outperforms existing models across six diverse benchmarks, effectively resolving the challenges of long-horizon, knowledge-intensive visual reasoning.

A Sanity Check on Composed Image Retrieval

Composed Image Retrieval (CIR) aims to retrieve a target image based on a query composed of a reference image, and a relative caption that specifies the desired modification. Despite the rapid development of CIR models, their performance is not well characterized by existing benchmarks, which inherently contain indeterminate queries degrading the evaluation (i.e., multiple candidate images, rather than solely the target image, meet the query criteria), and have not considered their effectiveness in the context of the multi-round system. Motivated by this, we consider improving the evaluation procedure from two aspects: 1) we introduce FISD, a Fully-Informed Semantically-Diverse benchmark, which employs generative models to precisely control the variables of reference-target image pairs, enabling a more accurate evaluation of CIR methods across six dimensions, without query ambiguity; 2) we propose an automatic multi-round agentic evaluation framework to probe the potential of the existing models in the interactive scenarios. By observing how models adapt and refine their choices over successive rounds of queries, this framework provides a more realistic appraisal of their efficacy in practical applications. Extensive experiments and comparisons prove the value of our novel evaluation on typical CIR methods.

POINTS-Long: Adaptive Dual-Mode Visual Reasoning in MLLMs

Multimodal Large Language Models (MLLMs) have recently demonstrated remarkable capabilities in cross-modal understanding and generation. However, the rapid growth of visual token sequences--especially in long-video and streaming scenarios--poses a major challenge to their scalability and real-world deployment. Thus, we introduce POINTS-Long, a native dual-mode MLLM featuring dynamic visual token scaling inspired by the human visual system. The model supports two complementary perception modes: focus mode and standby mode, enabling users to dynamically trade off efficiency and accuracy during inference. On fine-grained visual tasks, the focus mode retains the optimal performance, while on long-form general visual understanding, the standby mode retains 97.7-99.7% of the original accuracy using only 1/40-1/10th of the visual tokens. Moreover, POINTS-Long natively supports streaming visual understanding via a dynamically detachable KV-cache design, allowing efficient maintenance of ultra-long visual memory. Our work provides new insights into the design of future MLLMs and lays the foundation for adaptive and efficient long-form visual understanding.

GenTac: Generative Modeling and Forecasting of Soccer Tactics

Modeling open-play soccer tactics is a formidable challenge due to the stochastic, multi-agent nature of the game. Existing computational approaches typically produce single, deterministic trajectory forecasts or focus on highly structured set-pieces, fundamentally failing to capture the inherent variance and branching possibilities of real-world match evolution. Here, we introduce GenTac, a diffusion-based generative framework that conceptualizes soccer tactics as a stochastic process over continuous multi-player trajectories and discrete semantic events. By learning the underlying distribution of player movements from historical tracking data, GenTac samples diverse, plausible, long-horizon future trajectories. The framework supports rich contextual conditioning, including opponent behavior, specific team or league playing styles, and strategic objectives, while grounding continuous spatial dynamics into a 15-class tactical event space. Extensive evaluations on our proposed benchmark, TacBench, demonstrate four key capabilities: (1) GenTac achieves high geometric accuracy while strictly preserving the collective structural consistency of the team; (2) it accurately simulates stylistic nuances, distinguishing between specific teams (e.g., Auckland FC) and leagues (e.g., A-League versus German leagues); (3) it enables controllable counterfactual simulations, demonstrably altering spatial control and expected threat metrics based on offensive or defensive guidance; and (4) it reliably anticipates future tactical outcomes directly from generated rollouts. Finally, we demonstrate that GenTac can be successfully trained to generalize to other dynamic team sports, including basketball, American football, and ice hockey.

Eliciting Medical Reasoning with Knowledge-enhanced Data Synthesis: A Semi-Supervised Reinforcement Learning Approach

While large language models hold promise for complex medical applications, their development is hindered by the scarcity of high-quality reasoning data. To address this issue, existing approaches typically distill chain-of-thought reasoning traces from large proprietary models via supervised fine-tuning, then conduct reinforcement learning (RL). These methods exhibit limited improvement on underrepresented domains like rare diseases while incurring substantial costs from generating complex reasoning chains. To efficiently enhance medical reasoning, we propose MedSSR, a Medical Knowledge-enhanced data Synthesis and Semi-supervised Reinforcement learning framework. Our framework first employs rare disease knowledge to synthesize distribution-controllable reasoning questions. We then utilize the policy model itself to generate high-quality pseudo-labels. This enables a two-stage, intrinsic-to-extrinsic training paradigm: self-supervised RL on the pseudo-labeled synthetic data, followed by supervised RL on the human-annotated real data. MedSSR scales model training efficiently without relying on costly trace distillation. Extensive experiments on Qwen and Llama demonstrate that our method outperforms existing methods across ten medical benchmarks, achieving up to +5.93% gain on rare-disease tasks. Our code is available at https://github.com/tdlhl/MedSSR.

Cross-Modal Coreference Alignment: Enabling Reliable Information Transfer in Omni-LLMs

Omni Large Language Models (Omni-LLMs) have demonstrated impressive capabilities in holistic multi-modal perception, yet they consistently falter in complex scenarios requiring synergistic omni-modal reasoning. Beyond understanding global multimodal context, effective reasoning also hinges on fine-grained cross-modal alignment, especially identifying shared referents across modalities, yet this aspect has been largely overlooked. To bridge this gap, we formalize the challenge as a cross-modal coreference problem, where a model must localize a referent in a source modality and re-identify it in a target modality. Building on this paradigm, we introduce CrossOmni, a dataset comprising nine tasks equipped with human-designed reasoning rationales to evaluate and enhance this capability. Experiments on 13 Omni-LLMs reveal systematic weaknesses in cross-modal coreference, which we attribute to the absence of coreference-aware thinking patterns. To address this, we enhance cross-modal alignment via two strategies: a training-free In-Context Learning method and a training-based SFT+GRPO framework designed to induce such thinking patterns. Both approaches yield substantial performance gains and generalize effectively to collaborative reasoning tasks. Overall, our findings highlight cross-modal coreference as a crucial missing piece for advancing robust omni-modal reasoning.

Predicting Neuromodulation Outcome for Parkinson's Disease with Generative Virtual Brain Model

Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing non-negligible surgical risk and cost. Previous explorations either resort to limited statistical biomarkers that are insufficient to characterize variability, or employ AI-driven methods which is prone to overfitting and opacity. We bridge this gap with a pretraining-finetuning framework to predict outcomes directly from resting-state fMRI. Critically, a generative virtual brain foundation model, pretrained on a collective dataset (2707 subjects, 5621 sessions) to capture universal disorder patterns, was finetuned on PD cohorts receiving TI (n=51) or DBS (n=55) to yield individualized virtual brains with high fidelity to empirical functional connectivity (r=0.935). By constructing counterfactual estimations between pathological and healthy neural states within these personalized models, we predicted clinical responses (TI: AUPR=0.853; DBS: AUPR=0.915), substantially outperforming baselines. External and prospective validations (n=14, n=11) highlight the feasibility of clinical translation. Moreover, our framework provides state-dependent regional patterns linked to response, offering hypothesis-generating mechanistic insights.

GenMask: Adapting DiT for Segmentation via Direct Mask

Recent approaches for segmentation have leveraged pretrained generative models as feature extractors, treating segmentation as a downstream adaptation task via indirect feature retrieval. This implicit use suffers from a fundamental misalignment in representation. It also depends heavily on indirect feature extraction pipelines, which complicate the workflow and limit adaptation. In this paper, we argue that instead of indirect adaptation, segmentation tasks should be trained directly in a generative manner. We identify a key obstacle to this unified formulation: VAE latents of binary masks are sharply distributed, noise robust, and linearly separable, distinct from natural image latents. To bridge this gap, we introduce timesteps sampling strategy for binary masks that emphasizes extreme noise levels for segmentation and moderate noise for image generation, enabling harmonious joint training. We present GenMask, a DiT trains to generate black-and-white segmentation masks as well as colorful images in RGB space under the original generative objective. GenMask preserves the original DiT architecture while removing the need of feature extraction pipelines tailored for segmentation tasks. Empirically, GenMask attains state-of-the-art performance on referring and reasoning segmentation benchmarks and ablations quantify the contribution of each component.

Demographic-Aware Self-Supervised Anomaly Detection Pretraining for Equitable Rare Cardiac Diagnosis

Rare cardiac anomalies are difficult to detect from electrocardiograms (ECGs) due to their long-tailed distribution with extremely limited case counts and demographic disparities in diagnostic performance. These limitations contribute to delayed recognition and uneven quality of care, creating an urgent need for a generalizable framework that enhances sensitivity while ensuring equity across diverse populations. In this study, we developed an AI-assisted two-stage ECG framework integrating self-supervised anomaly detection with demographic-aware representation learning. The first stage performs self-supervised anomaly detection pretraining by reconstructing masked global and local ECG signals, modeling signal trends, and predicting patient attributes to learn robust ECG representations without diagnostic labels. The pretrained model is then fine-tuned for multi-label ECG classification using asymmetric loss to better handle long-tail cardiac abnormalities, and additionally produces anomaly score maps for localization, with CPU-based optimization enabling practical deployment. Evaluated on a longitudinal cohort of over one million clinical ECGs, our method achieves an AUROC of 94.7% for rare anomalies and reduces the common-rare performance gap by 73%, while maintaining consistent diagnostic accuracy across age and sex groups. In conclusion, the proposed equity-aware AI framework demonstrates strong clinical utility, interpretable anomaly localization, and scalable performance across multiple cohorts, highlighting its potential to mitigate diagnostic disparities and advance equitable anomaly detection in biomedical signals and digital health. Source code is available at https://github.com/MediaBrain-SJTU/Rare-ECG.