M^3Builder: A Multi-Agent System for Automated Machine Learning in Medical Imaging

Agentic AI systems have gained significant attention for their ability to autonomously perform complex tasks. However, their reliance on well-prepared tools limits their applicability in the medical domain, which requires to train specialized models. In this paper, we make three contributions: (i) We present M3Builder, a novel multi-agent system designed to automate machine learning (ML) in medical imaging. At its core, M3Builder employs four specialized agents that collaborate to tackle complex, multi-step medical ML workflows, from automated data processing and environment configuration to self-contained auto debugging and model training. These agents operate within a medical imaging ML workspace, a structured environment designed to provide agents with free-text descriptions of datasets, training codes, and interaction tools, enabling seamless communication and task execution. (ii) To evaluate progress in automated medical imaging ML, we propose M3Bench, a benchmark comprising four general tasks on 14 training datasets, across five anatomies and three imaging modalities, covering both 2D and 3D data. (iii) We experiment with seven state-of-the-art large language models serving as agent cores for our system, such as Claude series, GPT-4o, and DeepSeek-V3. Compared to existing ML agentic designs, M3Builder shows superior performance on completing ML tasks in medical imaging, achieving a 94.29% success rate using Claude-3.7-Sonnet as the agent core, showing huge potential towards fully automated machine learning in medical imaging.

Contrast-Unity for Partially-Supervised Temporal Sentence Grounding

Temporal sentence grounding aims to detect event timestamps described by the natural language query from given untrimmed videos. The existing fully-supervised setting achieves great results but requires expensive annotation costs; while the weakly-supervised setting adopts cheap labels but performs poorly. To pursue high performance with less annotation costs, this paper introduces an intermediate partially-supervised setting, i.e., only short-clip is available during training. To make full use of partial labels, we specially design one contrast-unity framework, with the two-stage goal of implicit-explicit progressive grounding. In the implicit stage, we align event-query representations at fine granularity using comprehensive quadruple contrastive learning: event-query gather, event-background separation, intra-cluster compactness and inter-cluster separability. Then, high-quality representations bring acceptable grounding pseudo-labels. In the explicit stage, to explicitly optimize grounding objectives, we train one fully-supervised model using obtained pseudo-labels for grounding refinement and denoising. Extensive experiments and thoroughly ablations on Charades-STA and ActivityNet Captions demonstrate the significance of partial supervision, as well as our superior performance.

FedMobileAgent: Training Mobile Agents Using Decentralized Self-Sourced Data from Diverse Users

The advancement of mobile agents has opened new opportunities for automating tasks on mobile devices. Training these agents requires large-scale high-quality data, which is costly using human labor. Given the vast number of mobile phone users worldwide, if automated data collection from them is feasible, the resulting data volume and the subsequently trained mobile agents could reach unprecedented levels. Nevertheless, two major challenges arise: (1) extracting high-level and low-level user instructions without involving human and (2) utilizing distributed data from diverse users while preserving privacy. To tackle these challenges, we propose FedMobileAgent, a collaborative framework that trains mobile agents using self-sourced data from diverse users. Specifically, it includes two techniques. First, we propose Auto-Annotation, which enables the automatic collection of high-quality datasets during users' routine phone usage with minimal cost. Second, we introduce adapted aggregation to improve federated training of mobile agents on non-IID user data, by incorporating both episode- and step-level distributions. In distributed settings, FedMobileAgent achieves performance comparable to centralized human-annotated models at less than 0.02\% of the cost, highlighting its potential for real-world applications.

WanJuanSiLu: A High-Quality Open-Source Webtext Dataset for Low-Resource Languages

This paper introduces the open-source dataset WanJuanSiLu, designed to provide high-quality training corpora for low-resource languages, thereby advancing the research and development of multilingual models. To achieve this, we have developed a systematic data processing framework tailored for low-resource languages. This framework encompasses key stages such as data extraction, corpus cleaning, content deduplication, security filtering, quality evaluation, and theme classification. Through the implementation of this framework, we have significantly improved both the quality and security of the dataset, while maintaining its linguistic diversity. As of now, data for all five languages have been fully open-sourced. The dataset can be accessed at https://opendatalab.com/applyMultilingualCorpus, and GitHub repository is available at https://github.com/opendatalab/WanJuan3.0

MedS$^3$: Towards Medical Small Language Models with Self-Evolved Slow Thinking

Medical language models (MLMs) have become pivotal in advancing medical natural language processing. However, prior models that rely on pre-training or supervised fine-tuning often exhibit low data efficiency and limited practicality in real-world clinical applications. While OpenAIs O1 highlights test-time scaling in mathematics, attempts to replicate this approach in medicine typically distill responses from GPT-series models to open-source models, focusing primarily on multiple-choice tasks. This strategy, though straightforward, neglects critical concerns like data privacy and realistic deployment in clinical settings. In this work, we present a deployable, small-scale medical language model, \mone, designed for long-chain reasoning in clinical tasks using a self-evolution paradigm. Starting with a seed dataset of around 8,000 instances spanning five domains and 16 datasets, we prompt a base policy model to perform Monte Carlo Tree Search (MCTS) to construct verifiable reasoning chains. Each reasoning step is assigned an evolution rollout value, allowing verified trajectories to train the policy model and the reward model. During inference, the policy model generates multiple responses, and the reward model selects the one with the highest reward score. Experiments on eleven evaluation datasets demonstrate that \mone outperforms prior open-source models by 2 points, with the addition of the reward model further boosting performance ($\sim$13 points), surpassing GPT-4o-mini. Code and data are available at \url{https://github.com/pixas/MedSSS}.

Active Sampling for Node Attribute Completion on Graphs

Node attribute, a type of crucial information for graph analysis, may be partially or completely missing for certain nodes in real world applications. Restoring the missing attributes is expected to benefit downstream graph learning. Few attempts have been made on node attribute completion, but a novel framework called Structure-attribute Transformer (SAT) was recently proposed by using a decoupled scheme to leverage structures and attributes. SAT ignores the differences in contributing to the learning schedule and finding a practical way to model the different importance of nodes with observed attributes is challenging. This paper proposes a novel AcTive Sampling algorithm (ATS) to restore missing node attributes. The representativeness and uncertainty of each node's information are first measured based on graph structure, representation similarity and learning bias. To select nodes as train samples in the next optimization step, a weighting scheme controlled by Beta distribution is then introduced to linearly combine the two properties. Extensive experiments on four public benchmark datasets and two downstream tasks have shown the superiority of ATS in node attribute completion.

Towards Omni-RAG: Comprehensive Retrieval-Augmented Generation for Large Language Models in Medical Applications

Large language models (LLMs) hold promise for addressing healthcare challenges but often generate hallucinations due to limited integration of medical knowledge. Incorporating external medical knowledge is therefore critical, especially considering the breadth and complexity of medical content, which necessitates effective multi-source knowledge acquisition. We address this challenge by framing it as a source planning problem, where the task is to formulate context-appropriate queries tailored to the attributes of diverse knowledge sources. Existing approaches either overlook source planning or fail to achieve it effectively due to misalignment between the model's expectation of the sources and their actual content. To bridge this gap, we present MedOmniKB, a comprehensive repository comprising multigenre and multi-structured medical knowledge sources. Leveraging these sources, we propose the Source Planning Optimisation (SPO) method, which enhances multi-source utilisation through explicit planning optimisation. Our approach involves enabling an expert model to explore and evaluate potential plans while training a smaller model to learn source alignment using positive and negative planning samples. Experimental results demonstrate that our method substantially improves multi-source planning performance, enabling the optimised small model to achieve state-of-the-art results in leveraging diverse medical knowledge sources.

A Knowledge-enhanced Pathology Vision-language Foundation Model for Cancer Diagnosis

Deep learning has enabled the development of highly robust foundation models for various pathological tasks across diverse diseases and patient cohorts. Among these models, vision-language pre-training, which leverages large-scale paired data to align pathology image and text embedding spaces, and provides a novel zero-shot paradigm for downstream tasks. However, existing models have been primarily data-driven and lack the incorporation of domain-specific knowledge, which limits their performance in cancer diagnosis, especially for rare tumor subtypes. To address this limitation, we establish a Knowledge-enhanced Pathology (KEEP) foundation model that harnesses disease knowledge to facilitate vision-language pre-training. Specifically, we first construct a disease knowledge graph (KG) that covers 11,454 human diseases with 139,143 disease attributes, including synonyms, definitions, and hypernym relations. We then systematically reorganize the millions of publicly available noisy pathology image-text pairs, into 143K well-structured semantic groups linked through the hierarchical relations of the disease KG. To derive more nuanced image and text representations, we propose a novel knowledge-enhanced vision-language pre-training approach that integrates disease knowledge into the alignment within hierarchical semantic groups instead of unstructured image-text pairs. Validated on 18 diverse benchmarks with more than 14,000 whole slide images (WSIs), KEEP achieves state-of-the-art performance in zero-shot cancer diagnostic tasks. Notably, for cancer detection, KEEP demonstrates an average sensitivity of 89.8% at a specificity of 95.0% across 7 cancer types. For cancer subtyping, KEEP achieves a median balanced accuracy of 0.456 in subtyping 30 rare brain cancers, indicating strong generalizability for diagnosing rare tumors.

VRVVC: Variable-Rate NeRF-Based Volumetric Video Compression

Neural Radiance Field (NeRF)-based volumetric video has revolutionized visual media by delivering photorealistic Free-Viewpoint Video (FVV) experiences that provide audiences with unprecedented immersion and interactivity. However, the substantial data volumes pose significant challenges for storage and transmission. Existing solutions typically optimize NeRF representation and compression independently or focus on a single fixed rate-distortion (RD) tradeoff. In this paper, we propose VRVVC, a novel end-to-end joint optimization variable-rate framework for volumetric video compression that achieves variable bitrates using a single model while maintaining superior RD performance. Specifically, VRVVC introduces a compact tri-plane implicit residual representation for inter-frame modeling of long-duration dynamic scenes, effectively reducing temporal redundancy. We further propose a variable-rate residual representation compression scheme that leverages a learnable quantization and a tiny MLP-based entropy model. This approach enables variable bitrates through the utilization of predefined Lagrange multipliers to manage the quantization error of all latent representations. Finally, we present an end-to-end progressive training strategy combined with a multi-rate-distortion loss function to optimize the entire framework. Extensive experiments demonstrate that VRVVC achieves a wide range of variable bitrates within a single model and surpasses the RD performance of existing methods across various datasets.

Drawing the Line: Enhancing Trustworthiness of MLLMs Through the Power of Refusal

Multimodal large language models (MLLMs) excel at multimodal perception and understanding, yet their tendency to generate hallucinated or inaccurate responses undermines their trustworthiness. Existing methods have largely overlooked the importance of refusal responses as a means of enhancing MLLMs reliability. To bridge this gap, we present the Information Boundary-aware Learning Framework (InBoL), a novel approach that empowers MLLMs to refuse to answer user queries when encountering insufficient information. To the best of our knowledge, InBoL is the first framework that systematically defines the conditions under which refusal is appropriate for MLLMs using the concept of information boundaries proposed in our paper. This framework introduces a comprehensive data generation pipeline and tailored training strategies to improve the model's ability to deliver appropriate refusal responses. To evaluate the trustworthiness of MLLMs, we further propose a user-centric alignment goal along with corresponding metrics. Experimental results demonstrate a significant improvement in refusal accuracy without noticeably compromising the model's helpfulness, establishing InBoL as a pivotal advancement in building more trustworthy MLLMs.