A Knowledge-enhanced Pathology Vision-language Foundation Model for Cancer Diagnosis

Deep learning has enabled the development of highly robust foundation models for various pathological tasks across diverse diseases and patient cohorts. Among these models, vision-language pre-training, which leverages large-scale paired data to align pathology image and text embedding spaces, and provides a novel zero-shot paradigm for downstream tasks. However, existing models have been primarily data-driven and lack the incorporation of domain-specific knowledge, which limits their performance in cancer diagnosis, especially for rare tumor subtypes. To address this limitation, we establish a Knowledge-enhanced Pathology (KEEP) foundation model that harnesses disease knowledge to facilitate vision-language pre-training. Specifically, we first construct a disease knowledge graph (KG) that covers 11,454 human diseases with 139,143 disease attributes, including synonyms, definitions, and hypernym relations. We then systematically reorganize the millions of publicly available noisy pathology image-text pairs, into 143K well-structured semantic groups linked through the hierarchical relations of the disease KG. To derive more nuanced image and text representations, we propose a novel knowledge-enhanced vision-language pre-training approach that integrates disease knowledge into the alignment within hierarchical semantic groups instead of unstructured image-text pairs. Validated on 18 diverse benchmarks with more than 14,000 whole slide images (WSIs), KEEP achieves state-of-the-art performance in zero-shot cancer diagnostic tasks. Notably, for cancer detection, KEEP demonstrates an average sensitivity of 89.8% at a specificity of 95.0% across 7 cancer types. For cancer subtyping, KEEP achieves a median balanced accuracy of 0.456 in subtyping 30 rare brain cancers, indicating strong generalizability for diagnosing rare tumors.

Can Modern LLMs Act as Agent Cores in Radiology~Environments?

Advancements in large language models (LLMs) have paved the way for LLM-based agent systems that offer enhanced accuracy and interpretability across various domains. Radiology, with its complex analytical requirements, is an ideal field for the application of these agents. This paper aims to investigate the pre-requisite question for building concrete radiology agents which is, `Can modern LLMs act as agent cores in radiology environments?' To investigate it, we introduce RadABench with three-fold contributions: First, we present RadABench-Data, a comprehensive synthetic evaluation dataset for LLM-based agents, generated from an extensive taxonomy encompassing 6 anatomies, 5 imaging modalities, 10 tool categories, and 11 radiology tasks. Second, we propose RadABench-EvalPlat, a novel evaluation platform for agents featuring a prompt-driven workflow and the capability to simulate a wide range of radiology toolsets. Third, we assess the performance of 7 leading LLMs on our benchmark from 5 perspectives with multiple metrics. Our findings indicate that while current LLMs demonstrate strong capabilities in many areas, they are still not sufficiently advanced to serve as the central agent core in a fully operational radiology agent system. Additionally, we identify key factors influencing the performance of LLM-based agent cores, offering insights for clinicians on how to apply agent systems in real-world radiology practices effectively. All of our code and data are open-sourced in https://github.com/MAGIC-AI4Med/RadABench.

MRGen: Diffusion-based Controllable Data Engine for MRI Segmentation towards Unannotated Modalities

Medical image segmentation has recently demonstrated impressive progress with deep neural networks, yet the heterogeneous modalities and scarcity of mask annotations limit the development of segmentation models on unannotated modalities. This paper investigates a new paradigm for leveraging generative models in medical applications: controllably synthesizing data for unannotated modalities, without requiring registered data pairs. Specifically, we make the following contributions in this paper: (i) we collect and curate a large-scale radiology image-text dataset, MedGen-1M, comprising modality labels, attributes, region, and organ information, along with a subset of organ mask annotations, to support research in controllable medical image generation; (ii) we propose a diffusion-based data engine, termed MRGen, which enables generation conditioned on text prompts and masks, synthesizing MR images for diverse modalities lacking mask annotations, to train segmentation models on unannotated modalities; (iii) we conduct extensive experiments across various modalities, illustrating that our data engine can effectively synthesize training samples and extend MRI segmentation towards unannotated modalities.

Towards Universal Soccer Video Understanding

As a globally celebrated sport, soccer has attracted widespread interest from fans over the world. This paper aims to develop a comprehensive multi-modal framework for soccer video understanding. Specifically, we make the following contributions in this paper: (i) we introduce SoccerReplay-1988, the largest multi-modal soccer dataset to date, featuring videos and detailed annotations from 1,988 complete matches, with an automated annotation pipeline; (ii) we present the first visual-language foundation model in the soccer domain, MatchVision, which leverages spatiotemporal information across soccer videos and excels in various downstream tasks; (iii) we conduct extensive experiments and ablation studies on action classification, commentary generation, and multi-view foul recognition, and demonstrate state-of-the-art performance on all of them, substantially outperforming existing models, which has demonstrated the superiority of our proposed data and model. We believe that this work will offer a standard paradigm for sports understanding research. The code and model will be publicly available for reproduction.

Continual Task Learning through Adaptive Policy Self-Composition

Training a generalizable agent to continually learn a sequence of tasks from offline trajectories is a natural requirement for long-lived agents, yet remains a significant challenge for current offline reinforcement learning (RL) algorithms. Specifically, an agent must be able to rapidly adapt to new tasks using newly collected trajectories (plasticity), while retaining knowledge from previously learned tasks (stability). However, systematic analyses of this setting are scarce, and it remains unclear whether conventional continual learning (CL) methods are effective in continual offline RL (CORL) scenarios. In this study, we develop the Offline Continual World benchmark and demonstrate that traditional CL methods struggle with catastrophic forgetting, primarily due to the unique distribution shifts inherent to CORL scenarios. To address this challenge, we introduce CompoFormer, a structure-based continual transformer model that adaptively composes previous policies via a meta-policy network. Upon encountering a new task, CompoFormer leverages semantic correlations to selectively integrate relevant prior policies alongside newly trained parameters, thereby enhancing knowledge sharing and accelerating the learning process. Our experiments reveal that CompoFormer outperforms conventional CL methods, particularly in longer task sequences, showcasing a promising balance between plasticity and stability.

AuscultaBase: A Foundational Step Towards AI-Powered Body Sound Diagnostics

Auscultation of internal body sounds is essential for diagnosing a range of health conditions, yet its effectiveness is often limited by clinicians' expertise and the acoustic constraints of human hearing, restricting its use across various clinical scenarios. To address these challenges, we introduce AuscultaBase, a foundational framework aimed at advancing body sound diagnostics through innovative data integration and contrastive learning techniques. Our contributions include the following: First, we compile AuscultaBase-Corpus, a large-scale, multi-source body sound database encompassing 11 datasets with 40,317 audio recordings and totaling 322.4 hours of heart, lung, and bowel sounds. Second, we develop AuscultaBase-Model, a foundational diagnostic model for body sounds, utilizing contrastive learning on the compiled corpus. Third, we establish AuscultaBase-Bench, a comprehensive benchmark containing 16 sub-tasks, assessing the performance of various open-source acoustic pre-trained models. Evaluation results indicate that our model outperforms all other open-source models in 12 out of 16 tasks, demonstrating the efficacy of our approach in advancing diagnostic capabilities for body sound analysis.

Task-Aware Harmony Multi-Task Decision Transformer for Offline Reinforcement Learning

The purpose of offline multi-task reinforcement learning (MTRL) is to develop a unified policy applicable to diverse tasks without the need for online environmental interaction. Recent advancements approach this through sequence modeling, leveraging the Transformer architecture's scalability and the benefits of parameter sharing to exploit task similarities. However, variations in task content and complexity pose significant challenges in policy formulation, necessitating judicious parameter sharing and management of conflicting gradients for optimal policy performance. Furthermore, identifying the optimal parameter subspace for each task often necessitates prior knowledge of the task identifier during inference, limiting applicability in real-world scenarios with variable task content and unknown current tasks. In this work, we introduce the Harmony Multi-Task Decision Transformer (HarmoDT), a novel solution designed to identify an optimal harmony subspace of parameters for each task. We formulate this as a bi-level optimization problem within a meta-learning framework, where the upper level learns masks to define the harmony subspace, while the inner level focuses on updating parameters to improve the overall performance of the unified policy. To eliminate the need for task identifiers, we further design a group-wise variant (G-HarmoDT) that clusters tasks into coherent groups based on gradient information, and utilizes a gating network to determine task identifiers during inference. Empirical evaluations across various benchmarks highlight the superiority of our approach, demonstrating its effectiveness in the multi-task context with specific improvements of 8% gain in task-provided settings, 5% in task-agnostic settings, and 10% in unseen settings.

Prompt Tuning with Diffusion for Few-Shot Pre-trained Policy Generalization

Offline reinforcement learning (RL) methods harness previous experiences to derive an optimal policy, forming the foundation for pre-trained large-scale models (PLMs). When encountering tasks not seen before, PLMs often utilize several expert trajectories as prompts to expedite their adaptation to new requirements. Though a range of prompt-tuning methods have been proposed to enhance the quality of prompts, these methods often face optimization restrictions due to prompt initialization, which can significantly constrain the exploration domain and potentially lead to suboptimal solutions. To eliminate the reliance on the initial prompt, we shift our perspective towards the generative model, framing the prompt-tuning process as a form of conditional generative modeling, where prompts are generated from random noise. Our innovation, the Prompt Diffuser, leverages a conditional diffusion model to produce prompts of exceptional quality. Central to our framework is the approach to trajectory reconstruction and the meticulous integration of downstream task guidance during the training phase. Further experimental results underscore the potency of the Prompt Diffuser as a robust and effective tool for the prompt-tuning process, demonstrating strong performance in the meta-RL tasks.

Communication Learning in Multi-Agent Systems from Graph Modeling Perspective

In numerous artificial intelligence applications, the collaborative efforts of multiple intelligent agents are imperative for the successful attainment of target objectives. To enhance coordination among these agents, a distributed communication framework is often employed. However, indiscriminate information sharing among all agents can be resource-intensive, and the adoption of manually pre-defined communication architectures imposes constraints on inter-agent communication, thus limiting the potential for effective collaboration. Moreover, the communication framework often remains static during inference, which may result in sustained high resource consumption, as in most cases, only key decisions necessitate information sharing among agents. In this study, we introduce a novel approach wherein we conceptualize the communication architecture among agents as a learnable graph. We formulate this problem as the task of determining the communication graph while enabling the architecture parameters to update normally, thus necessitating a bi-level optimization process. Utilizing continuous relaxation of the graph representation and incorporating attention units, our proposed approach, CommFormer, efficiently optimizes the communication graph and concurrently refines architectural parameters through gradient descent in an end-to-end manner. Additionally, we introduce a temporal gating mechanism for each agent, enabling dynamic decisions on whether to receive shared information at a given time, based on current observations, thus improving decision-making efficiency. Extensive experiments on a variety of cooperative tasks substantiate the robustness of our model across diverse cooperative scenarios, where agents are able to develop more coordinated and sophisticated strategies regardless of changes in the number of agents.

CliMedBench: A Large-Scale Chinese Benchmark for Evaluating Medical Large Language Models in Clinical Scenarios

With the proliferation of Large Language Models (LLMs) in diverse domains, there is a particular need for unified evaluation standards in clinical medical scenarios, where models need to be examined very thoroughly. We present CliMedBench, a comprehensive benchmark with 14 expert-guided core clinical scenarios specifically designed to assess the medical ability of LLMs across 7 pivot dimensions. It comprises 33,735 questions derived from real-world medical reports of top-tier tertiary hospitals and authentic examination exercises. The reliability of this benchmark has been confirmed in several ways. Subsequent experiments with existing LLMs have led to the following findings: (i) Chinese medical LLMs underperform on this benchmark, especially where medical reasoning and factual consistency are vital, underscoring the need for advances in clinical knowledge and diagnostic accuracy. (ii) Several general-domain LLMs demonstrate substantial potential in medical clinics, while the limited input capacity of many medical LLMs hinders their practical use. These findings reveal both the strengths and limitations of LLMs in clinical scenarios and offer critical insights for medical research.