A Continual Learning-driven Model for Accurate and Generalizable Segmentation of Clinically Comprehensive and Fine-grained Whole-body Anatomies in CT

Precision medicine in the quantitative management of chronic diseases and oncology would be greatly improved if the Computed Tomography (CT) scan of any patient could be segmented, parsed and analyzed in a precise and detailed way. However, there is no such fully annotated CT dataset with all anatomies delineated for training because of the exceptionally high manual cost, the need for specialized clinical expertise, and the time required to finish the task. To this end, we proposed a novel continual learning-driven CT model that can segment complete anatomies presented using dozens of previously partially labeled datasets, dynamically expanding its capacity to segment new ones without compromising previously learned organ knowledge. Existing multi-dataset approaches are not able to dynamically segment new anatomies without catastrophic forgetting and would encounter optimization difficulty or infeasibility when segmenting hundreds of anatomies across the whole range of body regions. Our single unified CT segmentation model, CL-Net, can highly accurately segment a clinically comprehensive set of 235 fine-grained whole-body anatomies. Composed of a universal encoder, multiple optimized and pruned decoders, CL-Net is developed using 13,952 CT scans from 20 public and 16 private high-quality partially labeled CT datasets of various vendors, different contrast phases, and pathologies. Extensive evaluation demonstrates that CL-Net consistently outperforms the upper limit of an ensemble of 36 specialist nnUNets trained per dataset with the complexity of 5% model size and significantly surpasses the segmentation accuracy of recent leading Segment Anything-style medical image foundation models by large margins. Our continual learning-driven CL-Net model would lay a solid foundation to facilitate many downstream tasks of oncology and chronic diseases using the most widely adopted CT imaging.

Dual-domain Modulation Network for Lightweight Image Super-Resolution

Lightweight image super-resolution (SR) aims to reconstruct high-resolution images from low-resolution images with limited computational costs. We find existing frequency-based SR methods cannot balance the reconstruction of overall structures and high-frequency parts. Meanwhile, these methods are inefficient for handling frequency features and unsuitable for lightweight SR. In this paper, we show introducing both wavelet and Fourier information allows our model to consider both high-frequency features and overall SR structure reconstruction while reducing costs. Specifically, we propose a dual-domain modulation network that utilize wavelet-domain modulation self-Transformer (WMT) plus Fourier supervision to modulate frequency features in addition to spatial domain modulation. Compared to existing frequency-based SR modules, our WMT is more suitable for frequency learning in lightweight SR. Experimental results show that our method achieves a comparable PSNR of SRFormer and MambaIR while with less than 50% and 60% of their FLOPs and achieving inference speeds 15.4x and 5.4x faster, respectively, demonstrating the effectiveness of our method on SR quality and lightweight. Codes will be released upon acceptance.

FourierSR: A Fourier Token-based Plugin for Efficient Image Super-Resolution

Image super-resolution (SR) aims to recover low-resolution images to high-resolution images, where improving SR efficiency is a high-profile challenge. However, commonly used units in SR, like convolutions and window-based Transformers, have limited receptive fields, making it challenging to apply them to improve SR under extremely limited computational cost. To address this issue, inspired by modeling convolution theorem through token mix, we propose a Fourier token-based plugin called FourierSR to improve SR uniformly, which avoids the instability or inefficiency of existing token mix technologies when applied as plug-ins. Furthermore, compared to convolutions and windows-based Transformers, our FourierSR only utilizes Fourier transform and multiplication operations, greatly reducing complexity while having global receptive fields. Experimental results show that our FourierSR as a plug-and-play unit brings an average PSNR gain of 0.34dB for existing efficient SR methods on Manga109 test set at the scale of x4, while the average increase in the number of Params and FLOPs is only 0.6% and 1.5% of original sizes. We will release our codes upon acceptance.

SymmeTac: Symmetric Color LED Driven Efficient Photometric Stereo Reconstruction Methods for Camera-based Tactile Sensors

Camera-based tactile sensors can provide high-density surface geometry and force information for robots in the interaction process with the target. However, most existing methods cannot achieve accurate reconstruction with high efficiency, impeding the applications in robots. To address these problems, we propose an efficient two-shot photometric stereo method based on symmetric color LED distribution. Specifically, based on the sensing response curve of CMOS channels, we design orthogonal red and blue LEDs as illumination to acquire four observation maps using channel-splitting in a two-shot manner. Subsequently, we develop a two-shot photometric stereo theory, which can estimate accurate surface normal and greatly reduce the computing overhead in magnitude. Finally, leveraging the characteristics of the camera-based tactile sensor, we optimize the algorithm to be a highly efficient, pure addition operation. Simulation and real-world experiments demonstrate the advantages of our approach. Further details are available on: https://github.com/Tacxels/SymmeTac.

Efficient Face Super-Resolution via Wavelet-based Feature Enhancement Network

Face super-resolution aims to reconstruct a high-resolution face image from a low-resolution face image. Previous methods typically employ an encoder-decoder structure to extract facial structural features, where the direct downsampling inevitably introduces distortions, especially to high-frequency features such as edges. To address this issue, we propose a wavelet-based feature enhancement network, which mitigates feature distortion by losslessly decomposing the input feature into high and low-frequency components using the wavelet transform and processing them separately. To improve the efficiency of facial feature extraction, a full domain Transformer is further proposed to enhance local, regional, and global facial features. Such designs allow our method to perform better without stacking many modules as previous methods did. Experiments show that our method effectively balances performance, model size, and speed. Code link: https://github.com/PRIS-CV/WFEN.

Representing Topological Self-Similarity Using Fractal Feature Maps for Accurate Segmentation of Tubular Structures

Accurate segmentation of long and thin tubular structures is required in a wide variety of areas such as biology, medicine, and remote sensing. The complex topology and geometry of such structures often pose significant technical challenges. A fundamental property of such structures is their topological self-similarity, which can be quantified by fractal features such as fractal dimension (FD). In this study, we incorporate fractal features into a deep learning model by extending FD to the pixel-level using a sliding window technique. The resulting fractal feature maps (FFMs) are then incorporated as additional input to the model and additional weight in the loss function to enhance segmentation performance by utilizing the topological self-similarity. Moreover, we extend the U-Net architecture by incorporating an edge decoder and a skeleton decoder to improve boundary accuracy and skeletal continuity of segmentation, respectively. Extensive experiments on five tubular structure datasets validate the effectiveness and robustness of our approach. Furthermore, the integration of FFMs with other popular segmentation models such as HR-Net also yields performance enhancement, suggesting FFM can be incorporated as a plug-in module with different model architectures. Code and data are openly accessible at https://github.com/cbmi-group/FFM-Multi-Decoder-Network.

NeRSP: Neural 3D Reconstruction for Reflective Objects with Sparse Polarized Images

We present NeRSP, a Neural 3D reconstruction technique for Reflective surfaces with Sparse Polarized images. Reflective surface reconstruction is extremely challenging as specular reflections are view-dependent and thus violate the multiview consistency for multiview stereo. On the other hand, sparse image inputs, as a practical capture setting, commonly cause incomplete or distorted results due to the lack of correspondence matching. This paper jointly handles the challenges from sparse inputs and reflective surfaces by leveraging polarized images. We derive photometric and geometric cues from the polarimetric image formation model and multiview azimuth consistency, which jointly optimize the surface geometry modeled via implicit neural representation. Based on the experiments on our synthetic and real datasets, we achieve the state-of-the-art surface reconstruction results with only 6 views as input.

CycleINR: Cycle Implicit Neural Representation for Arbitrary-Scale Volumetric Super-Resolution of Medical Data

In the realm of medical 3D data, such as CT and MRI images, prevalent anisotropic resolution is characterized by high intra-slice but diminished inter-slice resolution. The lowered resolution between adjacent slices poses challenges, hindering optimal viewing experiences and impeding the development of robust downstream analysis algorithms. Various volumetric super-resolution algorithms aim to surmount these challenges, enhancing inter-slice resolution and overall 3D medical imaging quality. However, existing approaches confront inherent challenges: 1) often tailored to specific upsampling factors, lacking flexibility for diverse clinical scenarios; 2) newly generated slices frequently suffer from over-smoothing, degrading fine details, and leading to inter-slice inconsistency. In response, this study presents CycleINR, a novel enhanced Implicit Neural Representation model for 3D medical data volumetric super-resolution. Leveraging the continuity of the learned implicit function, the CycleINR model can achieve results with arbitrary up-sampling rates, eliminating the need for separate training. Additionally, we enhance the grid sampling in CycleINR with a local attention mechanism and mitigate over-smoothing by integrating cycle-consistent loss. We introduce a new metric, Slice-wise Noise Level Inconsistency (SNLI), to quantitatively assess inter-slice noise level inconsistency. The effectiveness of our approach is demonstrated through image quality evaluations on an in-house dataset and a downstream task analysis on the Medical Segmentation Decathlon liver tumor dataset.

Towards a Comprehensive, Efficient and Promptable Anatomic Structure Segmentation Model using 3D Whole-body CT Scans

Segment anything model (SAM) demonstrates strong generalization ability on natural image segmentation. However, its direct adaption in medical image segmentation tasks shows significant performance drops with inferior accuracy and unstable results. It may also requires an excessive number of prompt points to obtain a reasonable accuracy. For segmenting 3D radiological CT or MRI scans, a 2D SAM model has to separately handle hundreds of 2D slices. Although quite a few studies explore adapting SAM into medical image volumes, the efficiency of 2D adaption methods is unsatisfactory and 3D adaptation methods only capable of segmenting specific organs/tumors. In this work, we propose a comprehensive and scalable 3D SAM model for whole-body CT segmentation, named CT-SAM3D. Instead of adapting SAM, we propose a 3D promptable segmentation model using a (nearly) fully labeled CT dataset. To train CT-SAM3D effectively, ensuring the model's accurate responses to higher-dimensional spatial prompts is crucial, and 3D patch-wise training is required due to GPU memory constraints. For this purpose, we propose two key technical developments: 1) a progressively and spatially aligned prompt encoding method to effectively encode click prompts in local 3D space; and 2) a cross-patch prompt learning scheme to capture more 3D spatial context, which is beneficial for reducing the editing workloads when interactively prompting on large organs. CT-SAM3D is trained and validated using a curated dataset of 1204 CT scans containing 107 whole-body anatomies, reporting significantly better quantitative performance against all previous SAM-derived models by a large margin with much fewer click prompts. Our model can handle segmenting unseen organ as well. Code, data, and our 3D interactive segmentation tool with quasi-real-time responses will be made publicly available.

Anatomical Invariance Modeling and Semantic Alignment for Self-supervised Learning in 3D Medical Image Segmentation

Self-supervised learning (SSL) has recently achieved promising performance for 3D medical image segmentation tasks. Most current methods follow existing SSL paradigm originally designed for photographic or natural images, which cannot explicitly and thoroughly exploit the intrinsic similar anatomical structures across varying medical images. This may in fact degrade the quality of learned deep representations by maximizing the similarity among features containing spatial misalignment information and different anatomical semantics. In this work, we propose a new self-supervised learning framework, namely Alice, that explicitly fulfills Anatomical invariance modeling and semantic alignment via elaborately combining discriminative and generative objectives. Alice introduces a new contrastive learning strategy which encourages the similarity between views that are diversely mined but with consistent high-level semantics, in order to learn invariant anatomical features. Moreover, we design a conditional anatomical feature alignment module to complement corrupted embeddings with globally matched semantics and inter-patch topology information, conditioned by the distribution of local image content, which permits to create better contrastive pairs. Our extensive quantitative experiments on two public 3D medical image segmentation benchmarks of FLARE 2022 and BTCV demonstrate and validate the performance superiority of Alice, surpassing the previous best SSL counterpart methods by 2.11% and 1.77% in Dice coefficients, respectively.