A Mixture of Experts Foundation Model for Scanning Electron Microscopy Image Analysis

Scanning Electron Microscopy (SEM) is indispensable in modern materials science, enabling high-resolution imaging across a wide range of structural, chemical, and functional investigations. However, SEM imaging remains constrained by task-specific models and labor-intensive acquisition processes that limit its scalability across diverse applications. Here, we introduce the first foundation model for SEM images, pretrained on a large corpus of multi-instrument, multi-condition scientific micrographs, enabling generalization across diverse material systems and imaging conditions. Leveraging a self-supervised transformer architecture, our model learns rich and transferable representations that can be fine-tuned or adapted to a wide range of downstream tasks. As a compelling demonstration, we focus on defocus-to-focus image translation-an essential yet underexplored challenge in automated microscopy pipelines. Our method not only restores focused detail from defocused inputs without paired supervision but also outperforms state-of-the-art techniques across multiple evaluation metrics. This work lays the groundwork for a new class of adaptable SEM models, accelerating materials discovery by bridging foundational representation learning with real-world imaging needs.

Action Images: End-to-End Policy Learning via Multiview Video Generation

World action models (WAMs) have emerged as a promising direction for robot policy learning, as they can leverage powerful video backbones to model the future states. However, existing approaches often rely on separate action modules, or use action representations that are not pixel-grounded, making it difficult to fully exploit the pretrained knowledge of video models and limiting transfer across viewpoints and environments. In this work, we present Action Images, a unified world action model that formulates policy learning as multiview video generation. Instead of encoding control as low-dimensional tokens, we translate 7-DoF robot actions into interpretable action images: multi-view action videos that are grounded in 2D pixels and explicitly track robot-arm motion. This pixel-grounded action representation allows the video backbone itself to act as a zero-shot policy, without a separate policy head or action module. Beyond control, the same unified model supports video-action joint generation, action-conditioned video generation, and action labeling under a shared representation. On RLBench and real-world evaluations, our model achieves the strongest zero-shot success rates and improves video-action joint generation quality over prior video-space world models, suggesting that interpretable action images are a promising route to policy learning.

CRISP: Rank-Guided Iterative Squeezing for Robust Medical Image Segmentation under Domain Shift

Distribution shift in medical imaging remains a central bottleneck for the clinical translation of medical AI. Failure to address it can lead to severe performance degradation in unseen environments and exacerbate health inequities. Existing methods for domain adaptation are inherently limited by exhausting predefined possibilities through simulated shifts or pseudo-supervision. Such strategies struggle in the open-ended and unpredictable real world, where distribution shifts are effectively infinite. To address this challenge, we introduce an empirical law called ``Rank Stability of Positive Regions'', which states that the relative rank of predicted probabilities for positive voxels remains stable under distribution shift. Guided by this principle, we propose CRISP, a parameter-free and model-agnostic framework requiring no target-domain information. CRISP is the first framework to make segmentation based on rank rather than probabilities. CRISP simulates model behavior under distribution shift via latent feature perturbation, where voxel probability rankings exhibit two stable patterns: regions that consistently retain high probabilities (destined positives according to the principle) and those that remain low-probability (can be safely classified as negatives). Based on these patterns, we construct high-precision (HP) and high-recall (HR) priors and recursively refine them under perturbation. We then design an iterative training framework, making HP and HR progressively ``squeeze'' to the final segmentation. Extensive evaluations on multi-center cardiac MRI and CT-based lung vessel segmentation demonstrate CRISP's superior robustness, significantly outperforming state-of-the-art methods with striking HD95 reductions of up to 0.14 (7.0\% improvement), 1.90 (13.1\% improvement), and 8.39 (38.9\% improvement) pixels across multi-center, demographic, and modality shifts, respectively.

Graphic-Design-Bench: A Comprehensive Benchmark for Evaluating AI on Graphic Design Tasks

We introduce GraphicDesignBench (GDB), the first comprehensive benchmark suite designed specifically to evaluate AI models on the full breadth of professional graphic design tasks. Unlike existing benchmarks that focus on natural-image understanding or generic text-to-image synthesis, GDB targets the unique challenges of professional design work: translating communicative intent into structured layouts, rendering typographically faithful text, manipulating layered compositions, producing valid vector graphics, and reasoning about animation. The suite comprises 50 tasks organized along five axes: layout, typography, infographics, template & design semantics and animation, each evaluated under both understanding and generation settings, and grounded in real-world design templates drawn from the LICA layered-composition dataset. We evaluate a set of frontier closed-source models using a standardized metric taxonomy covering spatial accuracy, perceptual quality, text fidelity, semantic alignment, and structural validity. Our results reveal that current models fall short on the core challenges of professional design: spatial reasoning over complex layouts, faithful vector code generation, fine-grained typographic perception, and temporal decomposition of animations remain largely unsolved. While high-level semantic understanding is within reach, the gap widens sharply as tasks demand precision, structure, and compositional awareness. GDB provides a rigorous, reproducible testbed for tracking progress toward AI systems that can function as capable design collaborators. The full evaluation framework is publicly available.

MPM: Mutual Pair Merging for Efficient Vision Transformers

Decreasing sequence length is a common way to accelerate transformers, but prior token reduction work often targets classification and reports proxy metrics rather than end-to-end latency. For semantic segmentation, token reduction is further constrained by the need to reconstruct dense, pixel-aligned features, and on modern accelerators the overhead of computing merge maps can erase expected gains. We propose Mutual Pair Merging (MPM), a training-free token aggregation module that forms mutual nearest-neighbor pairs in cosine space, averages each pair, and records a merge map enabling a gather-based reconstruction before the decoder so that existing segmentation heads can be used unchanged. MPM introduces no learned parameters and no continuous compression knob (no keep-rate or threshold). The speed-accuracy trade-off is set by a discrete insertion schedule. We benchmark end-to-end latency on an NVIDIA H100 GPU (with and without FlashAttention-2) and a Raspberry Pi 5 across standard segmentation datasets. On ADE20K, MPM reduces per-image latency by up to 60% for ViT-Tiny on Raspberry Pi 5, and increases throughput by up to 20% on H100 with FlashAttention-2 while keeping the mIoU drop below 3%. These results suggest that simple, reconstruction-aware, training-free token merging can translate into practical wall-clock gains for segmentation when overhead is explicitly accounted for.

Veo-Act: How Far Can Frontier Video Models Advance Generalizable Robot Manipulation?

Video generation models have advanced rapidly and are beginning to show a strong understanding of physical dynamics. In this paper, we investigate how far an advanced video generation model such as Veo-3 can support generalizable robotic manipulation. We first study a zero-shot approach in which Veo-3 predicts future image sequences from current robot observations, while an inverse dynamics model IDM recovers the corresponding robot actions. The IDM is trained solely on random-play data, requiring neither human supervision nor expert demonstrations. The key intuition is that, if a video model can generate physically plausible future motions in image space, an IDM can translate those visual trajectories into executable robot actions. We evaluate this "Veo-3+IDM" approach in both simulation and the real world using a high-dimensional dexterous hand. We find that, owing to the strong generalization capability of frontier video models, Veo-3+IDM can consistently generate approximately correct task-level trajectories. However, its low-level control accuracy remains insufficient to solve most tasks reliably. Motivated by this observation, we develop a hierarchical framework, Veo-Act, which uses Veo-3 as a high-level motion planner and a VLA policy as the low-level executor, significantly improving the instruction-following performance of a state-of-the-art vision-language-action policy. Overall, our results suggest that, as video generation models continue to improve, video models can be a valuable component for generalizable robot learning.

AnyUser: Translating Sketched User Intent into Domestic Robots

We introduce AnyUser, a unified robotic instruction system for intuitive domestic task instruction via free-form sketches on camera images, optionally with language. AnyUser interprets multimodal inputs (sketch, vision, language) as spatial-semantic primitives to generate executable robot actions requiring no prior maps or models. Novel components include multimodal fusion for understanding and a hierarchical policy for robust action generation. Efficacy is shown via extensive evaluations: (1) Quantitative benchmarks on the large-scale dataset showing high accuracy in interpreting diverse sketch-based commands across various simulated domestic scenes. (2) Real-world validation on two distinct robotic platforms, a statically mounted 7-DoF assistive arm (KUKA LBR iiwa) and a dual-arm mobile manipulator (Realman RMC-AIDAL), performing representative tasks like targeted wiping and area cleaning, confirming the system's ability to ground instructions and execute them reliably in physical environments. (3) A comprehensive user study involving diverse demographics (elderly, simulated non-verbal, low technical literacy) demonstrating significant improvements in usability and task specification efficiency, achieving high task completion rates (85.7%-96.4%) and user satisfaction. AnyUser bridges the gap between advanced robotic capabilities and the need for accessible non-expert interaction, laying the foundation for practical assistive robots adaptable to real-world human environments.

Relational Epipolar Graphs for Robust Relative Camera Pose Estimation

A key component of Visual Simultaneous Localization and Mapping (VSLAM) is estimating relative camera poses using matched keypoints. Accurate estimation is challenged by noisy correspondences. Classical methods rely on stochastic hypothesis sampling and iterative estimation, while learning-based methods often lack explicit geometric structure. In this work, we reformulate relative pose estimation as a relational inference problem over epipolar correspondence graphs, where matched keypoints are nodes and nearby ones are connected by edges. Graph operations such as pruning, message passing, and pooling estimate a quaternion rotation, translation vector, and the Essential Matrix (EM). Minimizing a loss comprising (i) $\mathcal{L}_2$ differences with ground truth (GT), (ii) Frobenius norm between estimated and GT EMs, (iii) singular value differences, (iv) heading angle differences, and (v) scale differences, yields the relative pose between image pairs. The dense detector-free method LoFTR is used for matching. Experiments on indoor and outdoor benchmarks show improved robustness to dense noise and large baseline variation compared to classical and learning-guided approaches, highlighting the effectiveness of global relational consensus.

Visual Instruction-Finetuned Language Model for Versatile Brain MR Image Tasks

LLMs have demonstrated remarkable capabilities in linguistic reasoning and are increasingly adept at vision-language tasks. The integration of image tokens into transformers has enabled direct visual input and output, advancing research from image-to-text descriptions to text-to-image generation. However, simple text-to-image generation holds limited clinical utility. In medical imaging, tasks such as image segmentation for localizing pathologies or image translation for reconstructing missing sequences have much greater clinical importance. Despite this, integrating these diverse, clinically relevant tasks within a single, versatile language model remains unexplored. Our method, LLaBIT (Large Language Model for Brain Image Translation), extends the visual reasoning of LLMs to these clinically meaningful tasks in the brain MRI domain. To mitigate the spatial information loss inherent in image tokenization, we incorporate a mechanism to reuse feature maps from the image encoder, minimizing data degradation. We also generate text data using LLMs with strict predefined instructions to augment limited image-text paired data in brain MRI. We comprehensively evaluated our method on five brain MRI datasets across four distinct tasks: report generation, visual question answering, image segmentation, and image translation. Our model not only demonstrated superior performance across all tasks but also outperformed specialized, task-specific models in direct comparisons, highlighting its efficacy and versatility

A Generative Foundation Model for Multimodal Histopathology

Accurate diagnosis and treatment of complex diseases require integrating histological, molecular, and clinical data, yet in practice these modalities are often incomplete owing to tissue scarcity, assay cost, and workflow constraints. Existing computational approaches attempt to impute missing modalities from available data but rely on task-specific models trained on narrow, single source-target pairs, limiting their generalizability. Here we introduce MuPD (Multimodal Pathology Diffusion), a generative foundation model that embeds hematoxylin and eosin (H&E)-stained histology, molecular RNA profiles, and clinical text into a shared latent space through a diffusion transformer with decoupled cross-modal attention. Pretrained on 100 million histology image patches, 1.6 million text-histology pairs, and 10.8 million RNA-histology pairs spanning 34 human organs, MuPD supports diverse cross-modal synthesis tasks with minimal or no task-specific fine-tuning. For text-conditioned and image-to-image generation, MuPD synthesizes histologically faithful tissue architectures, reducing Fréchet inception distance (FID) scores by 50% relative to domain-specific models and improving few-shot classification accuracy by up to 47% through synthetic data augmentation. For RNA-conditioned histology generation, MuPD reduces FID by 23% compared with the next-best method while preserving cell-type distributions across five cancer types. As a virtual stainer, MuPD translates H&E images to immunohistochemistry and multiplex immunofluorescence, improving average marker correlation by 37% over existing approaches. These results demonstrate that a single, unified generative model pretrained across heterogeneous pathology modalities can substantially outperform specialized alternatives, providing a scalable computational framework for multimodal histopathology.