Unsupervised Detection of Fetal Brain Anomalies using Denoising Diffusion Models

Congenital malformations of the brain are among the most common fetal abnormalities that impact fetal development. Previous anomaly detection methods on ultrasound images are based on supervised learning, rely on manual annotations, and risk missing underrepresented categories. In this work, we frame fetal brain anomaly detection as an unsupervised task using diffusion models. To this end, we employ an inpainting-based Noise Agnostic Anomaly Detection approach that identifies the abnormality using diffusion-reconstructed fetal brain images from multiple noise levels. Our approach only requires normal fetal brain ultrasound images for training, addressing the limited availability of abnormal data. Our experiments on a real-world clinical dataset show the potential of using unsupervised methods for fetal brain anomaly detection. Additionally, we comprehensively evaluate how different noise types affect diffusion models in the fetal anomaly detection domain.

AMAES: Augmented Masked Autoencoder Pretraining on Public Brain MRI Data for 3D-Native Segmentation

This study investigates the impact of self-supervised pretraining of 3D semantic segmentation models on a large-scale, domain-specific dataset. We introduce BRAINS-45K, a dataset of 44,756 brain MRI volumes from public sources, the largest public dataset available, and revisit a number of design choices for pretraining modern segmentation architectures by simplifying and optimizing state-of-the-art methods, and combining them with a novel augmentation strategy. The resulting AMAES framework is based on masked-image-modeling and intensity-based augmentation reversal and balances memory usage, runtime, and finetuning performance. Using the popular U-Net and the recent MedNeXt architecture as backbones, we evaluate the effect of pretraining on three challenging downstream tasks, covering single-sequence, low-resource settings, and out-of-domain generalization. The results highlight that pretraining on the proposed dataset with AMAES significantly improves segmentation performance in the majority of evaluated cases, and that it is beneficial to pretrain the model with augmentations, despite pretraing on a large-scale dataset. Code and model checkpoints for reproducing results, as well as the BRAINS-45K dataset are available at \url{https://github.com/asbjrnmunk/amaes}.

Yucca: A Deep Learning Framework For Medical Image Analysis

Medical image analysis using deep learning frameworks has advanced healthcare by automating complex tasks, but many existing frameworks lack flexibility, modularity, and user-friendliness. To address these challenges, we introduce Yucca, an open-source AI framework available at https://github.com/Sllambias/yucca, designed specifically for medical imaging applications and built on PyTorch and PyTorch Lightning. Yucca features a three-tiered architecture: Functional, Modules, and Pipeline, providing a comprehensive and customizable solution. Evaluated across diverse tasks such as cerebral microbleeds detection, white matter hyperintensity segmentation, and hippocampus segmentation, Yucca achieves state-of-the-art results, demonstrating its robustness and versatility. Yucca offers a powerful, flexible, and user-friendly platform for medical image analysis, inviting community contributions to advance its capabilities and impact.

Learning semantic image quality for fetal ultrasound from noisy ranking annotation

We introduce the notion of semantic image quality for applications where image quality relies on semantic requirements. Working in fetal ultrasound, where ranking is challenging and annotations are noisy, we design a robust coarse-to-fine model that ranks images based on their semantic image quality and endow our predicted rankings with an uncertainty estimate. To annotate rankings on training data, we design an efficient ranking annotation scheme based on the merge sort algorithm. Finally, we compare our ranking algorithm to a number of state-of-the-art ranking algorithms on a challenging fetal ultrasound quality assessment task, showing the superior performance of our method on the majority of rank correlation metrics.

Benchmarking Faithfulness: Towards Accurate Natural Language Explanations in Vision-Language Tasks

With deep neural models increasingly permeating our daily lives comes a need for transparent and comprehensible explanations of their decision-making. However, most explanation methods that have been developed so far are not intuitively understandable for lay users. In contrast, natural language explanations (NLEs) promise to enable the communication of a model's decision-making in an easily intelligible way. While current models successfully generate convincing explanations, it is an open question how well the NLEs actually represent the reasoning process of the models - a property called faithfulness. Although the development of metrics to measure faithfulness is crucial to designing more faithful models, current metrics are either not applicable to NLEs or are not designed to compare different model architectures across multiple modalities. Building on prior research on faithfulness measures and based on a detailed rationale, we address this issue by proposing three faithfulness metrics: Attribution-Similarity, NLE-Sufficiency, and NLE-Comprehensiveness. The efficacy of the metrics is evaluated on the VQA-X and e-SNLI-VE datasets of the e-ViL benchmark for vision-language NLE generation by systematically applying modifications to the performant e-UG model for which we expect changes in the measured explanation faithfulness. We show on the e-SNLI-VE dataset that the removal of redundant inputs to the explanation-generation module of e-UG successively increases the model's faithfulness on the linguistic modality as measured by Attribution-Similarity. Further, our analysis demonstrates that NLE-Sufficiency and -Comprehensiveness are not necessarily correlated to Attribution-Similarity, and we discuss how the two metrics can be utilized to gain further insights into the explanation generation process.

Harnessing the Power of Multi-Task Pretraining for Ground-Truth Level Natural Language Explanations

Natural language explanations promise to offer intuitively understandable explanations of a neural network's decision process in complex vision-language tasks, as pursued in recent VL-NLE models. While current models offer impressive performance on task accuracy and explanation plausibility, they suffer from a range of issues: Some models feature a modular design where the explanation generation module is poorly integrated with a separate module for task-answer prediction, employ backbone models trained on limited sets of tasks, or incorporate ad hoc solutions to increase performance on single datasets. We propose to evade these limitations by applying recent advances in large-scale multi-task pretraining of generative Transformer models to the problem of VL-NLE tasks. Our approach outperforms recent models by a large margin, with human annotators preferring the generated explanations over the ground truth in two out of three evaluated datasets. As a novel challenge in VL-NLE research, we propose the problem of multi-task VL-NLE and show that jointly training on multiple tasks can increase the explanation quality. We discuss the ethical implications of high-quality NLE generation and other issues in recent VL-NLE research.

Explain yourself! Effects of Explanations in Human-Robot Interaction

Recent developments in explainable artificial intelligence promise the potential to transform human-robot interaction: Explanations of robot decisions could affect user perceptions, justify their reliability, and increase trust. However, the effects on human perceptions of robots that explain their decisions have not been studied thoroughly. To analyze the effect of explainable robots, we conduct a study in which two simulated robots play a competitive board game. While one robot explains its moves, the other robot only announces them. Providing explanations for its actions was not sufficient to change the perceived competence, intelligence, likeability or safety ratings of the robot. However, the results show that the robot that explains its moves is perceived as more lively and human-like. This study demonstrates the need for and potential of explainable human-robot interaction and the wider assessment of its effects as a novel research direction.