Angio-Diff: Learning a Self-Supervised Adversarial Diffusion Model for Angiographic Geometry Generation

Vascular diseases pose a significant threat to human health, with X-ray angiography established as the gold standard for diagnosis, allowing for detailed observation of blood vessels. However, angiographic X-rays expose personnel and patients to higher radiation levels than non-angiographic X-rays, which are unwanted. Thus, modality translation from non-angiographic to angiographic X-rays is desirable. Data-driven deep approaches are hindered by the lack of paired large-scale X-ray angiography datasets. While making high-quality vascular angiography synthesis crucial, it remains challenging. We find that current medical image synthesis primarily operates at pixel level and struggles to adapt to the complex geometric structure of blood vessels, resulting in unsatisfactory quality of blood vessel image synthesis, such as disconnections or unnatural curvatures. To overcome this issue, we propose a self-supervised method via diffusion models to transform non-angiographic X-rays into angiographic X-rays, mitigating data shortages for data-driven approaches. Our model comprises a diffusion model that learns the distribution of vascular data from diffusion latent, a generator for vessel synthesis, and a mask-based adversarial module. To enhance geometric accuracy, we propose a parametric vascular model to fit the shape and distribution of blood vessels. The proposed method contributes a pipeline and a synthetic dataset for X-ray angiography. We conducted extensive comparative and ablation experiments to evaluate the Angio-Diff. The results demonstrate that our method achieves state-of-the-art performance in synthetic angiography image quality and more accurately synthesizes the geometric structure of blood vessels. The code is available at https://github.com/zfw-cv/AngioDiff.

Dynamic Graph Condensation

Recent research on deep graph learning has shifted from static to dynamic graphs, motivated by the evolving behaviors observed in complex real-world systems. However, the temporal extension in dynamic graphs poses significant data efficiency challenges, including increased data volume, high spatiotemporal redundancy, and reliance on costly dynamic graph neural networks (DGNNs). To alleviate the concerns, we pioneer the study of dynamic graph condensation (DGC), which aims to substantially reduce the scale of dynamic graphs for data-efficient DGNN training. Accordingly, we propose DyGC, a novel framework that condenses the real dynamic graph into a compact version while faithfully preserving the inherent spatiotemporal characteristics. Specifically, to endow synthetic graphs with realistic evolving structures, a novel spiking structure generation mechanism is introduced. It draws on the dynamic behavior of spiking neurons to model temporally-aware connectivity in dynamic graphs. Given the tightly coupled spatiotemporal dependencies, DyGC proposes a tailored distribution matching approach that first constructs a semantically rich state evolving field for dynamic graphs, and then performs fine-grained spatiotemporal state alignment to guide the optimization of the condensed graph. Experiments across multiple dynamic graph datasets and representative DGNN architectures demonstrate the effectiveness of DyGC. Notably, our method retains up to 96.2% DGNN performance with only 0.5% of the original graph size, and achieves up to 1846 times training speedup.

Causally-informed Deep Learning towards Explainable and Generalizable Outcomes Prediction in Critical Care

Recent advances in deep learning (DL) have prompted the development of high-performing early warning score (EWS) systems, predicting clinical deteriorations such as acute kidney injury, acute myocardial infarction, or circulatory failure. DL models have proven to be powerful tools for various tasks but come with the cost of lacking interpretability and limited generalizability, hindering their clinical applications. To develop a practical EWS system applicable to various outcomes, we propose causally-informed explainable early prediction model, which leverages causal discovery to identify the underlying causal relationships of prediction and thus owns two unique advantages: demonstrating the explicit interpretation of the prediction while exhibiting decent performance when applied to unfamiliar environments. Benefiting from these features, our approach achieves superior accuracy for 6 different critical deteriorations and achieves better generalizability across different patient groups, compared to various baseline algorithms. Besides, we provide explicit causal pathways to serve as references for assistant clinical diagnosis and potential interventions. The proposed approach enhances the practical application of deep learning in various medical scenarios.

A Joint Representation Using Continuous and Discrete Features for Cardiovascular Diseases Risk Prediction on Chest CT Scans

Cardiovascular diseases (CVD) remain a leading health concern and contribute significantly to global mortality rates. While clinical advancements have led to a decline in CVD mortality, accurately identifying individuals who could benefit from preventive interventions remains an unsolved challenge in preventive cardiology. Current CVD risk prediction models, recommended by guidelines, are based on limited traditional risk factors or use CT imaging to acquire quantitative biomarkers, and still have limitations in predictive accuracy and applicability. On the other hand, end-to-end trained CVD risk prediction methods leveraging deep learning on CT images often fail to provide transparent and explainable decision grounds for assisting physicians. In this work, we proposed a novel joint representation that integrates discrete quantitative biomarkers and continuous deep features extracted from chest CT scans. Our approach initiated with a deep CVD risk classification model by capturing comprehensive continuous deep learning features while jointly obtaining currently clinical-established quantitative biomarkers via segmentation models. In the feature joint representation stage, we use an instance-wise feature-gated mechanism to align the continuous and discrete features, followed by a soft instance-wise feature interaction mechanism fostering independent and effective feature interaction for the final CVD risk prediction. Our method substantially improves CVD risk predictive performance and offers individual contribution analysis of each biomarker, which is important in assisting physicians' decision-making processes. We validated our method on a public chest low-dose CT dataset and a private external chest standard-dose CT patient cohort of 17,207 CT volumes from 6,393 unique subjects, and demonstrated superior predictive performance, achieving AUCs of 0.875 and 0.843, respectively.

Active-Passive Federated Learning for Vertically Partitioned Multi-view Data

Vertical federated learning is a natural and elegant approach to integrate multi-view data vertically partitioned across devices (clients) while preserving their privacies. Apart from the model training, existing methods requires the collaboration of all clients in the model inference. However, the model inference is probably maintained for service in a long time, while the collaboration, especially when the clients belong to different organizations, is unpredictable in real-world scenarios, such as concellation of contract, network unavailablity, etc., resulting in the failure of them. To address this issue, we, at the first attempt, propose a flexible Active-Passive Federated learning (APFed) framework. Specifically, the active client is the initiator of a learning task and responsible to build the complete model, while the passive clients only serve as assistants. Once the model built, the active client can make inference independently. In addition, we instance the APFed framework into two classification methods with employing the reconstruction loss and the contrastive loss on passive clients, respectively. Meanwhile, the two methods are tested in a set of experiments and achieves desired results, validating their effectiveness.

FlexCare: Leveraging Cross-Task Synergy for Flexible Multimodal Healthcare Prediction

Multimodal electronic health record (EHR) data can offer a holistic assessment of a patient's health status, supporting various predictive healthcare tasks. Recently, several studies have embraced the multitask learning approach in the healthcare domain, exploiting the inherent correlations among clinical tasks to predict multiple outcomes simultaneously. However, existing methods necessitate samples to possess complete labels for all tasks, which places heavy demands on the data and restricts the flexibility of the model. Meanwhile, within a multitask framework with multimodal inputs, how to comprehensively consider the information disparity among modalities and among tasks still remains a challenging problem. To tackle these issues, a unified healthcare prediction model, also named by \textbf{FlexCare}, is proposed to flexibly accommodate incomplete multimodal inputs, promoting the adaption to multiple healthcare tasks. The proposed model breaks the conventional paradigm of parallel multitask prediction by decomposing it into a series of asynchronous single-task prediction. Specifically, a task-agnostic multimodal information extraction module is presented to capture decorrelated representations of diverse intra- and inter-modality patterns. Taking full account of the information disparities between different modalities and different tasks, we present a task-guided hierarchical multimodal fusion module that integrates the refined modality-level representations into an individual patient-level representation. Experimental results on multiple tasks from MIMIC-IV/MIMIC-CXR/MIMIC-NOTE datasets demonstrate the effectiveness of the proposed method. Additionally, further analysis underscores the feasibility and potential of employing such a multitask strategy in the healthcare domain. The source code is available at https://github.com/mhxu1998/FlexCare.

UniCompress: Enhancing Multi-Data Medical Image Compression with Knowledge Distillation

In the field of medical image compression, Implicit Neural Representation (INR) networks have shown remarkable versatility due to their flexible compression ratios, yet they are constrained by a one-to-one fitting approach that results in lengthy encoding times. Our novel method, ``\textbf{UniCompress}'', innovatively extends the compression capabilities of INR by being the first to compress multiple medical data blocks using a single INR network. By employing wavelet transforms and quantization, we introduce a codebook containing frequency domain information as a prior input to the INR network. This enhances the representational power of INR and provides distinctive conditioning for different image blocks. Furthermore, our research introduces a new technique for the knowledge distillation of implicit representations, simplifying complex model knowledge into more manageable formats to improve compression ratios. Extensive testing on CT and electron microscopy (EM) datasets has demonstrated that UniCompress outperforms traditional INR methods and commercial compression solutions like HEVC, especially in complex and high compression scenarios. Notably, compared to existing INR techniques, UniCompress achieves a 4$\sim$5 times increase in compression speed, marking a significant advancement in the field of medical image compression. Codes will be publicly available.

CausalTime: Realistically Generated Time-series for Benchmarking of Causal Discovery

Time-series causal discovery (TSCD) is a fundamental problem of machine learning. However, existing synthetic datasets cannot properly evaluate or predict the algorithms' performance on real data. This study introduces the CausalTime pipeline to generate time-series that highly resemble the real data and with ground truth causal graphs for quantitative performance evaluation. The pipeline starts from real observations in a specific scenario and produces a matching benchmark dataset. Firstly, we harness deep neural networks along with normalizing flow to accurately capture realistic dynamics. Secondly, we extract hypothesized causal graphs by performing importance analysis on the neural network or leveraging prior knowledge. Thirdly, we derive the ground truth causal graphs by splitting the causal model into causal term, residual term, and noise term. Lastly, using the fitted network and the derived causal graph, we generate corresponding versatile time-series proper for algorithm assessment. In the experiments, we validate the fidelity of the generated data through qualitative and quantitative experiments, followed by a benchmarking of existing TSCD algorithms using these generated datasets. CausalTime offers a feasible solution to evaluating TSCD algorithms in real applications and can be generalized to a wide range of fields. For easy use of the proposed approach, we also provide a user-friendly website, hosted on www.causaltime.cc.

Medical Federated Model with Mixture of Personalized and Sharing Components

Although data-driven methods usually have noticeable performance on disease diagnosis and treatment, they are suspected of leakage of privacy due to collecting data for model training. Recently, federated learning provides a secure and trustable alternative to collaboratively train model without any exchange of medical data among multiple institutes. Therefore, it has draw much attention due to its natural merit on privacy protection. However, when heterogenous medical data exists between different hospitals, federated learning usually has to face with degradation of performance. In the paper, we propose a new personalized framework of federated learning to handle the problem. It successfully yields personalized models based on awareness of similarity between local data, and achieves better tradeoff between generalization and personalization than existing methods. After that, we further design a differentially sparse regularizer to improve communication efficiency during procedure of model training. Additionally, we propose an effective method to reduce the computational cost, which improves computation efficiency significantly. Furthermore, we collect 5 real medical datasets, including 2 public medical image datasets and 3 private multi-center clinical diagnosis datasets, and evaluate its performance by conducting nodule classification, tumor segmentation, and clinical risk prediction tasks. Comparing with 13 existing related methods, the proposed method successfully achieves the best model performance, and meanwhile up to 60% improvement of communication efficiency. Source code is public, and can be accessed at: https://github.com/ApplicationTechnologyOfMedicalBigData/pFedNet-code.

CUTS+: High-dimensional Causal Discovery from Irregular Time-series

Causal discovery in time-series is a fundamental problem in the machine learning community, enabling causal reasoning and decision-making in complex scenarios. Recently, researchers successfully discover causality by combining neural networks with Granger causality, but their performances degrade largely when encountering high-dimensional data because of the highly redundant network design and huge causal graphs. Moreover, the missing entries in the observations further hamper the causal structural learning. To overcome these limitations, We propose CUTS+, which is built on the Granger-causality-based causal discovery method CUTS and raises the scalability by introducing a technique called Coarse-to-fine-discovery (C2FD) and leveraging a message-passing-based graph neural network (MPGNN). Compared to previous methods on simulated, quasi-real, and real datasets, we show that CUTS+ largely improves the causal discovery performance on high-dimensional data with different types of irregular sampling.