ContrastiveGaussian: High-Fidelity 3D Generation with Contrastive Learning and Gaussian Splatting

Creating 3D content from single-view images is a challenging problem that has attracted considerable attention in recent years. Current approaches typically utilize score distillation sampling (SDS) from pre-trained 2D diffusion models to generate multi-view 3D representations. Although some methods have made notable progress by balancing generation speed and model quality, their performance is often limited by the visual inconsistencies of the diffusion model outputs. In this work, we propose ContrastiveGaussian, which integrates contrastive learning into the generative process. By using a perceptual loss, we effectively differentiate between positive and negative samples, leveraging the visual inconsistencies to improve 3D generation quality. To further enhance sample differentiation and improve contrastive learning, we incorporate a super-resolution model and introduce another Quantity-Aware Triplet Loss to address varying sample distributions during training. Our experiments demonstrate that our approach achieves superior texture fidelity and improved geometric consistency.

SCORE: Story Coherence and Retrieval Enhancement for AI Narratives

Large Language Models (LLMs) excel at generating creative narratives but struggle with long-term coherence and emotional consistency in complex stories. To address this, we propose SCORE (Story Coherence and Retrieval Enhancement), a framework integrating three components: 1) Dynamic State Tracking (monitoring objects/characters via symbolic logic), 2) Context-Aware Summarization (hierarchical episode summaries for temporal progression), and 3) Hybrid Retrieval (combining TF-IDF keyword relevance with cosine similarity-based semantic embeddings). The system employs a temporally-aligned Retrieval-Augmented Generation (RAG) pipeline to validate contextual consistency. Evaluations show SCORE achieves 23.6% higher coherence (NCI-2.0 benchmark), 89.7% emotional consistency (EASM metric), and 41.8% fewer hallucinations versus baseline GPT models. Its modular design supports incremental knowledge graph construction for persistent story memory and multi-LLM backend compatibility, offering an explainable solution for industrial-scale narrative systems requiring long-term consistency.

Interpretable Deep Regression Models with Interval-Censored Failure Time Data

Deep neural networks (DNNs) have become powerful tools for modeling complex data structures through sequentially integrating simple functions in each hidden layer. In survival analysis, recent advances of DNNs primarily focus on enhancing model capabilities, especially in exploring nonlinear covariate effects under right censoring. However, deep learning methods for interval-censored data, where the unobservable failure time is only known to lie in an interval, remain underexplored and limited to specific data type or model. This work proposes a general regression framework for interval-censored data with a broad class of partially linear transformation models, where key covariate effects are modeled parametrically while nonlinear effects of nuisance multi-modal covariates are approximated via DNNs, balancing interpretability and flexibility. We employ sieve maximum likelihood estimation by leveraging monotone splines to approximate the cumulative baseline hazard function. To ensure reliable and tractable estimation, we develop an EM algorithm incorporating stochastic gradient descent. We establish the asymptotic properties of parameter estimators and show that the DNN estimator achieves minimax-optimal convergence. Extensive simulations demonstrate superior estimation and prediction accuracy over state-of-the-art methods. Applying our method to the Alzheimer's Disease Neuroimaging Initiative dataset yields novel insights and improved predictive performance compared to traditional approaches.

SDF-TopoNet: A Two-Stage Framework for Tubular Structure Segmentation via SDF Pre-training and Topology-Aware Fine-Tuning

Accurate segmentation of tubular and curvilinear structures, such as blood vessels, neurons, and road networks, is crucial in various applications. A key challenge is ensuring topological correctness while maintaining computational efficiency. Existing approaches often employ topological loss functions based on persistent homology, such as Betti error, to enforce structural consistency. However, these methods suffer from high computational costs and are insensitive to pixel-level accuracy, often requiring additional loss terms like Dice or MSE to compensate. To address these limitations, we propose \textbf{SDF-TopoNet}, an improved topology-aware segmentation framework that enhances both segmentation accuracy and training efficiency. Our approach introduces a novel two-stage training strategy. In the pre-training phase, we utilize the signed distance function (SDF) as an auxiliary learning target, allowing the model to encode topological information without directly relying on computationally expensive topological loss functions. In the fine-tuning phase, we incorporate a dynamic adapter alongside a refined topological loss to ensure topological correctness while mitigating overfitting and computational overhead. We evaluate our method on five benchmark datasets. Experimental results demonstrate that SDF-TopoNet outperforms existing methods in both topological accuracy and quantitative segmentation metrics, while significantly reducing training complexity.

Generative Adversarial Networks Bridging Art and Machine Intelligence

Generative Adversarial Networks (GAN) have greatly influenced the development of computer vision and artificial intelligence in the past decade and also connected art and machine intelligence together. This book begins with a detailed introduction to the fundamental principles and historical development of GANs, contrasting them with traditional generative models and elucidating the core adversarial mechanisms through illustrative Python examples. The text systematically addresses the mathematical and theoretical underpinnings including probability theory, statistics, and game theory providing a solid framework for understanding the objectives, loss functions, and optimisation challenges inherent to GAN training. Subsequent chapters review classic variants such as Conditional GANs, DCGANs, InfoGAN, and LAPGAN before progressing to advanced training methodologies like Wasserstein GANs, GANs with gradient penalty, least squares GANs, and spectral normalisation techniques. The book further examines architectural enhancements and task-specific adaptations in generators and discriminators, showcasing practical implementations in high resolution image generation, artistic style transfer, video synthesis, text to image generation and other multimedia applications. The concluding sections offer insights into emerging research trends, including self-attention mechanisms, transformer-based generative models, and a comparative analysis with diffusion models, thus charting promising directions for future developments in both academic and applied settings.

The Curse of Depth in Large Language Models

In this paper, we introduce the Curse of Depth, a concept that highlights, explains, and addresses the recent observation in modern Large Language Models(LLMs) where nearly half of the layers are less effective than expected. We first confirm the wide existence of this phenomenon across the most popular families of LLMs such as Llama, Mistral, DeepSeek, and Qwen. Our analysis, theoretically and empirically, identifies that the underlying reason for the ineffectiveness of deep layers in LLMs is the widespread usage of Pre-Layer Normalization (Pre-LN). While Pre-LN stabilizes the training of Transformer LLMs, its output variance exponentially grows with the model depth, which undesirably causes the derivative of the deep Transformer blocks to be an identity matrix, and therefore barely contributes to the training. To resolve this training pitfall, we propose LayerNorm Scaling, which scales the variance of output of the layer normalization inversely by the square root of its depth. This simple modification mitigates the output variance explosion of deeper Transformer layers, improving their contribution. Our experimental results, spanning model sizes from 130M to 1B, demonstrate that LayerNorm Scaling significantly enhances LLM pre-training performance compared to Pre-LN. Moreover, this improvement seamlessly carries over to supervised fine-tuning. All these gains can be attributed to the fact that LayerNorm Scaling enables deeper layers to contribute more effectively during training.

From Aleatoric to Epistemic: Exploring Uncertainty Quantification Techniques in Artificial Intelligence

Uncertainty quantification (UQ) is a critical aspect of artificial intelligence (AI) systems, particularly in high-risk domains such as healthcare, autonomous systems, and financial technology, where decision-making processes must account for uncertainty. This review explores the evolution of uncertainty quantification techniques in AI, distinguishing between aleatoric and epistemic uncertainties, and discusses the mathematical foundations and methods used to quantify these uncertainties. We provide an overview of advanced techniques, including probabilistic methods, ensemble learning, sampling-based approaches, and generative models, while also highlighting hybrid approaches that integrate domain-specific knowledge. Furthermore, we examine the diverse applications of UQ across various fields, emphasizing its impact on decision-making, predictive accuracy, and system robustness. The review also addresses key challenges such as scalability, efficiency, and integration with explainable AI, and outlines future directions for research in this rapidly developing area. Through this comprehensive survey, we aim to provide a deeper understanding of UQ's role in enhancing the reliability, safety, and trustworthiness of AI systems.

From Noise to Nuance: Advances in Deep Generative Image Models

Deep learning-based image generation has undergone a paradigm shift since 2021, marked by fundamental architectural breakthroughs and computational innovations. Through reviewing architectural innovations and empirical results, this paper analyzes the transition from traditional generative methods to advanced architectures, with focus on compute-efficient diffusion models and vision transformer architectures. We examine how recent developments in Stable Diffusion, DALL-E, and consistency models have redefined the capabilities and performance boundaries of image synthesis, while addressing persistent challenges in efficiency and quality. Our analysis focuses on the evolution of latent space representations, cross-attention mechanisms, and parameter-efficient training methodologies that enable accelerated inference under resource constraints. While more efficient training methods enable faster inference, advanced control mechanisms like ControlNet and regional attention systems have simultaneously improved generation precision and content customization. We investigate how enhanced multi-modal understanding and zero-shot generation capabilities are reshaping practical applications across industries. Our analysis demonstrates that despite remarkable advances in generation quality and computational efficiency, critical challenges remain in developing resource-conscious architectures and interpretable generation systems for industrial applications. The paper concludes by mapping promising research directions, including neural architecture optimization and explainable generation frameworks.

Deep Learning Model Security: Threats and Defenses

Deep learning has transformed AI applications but faces critical security challenges, including adversarial attacks, data poisoning, model theft, and privacy leakage. This survey examines these vulnerabilities, detailing their mechanisms and impact on model integrity and confidentiality. Practical implementations, including adversarial examples, label flipping, and backdoor attacks, are explored alongside defenses such as adversarial training, differential privacy, and federated learning, highlighting their strengths and limitations. Advanced methods like contrastive and self-supervised learning are presented for enhancing robustness. The survey concludes with future directions, emphasizing automated defenses, zero-trust architectures, and the security challenges of large AI models. A balanced approach to performance and security is essential for developing reliable deep learning systems.

From Bench to Bedside: A Review of Clinical Trialsin Drug Discovery and Development

Clinical trials are an indispensable part of the drug development process, bridging the gap between basic research and clinical application. During the development of new drugs, clinical trials are used not only to evaluate the safety and efficacy of the drug but also to explore its dosage, treatment regimens, and potential side effects. This review discusses the various stages of clinical trials, including Phase I (safety assessment), Phase II (preliminary efficacy evaluation), Phase III (large-scale validation), and Phase IV (post-marketing surveillance), highlighting the characteristics of each phase and their interrelationships. Additionally, the paper addresses the major challenges encountered in clinical trials, such as ethical issues, subject recruitment difficulties, diversity and representativeness concerns, and proposes strategies for overcoming these challenges. With the advancement of technology, innovative technologies such as artificial intelligence, big data, and digitalization are gradually transforming clinical trial design and implementation, improving trial efficiency and data quality. The article also looks forward to the future of clinical trials, particularly the impact of emerging therapies such as gene therapy and immunotherapy on trial design, as well as the importance of regulatory reforms and global collaboration. In conclusion, the core role of clinical trials in drug development will continue to drive the progress of innovative drug development and clinical treatment.