Breast Cancer Immunohistochemical Image Generation: a Benchmark Dataset and Challenge Review

For invasive breast cancer, immunohistochemical (IHC) techniques are often used to detect the expression level of human epidermal growth factor receptor-2 (HER2) in breast tissue to formulate a precise treatment plan. From the perspective of saving manpower, material and time costs, directly generating IHC-stained images from hematoxylin and eosin (H&E) stained images is a valuable research direction. Therefore, we held the breast cancer immunohistochemical image generation challenge, aiming to explore novel ideas of deep learning technology in pathological image generation and promote research in this field. The challenge provided registered H&E and IHC-stained image pairs, and participants were required to use these images to train a model that can directly generate IHC-stained images from corresponding H&E-stained images. We selected and reviewed the five highest-ranking methods based on their PSNR and SSIM metrics, while also providing overviews of the corresponding pipelines and implementations. In this paper, we further analyze the current limitations in the field of breast cancer immunohistochemical image generation and forecast the future development of this field. We hope that the released dataset and the challenge will inspire more scholars to jointly study higher-quality IHC-stained image generation.

Discovering A Variety of Objects in Spatio-Temporal Human-Object Interactions

Spatio-temporal Human-Object Interaction (ST-HOI) detection aims at detecting HOIs from videos, which is crucial for activity understanding. In daily HOIs, humans often interact with a variety of objects, e.g., holding and touching dozens of household items in cleaning. However, existing whole body-object interaction video benchmarks usually provide limited object classes. Here, we introduce a new benchmark based on AVA: Discovering Interacted Objects (DIO) including 51 interactions and 1,000+ objects. Accordingly, an ST-HOI learning task is proposed expecting vision systems to track human actors, detect interactions and simultaneously discover interacted objects. Even though today's detectors/trackers excel in object detection/tracking tasks, they perform unsatisfied to localize diverse/unseen objects in DIO. This profoundly reveals the limitation of current vision systems and poses a great challenge. Thus, how to leverage spatio-temporal cues to address object discovery is explored, and a Hierarchical Probe Network (HPN) is devised to discover interacted objects utilizing hierarchical spatio-temporal human/context cues. In extensive experiments, HPN demonstrates impressive performance. Data and code are available at https://github.com/DirtyHarryLYL/HAKE-AVA.

Facial Expression Recognition Research Based on Deep Learning

With the development of deep learning, the structure of convolution neural network is becoming more and more complex and the performance of object recognition is getting better. However, the classification mechanism of convolution neural networks is still an unsolved core problem. The main problem is that convolution neural networks have too many parameters, which makes it difficult to analyze them. In this paper, we design and train a convolution neural network based on the expression recognition, and explore the classification mechanism of the network. By using the Deconvolution visualization method, the extremum point of the convolution neural network is projected back to the pixel space of the original image, and we qualitatively verify that the trained expression recognition convolution neural network forms a detector for the specific facial action unit. At the same time, we design the distance function to measure the distance between the presence of facial feature unit and the maximal value of the response on the feature map of convolution neural network. The greater the distance, the more sensitive the feature map is to the facial feature unit. By comparing the maximum distance of all facial feature elements in the feature graph, the mapping relationship between facial feature element and convolution neural network feature map is determined. Therefore, we have verified that the convolution neural network has formed a detector for the facial Action unit in the training process to realize the expression recognition.