Beyond the Eye: A Relational Model for Early Dementia Detection Using Retinal OCTA Images

Early detection of dementia, such as Alzheimer's disease (AD) or mild cognitive impairment (MCI), is essential to enable timely intervention and potential treatment. Accurate detection of AD/MCI is challenging due to the high complexity, cost, and often invasive nature of current diagnostic techniques, which limit their suitability for large-scale population screening. Given the shared embryological origins and physiological characteristics of the retina and brain, retinal imaging is emerging as a potentially rapid and cost-effective alternative for the identification of individuals with or at high risk of AD. In this paper, we present a novel PolarNet+ that uses retinal optical coherence tomography angiography (OCTA) to discriminate early-onset AD (EOAD) and MCI subjects from controls. Our method first maps OCTA images from Cartesian coordinates to polar coordinates, allowing approximate sub-region calculation to implement the clinician-friendly early treatment of diabetic retinopathy study (ETDRS) grid analysis. We then introduce a multi-view module to serialize and analyze the images along three dimensions for comprehensive, clinically useful information extraction. Finally, we abstract the sequence embedding into a graph, transforming the detection task into a general graph classification problem. A regional relationship module is applied after the multi-view module to excavate the relationship between the sub-regions. Such regional relationship analyses validate known eye-brain links and reveal new discriminative patterns.

A Neural Matrix Decomposition Recommender System Model based on the Multimodal Large Language Model

Recommendation systems have become an important solution to information search problems. This article proposes a neural matrix factorization recommendation system model based on the multimodal large language model called BoNMF. This model combines BoBERTa's powerful capabilities in natural language processing, ViT in computer in vision, and neural matrix decomposition technology. By capturing the potential characteristics of users and items, and after interacting with a low-dimensional matrix composed of user and item IDs, the neural network outputs the results. recommend. Cold start and ablation experimental results show that the BoNMF model exhibits excellent performance on large public data sets and significantly improves the accuracy of recommendations.

Automated Loss function Search for Class-imbalanced Node Classification

Class-imbalanced node classification tasks are prevalent in real-world scenarios. Due to the uneven distribution of nodes across different classes, learning high-quality node representations remains a challenging endeavor. The engineering of loss functions has shown promising potential in addressing this issue. It involves the meticulous design of loss functions, utilizing information about the quantities of nodes in different categories and the network's topology to learn unbiased node representations. However, the design of these loss functions heavily relies on human expert knowledge and exhibits limited adaptability to specific target tasks. In this paper, we introduce a high-performance, flexible, and generalizable automated loss function search framework to tackle this challenge. Across 15 combinations of graph neural networks and datasets, our framework achieves a significant improvement in performance compared to state-of-the-art methods. Additionally, we observe that homophily in graph-structured data significantly contributes to the transferability of the proposed framework.

View Transition based Dual Camera Image Fusion

The dual camera system of wide-angle ($\bf{W}$) and telephoto ($\bf{T}$) cameras has been widely adopted by popular phones. In the overlap region, fusing the $\bf{W}$ and $\bf{T}$ images can generate a higher quality image. Related works perform pixel-level motion alignment or high-dimensional feature alignment of the $\bf{T}$ image to the view of the $\bf{W}$ image and then perform image/feature fusion, but the enhancement in occlusion area is ill-posed and can hardly utilize data from $\bf{T}$ images. Our insight is to minimize the occlusion area and thus maximize the use of pixels from $\bf{T}$ images. Instead of insisting on placing the output in the $\bf{W}$ view, we propose a view transition method to transform both $\bf{W}$ and $\bf{T}$ images into a mixed view and then blend them into the output. The transformation ratio is kept small and not apparent to users, and the center area of the output, which has accumulated a sufficient amount of transformation, can directly use the contents from the T view to minimize occlusions. Experimental results show that, in comparison with the SOTA methods, occlusion area is largely reduced by our method and thus more pixels of the $\bf{T}$ image can be used for improving the quality of the output image.

Polar-Net: A Clinical-Friendly Model for Alzheimer's Disease Detection in OCTA Images

Optical Coherence Tomography Angiography (OCTA) is a promising tool for detecting Alzheimer's disease (AD) by imaging the retinal microvasculature. Ophthalmologists commonly use region-based analysis, such as the ETDRS grid, to study OCTA image biomarkers and understand the correlation with AD. However, existing studies have used general deep computer vision methods, which present challenges in providing interpretable results and leveraging clinical prior knowledge. To address these challenges, we propose a novel deep-learning framework called Polar-Net. Our approach involves mapping OCTA images from Cartesian coordinates to polar coordinates, which allows for the use of approximate sector convolution and enables the implementation of the ETDRS grid-based regional analysis method commonly used in clinical practice. Furthermore, Polar-Net incorporates clinical prior information of each sector region into the training process, which further enhances its performance. Additionally, our framework adapts to acquire the importance of the corresponding retinal region, which helps researchers and clinicians understand the model's decision-making process in detecting AD and assess its conformity to clinical observations. Through evaluations on private and public datasets, we have demonstrated that Polar-Net outperforms existing state-of-the-art methods and provides more valuable pathological evidence for the association between retinal vascular changes and AD. In addition, we also show that the two innovative modules introduced in our framework have a significant impact on improving overall performance.