Touchstone Benchmark: Are We on the Right Way for Evaluating AI Algorithms for Medical Segmentation?

How can we test AI performance? This question seems trivial, but it isn't. Standard benchmarks often have problems such as in-distribution and small-size test sets, oversimplified metrics, unfair comparisons, and short-term outcome pressure. As a consequence, good performance on standard benchmarks does not guarantee success in real-world scenarios. To address these problems, we present Touchstone, a large-scale collaborative segmentation benchmark of 9 types of abdominal organs. This benchmark is based on 5,195 training CT scans from 76 hospitals around the world and 5,903 testing CT scans from 11 additional hospitals. This diverse test set enhances the statistical significance of benchmark results and rigorously evaluates AI algorithms across various out-of-distribution scenarios. We invited 14 inventors of 19 AI algorithms to train their algorithms, while our team, as a third party, independently evaluated these algorithms on three test sets. In addition, we also evaluated pre-existing AI frameworks--which, differing from algorithms, are more flexible and can support different algorithms--including MONAI from NVIDIA, nnU-Net from DKFZ, and numerous other open-source frameworks. We are committed to expanding this benchmark to encourage more innovation of AI algorithms for the medical domain.

Comprehensive Online Training and Deployment for Spiking Neural Networks

Spiking Neural Networks (SNNs) are considered to have enormous potential in the future development of Artificial Intelligence (AI) due to their brain-inspired and energy-efficient properties. In the current supervised learning domain of SNNs, compared to vanilla Spatial-Temporal Back-propagation (STBP) training, online training can effectively overcome the risk of GPU memory explosion and has received widespread academic attention. However, the current proposed online training methods cannot tackle the inseparability problem of temporal dependent gradients and merely aim to optimize the training memory, resulting in no performance advantages compared to the STBP training models in the inference phase. To address the aforementioned challenges, we propose Efficient Multi-Precision Firing (EM-PF) model, which is a family of advanced spiking models based on floating-point spikes and binary synaptic weights. We point out that EM-PF model can effectively separate temporal gradients and achieve full-stage optimization towards computation speed and memory footprint. Experimental results have demonstrated that EM-PF model can be flexibly combined with various techniques including random back-propagation, parallel computation and channel attention mechanism, to achieve state-of-the-art performance with extremely low computational overhead in the field of online learning.

CopyLens: Dynamically Flagging Copyrighted Sub-Dataset Contributions to LLM Outputs

Large Language Models (LLMs) have become pervasive due to their knowledge absorption and text-generation capabilities. Concurrently, the copyright issue for pretraining datasets has been a pressing concern, particularly when generation includes specific styles. Previous methods either focus on the defense of identical copyrighted outputs or find interpretability by individual tokens with computational burdens. However, the gap between them exists, where direct assessments of how dataset contributions impact LLM outputs are missing. Once the model providers ensure copyright protection for data holders, a more mature LLM community can be established. To address these limitations, we introduce CopyLens, a new framework to analyze how copyrighted datasets may influence LLM responses. Specifically, a two-stage approach is employed: First, based on the uniqueness of pretraining data in the embedding space, token representations are initially fused for potential copyrighted texts, followed by a lightweight LSTM-based network to analyze dataset contributions. With such a prior, a contrastive-learning-based non-copyright OOD detector is designed. Our framework can dynamically face different situations and bridge the gap between current copyright detection methods. Experiments show that CopyLens improves efficiency and accuracy by 15.2% over our proposed baseline, 58.7% over prompt engineering methods, and 0.21 AUC over OOD detection baselines.

Emu3: Next-Token Prediction is All You Need

While next-token prediction is considered a promising path towards artificial general intelligence, it has struggled to excel in multimodal tasks, which are still dominated by diffusion models (e.g., Stable Diffusion) and compositional approaches (e.g., CLIP combined with LLMs). In this paper, we introduce Emu3, a new suite of state-of-the-art multimodal models trained solely with next-token prediction. By tokenizing images, text, and videos into a discrete space, we train a single transformer from scratch on a mixture of multimodal sequences. Emu3 outperforms several well-established task-specific models in both generation and perception tasks, surpassing flagship models such as SDXL and LLaVA-1.6, while eliminating the need for diffusion or compositional architectures. Emu3 is also capable of generating high-fidelity video via predicting the next token in a video sequence. We simplify complex multimodal model designs by converging on a singular focus: tokens, unlocking great potential for scaling both during training and inference. Our results demonstrate that next-token prediction is a promising path towards building general multimodal intelligence beyond language. We open-source key techniques and models to support further research in this direction.

Learning from Pattern Completion: Self-supervised Controllable Generation

The human brain exhibits a strong ability to spontaneously associate different visual attributes of the same or similar visual scene, such as associating sketches and graffiti with real-world visual objects, usually without supervising information. In contrast, in the field of artificial intelligence, controllable generation methods like ControlNet heavily rely on annotated training datasets such as depth maps, semantic segmentation maps, and poses, which limits the method's scalability. Inspired by the neural mechanisms that may contribute to the brain's associative power, specifically the cortical modularization and hippocampal pattern completion, here we propose a self-supervised controllable generation (SCG) framework. Firstly, we introduce an equivariant constraint to promote inter-module independence and intra-module correlation in a modular autoencoder network, thereby achieving functional specialization. Subsequently, based on these specialized modules, we employ a self-supervised pattern completion approach for controllable generation training. Experimental results demonstrate that the proposed modular autoencoder effectively achieves functional specialization, including the modular processing of color, brightness, and edge detection, and exhibits brain-like features including orientation selectivity, color antagonism, and center-surround receptive fields. Through self-supervised training, associative generation capabilities spontaneously emerge in SCG, demonstrating excellent generalization ability to various tasks such as associative generation on painting, sketches, and ancient graffiti. Compared to the previous representative method ControlNet, our proposed approach not only demonstrates superior robustness in more challenging high-noise scenarios but also possesses more promising scalability potential due to its self-supervised manner.

Video-XL: Extra-Long Vision Language Model for Hour-Scale Video Understanding

Although current Multi-modal Large Language Models (MLLMs) demonstrate promising results in video understanding, processing extremely long videos remains an ongoing challenge. Typically, MLLMs struggle with handling thousands of tokens that exceed the maximum context length of LLMs, and they experience reduced visual clarity due to token aggregation. Another challenge is the high computational cost stemming from the large number of video tokens. To tackle these issues, we propose Video-XL, an extra-long vision language model designed for efficient hour-scale video understanding. Specifically, we argue that LLMs can be adapted as effective visual condensers and introduce Visual Context Latent Summarization, which condenses visual contexts into highly compact forms. Extensive experiments demonstrate that our model achieves promising results on popular long video understanding benchmarks, despite being trained on limited image data. Moreover, Video-XL strikes a promising balance between efficiency and effectiveness, processing 1024 frames on a single 80GB GPU while achieving nearly 100\% accuracy in the Needle-in-a-Haystack evaluation. We envision Video-XL becoming a valuable tool for long video applications such as video summarization, surveillance anomaly detection, and Ad placement identification.

OmniGen: Unified Image Generation

In this work, we introduce OmniGen, a new diffusion model for unified image generation. Unlike popular diffusion models (e.g., Stable Diffusion), OmniGen no longer requires additional modules such as ControlNet or IP-Adapter to process diverse control conditions. OmniGenis characterized by the following features: 1) Unification: OmniGen not only demonstrates text-to-image generation capabilities but also inherently supports other downstream tasks, such as image editing, subject-driven generation, and visual-conditional generation. Additionally, OmniGen can handle classical computer vision tasks by transforming them into image generation tasks, such as edge detection and human pose recognition. 2) Simplicity: The architecture of OmniGen is highly simplified, eliminating the need for additional text encoders. Moreover, it is more user-friendly compared to existing diffusion models, enabling complex tasks to be accomplished through instructions without the need for extra preprocessing steps (e.g., human pose estimation), thereby significantly simplifying the workflow of image generation. 3) Knowledge Transfer: Through learning in a unified format, OmniGen effectively transfers knowledge across different tasks, manages unseen tasks and domains, and exhibits novel capabilities. We also explore the model's reasoning capabilities and potential applications of chain-of-thought mechanism. This work represents the first attempt at a general-purpose image generation model, and there remain several unresolved issues. We will open-source the related resources at https://github.com/VectorSpaceLab/OmniGen to foster advancements in this field.

ShapeMamba-EM: Fine-Tuning Foundation Model with Local Shape Descriptors and Mamba Blocks for 3D EM Image Segmentation

Electron microscopy (EM) imaging offers unparalleled resolution for analyzing neural tissues, crucial for uncovering the intricacies of synaptic connections and neural processes fundamental to understanding behavioral mechanisms. Recently, the foundation models have demonstrated impressive performance across numerous natural and medical image segmentation tasks. However, applying these foundation models to EM segmentation faces significant challenges due to domain disparities. This paper presents ShapeMamba-EM, a specialized fine-tuning method for 3D EM segmentation, which employs adapters for long-range dependency modeling and an encoder for local shape description within the original foundation model. This approach effectively addresses the unique volumetric and morphological complexities of EM data. Tested over a wide range of EM images, covering five segmentation tasks and 10 datasets, ShapeMamba-EM outperforms existing methods, establishing a new standard in EM image segmentation and enhancing the understanding of neural tissue architecture.

PRTGS: Precomputed Radiance Transfer of Gaussian Splats for Real-Time High-Quality Relighting

We proposed Precomputed RadianceTransfer of GaussianSplats (PRTGS), a real-time high-quality relighting method for Gaussian splats in low-frequency lighting environments that captures soft shadows and interreflections by precomputing 3D Gaussian splats' radiance transfer. Existing studies have demonstrated that 3D Gaussian splatting (3DGS) outperforms neural fields' efficiency for dynamic lighting scenarios. However, the current relighting method based on 3DGS still struggles to compute high-quality shadow and indirect illumination in real time for dynamic light, leading to unrealistic rendering results. We solve this problem by precomputing the expensive transport simulations required for complex transfer functions like shadowing, the resulting transfer functions are represented as dense sets of vectors or matrices for every Gaussian splat. We introduce distinct precomputing methods tailored for training and rendering stages, along with unique ray tracing and indirect lighting precomputation techniques for 3D Gaussian splats to accelerate training speed and compute accurate indirect lighting related to environment light. Experimental analyses demonstrate that our approach achieves state-of-the-art visual quality while maintaining competitive training times and allows high-quality real-time (30+ fps) relighting for dynamic light and relatively complex scenes at 1080p resolution.

Multimodal Large Language Models for Bioimage Analysis

Rapid advancements in imaging techniques and analytical methods over the past decade have revolutionized our ability to comprehensively probe the biological world at multiple scales, pinpointing the type, quantity, location, and even temporal dynamics of biomolecules. The surge in data complexity and volume presents significant challenges in translating this wealth of information into knowledge. The recently emerged Multimodal Large Language Models (MLLMs) exhibit strong emergent capacities, such as understanding, analyzing, reasoning, and generalization. With these capabilities, MLLMs hold promise to extract intricate information from biological images and data obtained through various modalities, thereby expediting our biological understanding and aiding in the development of novel computational frameworks. Previously, such capabilities were mostly attributed to humans for interpreting and summarizing meaningful conclusions from comprehensive observations and analysis of biological images. However, the current development of MLLMs shows increasing promise in serving as intelligent assistants or agents for augmenting human researchers in biology research