Immunogenicity Prediction with Dual Attention Enables Vaccine Target Selection

Immunogenicity prediction is a central topic in reverse vaccinology for finding candidate vaccines that can trigger protective immune responses. Existing approaches typically rely on highly compressed features and simple model architectures, leading to limited prediction accuracy and poor generalizability. To address these challenges, we introduce ProVaccine, a novel deep learning solution with a dual attention mechanism that integrates pre-trained latent vector representations of protein sequences and structures. We also compile the most comprehensive immunogenicity dataset to date, encompassing over 9,500 antigen sequences, structures, and immunogenicity labels from bacteria, viruses, and tumors. Extensive experiments demonstrate that ProVaccine outperforms existing methods across a wide range of evaluation metrics. Furthermore, we establish a post-hoc validation protocol to assess the practical significance of deep learning models in tackling vaccine design challenges. Our work provides an effective tool for vaccine design and sets valuable benchmarks for future research.

Air-to-Ground Cooperative OAM Communications

For users in hotspot region, orbital angular momentum (OAM) can realize multifold increase of spectrum efficiency (SE), and the flying base station (FBS) can rapidly support the real-time communication demand. However, the hollow divergence and alignment requirement impose crucial challenges for users to achieve air-to-ground OAM communications, where there exists the line-of-sight path. Therefore, we propose the air-to-ground cooperative OAM communication (ACOC) scheme, which can realize OAM communications for users with size-limited devices. The waist radius is adjusted to guarantee the maximum intensity at the cooperative users (CUs). We derive the closed-form expression of the optimal FBS position, which satisfies the antenna alignment for two cooperative user groups (CUGs). Furthermore, the selection constraint is given to choose two CUGs composed of four CUs. Simulation results are provided to validate the optimal FBS position and the SE superiority of the proposed ACOC scheme.

MSR-86K: An Evolving, Multilingual Corpus with 86,300 Hours of Transcribed Audio for Speech Recognition Research

Recently, multilingual artificial intelligence assistants, exemplified by ChatGPT, have gained immense popularity. As a crucial gateway to human-computer interaction, multilingual automatic speech recognition (ASR) has also garnered significant attention, as evidenced by systems like Whisper. However, the proprietary nature of the training data has impeded researchers' efforts to study multilingual ASR. This paper introduces MSR-86K, an evolving, large-scale multilingual corpus for speech recognition research. The corpus is derived from publicly accessible videos on YouTube, comprising 15 languages and a total of 86,300 hours of transcribed ASR data. We also introduce how to use the MSR-86K corpus and other open-source corpora to train a robust multilingual ASR model that is competitive with Whisper. MSR-86K will be publicly released on HuggingFace, and we believe that such a large corpus will pave new avenues for research in multilingual ASR.

Enhancing Multilingual Speech Recognition through Language Prompt Tuning and Frame-Level Language Adapter

Multilingual intelligent assistants, such as ChatGPT, have recently gained popularity. To further expand the applications of multilingual artificial intelligence assistants and facilitate international communication, it is essential to enhance the performance of multilingual speech recognition, which is a crucial component of speech interaction. In this paper, we propose two simple and parameter-efficient methods: language prompt tuning and frame-level language adapter, to respectively enhance language-configurable and language-agnostic multilingual speech recognition. Additionally, we explore the feasibility of integrating these two approaches using parameter-efficient fine-tuning methods. Our experiments demonstrate significant performance improvements across seven languages using our proposed methods.

Boosting long-term forecasting performance for continuous-time dynamic graph networks via data augmentation

This study focuses on long-term forecasting (LTF) on continuous-time dynamic graph networks (CTDGNs), which is important for real-world modeling. Existing CTDGNs are effective for modeling temporal graph data due to their ability to capture complex temporal dependencies but perform poorly on LTF due to the substantial requirement for historical data, which is not practical in most cases. To relieve this problem, a most intuitive way is data augmentation. In this study, we propose \textbf{\underline{U}ncertainty \underline{M}asked \underline{M}ix\underline{U}p (UmmU)}: a plug-and-play module that conducts uncertainty estimation to introduce uncertainty into the embedding of intermediate layer of CTDGNs, and perform masked mixup to further enhance the uncertainty of the embedding to make it generalize to more situations. UmmU can be easily inserted into arbitrary CTDGNs without increasing the number of parameters. We conduct comprehensive experiments on three real-world dynamic graph datasets, the results demonstrate that UmmU can effectively improve the long-term forecasting performance for CTDGNs.

Motif-aware temporal GCN for fraud detection in signed cryptocurrency trust networks

Graph convolutional networks (GCNs) is a class of artificial neural networks for processing data that can be represented as graphs. Since financial transactions can naturally be constructed as graphs, GCNs are widely applied in the financial industry, especially for financial fraud detection. In this paper, we focus on fraud detection on cryptocurrency truct networks. In the literature, most works focus on static networks. Whereas in this study, we consider the evolving nature of cryptocurrency networks, and use local structural as well as the balance theory to guide the training process. More specifically, we compute motif matrices to capture the local topological information, then use them in the GCN aggregation process. The generated embedding at each snapshot is a weighted average of embeddings within a time window, where the weights are learnable parameters. Since the trust networks is signed on each edge, balance theory is used to guide the training process. Experimental results on bitcoin-alpha and bitcoin-otc datasets show that the proposed model outperforms those in the literature.

A Review of Intelligent Music Generation Systems

Intelligent music generation, one of the most popular subfields of computer creativity, can lower the creative threshold for non-specialists and increase the efficiency of music creation. In the last five years, the quality of algorithm-based automatic music generation has increased significantly, motivated by the use of modern generative algorithms to learn the patterns implicit within a piece of music based on rule constraints or a musical corpus, thus generating music samples in various styles. Some of the available literature reviews lack a systematic benchmark of generative models and are traditional and conservative in their perspective, resulting in a vision of the future development of the field that is not deeply integrated with the current rapid scientific progress. In this paper, we conduct a comprehensive survey and analysis of recent intelligent music generation techniques,provide a critical discussion, explicitly identify their respective characteristics, and present them in a general table. We first introduce how music as a stream of information is encoded and the relevant datasets, then compare different types of generation algorithms, summarize their strengths and weaknesses, and discuss existing methods for evaluation. Finally, the development of artificial intelligence in composition is studied, especially by comparing the different characteristics of music generation techniques in the East and West and analyzing the development prospects in this field.

Spatial-aware Speaker Diarization for Multi-channel Multi-party Meeting

This paper describes a spatial-aware speaker diarization system for the multi-channel multi-party meeting. The diarization system obtains direction information of speaker by microphone array. Speaker spatial embedding is generated by xvector and s-vector derived from superdirective beamforming (SDB) which makes the embedding more robust. Specifically, we propose a novel multi-channel sequence-to-sequence neural network architecture named discriminative multi-stream neural network (DMSNet) which consists of attention superdirective beamforming (ASDB) block and Conformer encoder. The proposed ASDB is a self-adapted channel-wise block that extracts the latent spatial features of array audios by modeling interdependencies between channels. We explore DMSNet to address overlapped speech problem on multi-channel audio and achieve 93.53% accuracy on evaluation set. By performing DMSNet based overlapped speech detection (OSD) module, the diarization error rate (DER) of cluster-based diarization system decrease significantly from 13.45% to 7.64%.

A Ligand-and-structure Dual-driven Deep Learning Method for the Discovery of Highly Potent GnRH1R Antagonist to treat Uterine Diseases

Gonadotrophin-releasing hormone receptor (GnRH1R) is a promising therapeutic target for the treatment of uterine diseases. To date, several GnRH1R antagonists are available in clinical investigation without satisfying multiple property constraints. To fill this gap, we aim to develop a deep learning-based framework to facilitate the effective and efficient discovery of a new orally active small-molecule drug targeting GnRH1R with desirable properties. In the present work, a ligand-and-structure combined model, namely LS-MolGen, was firstly proposed for molecular generation by fully utilizing the information on the known active compounds and the structure of the target protein, which was demonstrated by its superior performance than ligand- or structure-based methods separately. Then, a in silico screening including activity prediction, ADMET evaluation, molecular docking and FEP calculation was conducted, where ~30,000 generated novel molecules were narrowed down to 8 for experimental synthesis and validation. In vitro and in vivo experiments showed that three of them exhibited potent inhibition activities (compound 5 IC50 = 0.856 nM, compound 6 IC50 = 0.901 nM, compound 7 IC50 = 2.54 nM) against GnRH1R, and compound 5 performed well in fundamental PK properties, such as half-life, oral bioavailability, and PPB, etc. We believed that the proposed ligand-and-structure combined molecular generative model and the whole computer-aided workflow can potentially be extended to similar tasks for de novo drug design or lead optimization.

An Interpretable Federated Learning-based Network Intrusion Detection Framework

Learning-based Network Intrusion Detection Systems (NIDSs) are widely deployed for defending various cyberattacks. Existing learning-based NIDS mainly uses Neural Network (NN) as a classifier that relies on the quality and quantity of cyberattack data. Such NN-based approaches are also hard to interpret for improving efficiency and scalability. In this paper, we design a new local-global computation paradigm, FEDFOREST, a novel learning-based NIDS by combining the interpretable Gradient Boosting Decision Tree (GBDT) and Federated Learning (FL) framework. Specifically, FEDFOREST is composed of multiple clients that extract local cyberattack data features for the server to train models and detect intrusions. A privacy-enhanced technology is also proposed in FEDFOREST to further defeat the privacy of the FL systems. Extensive experiments on 4 cyberattack datasets of different tasks demonstrate that FEDFOREST is effective, efficient, interpretable, and extendable. FEDFOREST ranks first in the collaborative learning and cybersecurity competition 2021 for Chinese college students.