Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
Abstract:We propose a real-time 3D human pose estimation and motion analysis method termed RePose for rehabilitation training. It is capable of real-time monitoring and evaluation of patients'motion during rehabilitation, providing immediate feedback and guidance to assist patients in executing rehabilitation exercises correctly. Firstly, we introduce a unified pipeline for end-to-end real-time human pose estimation and motion analysis using RGB video input from multiple cameras which can be applied to the field of rehabilitation training. The pipeline can help to monitor and correct patients'actions, thus aiding them in regaining muscle strength and motor functions. Secondly, we propose a fast tracking method for medical rehabilitation scenarios with multiple-person interference, which requires less than 1ms for tracking for a single frame. Additionally, we modify SmoothNet for real-time posture estimation, effectively reducing pose estimation errors and restoring the patient's true motion state, making it visually smoother. Finally, we use Unity platform for real-time monitoring and evaluation of patients' motion during rehabilitation, and to display the muscle stress conditions to assist patients with their rehabilitation training.
Abstract:Multi-omics studies often rely on pathway enrichment to interpret heterogeneous molecular changes, but pathway enrichment (PE)-based workflows inherit structural limitations of pathway resources, including curation lag, functional redundancy, and limited sensitivity to molecular states and interventions. Although recent work has explored using large language models (LLMs) to improve PE-based interpretation, the lack of a standardized benchmark for end-to-end multi-omics pathway mechanism elucidation has largely confined evaluation to small, manually curated datasets or ad hoc case studies, hindering reproducible progress. To address this issue, we introduce BIOME-Bench, constructed via a rigorous four-stage workflow, to evaluate two core capabilities of LLMs in multi-omics analysis: Biomolecular Interaction Inference and end-to-end Multi-Omics Pathway Mechanism Elucidation. We develop evaluation protocols for both tasks and conduct comprehensive experiments across multiple strong contemporary models. Experimental results demonstrate that existing models still exhibit substantial deficiencies in multi-omics analysis, struggling to reliably distinguish fine-grained biomolecular relation types and to generate faithful, robust pathway-level mechanistic explanations.
Abstract:Iterative refinement methods based on a denoising-inversion cycle are powerful tools for enhancing the quality and control of diffusion models. However, their effectiveness is critically limited when combined with standard Classifier-Free Guidance (CFG). We identify a fundamental limitation: CFG's extrapolative nature systematically pushes the sampling path off the data manifold, causing the approximation error to diverge and undermining the refinement process. To address this, we propose Guided Path Sampling (GPS), a new paradigm for iterative refinement. GPS replaces unstable extrapolation with a principled, manifold-constrained interpolation, ensuring the sampling path remains on the data manifold. We theoretically prove that this correction transforms the error series from unbounded amplification to strictly bounded, guaranteeing stability. Furthermore, we devise an optimal scheduling strategy that dynamically adjusts guidance strength, aligning semantic injection with the model's natural coarse-to-fine generation process. Extensive experiments on modern backbones like SDXL and Hunyuan-DiT show that GPS outperforms existing methods in both perceptual quality and complex prompt adherence. For instance, GPS achieves a superior ImageReward of 0.79 and HPS v2 of 0.2995 on SDXL, while improving overall semantic alignment accuracy on GenEval to 57.45%. Our work establishes that path stability is a prerequisite for effective iterative refinement, and GPS provides a robust framework to achieve it.
Abstract:Real-time instance segmentation for spinal endoscopy is important for identifying and protecting critical anatomy during surgery, but it is difficult because of the narrow field of view, specular highlights, smoke/bleeding, unclear boundaries, and large scale changes. Deployment is also constrained by limited surgical hardware, so the model must balance accuracy and speed and remain stable under small-batch (even batch-1) training. We propose LMSF-A, a lightweight multi-scale attention framework co-designed across backbone, neck, and head. The backbone uses a C2f-Pro module that combines RepViT-style re-parameterized convolution (RVB) with efficient multi-scale attention (EMA), enabling multi-branch training while collapsing into a single fast path for inference. The neck improves cross-scale consistency and boundary detail using Scale-Sequence Feature Fusion (SSFF) and Triple Feature Encoding (TFE), which strengthens high-resolution features. The head adopts a Lightweight Multi-task Shared Head (LMSH) with shared convolutions and GroupNorm to reduce parameters and support batch-1 stability. We also release the clinically reviewed PELD dataset (61 patients, 610 images) with instance masks for adipose tissue, bone, ligamentum flavum, and nerve. Experiments show that LMSF-A is highly competitive (or even better than) in all evaluation metrics and much lighter than most instance segmentation methods requiring only 1.8M parameters and 8.8 GFLOPs, and it generalizes well to a public teeth benchmark. Code and dataset: https://github.com/hhwmortal/PELD-Instance-segmentation.
Abstract:A fundamental challenge in Continual Learning (CL) is catastrophic forgetting, where adapting to new tasks degrades the performance on previous ones. While the field has evolved with diverse methods, this rapid surge in diverse methodologies has culminated in a fragmented research landscape. The lack of a unified framework, including inconsistent implementations, conflicting dependencies, and varying evaluation protocols, makes fair comparison and reproducible research increasingly difficult. To address this challenge, we propose LibContinual, a comprehensive and reproducible library designed to serve as a foundational platform for realistic CL. Built upon a high-cohesion, low-coupling modular architecture, LibContinual integrates 19 representative algorithms across five major methodological categories, providing a standardized execution environment. Meanwhile, leveraging this unified framework, we systematically identify and investigate three implicit assumptions prevalent in mainstream evaluation: (1) offline data accessibility, (2) unregulated memory resources, and (3) intra-task semantic homogeneity. We argue that these assumptions often overestimate the real-world applicability of CL methods. Through our comprehensive analysis using strict online CL settings, a novel unified memory budget protocol, and a proposed category-randomized setting, we reveal significant performance drops in many representative CL methods when subjected to these real-world constraints. Our study underscores the necessity of resource-aware and semantically robust CL strategies, and offers LibContinual as a foundational toolkit for future research in realistic continual learning. The source code is available from \href{https://github.com/RL-VIG/LibContinual}{https://github.com/RL-VIG/LibContinual}.
Abstract:Video prediction is plagued by a fundamental trilemma: achieving high-resolution and perceptual quality typically comes at the cost of real-time speed, hindering its use in latency-critical applications. This challenge is most acute for autonomous UAVs in dense urban environments, where foreseeing events from high-resolution imagery is non-negotiable for safety. Existing methods, reliant on iterative generation (diffusion, autoregressive models) or quadratic-complexity attention, fail to meet these stringent demands on edge hardware. To break this long-standing trade-off, we introduce RAPTOR, a video prediction architecture that achieves real-time, high-resolution performance. RAPTOR's single-pass design avoids the error accumulation and latency of iterative approaches. Its core innovation is Efficient Video Attention (EVA), a novel translator module that factorizes spatiotemporal modeling. Instead of processing flattened spacetime tokens with $O((ST)^2)$ or $O(ST)$ complexity, EVA alternates operations along the spatial (S) and temporal (T) axes. This factorization reduces the time complexity to $O(S + T)$ and memory complexity to $O(max(S, T))$, enabling global context modeling at $512^2$ resolution and beyond, operating directly on dense feature maps with a patch-free design. Complementing this architecture is a 3-stage training curriculum that progressively refines predictions from coarse structure to sharp, temporally coherent details. Experiments show RAPTOR is the first predictor to exceed 30 FPS on a Jetson AGX Orin for $512^2$ video, setting a new state-of-the-art on UAVid, KTH, and a custom high-resolution dataset in PSNR, SSIM, and LPIPS. Critically, RAPTOR boosts the mission success rate in a real-world UAV navigation task by 18/%, paving the way for safer and more anticipatory embodied agents.
Abstract:Although Graph Neural Networks (GNNs) have become the dominant approach for graph representation learning, their performance on link prediction tasks does not always surpass that of traditional heuristic methods such as Common Neighbors and Jaccard Coefficient. This is mainly because existing GNNs tend to focus on learning local node representations, making it difficult to effectively capture structural relationships between node pairs. Furthermore, excessive reliance on local neighborhood information can lead to over-smoothing. Prior studies have shown that introducing global structural encoding can partially alleviate this issue. To address these limitations, we propose a Community-Enhanced Link Prediction (CELP) framework that incorporates community structure to jointly model local and global graph topology. Specifically, CELP enhances the graph via community-aware, confidence-guided edge completion and pruning, while integrating multi-scale structural features to achieve more accurate link prediction. Experimental results across multiple benchmark datasets demonstrate that CELP achieves superior performance, validating the crucial role of community structure in improving link prediction accuracy.
Abstract:Multimodal clinical reasoning in the field of gastrointestinal (GI) oncology necessitates the integrated interpretation of endoscopic imagery, radiological data, and biochemical markers. Despite the evident potential exhibited by Multimodal Large Language Models (MLLMs), they frequently encounter challenges such as context dilution and hallucination when confronted with intricate, heterogeneous medical histories. In order to address these limitations, a hierarchical Multi-Agent Framework is proposed, which emulates the collaborative workflow of a human Multidisciplinary Team (MDT). The system attained a composite expert evaluation score of 4.60/5.00, thereby demonstrating a substantial improvement over the monolithic baseline. It is noteworthy that the agent-based architecture yielded the most substantial enhancements in reasoning logic and medical accuracy. The findings indicate that mimetic, agent-based collaboration provides a scalable, interpretable, and clinically robust paradigm for automated decision support in oncology.
Abstract:Crystal structure prediction is a fundamental problem in materials science. We present CrystalFormer-CSP, an efficient framework that unifies data-driven heuristic and physics-driven optimization approaches to predict stable crystal structures for given chemical compositions. The approach combines pretrained generative models for space-group-informed structure generation and a universal machine learning force field for energy minimization. Reinforcement fine-tuning can be employed to further boost the accuracy of the framework. We demonstrate the effectiveness of CrystalFormer-CSP on benchmark problems and showcase its usage via web interface and language model integration.




Abstract:The crystal structure of high-pressure solid hydrogen remains a fundamental open problem. Although the research frontier has mostly shifted toward ultra-high pressure phases above 400 GPa, we show that even the broken symmetry phase observed around 130~GPa requires revisiting due to its intricate coupling of electronic and nuclear degrees of freedom. Here, we develop a first principle quantum Monte Carlo framework based on a deep neural network wave function that treats both electrons and nuclei quantum mechanically within the constant pressure ensemble. Our calculations reveal an unreported ground-state structure candidate for the broken symmetry phase with $Cmcm$ space group symmetry, and we test its stability up to 96 atoms. The predicted structure quantitatively matches the experimental equation of state and X-ray diffraction patterns. Furthermore, our group-theoretical analysis shows that the $Cmcm$ structure is compatible with existing Raman and infrared spectroscopic data. Crucially, static density functional theory calculation reveals the $Cmcm$ structure as a dynamically unstable saddle point on the Born-Oppenheimer potential energy surface, demonstrating that a full quantum many-body treatment of the problem is necessary. These results shed new light on the phase diagram of high-pressure hydrogen and call for further experimental verifications.