Enhancing Hepatopathy Clinical Trial Efficiency: A Secure, Large Language Model-Powered Pre-Screening Pipeline

Background: Recruitment for cohorts involving complex liver diseases, such as hepatocellular carcinoma and liver cirrhosis, often requires interpreting semantically complex criteria. Traditional manual screening methods are time-consuming and prone to errors. While AI-powered pre-screening offers potential solutions, challenges remain regarding accuracy, efficiency, and data privacy. Methods: We developed a novel patient pre-screening pipeline that leverages clinical expertise to guide the precise, safe, and efficient application of large language models. The pipeline breaks down complex criteria into a series of composite questions and then employs two strategies to perform semantic question-answering through electronic health records - (1) Pathway A, Anthropomorphized Experts' Chain of Thought strategy, and (2) Pathway B, Preset Stances within an Agent Collaboration strategy, particularly in managing complex clinical reasoning scenarios. The pipeline is evaluated on three key metrics-precision, time consumption, and counterfactual inference - at both the question and criterion levels. Results: Our pipeline achieved high precision (0.921, in criteria level) and efficiency (0.44s per task). Pathway B excelled in complex reasoning, while Pathway A was effective in precise data extraction with faster processing times. Both pathways achieved comparable precision. The pipeline showed promising results in hepatocellular carcinoma (0.878) and cirrhosis trials (0.843). Conclusions: This data-secure and time-efficient pipeline shows high precision in hepatopathy trials, providing promising solutions for streamlining clinical trial workflows. Its efficiency and adaptability make it suitable for improving patient recruitment. And its capability to function in resource-constrained environments further enhances its utility in clinical settings.

AttentionEngine: A Versatile Framework for Efficient Attention Mechanisms on Diverse Hardware Platforms

Transformers and large language models (LLMs) have revolutionized machine learning, with attention mechanisms at the core of their success. As the landscape of attention variants expands, so too do the challenges of optimizing their performance, particularly across different hardware platforms. Current optimization strategies are often narrowly focused, requiring extensive manual intervention to accommodate changes in model configurations or hardware environments. In this paper, we introduce AttentionEngine, a comprehensive framework designed to streamline the optimization of attention mechanisms across heterogeneous hardware backends. By decomposing attention computation into modular operations with customizable components, AttentionEngine enables flexible adaptation to diverse algorithmic requirements. The framework further automates kernel optimization through a combination of programmable templates and a robust cross-platform scheduling strategy. Empirical results reveal performance gains of up to 10x on configurations beyond the reach of existing methods. AttentionEngine offers a scalable, efficient foundation for developing and deploying attention mechanisms with minimal manual tuning. Our code has been open-sourced and is available at https://github.com/microsoft/AttentionEngine.

Reward Models Identify Consistency, Not Causality

Reward models (RMs) play a crucial role in aligning large language models (LLMs) with human preferences and enhancing reasoning quality. Traditionally, RMs are trained to rank candidate outputs based on their correctness and coherence. However, in this work, we present several surprising findings that challenge common assumptions about RM behavior. Our analysis reveals that state-of-the-art reward models prioritize structural consistency over causal correctness. Specifically, removing the problem statement has minimal impact on reward scores, whereas altering numerical values or disrupting the reasoning flow significantly affects RM outputs. Furthermore, RMs exhibit a strong dependence on complete reasoning trajectories truncated or incomplete steps lead to significant variations in reward assignments, indicating that RMs primarily rely on learned reasoning patterns rather than explicit problem comprehension. These findings hold across multiple architectures, datasets, and tasks, leading to three key insights: (1) RMs primarily assess coherence rather than true reasoning quality; (2) The role of explicit problem comprehension in reward assignment is overstated; (3) Current RMs may be more effective at ranking responses than verifying logical validity. Our results suggest a fundamental limitation in existing reward modeling approaches, emphasizing the need for a shift toward causality-aware reward models that go beyond consistency-driven evaluation.

PRIV-QA: Privacy-Preserving Question Answering for Cloud Large Language Models

The rapid development of large language models (LLMs) is redefining the landscape of human-computer interaction, and their integration into various user-service applications is becoming increasingly prevalent. However, transmitting user data to cloud-based LLMs presents significant risks of data breaches and unauthorized access to personal identification information. In this paper, we propose a privacy preservation pipeline for protecting privacy and sensitive information during interactions between users and LLMs in practical LLM usage scenarios. We construct SensitiveQA, the first privacy open-ended question-answering dataset. It comprises 57k interactions in Chinese and English, encompassing a diverse range of user-sensitive information within the conversations. Our proposed solution employs a multi-stage strategy aimed at preemptively securing user information while simultaneously preserving the response quality of cloud-based LLMs. Experimental validation underscores our method's efficacy in balancing privacy protection with maintaining robust interaction quality. The code and dataset are available at https://github.com/ligw1998/PRIV-QA.

Investigating and Extending Homans' Social Exchange Theory with Large Language Model based Agents

Homans' Social Exchange Theory (SET) is widely recognized as a basic framework for understanding the formation and emergence of human civilizations and social structures. In social science, this theory is typically studied based on simple simulation experiments or real-world human studies, both of which either lack realism or are too expensive to control. In artificial intelligence, recent advances in large language models (LLMs) have shown promising capabilities in simulating human behaviors. Inspired by these insights, we adopt an interdisciplinary research perspective and propose using LLM-based agents to study Homans' SET. Specifically, we construct a virtual society composed of three LLM agents and have them engage in a social exchange game to observe their behaviors. Through extensive experiments, we found that Homans' SET is well validated in our agent society, demonstrating the consistency between the agent and human behaviors. Building on this foundation, we intentionally alter the settings of the agent society to extend the traditional Homans' SET, making it more comprehensive and detailed. To the best of our knowledge, this paper marks the first step in studying Homans' SET with LLM-based agents. More importantly, it introduces a novel and feasible research paradigm that bridges the fields of social science and computer science through LLM-based agents. Code is available at https://github.com/Paitesanshi/SET.

A Block Term Decomposition Model Based Algorithm for Tensor Completion of Multidimensional Harmonic Signals

We consider tensor data completion of an incomplete observation of multidimensional harmonic (MH) signals. Unlike existing tensor-based techniques for MH retrieval (MHR), which mostly adopt the canonical polyadic decomposition (CPD) to model the simple "one-to-one" correspondence among harmonics across difference modes, we herein use the more flexible block term decomposition (BTD) model that can be used to describe the complex mutual correspondences among several groups of harmonics across different modes. An optimization principle that aims to fit the BTD model in the least squares sense, subject to rank minimization of hankelized MH components, is set up for the tensor completion task, and an algorithm based on alternating direction method of multipliers is proposed, of which the effectiveness and applicability are validated through both numerical simulations and an application in Sub-6GHz channel state information (CSI) completion.

A parametric non-negative coupled canonical polyadic decomposition algorithm for hyperspectral super-resolution

Recently, coupled tensor decomposition has been widely used in data fusion of a hyperspectral image (HSI) and a multispectral image (MSI) for hyperspectral super-resolution (HSR). However, exsiting works often ignore the inherent non-negative (NN) property of the image data, or impose the NN constraint via hard-thresholding which may interfere with the optimization procedure and cause the method to be sub-optimal. As such, we propose a novel NN coupled canonical polyadic decomposition (NN-C-CPD) algorithm, which makes use of the parametric method and nonlinear least squares (NLS) framework to impose the NN constraint into the C-CPD computation. More exactly, the NN constraint is converted into the squared relationship between the NN entries of the factor matrices and a set of latent parameters. Based on the chain rule for deriving the derivatives, the key entities such as gradient and Jacobian with regards to the latent parameters can be derived, thus the NN constraint is naturally integrated without interfering with the optimization procedure. Experimental results are provided to demonstrate the performance of the proposed NN-C-CPD algorithm in HSR applications.

DVM: Towards Controllable LLM Agents in Social Deduction Games

Large Language Models (LLMs) have advanced the capability of game agents in social deduction games (SDGs). These games rely heavily on conversation-driven interactions and require agents to infer, make decisions, and express based on such information. While this progress leads to more sophisticated and strategic non-player characters (NPCs) in SDGs, there exists a need to control the proficiency of these agents. This control not only ensures that NPCs can adapt to varying difficulty levels during gameplay, but also provides insights into the safety and fairness of LLM agents. In this paper, we present DVM, a novel framework for developing controllable LLM agents for SDGs, and demonstrate its implementation on one of the most popular SDGs, Werewolf. DVM comprises three main components: Predictor, Decider, and Discussor. By integrating reinforcement learning with a win rate-constrained decision chain reward mechanism, we enable agents to dynamically adjust their gameplay proficiency to achieve specified win rates. Experiments show that DVM not only outperforms existing methods in the Werewolf game, but also successfully modulates its performance levels to meet predefined win rate targets. These results pave the way for LLM agents' adaptive and balanced gameplay in SDGs, opening new avenues for research in controllable game agents.

Coarsened confounding for causal effects: a large-sample framework

There has been widespread use of causal inference methods for the rigorous analysis of observational studies and to identify policy evaluations. In this article, we consider coarsened exact matching, developed in Iacus et al. (2011). While they developed some statistical properties, in this article, we study the approach using asymptotics based on a superpopulation inferential framework. This methodology is generalized to what we termed as coarsened confounding, for which we propose two new algorithms. We develop asymptotic results for the average causal effect estimator as well as providing conditions for consistency. In addition, we provide an asymptotic justification for the variance formulae in Iacus et al. (2011). A bias correction technique is proposed, and we apply the proposed methodology to data from two well-known observational studi

RTLSquad: Multi-Agent Based Interpretable RTL Design

Optimizing Register-Transfer Level (RTL) code is crucial for improving hardware PPA performance. Large Language Models (LLMs) offer new approaches for automatic RTL code generation and optimization. However, existing methods often lack decision interpretability (sufficient, understandable justification for decisions), making it difficult for hardware engineers to trust the generated results, thus preventing these methods from being integrated into the design process. To address this, we propose RTLSquad, a novel LLM-Based Multi-Agent system for interpretable RTL code generation. RTLSquad divides the design process into exploration, implementation, and verification & evaluation stages managed by specialized agent squads, generating optimized RTL code through inter-agent collaboration, and providing decision interpretability through the communication process. Experiments show that RTLSquad excels in generating functionally correct RTL code and optimizing PPA performance, while also having the capability to provide decision paths, demonstrating the practical value of our system.