COMET: Benchmark for Comprehensive Biological Multi-omics Evaluation Tasks and Language Models

As key elements within the central dogma, DNA, RNA, and proteins play crucial roles in maintaining life by guaranteeing accurate genetic expression and implementation. Although research on these molecules has profoundly impacted fields like medicine, agriculture, and industry, the diversity of machine learning approaches-from traditional statistical methods to deep learning models and large language models-poses challenges for researchers in choosing the most suitable models for specific tasks, especially for cross-omics and multi-omics tasks due to the lack of comprehensive benchmarks. To address this, we introduce the first comprehensive multi-omics benchmark COMET (Benchmark for Biological COmprehensive Multi-omics Evaluation Tasks and Language Models), designed to evaluate models across single-omics, cross-omics, and multi-omics tasks. First, we curate and develop a diverse collection of downstream tasks and datasets covering key structural and functional aspects in DNA, RNA, and proteins, including tasks that span multiple omics levels. Then, we evaluate existing foundational language models for DNA, RNA, and proteins, as well as the newly proposed multi-omics method, offering valuable insights into their performance in integrating and analyzing data from different biological modalities. This benchmark aims to define critical issues in multi-omics research and guide future directions, ultimately promoting advancements in understanding biological processes through integrated and different omics data analysis.

All-in-One: Transferring Vision Foundation Models into Stereo Matching

As a fundamental vision task, stereo matching has made remarkable progress. While recent iterative optimization-based methods have achieved promising performance, their feature extraction capabilities still have room for improvement. Inspired by the ability of vision foundation models (VFMs) to extract general representations, in this work, we propose AIO-Stereo which can flexibly select and transfer knowledge from multiple heterogeneous VFMs to a single stereo matching model. To better reconcile features between heterogeneous VFMs and the stereo matching model and fully exploit prior knowledge from VFMs, we proposed a dual-level feature utilization mechanism that aligns heterogeneous features and transfers multi-level knowledge. Based on the mechanism, a dual-level selective knowledge transfer module is designed to selectively transfer knowledge and integrate the advantages of multiple VFMs. Experimental results show that AIO-Stereo achieves start-of-the-art performance on multiple datasets and ranks $1^{st}$ on the Middlebury dataset and outperforms all the published work on the ETH3D benchmark.

Critic-V: VLM Critics Help Catch VLM Errors in Multimodal Reasoning

Vision-language models (VLMs) have shown remarkable advancements in multimodal reasoning tasks. However, they still often generate inaccurate or irrelevant responses due to issues like hallucinated image understandings or unrefined reasoning paths. To address these challenges, we introduce Critic-V, a novel framework inspired by the Actor-Critic paradigm to boost the reasoning capability of VLMs. This framework decouples the reasoning process and critic process by integrating two independent components: the Reasoner, which generates reasoning paths based on visual and textual inputs, and the Critic, which provides constructive critique to refine these paths. In this approach, the Reasoner generates reasoning responses according to text prompts, which can evolve iteratively as a policy based on feedback from the Critic. This interaction process was theoretically driven by a reinforcement learning framework where the Critic offers natural language critiques instead of scalar rewards, enabling more nuanced feedback to boost the Reasoner's capability on complex reasoning tasks. The Critic model is trained using Direct Preference Optimization (DPO), leveraging a preference dataset of critiques ranked by Rule-based Reward~(RBR) to enhance its critic capabilities. Evaluation results show that the Critic-V framework significantly outperforms existing methods, including GPT-4V, on 5 out of 8 benchmarks, especially regarding reasoning accuracy and efficiency. Combining a dynamic text-based policy for the Reasoner and constructive feedback from the preference-optimized Critic enables a more reliable and context-sensitive multimodal reasoning process. Our approach provides a promising solution to enhance the reliability of VLMs, improving their performance in real-world reasoning-heavy multimodal applications such as autonomous driving and embodied intelligence.

Less is More: Efficient Model Merging with Binary Task Switch

As an effective approach to equip models with multi-task capabilities without additional training, model merging has garnered significant attention. However, existing methods face challenges of redundant parameter conflicts and the excessive storage burden of parameters. In this work, through controlled experiments, we reveal that for task vectors, only those parameters with magnitudes above a certain threshold contribute positively to the task, exhibiting a pulse-like characteristic. We then attempt leveraging this characteristic to binarize the task vectors and reduce storage overhead. Further controlled experiments show that the binarized task vectors incur almost no decrease in fine-tuning and merging performance, and even exhibit stronger performance improvements as the proportion of redundant parameters increases. Based on these insights, we propose Task Switch (T-Switch), which decomposes task vectors into three components: 1) an activation switch instantiated by a binarized mask vector, 2) a polarity switch instantiated by a binarized sign vector, and 3) a scaling knob instantiated by a scalar coefficient. By storing task vectors in a binarized form, T-Switch alleviates parameter conflicts while ensuring efficient task parameter storage. Furthermore, to enable automated switch combination in T-Switch, we further introduce Auto-Switch, which enables training-free switch combination via retrieval from a small query set. Experiments indicate that our methods achieve significant performance improvements over existing baselines, requiring only 1-3% of the storage space of full-precision parameters.

Transfer Learning Guided Noise Reduction for Automatic Modulation Classification

Automatic modulation classification (AMC) has emerged as a key technique in cognitive radio networks in sixth-generation (6G) communications. AMC enables effective data transmission without requiring prior knowledge of modulation schemes. However, the low classification accuracy under the condition of low signal-to-noise ratio (SNR) limits the implementation of AMC techniques under the rapidly changing physical channels in 6G and beyond. This paper investigates the AMC technique for the signals with dynamic and varying SNRs, and a deep learning based noise reduction network is proposed to reduce the noise introduced by the wireless channel and the receiving equipment. In particular, a transfer learning guided learning framework (TNR-AMC) is proposed to utilize the scarce annotated modulation signals and improve the classification accuracy for low SNR modulation signals. The numerical results show that the proposed noise reduction network achieves an accuracy improvement of over 20\% in low SNR scenarios, and the TNR-AMC framework can improve the classification accuracy under unstable SNRs.

The Limits of Differential Privacy in Online Learning

Differential privacy (DP) is a formal notion that restricts the privacy leakage of an algorithm when running on sensitive data, in which privacy-utility trade-off is one of the central problems in private data analysis. In this work, we investigate the fundamental limits of differential privacy in online learning algorithms and present evidence that separates three types of constraints: no DP, pure DP, and approximate DP. We first describe a hypothesis class that is online learnable under approximate DP but not online learnable under pure DP under the adaptive adversarial setting. This indicates that approximate DP must be adopted when dealing with adaptive adversaries. We then prove that any private online learner must make an infinite number of mistakes for almost all hypothesis classes. This essentially generalizes previous results and shows a strong separation between private and non-private settings since a finite mistake bound is always attainable (as long as the class is online learnable) when there is no privacy requirement.

A CLIP-Powered Framework for Robust and Generalizable Data Selection

Large-scale datasets have been pivotal to the advancements of deep learning models in recent years, but training on such large datasets invariably incurs substantial storage and computational overhead. Meanwhile, real-world datasets often contain redundant and noisy data, imposing a negative impact on training efficiency and model performance. Data selection has shown promise in identifying the most representative samples from the entire dataset, which aims to minimize the performance gap with reduced training costs. Existing works typically rely on single-modality information to assign importance scores for individual samples, which may lead to inaccurate assessments, especially when dealing with noisy or corrupted samples. To address this limitation, we propose a novel CLIP-powered data selection framework that leverages multimodal information for more robust and generalizable sample selection. Specifically, our framework consists of three key modules-dataset adaptation, sample scoring, and selection optimization-that together harness extensive pre-trained multimodal knowledge to comprehensively assess sample influence and optimize the selection results through multi-objective optimization. Extensive experiments demonstrate that our approach consistently outperforms existing state-of-the-art baselines on various benchmark datasets. Notably, our method effectively removes noisy or damaged samples from the dataset, enabling it to achieve even higher performance with less data. This indicates that it is not only a way to accelerate training but can also improve overall data quality.

S2HPruner: Soft-to-Hard Distillation Bridges the Discretization Gap in Pruning

Recently, differentiable mask pruning methods optimize the continuous relaxation architecture (soft network) as the proxy of the pruned discrete network (hard network) for superior sub-architecture search. However, due to the agnostic impact of the discretization process, the hard network struggles with the equivalent representational capacity as the soft network, namely discretization gap, which severely spoils the pruning performance. In this paper, we first investigate the discretization gap and propose a novel structural differentiable mask pruning framework named S2HPruner to bridge the discretization gap in a one-stage manner. In the training procedure, SH2Pruner forwards both the soft network and its corresponding hard network, then distills the hard network under the supervision of the soft network. To optimize the mask and prevent performance degradation, we propose a decoupled bidirectional knowledge distillation. It blocks the weight updating from the hard to the soft network while maintaining the gradient corresponding to the mask. Compared with existing pruning arts, S2HPruner achieves surpassing pruning performance without fine-tuning on comprehensive benchmarks, including CIFAR-100, Tiny ImageNet, and ImageNet with a variety of network architectures. Besides, investigation and analysis experiments explain the effectiveness of S2HPruner. Codes will be released soon.

HiSplat: Hierarchical 3D Gaussian Splatting for Generalizable Sparse-View Reconstruction

Reconstructing 3D scenes from multiple viewpoints is a fundamental task in stereo vision. Recently, advances in generalizable 3D Gaussian Splatting have enabled high-quality novel view synthesis for unseen scenes from sparse input views by feed-forward predicting per-pixel Gaussian parameters without extra optimization. However, existing methods typically generate single-scale 3D Gaussians, which lack representation of both large-scale structure and texture details, resulting in mislocation and artefacts. In this paper, we propose a novel framework, HiSplat, which introduces a hierarchical manner in generalizable 3D Gaussian Splatting to construct hierarchical 3D Gaussians via a coarse-to-fine strategy. Specifically, HiSplat generates large coarse-grained Gaussians to capture large-scale structures, followed by fine-grained Gaussians to enhance delicate texture details. To promote inter-scale interactions, we propose an Error Aware Module for Gaussian compensation and a Modulating Fusion Module for Gaussian repair. Our method achieves joint optimization of hierarchical representations, allowing for novel view synthesis using only two-view reference images. Comprehensive experiments on various datasets demonstrate that HiSplat significantly enhances reconstruction quality and cross-dataset generalization compared to prior single-scale methods. The corresponding ablation study and analysis of different-scale 3D Gaussians reveal the mechanism behind the effectiveness. Project website: https://open3dvlab.github.io/HiSplat/

A Novel Representation of Periodic Pattern and Its Application to Untrained Anomaly Detection

There are a variety of industrial products that possess periodic textures or surfaces, such as carbon fiber textiles and display panels. Traditional image-based quality inspection methods for these products require identifying the periodic patterns from normal images (without anomaly and noise) and subsequently detecting anomaly pixels with inconsistent appearances. However, it remains challenging to accurately extract the periodic pattern from a single image in the presence of unknown anomalies and measurement noise. To deal with this challenge, this paper proposes a novel self-representation of the periodic image defined on a set of continuous parameters. In this way, periodic pattern learning can be embedded into a joint optimization framework, which is named periodic-sparse decomposition, with simultaneously modeling the sparse anomalies and Gaussian noise. Finally, for the real-world industrial images that may not strictly satisfy the periodic assumption, we propose a novel pixel-level anomaly scoring strategy to enhance the performance of anomaly detection. Both simulated and real-world case studies demonstrate the effectiveness of the proposed methodology for periodic pattern learning and anomaly detection.