Addressing Domain Shift via Imbalance-Aware Domain Adaptation in Embryo Development Assessment

Deep learning models in medical imaging face dual challenges: domain shift, where models perform poorly when deployed in settings different from their training environment, and class imbalance, where certain disease conditions are naturally underrepresented. We present Imbalance-Aware Domain Adaptation (IADA), a novel framework that simultaneously tackles both challenges through three key components: (1) adaptive feature learning with class-specific attention mechanisms, (2) balanced domain alignment with dynamic weighting, and (3) adaptive threshold optimization. Our theoretical analysis establishes convergence guarantees and complexity bounds. Through extensive experiments on embryo development assessment across four imaging modalities, IADA demonstrates significant improvements over existing methods, achieving up to 25.19\% higher accuracy while maintaining balanced performance across classes. In challenging scenarios with low-quality imaging systems, IADA shows robust generalization with AUC improvements of up to 12.56\%. These results demonstrate IADA's potential for developing reliable and equitable medical imaging systems for diverse clinical settings. The code is made public available at \url{https://github.com/yinghemedical/imbalance-aware_domain_adaptation}

Reasoning-Enhanced Self-Training for Long-Form Personalized Text Generation

Personalized text generation requires a unique ability of large language models (LLMs) to learn from context that they often do not encounter during their standard training. One way to encourage LLMs to better use personalized context for generating outputs that better align with the user's expectations is to instruct them to reason over the user's past preferences, background knowledge, or writing style. To achieve this, we propose Reasoning-Enhanced Self-Training for Personalized Text Generation (REST-PG), a framework that trains LLMs to reason over personal data during response generation. REST-PG first generates reasoning paths to train the LLM's reasoning abilities and then employs Expectation-Maximization Reinforced Self-Training to iteratively train the LLM based on its own high-reward outputs. We evaluate REST-PG on the LongLaMP benchmark, consisting of four diverse personalized long-form text generation tasks. Our experiments demonstrate that REST-PG achieves significant improvements over state-of-the-art baselines, with an average relative performance gain of 14.5% on the benchmark.

Dolphin: Closed-loop Open-ended Auto-research through Thinking, Practice, and Feedback

The scientific research paradigm is undergoing a profound transformation owing to the development of Artificial Intelligence (AI). Recent works demonstrate that various AI-assisted research methods can largely improve research efficiency by improving data analysis, accelerating computation, and fostering novel idea generation. To further move towards the ultimate goal (i.e., automatic scientific research), in this paper, we propose Dolphin, the first closed-loop open-ended auto-research framework to further build the entire process of human scientific research. Dolphin can generate research ideas, perform experiments, and get feedback from experimental results to generate higher-quality ideas. More specifically, Dolphin first generates novel ideas based on relevant papers which are ranked by the topic and task attributes. Then, the codes are automatically generated and debugged with the exception-traceback-guided local code structure. Finally, Dolphin automatically analyzes the results of each idea and feeds the results back to the next round of idea generation. Experiments are conducted on the benchmark datasets of different topics and results show that Dolphin can generate novel ideas continuously and complete the experiment in a loop. We highlight that Dolphin can automatically propose methods that are comparable to the state-of-the-art in some tasks such as 2D image classification and 3D point classification.

Accuracy Can Lie: On the Impact of Surrogate Model in Configuration Tuning

To ease the expensive measurements during configuration tuning, it is natural to build a surrogate model as the replacement of the system, and thereby the configuration performance can be cheaply evaluated. Yet, a stereotype therein is that the higher the model accuracy, the better the tuning result would be. This "accuracy is all" belief drives our research community to build more and more accurate models and criticize a tuner for the inaccuracy of the model used. However, this practice raises some previously unaddressed questions, e.g., Do those somewhat small accuracy improvements reported in existing work really matter much to the tuners? What role does model accuracy play in the impact of tuning quality? To answer those related questions, we conduct one of the largest-scale empirical studies to date-running over the period of 13 months 24*7-that covers 10 models, 17 tuners, and 29 systems from the existing works while under four different commonly used metrics, leading to 13,612 cases of investigation. Surprisingly, our key findings reveal that the accuracy can lie: there are a considerable number of cases where higher accuracy actually leads to no improvement in the tuning outcomes (up to 58% cases under certain setting), or even worse, it can degrade the tuning quality (up to 24% cases under certain setting). We also discover that the chosen models in most proposed tuners are sub-optimal and that the required % of accuracy change to significantly improve tuning quality varies according to the range of model accuracy. Deriving from the fitness landscape analysis, we provide in-depth discussions of the rationale behind, offering several lessons learned as well as insights for future opportunities. Most importantly, this work poses a clear message to the community: we should take one step back from the natural "accuracy is all" belief for model-based configuration tuning.

EasySplat: View-Adaptive Learning makes 3D Gaussian Splatting Easy

3D Gaussian Splatting (3DGS) techniques have achieved satisfactory 3D scene representation. Despite their impressive performance, they confront challenges due to the limitation of structure-from-motion (SfM) methods on acquiring accurate scene initialization, or the inefficiency of densification strategy. In this paper, we introduce a novel framework EasySplat to achieve high-quality 3DGS modeling. Instead of using SfM for scene initialization, we employ a novel method to release the power of large-scale pointmap approaches. Specifically, we propose an efficient grouping strategy based on view similarity, and use robust pointmap priors to obtain high-quality point clouds and camera poses for 3D scene initialization. After obtaining a reliable scene structure, we propose a novel densification approach that adaptively splits Gaussian primitives based on the average shape of neighboring Gaussian ellipsoids, utilizing KNN scheme. In this way, the proposed method tackles the limitation on initialization and optimization, leading to an efficient and accurate 3DGS modeling. Extensive experiments demonstrate that EasySplat outperforms the current state-of-the-art (SOTA) in handling novel view synthesis.

Distilled Lifelong Self-Adaptation for Configurable Systems

Modern configurable systems provide tremendous opportunities for engineering future intelligent software systems. A key difficulty thereof is how to effectively self-adapt the configuration of a running system such that its performance (e.g., runtime and throughput) can be optimized under time-varying workloads. This unfortunately remains unaddressed in existing approaches as they either overlook the available past knowledge or rely on static exploitation of past knowledge without reasoning the usefulness of information when planning for self-adaptation. In this paper, we tackle this challenging problem by proposing DLiSA, a framework that self-adapts configurable systems. DLiSA comes with two properties: firstly, it supports lifelong planning, and thereby the planning process runs continuously throughout the lifetime of the system, allowing dynamic exploitation of the accumulated knowledge for rapid adaptation. Secondly, the planning for a newly emerged workload is boosted via distilled knowledge seeding, in which the knowledge is dynamically purified such that only useful past configurations are seeded when necessary, mitigating misleading information. Extensive experiments suggest that the proposed DLiSA significantly outperforms state-of-the-art approaches, demonstrating a performance improvement of up to 229% and a resource acceleration of up to 2.22x on generating promising adaptation configurations. All data and sources can be found at our repository: https://github.com/ideas-labo/dlisa.

Biology Instructions: A Dataset and Benchmark for Multi-Omics Sequence Understanding Capability of Large Language Models

Large language models have already demonstrated their formidable capabilities in general domains, ushering in a revolutionary transformation. However, exploring and exploiting the extensive knowledge of these models to comprehend multi-omics biology remains underexplored. To fill this research gap, we first introduce Biology-Instructions, the first large-scale multi-omics biological sequences-related instruction-tuning dataset including DNA, RNA, proteins, and multi-molecules, designed to bridge the gap between large language models (LLMs) and complex biological sequences-related tasks. This dataset can enhance the versatility of LLMs by integrating diverse biological sequenced-based prediction tasks with advanced reasoning capabilities, while maintaining conversational fluency. Additionally, we reveal significant performance limitations in even state-of-the-art LLMs on biological sequence-related multi-omics tasks without specialized pre-training and instruction-tuning. We further develop a strong baseline called ChatMultiOmics with a novel three-stage training pipeline, demonstrating the powerful ability to understand biology by using Biology-Instructions. Biology-Instructions and ChatMultiOmics are publicly available and crucial resources for enabling more effective integration of LLMs with multi-omics sequence analysis.

Overview of AI and Communication for 6G Network: Fundamentals, Challenges, and Future Research Opportunities

With the increasing demand for seamless connectivity and intelligent communication, the integration of artificial intelligence (AI) and communication for sixth-generation (6G) network is emerging as a revolutionary architecture. This paper presents a comprehensive overview of AI and communication for 6G networks, emphasizing their foundational principles, inherent challenges, and future research opportunities. We commence with a retrospective analysis of AI and the evolution of large-scale AI models, underscoring their pivotal roles in shaping contemporary communication technologies. The discourse then transitions to a detailed exposition of the envisioned integration of AI within 6G networks, delineated across three progressive developmental stages. The initial stage, AI for Network, focuses on employing AI to augment network performance, optimize efficiency, and enhance user service experiences. The subsequent stage, Network for AI, highlights the role of the network in facilitating and buttressing AI operations and presents key enabling technologies, including digital twins for AI and semantic communication. In the final stage, AI as a Service, it is anticipated that future 6G networks will innately provide AI functions as services and support application scenarios like immersive communication and intelligent industrial robots. Specifically, we have defined the quality of AI service, which refers to the measurement framework system of AI services within the network. In addition to these developmental stages, we thoroughly examine the standardization processes pertinent to AI in network contexts, highlighting key milestones and ongoing efforts. Finally, we outline promising future research opportunities that could drive the evolution and refinement of AI and communication for 6G, positioning them as a cornerstone of next-generation communication infrastructure.

GeoX: Geometric Problem Solving Through Unified Formalized Vision-Language Pre-training

Despite their proficiency in general tasks, Multi-modal Large Language Models (MLLMs) struggle with automatic Geometry Problem Solving (GPS), which demands understanding diagrams, interpreting symbols, and performing complex reasoning. This limitation arises from their pre-training on natural images and texts, along with the lack of automated verification in the problem-solving process. Besides, current geometric specialists are limited by their task-specific designs, making them less effective for broader geometric problems. To this end, we present GeoX, a multi-modal large model focusing on geometric understanding and reasoning tasks. Given the significant differences between geometric diagram-symbol and natural image-text, we introduce unimodal pre-training to develop a diagram encoder and symbol decoder, enhancing the understanding of geometric images and corpora. Furthermore, we introduce geometry-language alignment, an effective pre-training paradigm that bridges the modality gap between unimodal geometric experts. We propose a Generator-And-Sampler Transformer (GS-Former) to generate discriminative queries and eliminate uninformative representations from unevenly distributed geometric signals. Finally, GeoX benefits from visual instruction tuning, empowering it to take geometric images and questions as input and generate verifiable solutions. Experiments show that GeoX outperforms both generalists and geometric specialists on publicly recognized benchmarks, such as GeoQA, UniGeo, Geometry3K, and PGPS9k.

COMET: Benchmark for Comprehensive Biological Multi-omics Evaluation Tasks and Language Models

As key elements within the central dogma, DNA, RNA, and proteins play crucial roles in maintaining life by guaranteeing accurate genetic expression and implementation. Although research on these molecules has profoundly impacted fields like medicine, agriculture, and industry, the diversity of machine learning approaches-from traditional statistical methods to deep learning models and large language models-poses challenges for researchers in choosing the most suitable models for specific tasks, especially for cross-omics and multi-omics tasks due to the lack of comprehensive benchmarks. To address this, we introduce the first comprehensive multi-omics benchmark COMET (Benchmark for Biological COmprehensive Multi-omics Evaluation Tasks and Language Models), designed to evaluate models across single-omics, cross-omics, and multi-omics tasks. First, we curate and develop a diverse collection of downstream tasks and datasets covering key structural and functional aspects in DNA, RNA, and proteins, including tasks that span multiple omics levels. Then, we evaluate existing foundational language models for DNA, RNA, and proteins, as well as the newly proposed multi-omics method, offering valuable insights into their performance in integrating and analyzing data from different biological modalities. This benchmark aims to define critical issues in multi-omics research and guide future directions, ultimately promoting advancements in understanding biological processes through integrated and different omics data analysis.