Probability Map Guided Bi-directional Recurrent UNet for Pancreas Segmentation

Pancreatic cancer is one of the most lethal cancers as morbidity approximates mortality. A method for accurately segmenting the pancreas can assist doctors in the diagnosis and treatment of pancreatic cancer, but huge differences in shape and volume bring difficulties in segmentation. Among the current widely used approaches, the 2D method ignores the spatial information, and the 3D model is limited by high resource consumption and GPU memory occupancy. To address these issues, we propose a bi-directional recurrent UNet based on probabilistic map guidance (PBR-UNet). PBR-UNet includes a feature extraction module for extracting pixel-level probabilistic maps and a bi-directional recurrent module for fine segmentation. The extracted probabilistic map will be used to guide the fine segmentation and bi-directional recurrent module integrates contextual information into the entire network to avoid the loss of spatial information in propagation. By combining the probabilistic map of the adjacent slices with the bi-directional recurrent segmentation of intermediary slice, this paper solves the problem that the 2D network loses three-dimensional information and the 3D model leads to large computational resource consumption. We used Dice similarity coefficients (DSC) to evaluate our approach on NIH pancreatic datasets and eventually achieved a competitive result of 83.35%.

Pancreas Segmentation via Spatial Context based U-net and Bidirectional LSTM

Pancreas is characterized by small size and irregular shape, so achieving accurate pancreas segmentation is challenging. Traditional 2D pancreas segmentation network based on the independent 2D image slices, which often leads to spatial discontinuity problem. Therefore, how to utility spatial context information is the key point to improve the segmentation quality. In this paper, we proposed a divide-and-conquer strategy, divided the abdominal CT scans into several isometric blocks. And we designed a multiple channels convolutional neural network to learn the local spatial context characteristics from blocks called SCU-Net. SCU-Net is a partial 3D segmentation idea, which transforms overall pancreas segmentation into a combination of multiple local segmentation results. In order to improve the segmentation accuracy for each layer, we also proposed a new loss function for inter-slice constrain and regularization. Thereafter, we introduced the BiCLSTM network for stimulating the interaction between bidirectional segmentation sequence, thus making up the boundary defect and fault problem of the segmentation results. We trained SCU-Net+BiLSTM network respectively, and evaluated segmentation result on the NIH data set. Keywords: Pancreas Segmentation, Convolutional Neural Networks, Recurrent Neural Networks, Deep Learning, Inter-slice Regularization

DC-Al GAN: Pseudoprogression and True Tumor Progression of Glioblastoma multiform Image Classification Based On DCGAN and Alexnet

Glioblastoma multiform (GBM) is a kind of head tumor with an extraordinarily complex treatment process. The survival period is typically 14-16 months, and the 2 year survival rate is approximately 26%-33%. The clinical treatment strategies for the pseudoprogression (PsP) and true tumor progression (TTP) of GBM are different, so accurately distinguishing these two conditions is particularly significant.As PsP and TTP of GBM are similar in shape and other characteristics, it is hard to distinguish these two forms with precision. In order to differentiate them accurately, this paper introduces a feature learning method based on a generative adversarial network: DC-Al GAN. GAN consists of two architectures: generator and discriminator. Alexnet is used as the discriminator in this work. Owing to the adversarial and competitive relationship between generator and discriminator, the latter extracts highly concise features during training. In DC-Al GAN, features are extracted from Alexnet in the final classification phase, and the highly nature of them contributes positively to the classification accuracy.The generator in DC-Al GAN is modified by the deep convolutional generative adversarial network (DCGAN) by adding three convolutional layers. This effectively generates higher resolution sample images. Feature fusion is used to combine high layer features with low layer features, allowing for the creation and use of more precise features for classification. The experimental results confirm that DC-Al GAN achieves high accuracy on GBM datasets for PsP and TTP image classification, which is superior to other state-of-the-art methods.