Harmony in Divergence: Towards Fast, Accurate, and Memory-efficient Zeroth-order LLM Fine-tuning

Large language models (LLMs) excel across various tasks, but standard first-order (FO) fine-tuning demands considerable memory, significantly limiting real-world deployment. Recently, zeroth-order (ZO) optimization stood out as a promising memory-efficient training paradigm, avoiding backward passes and relying solely on forward passes for gradient estimation, making it attractive for resource-constrained scenarios. However, ZO method lags far behind FO method in both convergence speed and accuracy. To bridge the gap, we introduce a novel layer-wise divergence analysis that uncovers the distinct update pattern of FO and ZO optimization. Aiming to resemble the learning capacity of FO method from the findings, we propose \textbf{Di}vergence-driven \textbf{Z}eroth-\textbf{O}rder (\textbf{DiZO}) optimization. DiZO conducts divergence-driven layer adaptation by incorporating projections to ZO updates, generating diverse-magnitude updates precisely scaled to layer-wise individual optimization needs. Our results demonstrate that DiZO significantly reduces the needed iterations for convergence without sacrificing throughput, cutting training GPU hours by up to 48\% on various datasets. Moreover, DiZO consistently outperforms the representative ZO baselines in fine-tuning RoBERTa-large, OPT-series, and Llama-series on downstream tasks and, in some cases, even surpasses memory-intensive FO fine-tuning.

Enhancing Visual Inspection Capability of Multi-Modal Large Language Models on Medical Time Series with Supportive Conformalized and Interpretable Small Specialized Models

Large language models (LLMs) exhibit remarkable capabilities in visual inspection of medical time-series data, achieving proficiency comparable to human clinicians. However, their broad scope limits domain-specific precision, and proprietary weights hinder fine-tuning for specialized datasets. In contrast, small specialized models (SSMs) excel in targeted tasks but lack the contextual reasoning required for complex clinical decision-making. To address these challenges, we propose ConMIL (Conformalized Multiple Instance Learning), a decision-support SSM that integrates seamlessly with LLMs. By using Multiple Instance Learning (MIL) to identify clinically significant signal segments and conformal prediction for calibrated set-valued outputs, ConMIL enhances LLMs' interpretative capabilities for medical time-series analysis. Experimental results demonstrate that ConMIL significantly improves the performance of state-of-the-art LLMs, such as ChatGPT4.0 and Qwen2-VL-7B. Specifically, \ConMIL{}-supported Qwen2-VL-7B achieves 94.92% and 96.82% precision for confident samples in arrhythmia detection and sleep staging, compared to standalone LLM accuracy of 46.13% and 13.16%. These findings highlight the potential of ConMIL to bridge task-specific precision and broader contextual reasoning, enabling more reliable and interpretable AI-driven clinical decision support.

Large Language Models for Bioinformatics

With the rapid advancements in large language model (LLM) technology and the emergence of bioinformatics-specific language models (BioLMs), there is a growing need for a comprehensive analysis of the current landscape, computational characteristics, and diverse applications. This survey aims to address this need by providing a thorough review of BioLMs, focusing on their evolution, classification, and distinguishing features, alongside a detailed examination of training methodologies, datasets, and evaluation frameworks. We explore the wide-ranging applications of BioLMs in critical areas such as disease diagnosis, drug discovery, and vaccine development, highlighting their impact and transformative potential in bioinformatics. We identify key challenges and limitations inherent in BioLMs, including data privacy and security concerns, interpretability issues, biases in training data and model outputs, and domain adaptation complexities. Finally, we highlight emerging trends and future directions, offering valuable insights to guide researchers and clinicians toward advancing BioLMs for increasingly sophisticated biological and clinical applications.

Towards Next-Generation Medical Agent: How o1 is Reshaping Decision-Making in Medical Scenarios

Artificial Intelligence (AI) has become essential in modern healthcare, with large language models (LLMs) offering promising advances in clinical decision-making. Traditional model-based approaches, including those leveraging in-context demonstrations and those with specialized medical fine-tuning, have demonstrated strong performance in medical language processing but struggle with real-time adaptability, multi-step reasoning, and handling complex medical tasks. Agent-based AI systems address these limitations by incorporating reasoning traces, tool selection based on context, knowledge retrieval, and both short- and long-term memory. These additional features enable the medical AI agent to handle complex medical scenarios where decision-making should be built on real-time interaction with the environment. Therefore, unlike conventional model-based approaches that treat medical queries as isolated questions, medical AI agents approach them as complex tasks and behave more like human doctors. In this paper, we study the choice of the backbone LLM for medical AI agents, which is the foundation for the agent's overall reasoning and action generation. In particular, we consider the emergent o1 model and examine its impact on agents' reasoning, tool-use adaptability, and real-time information retrieval across diverse clinical scenarios, including high-stakes settings such as intensive care units (ICUs). Our findings demonstrate o1's ability to enhance diagnostic accuracy and consistency, paving the way for smarter, more responsive AI tools that support better patient outcomes and decision-making efficacy in clinical practice.

HELENE: Hessian Layer-wise Clipping and Gradient Annealing for Accelerating Fine-tuning LLM with Zeroth-order Optimization

Fine-tuning large language models (LLMs) poses significant memory challenges, as the back-propagation process demands extensive resources, especially with growing model sizes. Recent work, MeZO, addresses this issue using a zeroth-order (ZO) optimization method, which reduces memory consumption by matching the usage to the inference phase. However, MeZO experiences slow convergence due to varying curvatures across model parameters. To overcome this limitation, we introduce HELENE, a novel scalable and memory-efficient optimizer that integrates annealed A-GNB gradients with a diagonal Hessian estimation and layer-wise clipping, serving as a second-order pre-conditioner. This combination allows for faster and more stable convergence. Our theoretical analysis demonstrates that HELENE improves convergence rates, particularly for models with heterogeneous layer dimensions, by reducing the dependency on the total parameter space dimension. Instead, the method scales with the largest layer dimension, making it highly suitable for modern LLM architectures. Experimental results on RoBERTa-large and OPT-1.3B across multiple tasks show that HELENE achieves up to a 20x speedup compared to MeZO, with average accuracy improvements of 1.5%. Furthermore, HELENE remains compatible with both full parameter tuning and parameter-efficient fine-tuning (PEFT), outperforming several state-of-the-art optimizers. The codes will be released after reviewing.

Evaluation of OpenAI o1: Opportunities and Challenges of AGI

This comprehensive study evaluates the performance of OpenAI's o1-preview large language model across a diverse array of complex reasoning tasks, spanning multiple domains, including computer science, mathematics, natural sciences, medicine, linguistics, and social sciences. Through rigorous testing, o1-preview demonstrated remarkable capabilities, often achieving human-level or superior performance in areas ranging from coding challenges to scientific reasoning and from language processing to creative problem-solving. Key findings include: -83.3% success rate in solving complex competitive programming problems, surpassing many human experts. -Superior ability in generating coherent and accurate radiology reports, outperforming other evaluated models. -100% accuracy in high school-level mathematical reasoning tasks, providing detailed step-by-step solutions. -Advanced natural language inference capabilities across general and specialized domains like medicine. -Impressive performance in chip design tasks, outperforming specialized models in areas such as EDA script generation and bug analysis. -Remarkable proficiency in anthropology and geology, demonstrating deep understanding and reasoning in these specialized fields. -Strong capabilities in quantitative investing. O1 has comprehensive financial knowledge and statistical modeling skills. -Effective performance in social media analysis, including sentiment analysis and emotion recognition. The model excelled particularly in tasks requiring intricate reasoning and knowledge integration across various fields. While some limitations were observed, including occasional errors on simpler problems and challenges with certain highly specialized concepts, the overall results indicate significant progress towards artificial general intelligence.

Rethinking the Threat and Accessibility of Adversarial Attacks against Face Recognition Systems

Face recognition pipelines have been widely deployed in various mission-critical systems in trust, equitable and responsible AI applications. However, the emergence of adversarial attacks has threatened the security of the entire recognition pipeline. Despite the sheer number of attack methods proposed for crafting adversarial examples in both digital and physical forms, it is never an easy task to assess the real threat level of different attacks and obtain useful insight into the key risks confronted by face recognition systems. Traditional attacks view imperceptibility as the most important measurement to keep perturbations stealthy, while we suspect that industry professionals may possess a different opinion. In this paper, we delve into measuring the threat brought about by adversarial attacks from the perspectives of the industry and the applications of face recognition. In contrast to widely studied sophisticated attacks in the field, we propose an effective yet easy-to-launch physical adversarial attack, named AdvColor, against black-box face recognition pipelines in the physical world. AdvColor fools models in the recognition pipeline via directly supplying printed photos of human faces to the system under adversarial illuminations. Experimental results show that physical AdvColor examples can achieve a fooling rate of more than 96% against the anti-spoofing model and an overall attack success rate of 88% against the face recognition pipeline. We also conduct a survey on the threats of prevailing adversarial attacks, including AdvColor, to understand the gap between the machine-measured and human-assessed threat levels of different forms of adversarial attacks. The survey results surprisingly indicate that, compared to deliberately launched imperceptible attacks, perceptible but accessible attacks pose more lethal threats to real-world commercial systems of face recognition.

LogoStyleFool: Vitiating Video Recognition Systems via Logo Style Transfer

Video recognition systems are vulnerable to adversarial examples. Recent studies show that style transfer-based and patch-based unrestricted perturbations can effectively improve attack efficiency. These attacks, however, face two main challenges: 1) Adding large stylized perturbations to all pixels reduces the naturalness of the video and such perturbations can be easily detected. 2) Patch-based video attacks are not extensible to targeted attacks due to the limited search space of reinforcement learning that has been widely used in video attacks recently. In this paper, we focus on the video black-box setting and propose a novel attack framework named LogoStyleFool by adding a stylized logo to the clean video. We separate the attack into three stages: style reference selection, reinforcement-learning-based logo style transfer, and perturbation optimization. We solve the first challenge by scaling down the perturbation range to a regional logo, while the second challenge is addressed by complementing an optimization stage after reinforcement learning. Experimental results substantiate the overall superiority of LogoStyleFool over three state-of-the-art patch-based attacks in terms of attack performance and semantic preservation. Meanwhile, LogoStyleFool still maintains its performance against two existing patch-based defense methods. We believe that our research is beneficial in increasing the attention of the security community to such subregional style transfer attacks.

Analysis of Weather and Time Features in Machine Learning-aided ERCOT Load Forecasting

Accurate load forecasting is critical for efficient and reliable operations of the electric power system. A large part of electricity consumption is affected by weather conditions, making weather information an important determinant of electricity usage. Personal appliances and industry equipment also contribute significantly to electricity demand with temporal patterns, making time a useful factor to consider in load forecasting. This work develops several machine learning (ML) models that take various time and weather information as part of the input features to predict the short-term system-wide total load. Ablation studies were also performed to investigate and compare the impacts of different weather factors on the prediction accuracy. Actual load and historical weather data for the same region were processed and then used to train the ML models. It is interesting to observe that using all available features, each of which may be correlated to the load, is unlikely to achieve the best forecasting performance; features with redundancy may even decrease the inference capabilities of ML models. This indicates the importance of feature selection for ML models. Overall, case studies demonstrated the effectiveness of ML models trained with different weather and time input features for ERCOT load forecasting.

Track-before-detect Algorithm based on Cost-reference Particle Filter Bank for Weak Target Detection

Detecting weak target is an important and challenging problem in many applications such as radar, sonar etc. However, conventional detection methods are often ineffective in this case because of low signal-to-noise ratio (SNR). This paper presents a track-before-detect (TBD) algorithm based on an improved particle filter, i.e. cost-reference particle filter bank (CRPFB), which turns the problem of target detection to the problem of two-layer hypothesis testing. The first layer is implemented by CRPFB for state estimation of possible target. CRPFB has entirely parallel structure, consisting amounts of cost-reference particle filters with different hypothesized prior information. The second layer is to compare a test metric with a given threshold, which is constructed from the output of the first layer and fits GEV distribution. The performance of our proposed TBD algorithm and the existed TBD algorithms are compared according to the experiments on nonlinear frequency modulated (NLFM) signal detection and tracking. Simulation results show that the proposed TBD algorithm has better performance than the state-of-the-arts in detection, tracking, and time efficiency.