Structured Outputs Enable General-Purpose LLMs to be Medical Experts

Medical question-answering (QA) is a critical task for evaluating how effectively large language models (LLMs) encode clinical knowledge and assessing their potential applications in medicine. Despite showing promise on multiple-choice tests, LLMs frequently struggle with open-ended medical questions, producing responses with dangerous hallucinations or lacking comprehensive coverage of critical aspects. Existing approaches attempt to address these challenges through domain-specific fine-tuning, but this proves resource-intensive and difficult to scale across models. To improve the comprehensiveness and factuality of medical responses, we propose a novel approach utilizing structured medical reasoning. Our method guides LLMs through an seven-step cognitive process inspired by clinical diagnosis, enabling more accurate and complete answers without additional training. Experiments on the MedLFQA benchmark demonstrate that our approach achieves the highest Factuality Score of 85.8, surpassing fine-tuned models. Notably, this improvement transfers to smaller models, highlighting the method's efficiency and scalability. Our code and datasets are available.

Synthia: Novel Concept Design with Affordance Composition

Text-to-image (T2I) models enable rapid concept design, making them widely used in AI-driven design. While recent studies focus on generating semantic and stylistic variations of given design concepts, functional coherence--the integration of multiple affordances into a single coherent concept--remains largely overlooked. In this paper, we introduce SYNTHIA, a framework for generating novel, functionally coherent designs based on desired affordances. Our approach leverages a hierarchical concept ontology that decomposes concepts into parts and affordances, serving as a crucial building block for functionally coherent design. We also develop a curriculum learning scheme based on our ontology that contrastively fine-tunes T2I models to progressively learn affordance composition while maintaining visual novelty. To elaborate, we (i) gradually increase affordance distance, guiding models from basic concept-affordance association to complex affordance compositions that integrate parts of distinct affordances into a single, coherent form, and (ii) enforce visual novelty by employing contrastive objectives to push learned representations away from existing concepts. Experimental results show that SYNTHIA outperforms state-of-the-art T2I models, demonstrating absolute gains of 25.1% and 14.7% for novelty and functional coherence in human evaluation, respectively.

MM-PoisonRAG: Disrupting Multimodal RAG with Local and Global Poisoning Attacks

Multimodal large language models (MLLMs) equipped with Retrieval Augmented Generation (RAG) leverage both their rich parametric knowledge and the dynamic, external knowledge to excel in tasks such as Question Answering. While RAG enhances MLLMs by grounding responses in query-relevant external knowledge, this reliance poses a critical yet underexplored safety risk: knowledge poisoning attacks, where misinformation or irrelevant knowledge is intentionally injected into external knowledge bases to manipulate model outputs to be incorrect and even harmful. To expose such vulnerabilities in multimodal RAG, we propose MM-PoisonRAG, a novel knowledge poisoning attack framework with two attack strategies: Localized Poisoning Attack (LPA), which injects query-specific misinformation in both text and images for targeted manipulation, and Globalized Poisoning Attack (GPA) to provide false guidance during MLLM generation to elicit nonsensical responses across all queries. We evaluate our attacks across multiple tasks, models, and access settings, demonstrating that LPA successfully manipulates the MLLM to generate attacker-controlled answers, with a success rate of up to 56% on MultiModalQA. Moreover, GPA completely disrupts model generation to 0% accuracy with just a single irrelevant knowledge injection. Our results highlight the urgent need for robust defenses against knowledge poisoning to safeguard multimodal RAG frameworks.

METAL: A Multi-Agent Framework for Chart Generation with Test-Time Scaling

Chart generation aims to generate code to produce charts satisfying the desired visual properties, e.g., texts, layout, color, and type. It has great potential to empower the automatic professional report generation in financial analysis, research presentation, education, and healthcare. In this work, we build a vision-language model (VLM) based multi-agent framework for effective automatic chart generation. Generating high-quality charts requires both strong visual design skills and precise coding capabilities that embed the desired visual properties into code. Such a complex multi-modal reasoning process is difficult for direct prompting of VLMs. To resolve these challenges, we propose METAL, a multi-agent framework that decomposes the task of chart generation into the iterative collaboration among specialized agents. METAL achieves 5.2% improvement in accuracy over the current best result in the chart generation task. The METAL framework exhibits the phenomenon of test-time scaling: its performance increases monotonically as the logarithmic computational budget grows from 512 to 8192 tokens. In addition, we find that separating different modalities during the critique process of METAL boosts the self-correction capability of VLMs in the multimodal context.

FIG: Forward-Inverse Generation for Low-Resource Domain-specific Event Detection

Event Detection (ED) is the task of identifying typed event mentions of interest from natural language text, which benefits domain-specific reasoning in biomedical, legal, and epidemiological domains. However, procuring supervised data for thousands of events for various domains is a laborious and expensive task. To this end, existing works have explored synthetic data generation via forward (generating labels for unlabeled sentences) and inverse (generating sentences from generated labels) generations. However, forward generation often produces noisy labels, while inverse generation struggles with domain drift and incomplete event annotations. To address these challenges, we introduce FIG, a hybrid approach that leverages inverse generation for high-quality data synthesis while anchoring it to domain-specific cues extracted via forward generation on unlabeled target data. FIG further enhances its synthetic data by adding missing annotations through forward generation-based refinement. Experimentation on three ED datasets from diverse domains reveals that FIG outperforms the best baseline achieving average gains of 3.3% F1 and 5.4% F1 in the zero-shot and few-shot settings respectively. Analyzing the generated trigger hit rate and human evaluation substantiates FIG's superior domain alignment and data quality compared to existing baselines.

Mind the Gesture: Evaluating AI Sensitivity to Culturally Offensive Non-Verbal Gestures

Gestures are an integral part of non-verbal communication, with meanings that vary across cultures, and misinterpretations that can have serious social and diplomatic consequences. As AI systems become more integrated into global applications, ensuring they do not inadvertently perpetuate cultural offenses is critical. To this end, we introduce Multi-Cultural Set of Inappropriate Gestures and Nonverbal Signs (MC-SIGNS), a dataset of 288 gesture-country pairs annotated for offensiveness, cultural significance, and contextual factors across 25 gestures and 85 countries. Through systematic evaluation using MC-SIGNS, we uncover critical limitations: text-to-image (T2I) systems exhibit strong US-centric biases, performing better at detecting offensive gestures in US contexts than in non-US ones; large language models (LLMs) tend to over-flag gestures as offensive; and vision-language models (VLMs) default to US-based interpretations when responding to universal concepts like wishing someone luck, frequently suggesting culturally inappropriate gestures. These findings highlight the urgent need for culturally-aware AI safety mechanisms to ensure equitable global deployment of AI technologies.

Contrastive Visual Data Augmentation

Large multimodal models (LMMs) often struggle to recognize novel concepts, as they rely on pre-trained knowledge and have limited ability to capture subtle visual details. Domain-specific knowledge gaps in training also make them prone to confusing visually similar, commonly misrepresented, or low-resource concepts. To help LMMs better align nuanced visual features with language, improving their ability to recognize and reason about novel or rare concepts, we propose a Contrastive visual Data Augmentation (CoDA) strategy. CoDA extracts key contrastive textual and visual features of target concepts against the known concepts they are misrecognized as, and then uses multimodal generative models to produce targeted synthetic data. Automatic filtering of extracted features and augmented images is implemented to guarantee their quality, as verified by human annotators. We show the effectiveness and efficiency of CoDA on low-resource concept and diverse scene recognition datasets including INaturalist and SUN. We additionally collect NovelSpecies, a benchmark dataset consisting of newly discovered animal species that are guaranteed to be unseen by LMMs. LLaVA-1.6 1-shot updating results on these three datasets show CoDA significantly improves SOTA visual data augmentation strategies by 12.3% (NovelSpecies), 5.1% (SUN), and 6.0% (iNat) absolute gains in accuracy.

Fact or Guesswork? Evaluating Large Language Model's Medical Knowledge with Structured One-Hop Judgment

Large language models (LLMs) have been widely adopted in various downstream task domains. However, their ability to directly recall and apply factual medical knowledge remains under-explored. Most existing medical QA benchmarks assess complex reasoning or multi-hop inference, making it difficult to isolate LLMs' inherent medical knowledge from their reasoning capabilities. Given the high-stakes nature of medical applications, where incorrect information can have critical consequences, it is essential to evaluate how well LLMs encode, retain, and recall fundamental medical facts. To bridge this gap, we introduce the Medical Knowledge Judgment, a dataset specifically designed to measure LLMs' one-hop factual medical knowledge. MKJ is constructed from the Unified Medical Language System (UMLS), a large-scale repository of standardized biomedical vocabularies and knowledge graphs. We frame knowledge assessment as a binary judgment task, requiring LLMs to verify the correctness of medical statements extracted from reliable and structured knowledge sources. Our experiments reveal that LLMs struggle with factual medical knowledge retention, exhibiting significant performance variance across different semantic categories, particularly for rare medical conditions. Furthermore, LLMs show poor calibration, often being overconfident in incorrect answers. To mitigate these issues, we explore retrieval-augmented generation, demonstrating its effectiveness in improving factual accuracy and reducing uncertainty in medical decision-making.

Enhancing LLM Character-Level Manipulation via Divide and Conquer

Large Language Models (LLMs) have demonstrated strong generalization capabilities across a wide range of natural language processing (NLP) tasks. However, they exhibit notable weaknesses in character-level string manipulation, struggling with fundamental operations such as character deletion, insertion, and substitution. These challenges stem primarily from tokenization constraints, despite the critical role of such operations in data preprocessing and code generation. Through systematic analysis, we derive two key insights: (1) LLMs face significant difficulties in leveraging intrinsic token knowledge for character-level reasoning, and (2) atomized word structures can substantially enhance LLMs' ability to process token-level structural information. Building on these insights, we propose Character-Level Manipulation via Divide and Conquer, a novel approach designed to bridge the gap between token-level processing and character-level manipulation. Our method decomposes complex operations into explicit character-level subtasks coupled with controlled token reconstruction phases, leading to significant improvements in accuracy. Without additional training, our method significantly improves accuracies on the $\texttt{Deletion}$, $\texttt{Insertion}$, and $\texttt{Substitution}$ tasks. To support further research, we open-source our implementation and benchmarks.

SafeWorld: Geo-Diverse Safety Alignment

In the rapidly evolving field of Large Language Models (LLMs), ensuring safety is a crucial and widely discussed topic. However, existing works often overlook the geo-diversity of cultural and legal standards across the world. To demonstrate the challenges posed by geo-diverse safety standards, we introduce SafeWorld, a novel benchmark specifically designed to evaluate LLMs' ability to generate responses that are not only helpful but also culturally sensitive and legally compliant across diverse global contexts. SafeWorld encompasses 2,342 test user queries, each grounded in high-quality, human-verified cultural norms and legal policies from 50 countries and 493 regions/races. On top of it, we propose a multi-dimensional automatic safety evaluation framework that assesses the contextual appropriateness, accuracy, and comprehensiveness of responses. Our evaluations reveal that current LLMs struggle to meet these criteria. To enhance LLMs' alignment with geo-diverse safety standards, we synthesize helpful preference pairs for Direct Preference Optimization (DPO) alignment training. The preference pair construction aims to encourage LLMs to behave appropriately and provide precise references to relevant cultural norms and policies when necessary. Our trained SafeWorldLM outperforms all competing models, including GPT-4o on all three evaluation dimensions by a large margin. Global human evaluators also note a nearly 20% higher winning rate in helpfulness and harmfulness evaluation. Our code and data can be found here: https://github.com/PlusLabNLP/SafeWorld.