Towards Lifelong Few-Shot Customization of Text-to-Image Diffusion

Lifelong few-shot customization for text-to-image diffusion aims to continually generalize existing models for new tasks with minimal data while preserving old knowledge. Current customization diffusion models excel in few-shot tasks but struggle with catastrophic forgetting problems in lifelong generations. In this study, we identify and categorize the catastrophic forgetting problems into two folds: relevant concepts forgetting and previous concepts forgetting. To address these challenges, we first devise a data-free knowledge distillation strategy to tackle relevant concepts forgetting. Unlike existing methods that rely on additional real data or offline replay of original concept data, our approach enables on-the-fly knowledge distillation to retain the previous concepts while learning new ones, without accessing any previous data. Second, we develop an In-Context Generation (ICGen) paradigm that allows the diffusion model to be conditioned upon the input vision context, which facilitates the few-shot generation and mitigates the issue of previous concepts forgetting. Extensive experiments show that the proposed Lifelong Few-Shot Diffusion (LFS-Diffusion) method can produce high-quality and accurate images while maintaining previously learned knowledge.

Photon-Counting CT in Cancer Radiotherapy: Technological Advances and Clinical Benefits

Photon-counting computed tomography (PCCT) marks a significant advancement over conventional energy-integrating detector (EID) CT systems. This review highlights PCCT's superior spatial and contrast resolution, reduced radiation dose, and multi-energy imaging capabilities, which address key challenges in radiotherapy, such as accurate tumor delineation, precise dose calculation, and treatment response monitoring. PCCT's improved anatomical clarity enhances tumor targeting while minimizing damage to surrounding healthy tissues. Additionally, metal artifact reduction (MAR) and quantitative imaging capabilities optimize workflows, enabling adaptive radiotherapy and radiomics-driven personalized treatment. Emerging clinical applications in brachytherapy and radiopharmaceutical therapy (RPT) show promising outcomes, although challenges like high costs and limited software integration remain. With advancements in artificial intelligence (AI) and dedicated radiotherapy packages, PCCT is poised to transform precision, safety, and efficacy in cancer radiotherapy, marking it as a pivotal technology for future clinical practice.

MotionCom: Automatic and Motion-Aware Image Composition with LLM and Video Diffusion Prior

This work presents MotionCom, a training-free motion-aware diffusion based image composition, enabling automatic and seamless integration of target objects into new scenes with dynamically coherent results without finetuning or optimization. Traditional approaches in this area suffer from two significant limitations: they require manual planning for object placement and often generate static compositions lacking motion realism. MotionCom addresses these issues by utilizing a Large Vision Language Model (LVLM) for intelligent planning, and a Video Diffusion prior for motion-infused image synthesis, streamlining the composition process. Our multi-modal Chain-of-Thought (CoT) prompting with LVLM automates the strategic placement planning of foreground objects, considering their potential motion and interaction within the scenes. Complementing this, we propose a novel method MotionPaint to distill motion-aware information from pretrained video diffusion models in the generation phase, ensuring that these objects are not only seamlessly integrated but also endowed with realistic motion. Extensive quantitative and qualitative results highlight MotionCom's superiority, showcasing its efficiency in streamlining the planning process and its capability to produce compositions that authentically depict motion and interaction.

T1-contrast Enhanced MRI Generation from Multi-parametric MRI for Glioma Patients with Latent Tumor Conditioning

Objective: Gadolinium-based contrast agents (GBCAs) are commonly used in MRI scans of patients with gliomas to enhance brain tumor characterization using T1-weighted (T1W) MRI. However, there is growing concern about GBCA toxicity. This study develops a deep-learning framework to generate T1-postcontrast (T1C) from pre-contrast multiparametric MRI. Approach: We propose the tumor-aware vision transformer (TA-ViT) model that predicts high-quality T1C images. The predicted tumor region is significantly improved (P < .001) by conditioning the transformer layers from predicted segmentation maps through adaptive layer norm zero mechanism. The predicted segmentation maps were generated with the multi-parametric residual (MPR) ViT model and transformed into a latent space to produce compressed, feature-rich representations. The TA-ViT model predicted T1C MRI images of 501 glioma cases. Selected patients were split into training (N=400), validation (N=50), and test (N=51) sets. Main Results: Both qualitative and quantitative results demonstrate that the TA-ViT model performs superior against the benchmark MRP-ViT model. Our method produces synthetic T1C MRI with high soft tissue contrast and more accurately reconstructs both the tumor and whole brain volumes. The synthesized T1C images achieved remarkable improvements in both tumor and healthy tissue regions compared to the MRP-ViT model. For healthy tissue and tumor regions, the results were as follows: NMSE: 8.53 +/- 4.61E-4; PSNR: 31.2 +/- 2.2; NCC: 0.908 +/- .041 and NMSE: 1.22 +/- 1.27E-4, PSNR: 41.3 +/- 4.7, and NCC: 0.879 +/- 0.042, respectively. Significance: The proposed method generates synthetic T1C images that closely resemble real T1C images. Future development and application of this approach may enable contrast-agent-free MRI for brain tumor patients, eliminating the risk of GBCA toxicity and simplifying the MRI scan protocol.

DeCo: Decoupled Human-Centered Diffusion Video Editing with Motion Consistency

Diffusion models usher a new era of video editing, flexibly manipulating the video contents with text prompts. Despite the widespread application demand in editing human-centered videos, these models face significant challenges in handling complex objects like humans. In this paper, we introduce DeCo, a novel video editing framework specifically designed to treat humans and the background as separate editable targets, ensuring global spatial-temporal consistency by maintaining the coherence of each individual component. Specifically, we propose a decoupled dynamic human representation that utilizes a parametric human body prior to generate tailored humans while preserving the consistent motions as the original video. In addition, we consider the background as a layered atlas to apply text-guided image editing approaches on it. To further enhance the geometry and texture of humans during the optimization, we extend the calculation of score distillation sampling into normal space and image space. Moreover, we tackle inconsistent lighting between the edited targets by leveraging a lighting-aware video harmonizer, a problem previously overlooked in decompose-edit-combine approaches. Extensive qualitative and numerical experiments demonstrate that DeCo outperforms prior video editing methods in human-centered videos, especially in longer videos.

AnatoMask: Enhancing Medical Image Segmentation with Reconstruction-guided Self-masking

Due to the scarcity of labeled data, self-supervised learning (SSL) has gained much attention in 3D medical image segmentation, by extracting semantic representations from unlabeled data. Among SSL strategies, Masked image modeling (MIM) has shown effectiveness by reconstructing randomly masked images to learn detailed representations. However, conventional MIM methods require extensive training data to achieve good performance, which still poses a challenge for medical imaging. Since random masking uniformly samples all regions within medical images, it may overlook crucial anatomical regions and thus degrade the pretraining efficiency. We propose AnatoMask, a novel MIM method that leverages reconstruction loss to dynamically identify and mask out anatomically significant regions to improve pretraining efficacy. AnatoMask takes a self-distillation approach, where the model learns both how to find more significant regions to mask and how to reconstruct these masked regions. To avoid suboptimal learning, Anatomask adjusts the pretraining difficulty progressively using a masking dynamics function. We have evaluated our method on 4 public datasets with multiple imaging modalities (CT, MRI, and PET). AnatoMask demonstrates superior performance and scalability compared to existing SSL methods. The code is available at https://github.com/ricklisz/AnatoMask.

Deep Learning Based Apparent Diffusion Coefficient Map Generation1 from Multi-parametric MR Images for Patients with Diffuse Gliomas

Purpose: Apparent diffusion coefficient (ADC) maps derived from diffusion weighted (DWI) MRI provides functional measurements about the water molecules in tissues. However, DWI is time consuming and very susceptible to image artifacts, leading to inaccurate ADC measurements. This study aims to develop a deep learning framework to synthesize ADC maps from multi-parametric MR images. Methods: We proposed the multiparametric residual vision transformer model (MPR-ViT) that leverages the long-range context of ViT layers along with the precision of convolutional operators. Residual blocks throughout the network significantly increasing the representational power of the model. The MPR-ViT model was applied to T1w and T2- fluid attenuated inversion recovery images of 501 glioma cases from a publicly available dataset including preprocessed ADC maps. Selected patients were divided into training (N=400), validation (N=50) and test (N=51) sets, respectively. Using the preprocessed ADC maps as ground truth, model performance was evaluated and compared against the Vision Convolutional Transformer (VCT) and residual vision transformer (ResViT) models. Results: The results are as follows using T1w + T2-FLAIR MRI as inputs: MPR-ViT - PSNR: 31.0 +/- 2.1, MSE: 0.009 +/- 0.0005, SSIM: 0.950 +/- 0.015. In addition, ablation studies showed the relative impact on performance of each input sequence. Both qualitative and quantitative results indicate that the proposed MR- ViT model performs favorably against the ground truth data. Conclusion: We show that high-quality ADC maps can be synthesized from structural MRI using a MPR- VCT model. Our predicted images show better conformality to the ground truth volume than ResViT and VCT predictions. These high-quality synthetic ADC maps would be particularly useful for disease diagnosis and intervention, especially when ADC maps have artifacts or are unavailable.

Adaptive Self-Supervised Consistency-Guided Diffusion Model for Accelerated MRI Reconstruction

Purpose: To propose a self-supervised deep learning-based compressed sensing MRI (DL-based CS-MRI) method named "Adaptive Self-Supervised Consistency Guided Diffusion Model (ASSCGD)" to accelerate data acquisition without requiring fully sampled datasets. Materials and Methods: We used the fastMRI multi-coil brain axial T2-weighted (T2-w) dataset from 1,376 cases and single-coil brain quantitative magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) T1 maps from 318 cases to train and test our model. Robustness against domain shift was evaluated using two out-of-distribution (OOD) datasets: multi-coil brain axial postcontrast T1 -weighted (T1c) dataset from 50 cases and axial T1-weighted (T1-w) dataset from 50 patients. Data were retrospectively subsampled at acceleration rates R in {2x, 4x, 8x}. ASSCGD partitions a random sampling pattern into two disjoint sets, ensuring data consistency during training. We compared our method with ReconFormer Transformer and SS-MRI, assessing performance using normalized mean squared error (NMSE), peak signal-to-noise ratio (PSNR), and structural similarity index (SSIM). Statistical tests included one-way analysis of variance (ANOVA) and multi-comparison Tukey's Honesty Significant Difference (HSD) tests. Results: ASSCGD preserved fine structures and brain abnormalities visually better than comparative methods at R = 8x for both multi-coil and single-coil datasets. It achieved the lowest NMSE at R in {4x, 8x}, and the highest PSNR and SSIM values at all acceleration rates for the multi-coil dataset. Similar trends were observed for the single-coil dataset, though SSIM values were comparable to ReconFormer at R in {2x, 8x}. These results were further confirmed by the voxel-wise correlation scatter plots. OOD results showed significant (p << 10^-5 ) improvements in undersampled image quality after reconstruction.

Text-to-Image Rectified Flow as Plug-and-Play Priors

Large-scale diffusion models have achieved remarkable performance in generative tasks. Beyond their initial training applications, these models have proven their ability to function as versatile plug-and-play priors. For instance, 2D diffusion models can serve as loss functions to optimize 3D implicit models. Rectified flow, a novel class of generative models, enforces a linear progression from the source to the target distribution and has demonstrated superior performance across various domains. Compared to diffusion-based methods, rectified flow approaches surpass in terms of generation quality and efficiency, requiring fewer inference steps. In this work, we present theoretical and experimental evidence demonstrating that rectified flow based methods offer similar functionalities to diffusion models - they can also serve as effective priors. Besides the generative capabilities of diffusion priors, motivated by the unique time-symmetry properties of rectified flow models, a variant of our method can additionally perform image inversion. Experimentally, our rectified flow-based priors outperform their diffusion counterparts - the SDS and VSD losses - in text-to-3D generation. Our method also displays competitive performance in image inversion and editing.

Sync4D: Video Guided Controllable Dynamics for Physics-Based 4D Generation

In this work, we introduce a novel approach for creating controllable dynamics in 3D-generated Gaussians using casually captured reference videos. Our method transfers the motion of objects from reference videos to a variety of generated 3D Gaussians across different categories, ensuring precise and customizable motion transfer. We achieve this by employing blend skinning-based non-parametric shape reconstruction to extract the shape and motion of reference objects. This process involves segmenting the reference objects into motion-related parts based on skinning weights and establishing shape correspondences with generated target shapes. To address shape and temporal inconsistencies prevalent in existing methods, we integrate physical simulation, driving the target shapes with matched motion. This integration is optimized through a displacement loss to ensure reliable and genuine dynamics. Our approach supports diverse reference inputs, including humans, quadrupeds, and articulated objects, and can generate dynamics of arbitrary length, providing enhanced fidelity and applicability. Unlike methods heavily reliant on diffusion video generation models, our technique offers specific and high-quality motion transfer, maintaining both shape integrity and temporal consistency.