Q-realign: Piggybacking Realignment on Quantization for Safe and Efficient LLM Deployment

Public large language models (LLMs) are typically safety-aligned during pretraining, yet task-specific fine-tuning required for deployment often erodes this alignment and introduces safety risks. Existing defenses either embed safety recovery into fine-tuning or rely on fine-tuning-derived priors for post-hoc correction, leaving safety recovery tightly coupled with training and incurring high computational overhead and a complex workflow. To address these challenges, we propose \texttt{Q-realign}, a post-hoc defense method based on post-training quantization, guided by an analysis of representational structure. By reframing quantization as a dual-objective procedure for compression and safety, \texttt{Q-realign} decouples safety alignment from fine-tuning and naturally piggybacks into modern deployment pipelines. Experiments across multiple models and datasets demonstrate that our method substantially reduces unsafe behaviors while preserving task performance, with significant reductions in memory usage and GPU hours. Notably, our approach can recover the safety alignment of a fine-tuned 7B LLM on a single RTX 4090 within 40 minutes. Overall, our work provides a practical, turnkey solution for safety-aware deployment.

RadFabric: Agentic AI System with Reasoning Capability for Radiology

Chest X ray (CXR) imaging remains a critical diagnostic tool for thoracic conditions, but current automated systems face limitations in pathology coverage, diagnostic accuracy, and integration of visual and textual reasoning. To address these gaps, we propose RadFabric, a multi agent, multimodal reasoning framework that unifies visual and textual analysis for comprehensive CXR interpretation. RadFabric is built on the Model Context Protocol (MCP), enabling modularity, interoperability, and scalability for seamless integration of new diagnostic agents. The system employs specialized CXR agents for pathology detection, an Anatomical Interpretation Agent to map visual findings to precise anatomical structures, and a Reasoning Agent powered by large multimodal reasoning models to synthesize visual, anatomical, and clinical data into transparent and evidence based diagnoses. RadFabric achieves significant performance improvements, with near-perfect detection of challenging pathologies like fractures (1.000 accuracy) and superior overall diagnostic accuracy (0.799) compared to traditional systems (0.229 to 0.527). By integrating cross modal feature alignment and preference-driven reasoning, RadFabric advances AI-driven radiology toward transparent, anatomically precise, and clinically actionable CXR analysis.

CDR-Agent: Intelligent Selection and Execution of Clinical Decision Rules Using Large Language Model Agents

Clinical decision-making is inherently complex and fast-paced, particularly in emergency departments (EDs) where critical, rapid and high-stakes decisions are made. Clinical Decision Rules (CDRs) are standardized evidence-based tools that combine signs, symptoms, and clinical variables into decision trees to make consistent and accurate diagnoses. CDR usage is often hindered by the clinician's cognitive load, limiting their ability to quickly recall and apply the appropriate rules. We introduce CDR-Agent, a novel LLM-based system designed to enhance ED decision-making by autonomously identifying and applying the most appropriate CDRs based on unstructured clinical notes. To validate CDR-Agent, we curated two novel ED datasets: synthetic and CDR-Bench, although CDR-Agent is applicable to non ED clinics. CDR-Agent achieves a 56.3\% (synthetic) and 8.7\% (CDR-Bench) accuracy gain relative to the standalone LLM baseline in CDR selection. Moreover, CDR-Agent significantly reduces computational overhead. Using these datasets, we demonstrated that CDR-Agent not only selects relevant CDRs efficiently, but makes cautious yet effective imaging decisions by minimizing unnecessary interventions while successfully identifying most positively diagnosed cases, outperforming traditional LLM prompting approaches. Code for our work can be found at: https://github.com/zhenxianglance/medagent-cdr-agent

SOSBENCH: Benchmarking Safety Alignment on Scientific Knowledge

Large language models (LLMs) exhibit advancing capabilities in complex tasks, such as reasoning and graduate-level question answering, yet their resilience against misuse, particularly involving scientifically sophisticated risks, remains underexplored. Existing safety benchmarks typically focus either on instructions requiring minimal knowledge comprehension (e.g., ``tell me how to build a bomb") or utilize prompts that are relatively low-risk (e.g., multiple-choice or classification tasks about hazardous content). Consequently, they fail to adequately assess model safety when handling knowledge-intensive, hazardous scenarios. To address this critical gap, we introduce SOSBench, a regulation-grounded, hazard-focused benchmark encompassing six high-risk scientific domains: chemistry, biology, medicine, pharmacology, physics, and psychology. The benchmark comprises 3,000 prompts derived from real-world regulations and laws, systematically expanded via an LLM-assisted evolutionary pipeline that introduces diverse, realistic misuse scenarios (e.g., detailed explosive synthesis instructions involving advanced chemical formulas). We evaluate frontier models within a unified evaluation framework using our SOSBench. Despite their alignment claims, advanced models consistently disclose policy-violating content across all domains, demonstrating alarmingly high rates of harmful responses (e.g., 79.1% for Deepseek-R1 and 47.3% for GPT-4.1). These results highlight significant safety alignment deficiencies and underscore urgent concerns regarding the responsible deployment of powerful LLMs.

How Memory Management Impacts LLM Agents: An Empirical Study of Experience-Following Behavior

Memory is a critical component in large language model (LLM)-based agents, enabling them to store and retrieve past executions to improve task performance over time. In this paper, we conduct an empirical study on how memory management choices impact the LLM agents' behavior, especially their long-term performance. Specifically, we focus on two fundamental memory operations that are widely used by many agent frameworks-addition, which incorporates new experiences into the memory base, and deletion, which selectively removes past experiences-to systematically study their impact on the agent behavior. Through our quantitative analysis, we find that LLM agents display an experience-following property: high similarity between a task input and the input in a retrieved memory record often results in highly similar agent outputs. Our analysis further reveals two significant challenges associated with this property: error propagation, where inaccuracies in past experiences compound and degrade future performance, and misaligned experience replay, where outdated or irrelevant experiences negatively influence current tasks. Through controlled experiments, we show that combining selective addition and deletion strategies can help mitigate these negative effects, yielding an average absolute performance gain of 10% compared to naive memory growth. Furthermore, we highlight how memory management choices affect agents' behavior under challenging conditions such as task distribution shifts and constrained memory resources. Our findings offer insights into the behavioral dynamics of LLM agent memory systems and provide practical guidance for designing memory components that support robust, long-term agent performance. We also release our code to facilitate further study.

Doxing via the Lens: Revealing Privacy Leakage in Image Geolocation for Agentic Multi-Modal Large Reasoning Model

The increasing capabilities of agentic multi-modal large reasoning models, such as ChatGPT o3, have raised critical concerns regarding privacy leakage through inadvertent image geolocation. In this paper, we conduct the first systematic and controlled study on the potential privacy risks associated with visual reasoning abilities of ChatGPT o3. We manually collect and construct a dataset comprising 50 real-world images that feature individuals alongside privacy-relevant environmental elements, capturing realistic and sensitive scenarios for analysis. Our experimental evaluation reveals that ChatGPT o3 can predict user locations with high precision, achieving street-level accuracy (within one mile) in 60% of cases. Through analysis, we identify key visual cues, including street layout and front yard design, that significantly contribute to the model inference success. Additionally, targeted occlusion experiments demonstrate that masking critical features effectively mitigates geolocation accuracy, providing insights into potential defense mechanisms. Our findings highlight an urgent need for privacy-aware development for agentic multi-modal large reasoning models, particularly in applications involving private imagery.

Large Language Model Empowered Privacy-Protected Framework for PHI Annotation in Clinical Notes

The de-identification of private information in medical data is a crucial process to mitigate the risk of confidentiality breaches, particularly when patient personal details are not adequately removed before the release of medical records. Although rule-based and learning-based methods have been proposed, they often struggle with limited generalizability and require substantial amounts of annotated data for effective performance. Recent advancements in large language models (LLMs) have shown significant promise in addressing these issues due to their superior language comprehension capabilities. However, LLMs present challenges, including potential privacy risks when using commercial LLM APIs and high computational costs for deploying open-source LLMs locally. In this work, we introduce LPPA, an LLM-empowered Privacy-Protected PHI Annotation framework for clinical notes, targeting the English language. By fine-tuning LLMs locally with synthetic notes, LPPA ensures strong privacy protection and high PHI annotation accuracy. Extensive experiments demonstrate LPPA's effectiveness in accurately de-identifying private information, offering a scalable and efficient solution for enhancing patient privacy protection.

MMDT: Decoding the Trustworthiness and Safety of Multimodal Foundation Models

Multimodal foundation models (MMFMs) play a crucial role in various applications, including autonomous driving, healthcare, and virtual assistants. However, several studies have revealed vulnerabilities in these models, such as generating unsafe content by text-to-image models. Existing benchmarks on multimodal models either predominantly assess the helpfulness of these models, or only focus on limited perspectives such as fairness and privacy. In this paper, we present the first unified platform, MMDT (Multimodal DecodingTrust), designed to provide a comprehensive safety and trustworthiness evaluation for MMFMs. Our platform assesses models from multiple perspectives, including safety, hallucination, fairness/bias, privacy, adversarial robustness, and out-of-distribution (OOD) generalization. We have designed various evaluation scenarios and red teaming algorithms under different tasks for each perspective to generate challenging data, forming a high-quality benchmark. We evaluate a range of multimodal models using MMDT, and our findings reveal a series of vulnerabilities and areas for improvement across these perspectives. This work introduces the first comprehensive and unique safety and trustworthiness evaluation platform for MMFMs, paving the way for developing safer and more reliable MMFMs and systems. Our platform and benchmark are available at https://mmdecodingtrust.github.io/.

A Practical Memory Injection Attack against LLM Agents

Agents based on large language models (LLMs) have demonstrated strong capabilities in a wide range of complex, real-world applications. However, LLM agents with a compromised memory bank may easily produce harmful outputs when the past records retrieved for demonstration are malicious. In this paper, we propose a novel Memory INJection Attack, MINJA, that enables the injection of malicious records into the memory bank by only interacting with the agent via queries and output observations. These malicious records are designed to elicit a sequence of malicious reasoning steps leading to undesirable agent actions when executing the victim user's query. Specifically, we introduce a sequence of bridging steps to link the victim query to the malicious reasoning steps. During the injection of the malicious record, we propose an indication prompt to guide the agent to autonomously generate our designed bridging steps. We also propose a progressive shortening strategy that gradually removes the indication prompt, such that the malicious record will be easily retrieved when processing the victim query comes after. Our extensive experiments across diverse agents demonstrate the effectiveness of MINJA in compromising agent memory. With minimal requirements for execution, MINJA enables any user to influence agent memory, highlighting practical risks of LLM agents.

Multi-Faceted Studies on Data Poisoning can Advance LLM Development

The lifecycle of large language models (LLMs) is far more complex than that of traditional machine learning models, involving multiple training stages, diverse data sources, and varied inference methods. While prior research on data poisoning attacks has primarily focused on the safety vulnerabilities of LLMs, these attacks face significant challenges in practice. Secure data collection, rigorous data cleaning, and the multistage nature of LLM training make it difficult to inject poisoned data or reliably influence LLM behavior as intended. Given these challenges, this position paper proposes rethinking the role of data poisoning and argue that multi-faceted studies on data poisoning can advance LLM development. From a threat perspective, practical strategies for data poisoning attacks can help evaluate and address real safety risks to LLMs. From a trustworthiness perspective, data poisoning can be leveraged to build more robust LLMs by uncovering and mitigating hidden biases, harmful outputs, and hallucinations. Moreover, from a mechanism perspective, data poisoning can provide valuable insights into LLMs, particularly the interplay between data and model behavior, driving a deeper understanding of their underlying mechanisms.