From Aleatoric to Epistemic: Exploring Uncertainty Quantification Techniques in Artificial Intelligence

Uncertainty quantification (UQ) is a critical aspect of artificial intelligence (AI) systems, particularly in high-risk domains such as healthcare, autonomous systems, and financial technology, where decision-making processes must account for uncertainty. This review explores the evolution of uncertainty quantification techniques in AI, distinguishing between aleatoric and epistemic uncertainties, and discusses the mathematical foundations and methods used to quantify these uncertainties. We provide an overview of advanced techniques, including probabilistic methods, ensemble learning, sampling-based approaches, and generative models, while also highlighting hybrid approaches that integrate domain-specific knowledge. Furthermore, we examine the diverse applications of UQ across various fields, emphasizing its impact on decision-making, predictive accuracy, and system robustness. The review also addresses key challenges such as scalability, efficiency, and integration with explainable AI, and outlines future directions for research in this rapidly developing area. Through this comprehensive survey, we aim to provide a deeper understanding of UQ's role in enhancing the reliability, safety, and trustworthiness of AI systems.

UDMC: Unified Decision-Making and Control Framework for Urban Autonomous Driving with Motion Prediction of Traffic Participants

Current autonomous driving systems often struggle to balance decision-making and motion control while ensuring safety and traffic rule compliance, especially in complex urban environments. Existing methods may fall short due to separate handling of these functionalities, leading to inefficiencies and safety compromises. To address these challenges, we introduce UDMC, an interpretable and unified Level 4 autonomous driving framework. UDMC integrates decision-making and motion control into a single optimal control problem (OCP), considering the dynamic interactions with surrounding vehicles, pedestrians, road lanes, and traffic signals. By employing innovative potential functions to model traffic participants and regulations, and incorporating a specialized motion prediction module, our framework enhances on-road safety and rule adherence. The integrated design allows for real-time execution of flexible maneuvers suited to diverse driving scenarios. High-fidelity simulations conducted in CARLA exemplify the framework's computational efficiency, robustness, and safety, resulting in superior driving performance when compared against various baseline models. Our open-source project is available at https://github.com/henryhcliu/udmc_carla.git.

Simulation-Free Hierarchical Latent Policy Planning for Proactive Dialogues

Recent advancements in proactive dialogues have garnered significant attention, particularly for more complex objectives (e.g. emotion support and persuasion). Unlike traditional task-oriented dialogues, proactive dialogues demand advanced policy planning and adaptability, requiring rich scenarios and comprehensive policy repositories to develop such systems. However, existing approaches tend to rely on Large Language Models (LLMs) for user simulation and online learning, leading to biases that diverge from realistic scenarios and result in suboptimal efficiency. Moreover, these methods depend on manually defined, context-independent, coarse-grained policies, which not only incur high expert costs but also raise concerns regarding their completeness. In our work, we highlight the potential for automatically discovering policies directly from raw, real-world dialogue records. To this end, we introduce a novel dialogue policy planning framework, LDPP. It fully automates the process from mining policies in dialogue records to learning policy planning. Specifically, we employ a variant of the Variational Autoencoder to discover fine-grained policies represented as latent vectors. After automatically annotating the data with these latent policy labels, we propose an Offline Hierarchical Reinforcement Learning (RL) algorithm in the latent space to develop effective policy planning capabilities. Our experiments demonstrate that LDPP outperforms existing methods on two proactive scenarios, even surpassing ChatGPT with only a 1.8-billion-parameter LLM.

Retrieval Augmented Image Harmonization

When embedding objects (foreground) into images (background), considering the influence of photography conditions like illumination, it is usually necessary to perform image harmonization to make the foreground object coordinate with the background image in terms of brightness, color, and etc. Although existing image harmonization methods have made continuous efforts toward visually pleasing results, they are still plagued by two main issues. Firstly, the image harmonization becomes highly ill-posed when there are no contents similar to the foreground object in the background, making the harmonization results unreliable. Secondly, even when similar contents are available, the harmonization process is often interfered with by irrelevant areas, mainly attributed to an insufficient understanding of image contents and inaccurate attention. As a remedy, we present a retrieval-augmented image harmonization (Raiha) framework, which seeks proper reference images to reduce the ill-posedness and restricts the attention to better utilize the useful information. Specifically, an efficient retrieval method is designed to find reference images that contain similar objects as the foreground while the illumination is consistent with the background. For training the Raiha framework to effectively utilize the reference information, a data augmentation strategy is delicately designed by leveraging existing non-reference image harmonization datasets. Besides, the image content priors are introduced to ensure reasonable attention. With the presented Raiha framework, the image harmonization performance is greatly boosted under both non-reference and retrieval-augmented settings. The source code and pre-trained models will be publicly available.

From Specific-MLLM to Omni-MLLM: A Survey about the MLLMs alligned with Multi-Modality

From the Specific-MLLM, which excels in single-modal tasks, to the Omni-MLLM, which extends the range of general modalities, this evolution aims to achieve understanding and generation of multimodal information. Omni-MLLM treats the features of different modalities as different "foreign languages," enabling cross-modal interaction and understanding within a unified space. To promote the advancement of related research, we have compiled 47 relevant papers to provide the community with a comprehensive introduction to Omni-MLLM. We first explain the four core components of Omni-MLLM for unified modeling and interaction of multiple modalities. Next, we introduce the effective integration achieved through "alignment pretraining" and "instruction fine-tuning," and discuss open-source datasets and testing of interaction capabilities. Finally, we summarize the main challenges facing current Omni-MLLM and outline future directions.

From Noise to Nuance: Advances in Deep Generative Image Models

Deep learning-based image generation has undergone a paradigm shift since 2021, marked by fundamental architectural breakthroughs and computational innovations. Through reviewing architectural innovations and empirical results, this paper analyzes the transition from traditional generative methods to advanced architectures, with focus on compute-efficient diffusion models and vision transformer architectures. We examine how recent developments in Stable Diffusion, DALL-E, and consistency models have redefined the capabilities and performance boundaries of image synthesis, while addressing persistent challenges in efficiency and quality. Our analysis focuses on the evolution of latent space representations, cross-attention mechanisms, and parameter-efficient training methodologies that enable accelerated inference under resource constraints. While more efficient training methods enable faster inference, advanced control mechanisms like ControlNet and regional attention systems have simultaneously improved generation precision and content customization. We investigate how enhanced multi-modal understanding and zero-shot generation capabilities are reshaping practical applications across industries. Our analysis demonstrates that despite remarkable advances in generation quality and computational efficiency, critical challenges remain in developing resource-conscious architectures and interpretable generation systems for industrial applications. The paper concludes by mapping promising research directions, including neural architecture optimization and explainable generation frameworks.

From Bench to Bedside: A Review of Clinical Trialsin Drug Discovery and Development

Clinical trials are an indispensable part of the drug development process, bridging the gap between basic research and clinical application. During the development of new drugs, clinical trials are used not only to evaluate the safety and efficacy of the drug but also to explore its dosage, treatment regimens, and potential side effects. This review discusses the various stages of clinical trials, including Phase I (safety assessment), Phase II (preliminary efficacy evaluation), Phase III (large-scale validation), and Phase IV (post-marketing surveillance), highlighting the characteristics of each phase and their interrelationships. Additionally, the paper addresses the major challenges encountered in clinical trials, such as ethical issues, subject recruitment difficulties, diversity and representativeness concerns, and proposes strategies for overcoming these challenges. With the advancement of technology, innovative technologies such as artificial intelligence, big data, and digitalization are gradually transforming clinical trial design and implementation, improving trial efficiency and data quality. The article also looks forward to the future of clinical trials, particularly the impact of emerging therapies such as gene therapy and immunotherapy on trial design, as well as the importance of regulatory reforms and global collaboration. In conclusion, the core role of clinical trials in drug development will continue to drive the progress of innovative drug development and clinical treatment.

Deep Learning Model Security: Threats and Defenses

Deep learning has transformed AI applications but faces critical security challenges, including adversarial attacks, data poisoning, model theft, and privacy leakage. This survey examines these vulnerabilities, detailing their mechanisms and impact on model integrity and confidentiality. Practical implementations, including adversarial examples, label flipping, and backdoor attacks, are explored alongside defenses such as adversarial training, differential privacy, and federated learning, highlighting their strengths and limitations. Advanced methods like contrastive and self-supervised learning are presented for enhancing robustness. The survey concludes with future directions, emphasizing automated defenses, zero-trust architectures, and the security challenges of large AI models. A balanced approach to performance and security is essential for developing reliable deep learning systems.

Learning Spatially Decoupled Color Representations for Facial Image Colorization

Image colorization methods have shown prominent performance on natural images. However, since humans are more sensitive to faces, existing methods are insufficient to meet the demands when applied to facial images, typically showing unnatural and uneven colorization results. In this paper, we investigate the facial image colorization task and find that the problems with facial images can be attributed to an insufficient understanding of facial components. As a remedy, by introducing facial component priors, we present a novel facial image colorization framework dubbed FCNet. Specifically, we learn a decoupled color representation for each face component (e.g., lips, skin, eyes, and hair) under the guidance of face parsing maps. A chromatic and spatial augmentation strategy is presented to facilitate the learning procedure, which requires only grayscale and color facial image pairs. After training, the presented FCNet can be naturally applied to facial image colorization with single or multiple reference images. To expand the application paradigms to scenarios with no reference images, we further train two alternative modules, which predict the color representations from the grayscale input or a random seed, respectively. Extensive experiments show that our method can perform favorably against existing methods in various application scenarios (i.e., no-, single-, and multi-reference facial image colorization). The source code and pre-trained models will be publicly available.

Deep Learning, Machine Learning, Advancing Big Data Analytics and Management

Advancements in artificial intelligence, machine learning, and deep learning have catalyzed the transformation of big data analytics and management into pivotal domains for research and application. This work explores the theoretical foundations, methodological advancements, and practical implementations of these technologies, emphasizing their role in uncovering actionable insights from massive, high-dimensional datasets. The study presents a systematic overview of data preprocessing techniques, including data cleaning, normalization, integration, and dimensionality reduction, to prepare raw data for analysis. Core analytics methodologies such as classification, clustering, regression, and anomaly detection are examined, with a focus on algorithmic innovation and scalability. Furthermore, the text delves into state-of-the-art frameworks for data mining and predictive modeling, highlighting the role of neural networks, support vector machines, and ensemble methods in tackling complex analytical challenges. Special emphasis is placed on the convergence of big data with distributed computing paradigms, including cloud and edge computing, to address challenges in storage, computation, and real-time analytics. The integration of ethical considerations, including data privacy and compliance with global standards, ensures a holistic perspective on data management. Practical applications across healthcare, finance, marketing, and policy-making illustrate the real-world impact of these technologies. Through comprehensive case studies and Python-based implementations, this work equips researchers, practitioners, and data enthusiasts with the tools to navigate the complexities of modern data analytics. It bridges the gap between theory and practice, fostering the development of innovative solutions for managing and leveraging data in the era of artificial intelligence.