Transfer Learning from One Cancer to Another via Deep Learning Domain Adaptation

Supervised deep learning models often achieve excellent performance within their training distribution but struggle to generalize beyond it. In cancer histopathology, for example, a convolutional neural network (CNN) may classify cancer severity accurately for cancer types represented in its training data, yet fail on related but unseen types. Although adenocarcinomas from different organs share morphological features that might support limited cross-domain generalization, addressing domain shift directly is necessary for robust performance. Domain adaptation offers a way to transfer knowledge from labeled data in one cancer type to unlabeled data in another, helping mitigate the scarcity of annotated medical images. This work evaluates cross-domain classification performance among lung, colon, breast, and kidney adenocarcinomas. A ResNet50 trained on any single adenocarcinoma achieves over 98% accuracy on its own domain but shows minimal generalization to others. Ensembling multiple supervised models does not resolve this limitation. In contrast, converting the ResNet50 into a domain adversarial neural network (DANN) substantially improves performance on unlabeled target domains. A DANN trained on labeled breast and colon data and adapted to unlabeled lung data reaches 95.56% accuracy. We also examine the impact of stain normalization on domain adaptation. Its effects vary by target domain: for lung, accuracy drops from 95.56% to 66.60%, while for breast and colon targets, stain normalization boosts accuracy from 49.22% to 81.29% and from 78.48% to 83.36%, respectively. Finally, using Integrated Gradients reveals that DANNs consistently attribute importance to biologically meaningful regions such as densely packed nuclei, indicating that the model learns clinically relevant features and can apply them to unlabeled cancer types.

Feedback-Enhanced Online Multiple Testing with Applications to Conformal Selection

We study online multiple testing with feedback, where decisions are made sequentially and the true state of the hypothesis is revealed after the decision has been made, either instantly or with a delay. We propose GAIF, a feedback-enhanced generalized alpha-investing framework that dynamically adjusts thresholds using revealed outcomes, ensuring finite-sample false discovery rate (FDR)/marginal FDR control. Extending GAIF to online conformal testing, we construct independent conformal $p$-values and introduce a feedback-driven model selection criterion to identify the best model/score, thereby improving statistical power. We demonstrate the effectiveness of our methods through numerical simulations and real-data applications.

Automating Safety Enhancement for LLM-based Agents with Synthetic Risk Scenarios

Large Language Model (LLM)-based agents are increasingly deployed in real-world applications such as "digital assistants, autonomous customer service, and decision-support systems", where their ability to "interact in multi-turn, tool-augmented environments" makes them indispensable. However, ensuring the safety of these agents remains a significant challenge due to the diverse and complex risks arising from dynamic user interactions, external tool usage, and the potential for unintended harmful behaviors. To address this critical issue, we propose AutoSafe, the first framework that systematically enhances agent safety through fully automated synthetic data generation. Concretely, 1) we introduce an open and extensible threat model, OTS, which formalizes how unsafe behaviors emerge from the interplay of user instructions, interaction contexts, and agent actions. This enables precise modeling of safety risks across diverse scenarios. 2) we develop a fully automated data generation pipeline that simulates unsafe user behaviors, applies self-reflective reasoning to generate safe responses, and constructs a large-scale, diverse, and high-quality safety training dataset-eliminating the need for hazardous real-world data collection. To evaluate the effectiveness of our framework, we design comprehensive experiments on both synthetic and real-world safety benchmarks. Results demonstrate that AutoSafe boosts safety scores by 45% on average and achieves a 28.91% improvement on real-world tasks, validating the generalization ability of our learned safety strategies. These results highlight the practical advancement and scalability of AutoSafe in building safer LLM-based agents for real-world deployment. We have released the project page at https://auto-safe.github.io/.

Comparative Analysis of Pre-trained Deep Learning Models and DINOv2 for Cushing's Syndrome Diagnosis in Facial Analysis

Cushing's syndrome is a condition caused by excessive glucocorticoid secretion from the adrenal cortex, often manifesting with moon facies and plethora, making facial data crucial for diagnosis. Previous studies have used pre-trained convolutional neural networks (CNNs) for diagnosing Cushing's syndrome using frontal facial images. However, CNNs are better at capturing local features, while Cushing's syndrome often presents with global facial features. Transformer-based models like ViT and SWIN, which utilize self-attention mechanisms, can better capture long-range dependencies and global features. Recently, DINOv2, a foundation model based on visual Transformers, has gained interest. This study compares the performance of various pre-trained models, including CNNs, Transformer-based models, and DINOv2, in diagnosing Cushing's syndrome. We also analyze gender bias and the impact of freezing mechanisms on DINOv2. Our results show that Transformer-based models and DINOv2 outperformed CNNs, with ViT achieving the highest F1 score of 85.74%. Both the pre-trained model and DINOv2 had higher accuracy for female samples. DINOv2 also showed improved performance when freezing parameters. In conclusion, Transformer-based models and DINOv2 are effective for Cushing's syndrome classification.

AIPatient: Simulating Patients with EHRs and LLM Powered Agentic Workflow

Simulated patient systems play a crucial role in modern medical education and research, providing safe, integrative learning environments and enabling clinical decision-making simulations. Large Language Models (LLM) could advance simulated patient systems by replicating medical conditions and patient-doctor interactions with high fidelity and low cost. However, ensuring the effectiveness and trustworthiness of these systems remains a challenge, as they require a large, diverse, and precise patient knowledgebase, along with a robust and stable knowledge diffusion to users. Here, we developed AIPatient, an advanced simulated patient system with AIPatient Knowledge Graph (AIPatient KG) as the input and the Reasoning Retrieval-Augmented Generation (Reasoning RAG) agentic workflow as the generation backbone. AIPatient KG samples data from Electronic Health Records (EHRs) in the Medical Information Mart for Intensive Care (MIMIC)-III database, producing a clinically diverse and relevant cohort of 1,495 patients with high knowledgebase validity (F1 0.89). Reasoning RAG leverages six LLM powered agents spanning tasks including retrieval, KG query generation, abstraction, checker, rewrite, and summarization. This agentic framework reaches an overall accuracy of 94.15% in EHR-based medical Question Answering (QA), outperforming benchmarks that use either no agent or only partial agent integration. Our system also presents high readability (median Flesch Reading Ease 77.23; median Flesch Kincaid Grade 5.6), robustness (ANOVA F-value 0.6126, p<0.1), and stability (ANOVA F-value 0.782, p<0.1). The promising performance of the AIPatient system highlights its potential to support a wide range of applications, including medical education, model evaluation, and system integration.

Conditional Testing based on Localized Conformal p-values

In this paper, we address conditional testing problems through the conformal inference framework. We define the localized conformal p-values by inverting prediction intervals and prove their theoretical properties. These defined p-values are then applied to several conditional testing problems to illustrate their practicality. Firstly, we propose a conditional outlier detection procedure to test for outliers in the conditional distribution with finite-sample false discovery rate (FDR) control. We also introduce a novel conditional label screening problem with the goal of screening multivariate response variables and propose a screening procedure to control the family-wise error rate (FWER). Finally, we consider the two-sample conditional distribution test and define a weighted U-statistic through the aggregation of localized p-values. Numerical simulations and real-data examples validate the superior performance of our proposed strategies.

GFPack++: Improving 2D Irregular Packing by Learning Gradient Field with Attention

2D irregular packing is a classic combinatorial optimization problem with various applications, such as material utilization and texture atlas generation. This NP-hard problem requires efficient algorithms to optimize space utilization. Conventional numerical methods suffer from slow convergence and high computational cost. Existing learning-based methods, such as the score-based diffusion model, also have limitations, such as no rotation support, frequent collisions, and poor adaptability to arbitrary boundaries, and slow inferring. The difficulty of learning from teacher packing is to capture the complex geometric relationships among packing examples, which include the spatial (position, orientation) relationships of objects, their geometric features, and container boundary conditions. Representing these relationships in latent space is challenging. We propose GFPack++, an attention-based gradient field learning approach that addresses this challenge. It consists of two pivotal strategies: \emph{attention-based geometry encoding} for effective feature encoding and \emph{attention-based relation encoding} for learning complex relationships. We investigate the utilization distribution between the teacher and inference data and design a weighting function to prioritize tighter teacher data during training, enhancing learning effectiveness. Our diffusion model supports continuous rotation and outperforms existing methods on various datasets. We achieve higher space utilization over several widely used baselines, one-order faster than the previous diffusion-based method, and promising generalization for arbitrary boundaries. We plan to release our source code and datasets to support further research in this direction.

Methodology and Real-World Applications of Dynamic Uncertain Causality Graph for Clinical Diagnosis with Explainability and Invariance

AI-aided clinical diagnosis is desired in medical care. Existing deep learning models lack explainability and mainly focus on image analysis. The recently developed Dynamic Uncertain Causality Graph (DUCG) approach is causality-driven, explainable, and invariant across different application scenarios, without problems of data collection, labeling, fitting, privacy, bias, generalization, high cost and high energy consumption. Through close collaboration between clinical experts and DUCG technicians, 46 DUCG models covering 54 chief complaints were constructed. Over 1,000 diseases can be diagnosed without triage. Before being applied in real-world, the 46 DUCG models were retrospectively verified by third-party hospitals. The verified diagnostic precisions were no less than 95%, in which the diagnostic precision for every disease including uncommon ones was no less than 80%. After verifications, the 46 DUCG models were applied in the real-world in China. Over one million real diagnosis cases have been performed, with only 17 incorrect diagnoses identified. Due to DUCG's transparency, the mistakes causing the incorrect diagnoses were found and corrected. The diagnostic abilities of the clinicians who applied DUCG frequently were improved significantly. Following the introduction to the earlier presented DUCG methodology, the recommendation algorithm for potential medical checks is presented and the key idea of DUCG is extracted.

FedDriveScore: Federated Scoring Driving Behavior with a Mixture of Metric Distributions

Scoring the driving performance of various drivers on a unified scale, based on how safe or economical they drive on their daily trips, is essential for the driver profile task. Connected vehicles provide the opportunity to collect real-world driving data, which is advantageous for constructing scoring models. However, the lack of pre-labeled scores impede the use of supervised regression models and the data privacy issues hinder the way of traditionally data-centralized learning on the cloud side for model training. To address them, an unsupervised scoring method is presented without the need for labels while still preserving fairness and objectiveness compared to subjective scoring strategies. Subsequently, a federated learning framework based on vehicle-cloud collaboration is proposed as a privacy-friendly alternative to centralized learning. This framework includes a consistently federated version of the scoring method to reduce the performance degradation of the global scoring model caused by the statistical heterogeneous challenge of local data. Theoretical and experimental analysis demonstrate that our federated scoring model is consistent with the utility of the centrally learned counterpart and is effective in evaluating driving performance.

Exploring the Robustness of Decentralized Training for Large Language Models

Decentralized training of large language models has emerged as an effective way to democratize this technology. However, the potential threats associated with this approach have not been carefully discussed, which would hinder the development of decentralized training infrastructures. This paper aims to initiate discussion towards this end by exploring the robustness of decentralized training from three main perspectives. First, we demonstrate the vulnerabilities inherent in decentralized training frameworks in terms of hardware, data, and models. Second, we highlight the fundamental difference between decentralized foundation model training and vanilla federated learning, where the security techniques employed in federated learning cannot be applied directly. Third, we discuss the essential components required for a robust and efficient decentralized training framework and present a case study by modeling a concrete threat model. Our objective in this vision paper is to emphasize the importance of addressing security concerns in the context of decentralized training for large language models.