Stanford University
Abstract:Modern vehicle platforms are equipped with a rich sensor suite, including LiDAR, calibrated multi-camera rigs, and accurate ego-motion, that in principle offers strong signal for re-rendering a driving scene from novel viewpoints. A growing line of recent work leverages video diffusion models for this task, using their generative priors to synthesize plausible novel views from sparse vehicle observations. In practice, however, existing methods exploit only a fragment of this signal, and their quality tends to degrade as the target trajectory departs from the recorded driving path. We argue that this is fundamentally a multi-sensor fusion problem: sparse LiDAR reprojections supply accurate but incomplete metric geometry, surround-view reference imagery supplies dense appearance but no metric depth, and camera poses tie the two together across views. We introduce StreetNVS, a video diffusion framework that jointly conditions on all three signals through a Reference-Enhanced Camera Attention module based on a relative ray-level positional encoding. We develop a two-stage curriculum training strategy that gradually exposes the model to increasingly sparse LiDAR. On the Waymo Open Dataset, StreetNVS substantially outperforms state-of-the-art baselines under sparse LiDAR conditioning, matches methods that rely on 10-100 times denser point clouds. We further show capabilities of synthesizing coherent videos along extreme out-of-trajectory paths such as elevation, lane-shift, pullback, and rotation. Our website: https://streetnvs.github.io
Abstract:Online 3D scene perception in real time is essential for robotics, AR/VR, and autonomous systems, particularly in edge computing scenarios where computational resources are limited and privacy is crucial. Recent state-of-the-art methods like EmbodiedSAM (ESAM) demonstrate the promise of online 3D perception by leveraging the Segment Anything Model (SAM) for real-time, fine-grained, and generalized 3D instance segmentation. However, ESAM still relies on a computationally expensive 3D sparse UNet for point cloud feature extraction, which accounts for the majority of the 3D inference time, hindering its practicality on resource-constrained devices. In this paper, we propose ESAM++, a lightweight and scalable alternative for online 3D scene perception tailored to edge devices without GPU acceleration. Our method introduces a 3D Sparse Feature Pyramid Network (SFPN) that efficiently captures multi-scale geometric features from streaming 3D point clouds while significantly reducing computational overhead and model size. We evaluate our approach on four challenging segmentation benchmarks, namely ScanNet, ScanNet200, SceneNN, and 3RScan, demonstrating that our model achieves competitive accuracy with up to 3 times faster inference with a 2 times smaller model size compared to ESAM, enabling practical deployment on edge devices.
Abstract:We present NeuroQA, a large-scale benchmark for visual question answering in 3D brain magnetic resonance imaging (MRI), with 56,953 QA pairs from 12,977 subjects across 12 datasets. It spans ages 5-104 and five clinical domains: Alzheimer's, Parkinson's, tumors, white matter disease, and neurodevelopment. Unlike prior medical Visual Question Answering (VQA) efforts that operate on 2D slices or rely on narrow diagnostic labels, NeuroQA pairs every item with a full 3D volume. It evaluates 11 clinically grounded reasoning skills across Yes/No, multiple-choice, and open-ended formats. Of the 203 templates, 131 are image-grounded (answerable from a 3-plane viewer) and 72 are image-informed (ground truth from quantitative volumetry or clinical instruments). To remove text-only shortcuts, we apply answer-distribution refinement, reducing closed-format text-only accuracy from $>$80% to 44.6%; image necessity is assessed separately through an image-grounding protocol released with the benchmark. A 38-rule deterministic pipeline and two rounds of expert review verify every QA pair against FreeSurfer measurements, metadata, or radiology report fields, with zero same-subject contradictions across templates. We conduct a clinician evaluation in which two clinicians independently assess 100 frozen test items on a three-plane viewer. On closed-format (Yes/No + multiple-choice) test-public items, the best zero-shot vision-language model and a supervised 3D CNN baseline reach 47.5% and 43.7% accuracy respectively, both below the 49.4% text-only majority-template floor. NeuroQA adopts a two-tier release with public QA pairs for open-access datasets and reproducible generation scripts for datasets restricted by data use agreements (DUAs), plus subject-level splits, a held-out private test set, and an online leaderboard.
Abstract:Brain MRI foundation models learn rich representations of anatomy, but interpreting what clinical information they encode remains an open problem. Standard sparse autoencoders (SAEs) suffer from severe feature collapse in deep transformer layers, and in Alzheimer's disease (AD) research, aging confounds nearly every clinical variable, making naive annotation unreliable. We propose GeoSAE, a geometry-guided SAE framework that uses the foundation model's learned manifold structure to prevent feature collapse and annotates each surviving feature via age-deconfounded partial correlations. Applied to ~14k T1-weighted MRI scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Australian Imaging biomarkers and Lifestyle (AIBL) datasets, GeoSAE identifies a compact, fully interpretable feature set that predicts mild cognitive impairment (MCI)-to-AD conversion (AUC 0.746) using only 2% of the embedding dimensions, while comorbidity-annotated features achieve only chance-level performance. The identified features replicate across cohorts without retraining (r=0.97) and localize to neuroanatomically distinct regions consistent with Braak staging. This shows that geometry-guided SAEs can extract interpretable, biomarkers from frozen brain MRI foundation models.
Abstract:Recent advances in model architectures, compute, and data scale have driven rapid progress in video generation, producing increasingly realistic content. Yet, no prior method systematically measures how faithfully these systems render human bodies and motion dynamics. In this paper, we present HumanScore, a systematic framework to evaluate the quality of human motions in AI-generated videos. HumanScore defines six interpretable metrics spanning kinematic plausibility, temporal stability, and biomechanical consistency, enabling fine-grained diagnosis beyond visual realism alone. Through carefully designed prompts, we elicit a diverse set of movements at varying intensities and evaluate videos generated by thirteen state-of-the-art models. Our analysis reveals consistent gaps between perceptual plausibility and motion biomechanical fidelity, identifies recurrent failure modes (e.g., temporal jitter, anatomically implausible poses, and motion drift), and produces robust model rankings from quantitative and physically meaningful criteria.
Abstract:Reconstructing 3D human motion and human-object interactions (HOI) from Internet videos is a fundamental step toward building large-scale datasets of human behavior. Existing methods struggle to recover globally consistent 3D motion under dynamic cameras, especially for motion types underrepresented in current motion-capture datasets, and face additional difficulty recovering coherent human-object interactions in 3D. We introduce a two-stage framework leveraging 2D diffusion that reconstructs 3D human motion and HOI from Internet videos. In the first stage, we synthesize multi-view 2D motion data for each domain, leveraging 2D keypoints extracted from Internet videos to incorporate human motions that rarely appear in existing MoCap datasets. In the second stage, a camera-conditioned multi-view 2D motion diffusion model is trained on the domain-specific synthetic data to recover 3D human motion and 3D HOI in the world space. We demonstrate the effectiveness of our method on Internet videos featuring challenging motions such as gymnastics, as well as in-the-wild HOI videos, and show that it outperforms prior work in producing realistic human motion and human-object interaction.
Abstract:Multimodal language models systematically underperform on visual perception tasks, yet the structure underlying this failure remains poorly understood. We propose centroid replacement, collapsing each token to its nearest K-means centroid, as a controlled probe for modal dependence. Across seven models spanning three architecture families, erasing text centroid structure costs 4$\times$ more accuracy than erasing visual centroid structure, exposing a universal imbalance where language representations overshadow vision even on tasks that demand visual reasoning. We exploit this asymmetry through text centroid contrastive decoding, recovering up to +16.9% accuracy on individual tasks by contrastively decoding against a text-centroid-erased reference. This intervention varies meaningfully with training approaches: standard fine-tuned models show larger gains (+5.6% on average) than preference-optimized models (+1.5% on average). Our findings suggest that modal competition is structurally localized, correctable at inference time without retraining, and quantifiable as a diagnostic signal to guide future multimodal training.
Abstract:Learning a robust Variational Autoencoder (VAE) is a fundamental step for many deep learning applications in medical image analysis, such as MRI synthesizes. Existing brain VAEs predominantly focus on single-modality data (i.e., T1-weighted MRI), overlooking the complementary diagnostic value of other modalities like T2-weighted MRIs. Here, we propose a modality-aware and anatomically grounded 3D vector-quantized VAE (VQ-VAE) for reconstructing multi-modal brain MRIs. Called NeuroQuant, it first learns a shared latent representation across modalities using factorized multi-axis attention, which can capture relationships between distant brain regions. It then employs a dual-stream 3D encoder that explicitly separates the encoding of modality-invariant anatomical structures from modality-dependent appearance. Next, the anatomical encoding is discretized using a shared codebook and combined with modality-specific appearance features via Feature-wise Linear Modulation (FiLM) during the decoding phase. This entire approach is trained using a joint 2D/3D strategy in order to account for the slice-based acquisition of 3D MRI data. Extensive experiments on two multi-modal brain MRI datasets demonstrate that NeuroQuant achieves superior reconstruction fidelity compared to existing VAEs, enabling a scalable foundation for downstream generative modeling and cross-modal brain image analysis.
Abstract:Accurate diagnosis and treatment of complex diseases require integrating histological, molecular, and clinical data, yet in practice these modalities are often incomplete owing to tissue scarcity, assay cost, and workflow constraints. Existing computational approaches attempt to impute missing modalities from available data but rely on task-specific models trained on narrow, single source-target pairs, limiting their generalizability. Here we introduce MuPD (Multimodal Pathology Diffusion), a generative foundation model that embeds hematoxylin and eosin (H&E)-stained histology, molecular RNA profiles, and clinical text into a shared latent space through a diffusion transformer with decoupled cross-modal attention. Pretrained on 100 million histology image patches, 1.6 million text-histology pairs, and 10.8 million RNA-histology pairs spanning 34 human organs, MuPD supports diverse cross-modal synthesis tasks with minimal or no task-specific fine-tuning. For text-conditioned and image-to-image generation, MuPD synthesizes histologically faithful tissue architectures, reducing Fréchet inception distance (FID) scores by 50% relative to domain-specific models and improving few-shot classification accuracy by up to 47% through synthetic data augmentation. For RNA-conditioned histology generation, MuPD reduces FID by 23% compared with the next-best method while preserving cell-type distributions across five cancer types. As a virtual stainer, MuPD translates H&E images to immunohistochemistry and multiplex immunofluorescence, improving average marker correlation by 37% over existing approaches. These results demonstrate that a single, unified generative model pretrained across heterogeneous pathology modalities can substantially outperform specialized alternatives, providing a scalable computational framework for multimodal histopathology.
Abstract:We present a feed-forward human performance capture method that renders novel views of a performer from a monocular RGB stream. A key challenge in this setting is the lack of sufficient observations, especially for unseen regions. Assuming the subject moves continuously over time, we take advantage of the fact that more body parts become observable by maintaining a canonical space that is progressively updated with each incoming frame. This canonical space accumulates appearance information over time and serves as a context bank when direct observations are missing in the current live frame. To effectively utilize this context while respecting the deformation of the live state, we formulate the rendering process as probabilistic regression. This resolves conflicts between past and current observations, producing sharper reconstructions than deterministic regression approaches. Furthermore, it enables plausible synthesis even in regions with no prior observations. Experiments on in-domain (4D-Dress) and out-of-distribution (MVHumanNet) datasets demonstrate the effectiveness of our approach.