Generating Novel Brain Morphology by Deforming Learned Templates

Designing generative models for 3D structural brain MRI that synthesize morphologically-plausible and attribute-specific (e.g., age, sex, disease state) samples is an active area of research. Existing approaches based on frameworks like GANs or diffusion models synthesize the image directly, which may limit their ability to capture intricate morphological details. In this work, we propose a 3D brain MRI generation method based on state-of-the-art latent diffusion models (LDMs), called MorphLDM, that generates novel images by applying synthesized deformation fields to a learned template. Instead of using a reconstruction-based autoencoder (as in a typical LDM), our encoder outputs a latent embedding derived from both an image and a learned template that is itself the output of a template decoder; this latent is passed to a deformation field decoder, whose output is applied to the learned template. A registration loss is minimized between the original image and the deformed template with respect to the encoder and both decoders. Empirically, our approach outperforms generative baselines on metrics spanning image diversity, adherence with respect to input conditions, and voxel-based morphometry. Our code is available at https://github.com/alanqrwang/morphldm.

Gradient Co-occurrence Analysis for Detecting Unsafe Prompts in Large Language Models

Unsafe prompts pose significant safety risks to large language models (LLMs). Existing methods for detecting unsafe prompts rely on data-driven fine-tuning to train guardrail models, necessitating significant data and computational resources. In contrast, recent few-shot gradient-based methods emerge, requiring only few safe and unsafe reference prompts. A gradient-based approach identifies unsafe prompts by analyzing consistent patterns of the gradients of safety-critical parameters in LLMs. Although effective, its restriction to directional similarity (cosine similarity) introduces ``directional bias'', limiting its capability to identify unsafe prompts. To overcome this limitation, we introduce GradCoo, a novel gradient co-occurrence analysis method that expands the scope of safety-critical parameter identification to include unsigned gradient similarity, thereby reducing the impact of ``directional bias'' and enhancing the accuracy of unsafe prompt detection. Comprehensive experiments on the widely-used benchmark datasets ToxicChat and XStest demonstrate that our proposed method can achieve state-of-the-art (SOTA) performance compared to existing methods. Moreover, we confirm the generalizability of GradCoo in detecting unsafe prompts across a range of LLM base models with various sizes and origins.

Diffusion Models for Computational Neuroimaging: A Survey

Computational neuroimaging involves analyzing brain images or signals to provide mechanistic insights and predictive tools for human cognition and behavior. While diffusion models have shown stability and high-quality generation in natural images, there is increasing interest in adapting them to analyze brain data for various neurological tasks such as data enhancement, disease diagnosis and brain decoding. This survey provides an overview of recent efforts to integrate diffusion models into computational neuroimaging. We begin by introducing the common neuroimaging data modalities, follow with the diffusion formulations and conditioning mechanisms. Then we discuss how the variations of the denoising starting point, condition input and generation target of diffusion models are developed and enhance specific neuroimaging tasks. For a comprehensive overview of the ongoing research, we provide a publicly available repository at https://github.com/JoeZhao527/dm4neuro.

Enhancing Semantic Consistency of Large Language Models through Model Editing: An Interpretability-Oriented Approach

A Large Language Model (LLM) tends to generate inconsistent and sometimes contradictory outputs when presented with a prompt that has equivalent semantics but is expressed differently from the original prompt. To achieve semantic consistency of an LLM, one of the key approaches is to finetune the model with prompt-output pairs with semantically equivalent meanings. Despite its effectiveness, a data-driven finetuning method incurs substantial computation costs in data preparation and model optimization. In this regime, an LLM is treated as a ``black box'', restricting our ability to gain deeper insights into its internal mechanism. In this paper, we are motivated to enhance the semantic consistency of LLMs through a more interpretable method (i.e., model editing) to this end. We first identify the model components (i.e., attention heads) that have a key impact on the semantic consistency of an LLM. We subsequently inject biases into the output of these model components along the semantic-consistency activation direction. It is noteworthy that these modifications are cost-effective, without reliance on mass manipulations of the original model parameters. Through comprehensive experiments on the constructed NLU and open-source NLG datasets, our method demonstrates significant improvements in the semantic consistency and task performance of LLMs. Additionally, our method exhibits promising generalization capabilities by performing well on tasks beyond the primary tasks.

LF-Steering: Latent Feature Activation Steering for Enhancing Semantic Consistency in Large Language Models

Large Language Models (LLMs) often generate inconsistent responses when prompted with semantically equivalent paraphrased inputs. Recently, activation steering, a technique that modulates LLM behavior by adjusting their latent representations during inference time, has been explored to improve the semantic consistency of LLMs. However, these methods typically operate at the model component level, such as layer hidden states or attention heads. They face a challenge due to the ``polysemanticity issue'', where the model components of LLMs typically encode multiple entangled features, making precise steering difficult. To address this challenge, we drill down to feature-level representations and propose LF-Steering, a novel activation steering approach to precisely identify latent feature representations responsible for semantic inconsistency. More specifically, our method maps the hidden states of relevant transformer layer into a sparsely activated, high-dimensional feature space based on a sparse autoencoder (SAE), ensuring model steering based on decoupled feature representations with minimal interference. Comprehensive experiments on both NLU and NLG datasets demonstrate the effectiveness of our method in enhancing semantic consistency, resulting in significant performance gains for various NLU and NLG tasks.

Diffusion Sampling Correction via Approximately 10 Parameters

Diffusion Probabilistic Models (DPMs) have demonstrated exceptional performance in generative tasks, but this comes at the expense of sampling efficiency. To enhance sampling speed without sacrificing quality, various distillation-based accelerated sampling algorithms have been recently proposed. However, they typically require significant additional training costs and model parameter storage, which limit their practical application. In this work, we propose PCA-based Adaptive Search (PAS), which optimizes existing solvers for DPMs with minimal learnable parameters and training costs. Specifically, we first employ PCA to obtain a few orthogonal unit basis vectors to span the high-dimensional sampling space, which enables us to learn just a set of coordinates to correct the sampling direction; furthermore, based on the observation that the cumulative truncation error exhibits an ``S''-shape, we design an adaptive search strategy that further enhances the sampling efficiency and reduces the number of stored parameters to approximately 10. Extensive experiments demonstrate that PAS can significantly enhance existing fast solvers in a plug-and-play manner with negligible costs. For instance, on CIFAR10, PAS requires only 12 parameters and less than 1 minute of training on a single NVIDIA A100 GPU to optimize the DDIM from 15.69 FID (NFE=10) to 4.37.

An Electoral Approach to Diversify LLM-based Multi-Agent Collective Decision-Making

Modern large language models (LLMs) have exhibited cooperative synergy on complex task-solving, and collective decision-making (CDM) is a pivotal component in LLM-based multi-agent collaboration frameworks. Our survey on 52 recent such systems uncovers a severe lack of diversity, with a heavy reliance on dictatorial and plurality voting for CDM. Through the lens of social choice theory, we scrutinize widely-adopted CDM methods and identify their limitations. To enrich current landscape of LLM-based CDM, we present GEDI, an electoral CDM module that incorporates various ordinal preferential voting mechanisms. Our empirical case study across three benchmarks shows that the integration of certain CDM methods can markedly improve the reasoning capabilities and robustness of some leading LLMs, all without requiring intricate system designs. Additionally, we find that some CDM mechanisms generate positive synergies even with as few as three agents. The voting-based methods also demonstrate robustness against single points of failure, as well as diversity in terms of hit-rate@k and subject-wise impacts.

ORCHID: A Chinese Debate Corpus for Target-Independent Stance Detection and Argumentative Dialogue Summarization

Dialogue agents have been receiving increasing attention for years, and this trend has been further boosted by the recent progress of large language models (LLMs). Stance detection and dialogue summarization are two core tasks of dialogue agents in application scenarios that involve argumentative dialogues. However, research on these tasks is limited by the insufficiency of public datasets, especially for non-English languages. To address this language resource gap in Chinese, we present ORCHID (Oral Chinese Debate), the first Chinese dataset for benchmarking target-independent stance detection and debate summarization. Our dataset consists of 1,218 real-world debates that were conducted in Chinese on 476 unique topics, containing 2,436 stance-specific summaries and 14,133 fully annotated utterances. Besides providing a versatile testbed for future research, we also conduct an empirical study on the dataset and propose an integrated task. The results show the challenging nature of the dataset and suggest a potential of incorporating stance detection in summarization for argumentative dialogue.

Semantics-Adaptive Activation Intervention for LLMs via Dynamic Steering Vectors

Large language models (LLMs) have achieved remarkable performance across many tasks, yet aligning them with desired behaviors remains challenging. Activation intervention has emerged as an effective and economical method to modify the behavior of LLMs. Despite considerable interest in this area, current intervention methods exclusively employ a fixed steering vector to modify model activations, lacking adaptability to diverse input semantics. To address this limitation, we propose Semantics-Adaptive Dynamic Intervention (SADI), a novel method that constructs a dynamic steering vector to intervene model activations at inference time. More specifically, SADI utilizes activation differences in contrastive pairs to precisely identify critical elements of an LLM (i.e., attention heads, hidden states, and neurons) for targeted intervention. During inference, SADI dynamically steers model behavior by scaling element-wise activations based on the directions of input semantics. Experimental results show that SADI outperforms established baselines by substantial margins, improving task performance without training. SADI's cost-effectiveness and generalizability across various LLM backbones and tasks highlight its potential as a versatile alignment technique. In addition, we release the code to foster research along this line:https://github.com/weixuan-wang123/SADI.

Measuring the Inconsistency of Large Language Models in Preferential Ranking

Despite large language models' (LLMs) recent advancements, their bias and hallucination issues persist, and their ability to offer consistent preferential rankings remains underexplored. This study investigates the capacity of LLMs to provide consistent ordinal preferences, a crucial aspect in scenarios with dense decision space or lacking absolute answers. We introduce a formalization of consistency based on order theory, outlining criteria such as transitivity, asymmetry, reversibility, and independence from irrelevant alternatives. Our diagnostic experiments on selected state-of-the-art LLMs reveal their inability to meet these criteria, indicating a strong positional bias and poor transitivity, with preferences easily swayed by irrelevant alternatives. These findings highlight a significant inconsistency in LLM-generated preferential rankings, underscoring the need for further research to address these limitations.