SChanger: Change Detection from a Semantic Change and Spatial Consistency Perspective

Change detection is a key task in Earth observation applications. Recently, deep learning methods have demonstrated strong performance and widespread application. However, change detection faces data scarcity due to the labor-intensive process of accurately aligning remote sensing images of the same area, which limits the performance of deep learning algorithms. To address the data scarcity issue, we develop a fine-tuning strategy called the Semantic Change Network (SCN). We initially pre-train the model on single-temporal supervised tasks to acquire prior knowledge of instance feature extraction. The model then employs a shared-weight Siamese architecture and extended Temporal Fusion Module (TFM) to preserve this prior knowledge and is fine-tuned on change detection tasks. The learned semantics for identifying all instances is changed to focus on identifying only the changes. Meanwhile, we observe that the locations of changes between the two images are spatially identical, a concept we refer to as spatial consistency. We introduce this inductive bias through an attention map that is generated by large-kernel convolutions and applied to the features from both time points. This enhances the modeling of multi-scale changes and helps capture underlying relationships in change detection semantics. We develop a binary change detection model utilizing these two strategies. The model is validated against state-of-the-art methods on six datasets, surpassing all benchmark methods and achieving F1 scores of 92.87%, 86.43%, 68.95%, 97.62%, 84.58%, and 93.20% on the LEVIR-CD, LEVIR-CD+, S2Looking, CDD, SYSU-CD, and WHU-CD datasets, respectively.

Gradient Co-occurrence Analysis for Detecting Unsafe Prompts in Large Language Models

Unsafe prompts pose significant safety risks to large language models (LLMs). Existing methods for detecting unsafe prompts rely on data-driven fine-tuning to train guardrail models, necessitating significant data and computational resources. In contrast, recent few-shot gradient-based methods emerge, requiring only few safe and unsafe reference prompts. A gradient-based approach identifies unsafe prompts by analyzing consistent patterns of the gradients of safety-critical parameters in LLMs. Although effective, its restriction to directional similarity (cosine similarity) introduces ``directional bias'', limiting its capability to identify unsafe prompts. To overcome this limitation, we introduce GradCoo, a novel gradient co-occurrence analysis method that expands the scope of safety-critical parameter identification to include unsigned gradient similarity, thereby reducing the impact of ``directional bias'' and enhancing the accuracy of unsafe prompt detection. Comprehensive experiments on the widely-used benchmark datasets ToxicChat and XStest demonstrate that our proposed method can achieve state-of-the-art (SOTA) performance compared to existing methods. Moreover, we confirm the generalizability of GradCoo in detecting unsafe prompts across a range of LLM base models with various sizes and origins.

LF-Steering: Latent Feature Activation Steering for Enhancing Semantic Consistency in Large Language Models

Large Language Models (LLMs) often generate inconsistent responses when prompted with semantically equivalent paraphrased inputs. Recently, activation steering, a technique that modulates LLM behavior by adjusting their latent representations during inference time, has been explored to improve the semantic consistency of LLMs. However, these methods typically operate at the model component level, such as layer hidden states or attention heads. They face a challenge due to the ``polysemanticity issue'', where the model components of LLMs typically encode multiple entangled features, making precise steering difficult. To address this challenge, we drill down to feature-level representations and propose LF-Steering, a novel activation steering approach to precisely identify latent feature representations responsible for semantic inconsistency. More specifically, our method maps the hidden states of relevant transformer layer into a sparsely activated, high-dimensional feature space based on a sparse autoencoder (SAE), ensuring model steering based on decoupled feature representations with minimal interference. Comprehensive experiments on both NLU and NLG datasets demonstrate the effectiveness of our method in enhancing semantic consistency, resulting in significant performance gains for various NLU and NLG tasks.

ACE: Anatomically Consistent Embeddings in Composition and Decomposition

Medical images acquired from standardized protocols show consistent macroscopic or microscopic anatomical structures, and these structures consist of composable/decomposable organs and tissues, but existing self-supervised learning (SSL) methods do not appreciate such composable/decomposable structure attributes inherent to medical images. To overcome this limitation, this paper introduces a novel SSL approach called ACE to learn anatomically consistent embedding via composition and decomposition with two key branches: (1) global consistency, capturing discriminative macro-structures via extracting global features; (2) local consistency, learning fine-grained anatomical details from composable/decomposable patch features via corresponding matrix matching. Experimental results across 6 datasets 2 backbones, evaluated in few-shot learning, fine-tuning, and property analysis, show ACE's superior robustness, transferability, and clinical potential. The innovations of our ACE lie in grid-wise image cropping, leveraging the intrinsic properties of compositionality and decompositionality of medical images, bridging the semantic gap from high-level pathologies to low-level tissue anomalies, and providing a new SSL method for medical imaging.

Integrated Brain Connectivity Analysis with fMRI, DTI, and sMRI Powered by Interpretable Graph Neural Networks

Multimodal neuroimaging modeling has becomes a widely used approach but confronts considerable challenges due to heterogeneity, which encompasses variability in data types, scales, and formats across modalities. This variability necessitates the deployment of advanced computational methods to integrate and interpret these diverse datasets within a cohesive analytical framework. In our research, we amalgamate functional magnetic resonance imaging, diffusion tensor imaging, and structural MRI into a cohesive framework. This integration capitalizes on the unique strengths of each modality and their inherent interconnections, aiming for a comprehensive understanding of the brain's connectivity and anatomical characteristics. Utilizing the Glasser atlas for parcellation, we integrate imaging derived features from various modalities: functional connectivity from fMRI, structural connectivity from DTI, and anatomical features from sMRI within consistent regions. Our approach incorporates a masking strategy to differentially weight neural connections, thereby facilitating a holistic amalgamation of multimodal imaging data. This technique enhances interpretability at connectivity level, transcending traditional analyses centered on singular regional attributes. The model is applied to the Human Connectome Project's Development study to elucidate the associations between multimodal imaging and cognitive functions throughout youth. The analysis demonstrates improved predictive accuracy and uncovers crucial anatomical features and essential neural connections, deepening our understanding of brain structure and function.

Time-optimal Flight in Cluttered Environments via Safe Reinforcement Learning

This paper addresses the problem of guiding a quadrotor through a predefined sequence of waypoints in cluttered environments, aiming to minimize the flight time while avoiding collisions. Previous approaches either suffer from prolonged computational time caused by solving complex non-convex optimization problems or are limited by the inherent smoothness of polynomial trajectory representations, thereby restricting the flexibility of movement. In this work, we present a safe reinforcement learning approach for autonomous drone racing with time-optimal flight in cluttered environments. The reinforcement learning policy, trained using safety and terminal rewards specifically designed to enforce near time-optimal and collision-free flight, outperforms current state-of-the-art algorithms. Additionally, experimental results demonstrate the efficacy of the proposed approach in achieving both minimum flight time and obstacle avoidance objectives in complex environments, with a commendable $66.7\%$ success rate in unseen, challenging settings.

Time-SSM: Simplifying and Unifying State Space Models for Time Series Forecasting

State Space Models (SSMs) have emerged as a potent tool in sequence modeling tasks in recent years. These models approximate continuous systems using a set of basis functions and discretize them to handle input data, making them well-suited for modeling time series data collected at specific frequencies from continuous systems. Despite its potential, the application of SSMs in time series forecasting remains underexplored, with most existing models treating SSMs as a black box for capturing temporal or channel dependencies. To address this gap, this paper proposes a novel theoretical framework termed Dynamic Spectral Operator, offering more intuitive and general guidance on applying SSMs to time series data. Building upon our theory, we introduce Time-SSM, a novel SSM-based foundation model with only one-seventh of the parameters compared to Mamba. Various experiments validate both our theoretical framework and the superior performance of Time-SSM.

A Demographic-Conditioned Variational Autoencoder for fMRI Distribution Sampling and Removal of Confounds

Objective: fMRI and derived measures such as functional connectivity (FC) have been used to predict brain age, general fluid intelligence, psychiatric disease status, and preclinical neurodegenerative disease. However, it is not always clear that all demographic confounds, such as age, sex, and race, have been removed from fMRI data. Additionally, many fMRI datasets are restricted to authorized researchers, making dissemination of these valuable data sources challenging. Methods: We create a variational autoencoder (VAE)-based model, DemoVAE, to decorrelate fMRI features from demographics and generate high-quality synthetic fMRI data based on user-supplied demographics. We train and validate our model using two large, widely used datasets, the Philadelphia Neurodevelopmental Cohort (PNC) and Bipolar and Schizophrenia Network for Intermediate Phenotypes (BSNIP). Results: We find that DemoVAE recapitulates group differences in fMRI data while capturing the full breadth of individual variations. Significantly, we also find that most clinical and computerized battery fields that are correlated with fMRI data are not correlated with DemoVAE latents. An exception are several fields related to schizophrenia medication and symptom severity. Conclusion: Our model generates fMRI data that captures the full distribution of FC better than traditional VAE or GAN models. We also find that most prediction using fMRI data is dependent on correlation with, and prediction of, demographics. Significance: Our DemoVAE model allows for generation of high quality synthetic data conditioned on subject demographics as well as the removal of the confounding effects of demographics. We identify that FC-based prediction tasks are highly influenced by demographic confounds.

Consisaug: A Consistency-based Augmentation for Polyp Detection in Endoscopy Image Analysis

Colorectal cancer (CRC), which frequently originates from initially benign polyps, remains a significant contributor to global cancer-related mortality. Early and accurate detection of these polyps via colonoscopy is crucial for CRC prevention. However, traditional colonoscopy methods depend heavily on the operator's experience, leading to suboptimal polyp detection rates. Besides, the public database are limited in polyp size and shape diversity. To enhance the available data for polyp detection, we introduce Consisaug, an innovative and effective methodology to augment data that leverages deep learning. We utilize the constraint that when the image is flipped the class label should be equal and the bonding boxes should be consistent. We implement our Consisaug on five public polyp datasets and at three backbones, and the results show the effectiveness of our method.

DeViDe: Faceted medical knowledge for improved medical vision-language pre-training

Vision-language pre-training for chest X-rays has made significant strides, primarily by utilizing paired radiographs and radiology reports. However, existing approaches often face challenges in encoding medical knowledge effectively. While radiology reports provide insights into the current disease manifestation, medical definitions (as used by contemporary methods) tend to be overly abstract, creating a gap in knowledge. To address this, we propose DeViDe, a novel transformer-based method that leverages radiographic descriptions from the open web. These descriptions outline general visual characteristics of diseases in radiographs, and when combined with abstract definitions and radiology reports, provide a holistic snapshot of knowledge. DeViDe incorporates three key features for knowledge-augmented vision language alignment: First, a large-language model-based augmentation is employed to homogenise medical knowledge from diverse sources. Second, this knowledge is aligned with image information at various levels of granularity. Third, a novel projection layer is proposed to handle the complexity of aligning each image with multiple descriptions arising in a multi-label setting. In zero-shot settings, DeViDe performs comparably to fully supervised models on external datasets and achieves state-of-the-art results on three large-scale datasets. Additionally, fine-tuning DeViDe on four downstream tasks and six segmentation tasks showcases its superior performance across data from diverse distributions.