Life-Code: Central Dogma Modeling with Multi-Omics Sequence Unification

The interactions between DNA, RNA, and proteins are fundamental to biological processes, as illustrated by the central dogma of molecular biology. While modern biological pre-trained models have achieved great success in analyzing these macromolecules individually, their interconnected nature remains under-explored. In this paper, we follow the guidance of the central dogma to redesign both the data and model pipeline and offer a comprehensive framework, Life-Code, that spans different biological functions. As for data flow, we propose a unified pipeline to integrate multi-omics data by reverse-transcribing RNA and reverse-translating amino acids into nucleotide-based sequences. As for the model, we design a codon tokenizer and a hybrid long-sequence architecture to encode the interactions of both coding and non-coding regions with masked modeling pre-training. To model the translation and folding process with coding sequences, Life-Code learns protein structures of the corresponding amino acids by knowledge distillation from off-the-shelf protein language models. Such designs enable Life-Code to capture complex interactions within genetic sequences, providing a more comprehensive understanding of multi-omics with the central dogma. Extensive Experiments show that Life-Code achieves state-of-the-art performance on various tasks across three omics, highlighting its potential for advancing multi-omics analysis and interpretation.

Dress-1-to-3: Single Image to Simulation-Ready 3D Outfit with Diffusion Prior and Differentiable Physics

Recent advances in large models have significantly advanced image-to-3D reconstruction. However, the generated models are often fused into a single piece, limiting their applicability in downstream tasks. This paper focuses on 3D garment generation, a key area for applications like virtual try-on with dynamic garment animations, which require garments to be separable and simulation-ready. We introduce Dress-1-to-3, a novel pipeline that reconstructs physics-plausible, simulation-ready separated garments with sewing patterns and humans from an in-the-wild image. Starting with the image, our approach combines a pre-trained image-to-sewing pattern generation model for creating coarse sewing patterns with a pre-trained multi-view diffusion model to produce multi-view images. The sewing pattern is further refined using a differentiable garment simulator based on the generated multi-view images. Versatile experiments demonstrate that our optimization approach substantially enhances the geometric alignment of the reconstructed 3D garments and humans with the input image. Furthermore, by integrating a texture generation module and a human motion generation module, we produce customized physics-plausible and realistic dynamic garment demonstrations. Project page: https://dress-1-to-3.github.io/

Hipandas: Hyperspectral Image Joint Denoising and Super-Resolution by Image Fusion with the Panchromatic Image

Hyperspectral images (HSIs) are frequently noisy and of low resolution due to the constraints of imaging devices. Recently launched satellites can concurrently acquire HSIs and panchromatic (PAN) images, enabling the restoration of HSIs to generate clean and high-resolution imagery through fusing PAN images for denoising and super-resolution. However, previous studies treated these two tasks as independent processes, resulting in accumulated errors. This paper introduces \textbf{H}yperspectral \textbf{I}mage Joint \textbf{Pand}enoising \textbf{a}nd Pan\textbf{s}harpening (Hipandas), a novel learning paradigm that reconstructs HRHS images from noisy low-resolution HSIs (LRHS) and high-resolution PAN images. The proposed zero-shot Hipandas framework consists of a guided denoising network, a guided super-resolution network, and a PAN reconstruction network, utilizing an HSI low-rank prior and a newly introduced detail-oriented low-rank prior. The interconnection of these networks complicates the training process, necessitating a two-stage training strategy to ensure effective training. Experimental results on both simulated and real-world datasets indicate that the proposed method surpasses state-of-the-art algorithms, yielding more accurate and visually pleasing HRHS images.

Revisiting Marr in Face: The Building of 2D--2.5D--3D Representations in Deep Neural Networks

David Marr's seminal theory of vision proposes that the human visual system operates through a sequence of three stages, known as the 2D sketch, the 2.5D sketch, and the 3D model. In recent years, Deep Neural Networks (DNN) have been widely thought to have reached a level comparable to human vision. However, the mechanisms by which DNNs accomplish this and whether they adhere to Marr's 2D--2.5D--3D construction theory remain unexplored. In this paper, we delve into the perception task to explore these questions and find evidence supporting Marr's theory. We introduce a graphics probe, a sub-network crafted to reconstruct the original image from the network's intermediate layers. The key to the graphics probe is its flexible architecture that supports image in both 2D and 3D formats, as well as in a transitional state between them. By injecting graphics probes into neural networks, and analyzing their behavior in reconstructing images, we find that DNNs initially encode images as 2D representations in low-level layers, and finally construct 3D representations in high-level layers. Intriguingly, in mid-level layers, DNNs exhibit a hybrid state, building a geometric representation that s sur normals within a narrow depth range, akin to the appearance of a low-relief sculpture. This stage resembles the 2.5D representations, providing a view of how DNNs evolve from 2D to 3D in the perception process. The graphics probe therefore serves as a tool for peering into the mechanisms of DNN, providing empirical support for Marr's theory.

ARM: Appearance Reconstruction Model for Relightable 3D Generation

Recent image-to-3D reconstruction models have greatly advanced geometry generation, but they still struggle to faithfully generate realistic appearance. To address this, we introduce ARM, a novel method that reconstructs high-quality 3D meshes and realistic appearance from sparse-view images. The core of ARM lies in decoupling geometry from appearance, processing appearance within the UV texture space. Unlike previous methods, ARM improves texture quality by explicitly back-projecting measurements onto the texture map and processing them in a UV space module with a global receptive field. To resolve ambiguities between material and illumination in input images, ARM introduces a material prior that encodes semantic appearance information, enhancing the robustness of appearance decomposition. Trained on just 8 H100 GPUs, ARM outperforms existing methods both quantitatively and qualitatively.

Embedded IPC: Fast and Intersection-free Simulation in Reduced Subspace for Robot Manipulation

Physics-based simulation is essential for developing and evaluating robot manipulation policies, particularly in scenarios involving deformable objects and complex contact interactions. However, existing simulators often struggle to balance computational efficiency with numerical accuracy, especially when modeling deformable materials with frictional contact constraints. We introduce an efficient subspace representation for the Incremental Potential Contact (IPC) method, leveraging model reduction to decrease the number of degrees of freedom. Our approach decouples simulation complexity from the resolution of the input model by representing elasticity in a low-resolution subspace while maintaining collision constraints on an embedded high-resolution surface. Our barrier formulation ensures intersection-free trajectories and configurations regardless of material stiffness, time step size, or contact severity. We validate our simulator through quantitative experiments with a soft bubble gripper grasping and qualitative demonstrations of placing a plate on a dish rack. The results demonstrate our simulator's efficiency, physical accuracy, computational stability, and robust handling of frictional contact, making it well-suited for generating demonstration data and evaluating downstream robot training applications.

AR Overlay: Training Image Pose Estimation on Curved Surface in a Synthetic Way

In the field of spatial computing, one of the most essential tasks is the pose estimation of 3D objects. While rigid transformations of arbitrary 3D objects are relatively hard to detect due to varying environment introducing factors like insufficient lighting or even occlusion, objects with pre-defined shapes are often easy to track, leveraging geometric constraints. Curved images, with flexible dimensions but a confined shape, are essential shapes often targeted in 3D tracking. Traditionally, proprietary algorithms often require specific curvature measures as the input along with the original flattened images to enable pose estimation for a single image target. In this paper, we propose a pipeline that can detect several logo images simultaneously and only requires the original images as the input, unlocking more effects in downstream fields such as Augmented Reality (AR).

A Survey on Mixup Augmentations and Beyond

As Deep Neural Networks have achieved thrilling breakthroughs in the past decade, data augmentations have garnered increasing attention as regularization techniques when massive labeled data are unavailable. Among existing augmentations, Mixup and relevant data-mixing methods that convexly combine selected samples and the corresponding labels are widely adopted because they yield high performances by generating data-dependent virtual data while easily migrating to various domains. This survey presents a comprehensive review of foundational mixup methods and their applications. We first elaborate on the training pipeline with mixup augmentations as a unified framework containing modules. A reformulated framework could contain various mixup methods and give intuitive operational procedures. Then, we systematically investigate the applications of mixup augmentations on vision downstream tasks, various data modalities, and some analysis \& theorems of mixup. Meanwhile, we conclude the current status and limitations of mixup research and point out further work for effective and efficient mixup augmentations. This survey can provide researchers with the current state of the art in mixup methods and provide some insights and guidance roles in the mixup arena. An online project with this survey is available at \url{https://github.com/Westlake-AI/Awesome-Mixup}.

Enhancing Healthcare through Large Language Models: A Study on Medical Question Answering

In recent years, the application of Large Language Models (LLMs) in healthcare has shown significant promise in improving the accessibility and dissemination of medical knowledge. This paper presents a detailed study of various LLMs trained on the MedQuAD medical question-answering dataset, with a focus on identifying the most effective model for providing accurate medical information. Among the models tested, the Sentence-t5 combined with Mistral 7B demonstrated superior performance, achieving a precision score of 0.762. This model's enhanced capabilities are attributed to its advanced pretraining techniques, robust architecture, and effective prompt construction methodologies. By leveraging these strengths, the Sentence-t5 + Mistral 7B model excels in understanding and generating precise medical answers. Our findings highlight the potential of integrating sophisticated LLMs in medical contexts to facilitate efficient and accurate medical knowledge retrieval, thus significantly enhancing patient education and support.

Advanced User Credit Risk Prediction Model using LightGBM, XGBoost and Tabnet with SMOTEENN

Bank credit risk is a significant challenge in modern financial transactions, and the ability to identify qualified credit card holders among a large number of applicants is crucial for the profitability of a bank'sbank's credit card business. In the past, screening applicants'applicants' conditions often required a significant amount of manual labor, which was time-consuming and labor-intensive. Although the accuracy and reliability of previously used ML models have been continuously improving, the pursuit of more reliable and powerful AI intelligent models is undoubtedly the unremitting pursuit by major banks in the financial industry. In this study, we used a dataset of over 40,000 records provided by a commercial bank as the research object. We compared various dimensionality reduction techniques such as PCA and T-SNE for preprocessing high-dimensional datasets and performed in-depth adaptation and tuning of distributed models such as LightGBM and XGBoost, as well as deep models like Tabnet. After a series of research and processing, we obtained excellent research results by combining SMOTEENN with these techniques. The experiments demonstrated that LightGBM combined with PCA and SMOTEENN techniques can assist banks in accurately predicting potential high-quality customers, showing relatively outstanding performance compared to other models.