ST-Prompt Guided Histological Hypergraph Learning for Spatial Gene Expression Prediction

Spatial Transcriptomics (ST) reveals the spatial distribution of gene expression in tissues, offering critical insights into biological processes and disease mechanisms. However, predicting ST from H\&E-stained histology images is challenging due to the heterogeneous relationship between histomorphology and gene expression, which arises from substantial variability across different patients and tissue sections. A more practical and valuable approach is to utilize ST data from a few local regions to predict the spatial transcriptomic landscape across the remaining regions in H&E slides. In response, we propose PHG2ST, an ST-prompt guided histological hypergraph learning framework, which leverages sparse ST signals as prompts to guide histological hypergraph learning for global spatial gene expression prediction. Our framework fuses histological hypergraph representations at multiple scales through a masked ST-prompt encoding mechanism, improving robustness and generalizability. Benchmark evaluations on two public ST datasets demonstrate that PHG2ST outperforms the existing state-of-the-art methods and closely aligns with the ground truth. These results underscore the potential of leveraging sparse local ST data for scalable and cost-effective spatial gene expression mapping in real-world biomedical applications.

Adaptive Group Policy Optimization: Towards Stable Training and Token-Efficient Reasoning

Since DeepSeek-R1 popularized, Group Relative Policy Optimization (GRPO) has become the core part of Reasoning LLMs training. However, we find some deficiency that influences RL stability and inference efficiency. Thus, we propose Adaptive Group Policy Optimization (AGPO) which contains two simple but effective modifications: a revised advantage estimation method to mitigate zero-variance situations; a length-based reward, incentivizing the model to avoid overthinking. The experiments demonstrate our methods achieve more stable training and comparable or superior performance with significantly fewer tokens in reasoning steps.

Leveraging Deep Neural Networks for Aspect-Based Sentiment Classification

Aspect-based sentiment analysis seeks to determine sentiment with a high level of detail. While graph convolutional networks (GCNs) are commonly used for extracting sentiment features, their straightforward use in syntactic feature extraction can lead to a loss of crucial information. This paper presents a novel edge-enhanced GCN, called EEGCN, which improves performance by preserving feature integrity as it processes syntactic graphs. We incorporate a bidirectional long short-term memory (Bi-LSTM) network alongside a self-attention-based transformer for effective text encoding, ensuring the retention of long-range dependencies. A bidirectional GCN (Bi-GCN) with message passing then captures the relationships between entities, while an aspect-specific masking technique removes extraneous information. Extensive evaluations and ablation studies on four benchmark datasets show that EEGCN significantly enhances aspect-based sentiment analysis, overcoming issues with syntactic feature extraction and advancing the field's methodologies.

A Reinforcement Learning-Driven Transformer GAN for Molecular Generation

Generating molecules with desired chemical properties presents a critical challenge in fields such as chemical synthesis and drug discovery. Recent advancements in artificial intelligence (AI) and deep learning have significantly contributed to data-driven molecular generation. However, challenges persist due to the inherent sensitivity of simplified molecular input line entry system (SMILES) representations and the difficulties in applying generative adversarial networks (GANs) to discrete data. This study introduces RL-MolGAN, a novel Transformer-based discrete GAN framework designed to address these challenges. Unlike traditional Transformer architectures, RL-MolGAN utilizes a first-decoder-then-encoder structure, facilitating the generation of drug-like molecules from both $de~novo$ and scaffold-based designs. In addition, RL-MolGAN integrates reinforcement learning (RL) and Monte Carlo tree search (MCTS) techniques to enhance the stability of GAN training and optimize the chemical properties of the generated molecules. To further improve the model's performance, RL-MolWGAN, an extension of RL-MolGAN, incorporates Wasserstein distance and mini-batch discrimination, which together enhance the stability of the GAN. Experimental results on two widely used molecular datasets, QM9 and ZINC, validate the effectiveness of our models in generating high-quality molecular structures with diverse and desirable chemical properties.

TimeStep Master: Asymmetrical Mixture of Timestep LoRA Experts for Versatile and Efficient Diffusion Models in Vision

Diffusion models have driven the advancement of vision generation over the past years. However, it is often difficult to apply these large models in downstream tasks, due to massive fine-tuning cost. Recently, Low-Rank Adaptation (LoRA) has been applied for efficient tuning of diffusion models. Unfortunately, the capabilities of LoRA-tuned diffusion models are limited, since the same LoRA is used for different timesteps of the diffusion process. To tackle this problem, we introduce a general and concise TimeStep Master (TSM) paradigm with two key fine-tuning stages. In the fostering stage (1-stage), we apply different LoRAs to fine-tune the diffusion model at different timestep intervals. This results in different TimeStep LoRA experts that can effectively capture different noise levels. In the assembling stage (2-stage), we design a novel asymmetrical mixture of TimeStep LoRA experts, via core-context collaboration of experts at multi-scale intervals. For each timestep, we leverage TimeStep LoRA expert within the smallest interval as the core expert without gating, and use experts within the bigger intervals as the context experts with time-dependent gating. Consequently, our TSM can effectively model the noise level via the expert in the finest interval, and adaptively integrate contexts from the experts of other scales, boosting the versatility of diffusion models. To show the effectiveness of our TSM paradigm, we conduct extensive experiments on three typical and popular LoRA-related tasks of diffusion models, including domain adaptation, post-pretraining, and model distillation. Our TSM achieves the state-of-the-art results on all these tasks, throughout various model structures (UNet, DiT and MM-DiT) and visual data modalities (Image, Video), showing its remarkable generalization capacity.

Get In Video: Add Anything You Want to the Video

Video editing increasingly demands the ability to incorporate specific real-world instances into existing footage, yet current approaches fundamentally fail to capture the unique visual characteristics of particular subjects and ensure natural instance/scene interactions. We formalize this overlooked yet critical editing paradigm as "Get-In-Video Editing", where users provide reference images to precisely specify visual elements they wish to incorporate into videos. Addressing this task's dual challenges, severe training data scarcity and technical challenges in maintaining spatiotemporal coherence, we introduce three key contributions. First, we develop GetIn-1M dataset created through our automated Recognize-Track-Erase pipeline, which sequentially performs video captioning, salient instance identification, object detection, temporal tracking, and instance removal to generate high-quality video editing pairs with comprehensive annotations (reference image, tracking mask, instance prompt). Second, we present GetInVideo, a novel end-to-end framework that leverages a diffusion transformer architecture with 3D full attention to process reference images, condition videos, and masks simultaneously, maintaining temporal coherence, preserving visual identity, and ensuring natural scene interactions when integrating reference objects into videos. Finally, we establish GetInBench, the first comprehensive benchmark for Get-In-Video Editing scenario, demonstrating our approach's superior performance through extensive evaluations. Our work enables accessible, high-quality incorporation of specific real-world subjects into videos, significantly advancing personalized video editing capabilities.

SOLAR: Scalable Optimization of Large-scale Architecture for Reasoning

Large Language Models (LLMs) excel in reasoning but remain constrained by their Chain-of-Thought (CoT) approach, which struggles with complex tasks requiring more nuanced topological reasoning. We introduce SOLAR, Scalable Optimization of Large-scale Architecture for Reasoning, a framework that dynamically optimizes various reasoning topologies to enhance accuracy and efficiency. Our Topological Annotation Generation (TAG) system automates topological dataset creation and segmentation, improving post-training and evaluation. Additionally, we propose Topological-Scaling, a reward-driven framework that aligns training and inference scaling, equipping LLMs with adaptive, task-aware reasoning. SOLAR achieves substantial gains on MATH and GSM8K: +5% accuracy with Topological Tuning, +9% with Topological Reward, and +10.02% with Hybrid Scaling. It also reduces response length by over 5% for complex problems, lowering inference latency. To foster the reward system, we train a multi-task Topological Reward Model (M-TRM), which autonomously selects the best reasoning topology and answer in a single pass, eliminating the need for training and inference on multiple single-task TRMs (S-TRMs), thus reducing both training cost and inference latency. In addition, in terms of performance, M-TRM surpasses all S-TRMs, improving accuracy by +10% and rank correlation by +9%. To the best of our knowledge, SOLAR sets a new benchmark for scalable, high-precision LLM reasoning while introducing an automated annotation process and a dynamic reasoning topology competition mechanism.

Pretrained LLMs as Real-Time Controllers for Robot Operated Serial Production Line

The manufacturing industry is undergoing a transformative shift, driven by cutting-edge technologies like 5G, AI, and cloud computing. Despite these advancements, effective system control, which is crucial for optimizing production efficiency, remains a complex challenge due to the intricate, knowledge-dependent nature of manufacturing processes and the reliance on domain-specific expertise. Conventional control methods often demand heavy customization, considerable computational resources, and lack transparency in decision-making. In this work, we investigate the feasibility of using Large Language Models (LLMs), particularly GPT-4, as a straightforward, adaptable solution for controlling manufacturing systems, specifically, mobile robot scheduling. We introduce an LLM-based control framework to assign mobile robots to different machines in robot assisted serial production lines, evaluating its performance in terms of system throughput. Our proposed framework outperforms traditional scheduling approaches such as First-Come-First-Served (FCFS), Shortest Processing Time (SPT), and Longest Processing Time (LPT). While it achieves performance that is on par with state-of-the-art methods like Multi-Agent Reinforcement Learning (MARL), it offers a distinct advantage by delivering comparable throughput without the need for extensive retraining. These results suggest that the proposed LLM-based solution is well-suited for scenarios where technical expertise, computational resources, and financial investment are limited, while decision transparency and system scalability are critical concerns.

WeGen: A Unified Model for Interactive Multimodal Generation as We Chat

Existing multimodal generative models fall short as qualified design copilots, as they often struggle to generate imaginative outputs once instructions are less detailed or lack the ability to maintain consistency with the provided references. In this work, we introduce WeGen, a model that unifies multimodal generation and understanding, and promotes their interplay in iterative generation. It can generate diverse results with high creativity for less detailed instructions. And it can progressively refine prior generation results or integrating specific contents from references following the instructions in its chat with users. During this process, it is capable of preserving consistency in the parts that the user is already satisfied with. To this end, we curate a large-scale dataset, extracted from Internet videos, containing rich object dynamics and auto-labeled dynamics descriptions by advanced foundation models to date. These two information are interleaved into a single sequence to enable WeGen to learn consistency-aware generation where the specified dynamics are generated while the consistency of unspecified content is preserved aligned with instructions. Besides, we introduce a prompt self-rewriting mechanism to enhance generation diversity. Extensive experiments demonstrate the effectiveness of unifying multimodal understanding and generation in WeGen and show it achieves state-of-the-art performance across various visual generation benchmarks. These also demonstrate the potential of WeGen as a user-friendly design copilot as desired. The code and models will be available at https://github.com/hzphzp/WeGen.

HiBench: Benchmarking LLMs Capability on Hierarchical Structure Reasoning

Structure reasoning is a fundamental capability of large language models (LLMs), enabling them to reason about structured commonsense and answer multi-hop questions. However, existing benchmarks for structure reasoning mainly focus on horizontal and coordinate structures (\emph{e.g.} graphs), overlooking the hierarchical relationships within them. Hierarchical structure reasoning is crucial for human cognition, particularly in memory organization and problem-solving. It also plays a key role in various real-world tasks, such as information extraction and decision-making. To address this gap, we propose HiBench, the first framework spanning from initial structure generation to final proficiency assessment, designed to benchmark the hierarchical reasoning capabilities of LLMs systematically. HiBench encompasses six representative scenarios, covering both fundamental and practical aspects, and consists of 30 tasks with varying hierarchical complexity, totaling 39,519 queries. To evaluate LLMs comprehensively, we develop five capability dimensions that depict different facets of hierarchical structure understanding. Through extensive evaluation of 20 LLMs from 10 model families, we reveal key insights into their capabilities and limitations: 1) existing LLMs show proficiency in basic hierarchical reasoning tasks; 2) they still struggle with more complex structures and implicit hierarchical representations, especially in structural modification and textual reasoning. Based on these findings, we create a small yet well-designed instruction dataset, which enhances LLMs' performance on HiBench by an average of 88.84\% (Llama-3.1-8B) and 31.38\% (Qwen2.5-7B) across all tasks. The HiBench dataset and toolkit are available here, https://github.com/jzzzzh/HiBench, to encourage evaluation.