Flip Learning: Weakly Supervised Erase to Segment Nodules in Breast Ultrasound

Accurate segmentation of nodules in both 2D breast ultrasound (BUS) and 3D automated breast ultrasound (ABUS) is crucial for clinical diagnosis and treatment planning. Therefore, developing an automated system for nodule segmentation can enhance user independence and expedite clinical analysis. Unlike fully-supervised learning, weakly-supervised segmentation (WSS) can streamline the laborious and intricate annotation process. However, current WSS methods face challenges in achieving precise nodule segmentation, as many of them depend on inaccurate activation maps or inefficient pseudo-mask generation algorithms. In this study, we introduce a novel multi-agent reinforcement learning-based WSS framework called Flip Learning, which relies solely on 2D/3D boxes for accurate segmentation. Specifically, multiple agents are employed to erase the target from the box to facilitate classification tag flipping, with the erased region serving as the predicted segmentation mask. The key contributions of this research are as follows: (1) Adoption of a superpixel/supervoxel-based approach to encode the standardized environment, capturing boundary priors and expediting the learning process. (2) Introduction of three meticulously designed rewards, comprising a classification score reward and two intensity distribution rewards, to steer the agents' erasing process precisely, thereby avoiding both under- and over-segmentation. (3) Implementation of a progressive curriculum learning strategy to enable agents to interact with the environment in a progressively challenging manner, thereby enhancing learning efficiency. Extensively validated on the large in-house BUS and ABUS datasets, our Flip Learning method outperforms state-of-the-art WSS methods and foundation models, and achieves comparable performance as fully-supervised learning algorithms.

Ctrl-GenAug: Controllable Generative Augmentation for Medical Sequence Classification

In the medical field, the limited availability of large-scale datasets and labor-intensive annotation processes hinder the performance of deep models. Diffusion-based generative augmentation approaches present a promising solution to this issue, having been proven effective in advancing downstream medical recognition tasks. Nevertheless, existing works lack sufficient semantic and sequential steerability for challenging video/3D sequence generation, and neglect quality control of noisy synthesized samples, resulting in unreliable synthetic databases and severely limiting the performance of downstream tasks. In this work, we present Ctrl-GenAug, a novel and general generative augmentation framework that enables highly semantic- and sequential-customized sequence synthesis and suppresses incorrectly synthesized samples, to aid medical sequence classification. Specifically, we first design a multimodal conditions-guided sequence generator for controllably synthesizing diagnosis-promotive samples. A sequential augmentation module is integrated to enhance the temporal/stereoscopic coherence of generated samples. Then, we propose a noisy synthetic data filter to suppress unreliable cases at semantic and sequential levels. Extensive experiments on 3 medical datasets, using 11 networks trained on 3 paradigms, comprehensively analyze the effectiveness and generality of Ctrl-GenAug, particularly in underrepresented high-risk populations and out-domain conditions.

HeartBeat: Towards Controllable Echocardiography Video Synthesis with Multimodal Conditions-Guided Diffusion Models

Echocardiography (ECHO) video is widely used for cardiac examination. In clinical, this procedure heavily relies on operator experience, which needs years of training and maybe the assistance of deep learning-based systems for enhanced accuracy and efficiency. However, it is challenging since acquiring sufficient customized data (e.g., abnormal cases) for novice training and deep model development is clinically unrealistic. Hence, controllable ECHO video synthesis is highly desirable. In this paper, we propose a novel diffusion-based framework named HeartBeat towards controllable and high-fidelity ECHO video synthesis. Our highlight is three-fold. First, HeartBeat serves as a unified framework that enables perceiving multimodal conditions simultaneously to guide controllable generation. Second, we factorize the multimodal conditions into local and global ones, with two insertion strategies separately provided fine- and coarse-grained controls in a composable and flexible manner. In this way, users can synthesize ECHO videos that conform to their mental imagery by combining multimodal control signals. Third, we propose to decouple the visual concepts and temporal dynamics learning using a two-stage training scheme for simplifying the model training. One more interesting thing is that HeartBeat can easily generalize to mask-guided cardiac MRI synthesis in a few shots, showcasing its scalability to broader applications. Extensive experiments on two public datasets show the efficacy of the proposed HeartBeat.

NOVA-3D: Non-overlapped Views for 3D Anime Character Reconstruction

In the animation industry, 3D modelers typically rely on front and back non-overlapped concept designs to guide the 3D modeling of anime characters. However, there is currently a lack of automated approaches for generating anime characters directly from these 2D designs. In light of this, we explore a novel task of reconstructing anime characters from non-overlapped views. This presents two main challenges: existing multi-view approaches cannot be directly applied due to the absence of overlapping regions, and there is a scarcity of full-body anime character data and standard benchmarks. To bridge the gap, we present Non-Overlapped Views for 3D \textbf{A}nime Character Reconstruction (NOVA-3D), a new framework that implements a method for view-aware feature fusion to learn 3D-consistent features effectively and synthesizes full-body anime characters from non-overlapped front and back views directly. To facilitate this line of research, we collected the NOVA-Human dataset, which comprises multi-view images and accurate camera parameters for 3D anime characters. Extensive experiments demonstrate that the proposed method outperforms baseline approaches, achieving superior reconstruction of anime characters with exceptional detail fidelity. In addition, to further verify the effectiveness of our method, we applied it to the animation head reconstruction task and improved the state-of-the-art baseline to 94.453 in SSIM, 7.726 in LPIPS, and 19.575 in PSNR on average. Codes and datasets are available at https://wanghongsheng01.github.io/NOVA-3D/.

Gaussian Control with Hierarchical Semantic Graphs in 3D Human Recovery

Although 3D Gaussian Splatting (3DGS) has recently made progress in 3D human reconstruction, it primarily relies on 2D pixel-level supervision, overlooking the geometric complexity and topological relationships of different body parts. To address this gap, we introduce the Hierarchical Graph Human Gaussian Control (HUGS) framework for achieving high-fidelity 3D human reconstruction. Our approach involves leveraging explicitly semantic priors of body parts to ensure the consistency of geometric topology, thereby enabling the capture of the complex geometrical and topological associations among body parts. Additionally, we disentangle high-frequency features from global human features to refine surface details in body parts. Extensive experiments demonstrate that our method exhibits superior performance in human body reconstruction, particularly in enhancing surface details and accurately reconstructing body part junctions. Codes are available at https://wanghongsheng01.github.io/HUGS/.

RemoCap: Disentangled Representation Learning for Motion Capture

Reconstructing 3D human bodies from realistic motion sequences remains a challenge due to pervasive and complex occlusions. Current methods struggle to capture the dynamics of occluded body parts, leading to model penetration and distorted motion. RemoCap leverages Spatial Disentanglement (SD) and Motion Disentanglement (MD) to overcome these limitations. SD addresses occlusion interference between the target human body and surrounding objects. It achieves this by disentangling target features along the dimension axis. By aligning features based on their spatial positions in each dimension, SD isolates the target object's response within a global window, enabling accurate capture despite occlusions. The MD module employs a channel-wise temporal shuffling strategy to simulate diverse scene dynamics. This process effectively disentangles motion features, allowing RemoCap to reconstruct occluded parts with greater fidelity. Furthermore, this paper introduces a sequence velocity loss that promotes temporal coherence. This loss constrains inter-frame velocity errors, ensuring the predicted motion exhibits realistic consistency. Extensive comparisons with state-of-the-art (SOTA) methods on benchmark datasets demonstrate RemoCap's superior performance in 3D human body reconstruction. On the 3DPW dataset, RemoCap surpasses all competitors, achieving the best results in MPVPE (81.9), MPJPE (72.7), and PA-MPJPE (44.1) metrics. Codes are available at https://wanghongsheng01.github.io/RemoCap/.

PE-MED: Prompt Enhancement for Interactive Medical Image Segmentation

Interactive medical image segmentation refers to the accurate segmentation of the target of interest through interaction (e.g., click) between the user and the image. It has been widely studied in recent years as it is less dependent on abundant annotated data and more flexible than fully automated segmentation. However, current studies have not fully explored user-provided prompt information (e.g., points), including the knowledge mined in one interaction, and the relationship between multiple interactions. Thus, in this paper, we introduce a novel framework equipped with prompt enhancement, called PE-MED, for interactive medical image segmentation. First, we introduce a Self-Loop strategy to generate warm initial segmentation results based on the first prompt. It can prevent the highly unfavorable scenarios, such as encountering a blank mask as the initial input after the first interaction. Second, we propose a novel Prompt Attention Learning Module (PALM) to mine useful prompt information in one interaction, enhancing the responsiveness of the network to user clicks. Last, we build a Time Series Information Propagation (TSIP) mechanism to extract the temporal relationships between multiple interactions and increase the model stability. Comparative experiments with other state-of-the-art (SOTA) medical image segmentation algorithms show that our method exhibits better segmentation accuracy and stability.

OnUVS: Online Feature Decoupling Framework for High-Fidelity Ultrasound Video Synthesis

Ultrasound (US) imaging is indispensable in clinical practice. To diagnose certain diseases, sonographers must observe corresponding dynamic anatomic structures to gather comprehensive information. However, the limited availability of specific US video cases causes teaching difficulties in identifying corresponding diseases, which potentially impacts the detection rate of such cases. The synthesis of US videos may represent a promising solution to this issue. Nevertheless, it is challenging to accurately animate the intricate motion of dynamic anatomic structures while preserving image fidelity. To address this, we present a novel online feature-decoupling framework called OnUVS for high-fidelity US video synthesis. Our highlights can be summarized by four aspects. First, we introduced anatomic information into keypoint learning through a weakly-supervised training strategy, resulting in improved preservation of anatomical integrity and motion while minimizing the labeling burden. Second, to better preserve the integrity and textural information of US images, we implemented a dual-decoder that decouples the content and textural features in the generator. Third, we adopted a multiple-feature discriminator to extract a comprehensive range of visual cues, thereby enhancing the sharpness and fine details of the generated videos. Fourth, we constrained the motion trajectories of keypoints during online learning to enhance the fluidity of generated videos. Our validation and user studies on in-house echocardiographic and pelvic floor US videos showed that OnUVS synthesizes US videos with high fidelity.

Inflated 3D Convolution-Transformer for Weakly-supervised Carotid Stenosis Grading with Ultrasound Videos

Localization of the narrowest position of the vessel and corresponding vessel and remnant vessel delineation in carotid ultrasound (US) are essential for carotid stenosis grading (CSG) in clinical practice. However, the pipeline is time-consuming and tough due to the ambiguous boundaries of plaque and temporal variation. To automatize this procedure, a large number of manual delineations are usually required, which is not only laborious but also not reliable given the annotation difficulty. In this study, we present the first video classification framework for automatic CSG. Our contribution is three-fold. First, to avoid the requirement of laborious and unreliable annotation, we propose a novel and effective video classification network for weakly-supervised CSG. Second, to ease the model training, we adopt an inflation strategy for the network, where pre-trained 2D convolution weights can be adapted into the 3D counterpart in our network for an effective warm start. Third, to enhance the feature discrimination of the video, we propose a novel attention-guided multi-dimension fusion (AMDF) transformer encoder to model and integrate global dependencies within and across spatial and temporal dimensions, where two lightweight cross-dimensional attention mechanisms are designed. Our approach is extensively validated on a large clinically collected carotid US video dataset, demonstrating state-of-the-art performance compared with strong competitors.

Fourier Test-time Adaptation with Multi-level Consistency for Robust Classification

Deep classifiers may encounter significant performance degradation when processing unseen testing data from varying centers, vendors, and protocols. Ensuring the robustness of deep models against these domain shifts is crucial for their widespread clinical application. In this study, we propose a novel approach called Fourier Test-time Adaptation (FTTA), which employs a dual-adaptation design to integrate input and model tuning, thereby jointly improving the model robustness. The main idea of FTTA is to build a reliable multi-level consistency measurement of paired inputs for achieving self-correction of prediction. Our contribution is two-fold. First, we encourage consistency in global features and local attention maps between the two transformed images of the same input. Here, the transformation refers to Fourier-based input adaptation, which can transfer one unseen image into source style to reduce the domain gap. Furthermore, we leverage style-interpolated images to enhance the global and local features with learnable parameters, which can smooth the consistency measurement and accelerate convergence. Second, we introduce a regularization technique that utilizes style interpolation consistency in the frequency space to encourage self-consistency in the logit space of the model output. This regularization provides strong self-supervised signals for robustness enhancement. FTTA was extensively validated on three large classification datasets with different modalities and organs. Experimental results show that FTTA is general and outperforms other strong state-of-the-art methods.