Point Cloud Registration for Fusion between SPECT MPI and CTA Images

Clinical fusion of Single Photon Emission Computed Tomography Myocardial Perfusion Imaging (SPECT MPI) and Computed Tomography Angiography (CTA) remains limited by cross-modality misregistration and reliance on manual landmarks, which can hinder accurate ischemia localization and lesion-level functional assessment. To address this issue, we propose a registration and fusion framework for SPECT MPI and CTA that integrates functional and structural information for comprehensive cardiac evaluation. The proposed pipeline performs U-Net-based segmentation on both modalities. On SPECT MPI, only the left ventricle (LV) is extracted, and anatomical landmarks are automatically derived from characteristic LV structures. On CTA, both ventricles are segmented, and their spatial relationship is used to automatically define landmarks at the interventricular septal junction. Scale-space consistency preprocessing and landmark-driven coarse registration are applied to mitigate initial misalignment. Based on this initialization, multiple fine registration methods are evaluated on LV epicardial surface point clouds, including ICP, SICP, CPD, CluReg, FFD, and BCPD-plus-plus. The resulting transformations are then propagated to voxel-level resampling for high-precision SPECT-CTA fusion. In a retrospective cohort of 60 patients, the proposed framework preserved sub-millimeter coronary detail from CTA while accurately overlaying quantitative SPECT perfusion. Among the evaluated methods, BCPD-plus-plus achieved the highest accuracy with a mean point cloud distance of 1.7 mm. By combining robust initialization, comparative fine registration, and voxel-level fusion, the proposed approach provides a practical solution for myocardial ischemia localization and functional evaluation of coronary lesions, while remaining independent of any specific fine registration algorithm.

Learning to Seek Help: Dynamic Collaboration Between Small and Large Language Models

Large language models (LLMs) offer strong capabilities but raise cost and privacy concerns, whereas small language models (SLMs) facilitate efficient and private local inference yet suffer from limited capacity. To synergize the complementary strengths, we introduce a dynamic collaboration framework, where an SLM learns to proactively decide how to request an LLM during multi-step reasoning, while the LLM provides adaptive feedback instead of acting as a passive tool. We further systematically investigate how collaboration strategies are shaped by SLM and LLM capabilities as well as efficiency and privacy constraints. Evaluation results reveal a distinct scaling effect: stronger SLMs become more self-reliant, while stronger LLMs enable fewer and more informative interactions. In addition, the learned dynamic collaboration strategies significantly outperform static pipelines and standalone inference, and transfer robustly to unseen LLMs.

TurboTalk: Progressive Distillation for One-Step Audio-Driven Talking Avatar Generation

Existing audio-driven video digital human generation models rely on multi-step denoising, resulting in substantial computational overhead that severely limits their deployment in real-world settings. While one-step distillation approaches can significantly accelerate inference, they often suffer from training instability. To address this challenge, we propose TurboTalk, a two-stage progressive distillation framework that effectively compresses a multi-step audio-driven video diffusion model into a single-step generator. We first adopt Distribution Matching Distillation to obtain a strong and stable 4-step student, and then progressively reduce the denoising steps from 4 to 1 through adversarial distillation. To ensure stable training under extreme step reduction, we introduce a progressive timestep sampling strategy and a self-compare adversarial objective that provides an intermediate adversarial reference that stabilizes progressive distillation. Our method achieve single-step generation of video talking avatar, boosting inference speed by 120 times while maintaining high generation quality.

From Myopic Selection to Long-Horizon Awareness: Sequential LLM Routing for Multi-Turn Dialogue

Multi-turn dialogue is the predominant form of interaction with large language models (LLMs). While LLM routing is effective in single-turn settings, existing methods fail to maximize cumulative performance in multi-turn dialogue due to interaction dynamics and delayed rewards. To address this challenge, we move from myopic, single-turn selection to long-horizon sequential routing for multi-turn dialogue. Accordingly, we propose DialRouter, which first performs MCTS to explore dialogue branches induced by different LLM selections and collect trajectories with high cumulative rewards. DialRouter then learns a lightweight routing policy from search-derived data, augmented with retrieval-based future state approximation, enabling multi-turn routing without online search. Experiments on both open-domain and domain-specific dialogue tasks across diverse candidate sets of both open-source and closed-source LLMs demonstrate that DialRouter significantly outperforms single LLMs and existing routing baselines in task success rate, while achieving a superior performance-cost trade-off when combined with a cost-aware reward.

The Evolution of Tool Use in LLM Agents: From Single-Tool Call to Multi-Tool Orchestration

Tool use enables large language models (LLMs) to access external information, invoke software systems, and act in digital environments beyond what can be solved from model parameters alone. Early research mainly studied whether a model could select and execute a correct single tool call. As agent systems evolve, however, the central problem has shifted from isolated invocation to multi-tool orchestration over long trajectories with intermediate state, execution feedback, changing environments, and practical constraints such as safety, cost, and verifiability. We comprehensively review recent progress in multi-tool LLM agents and analyzes the state of the art in this rapidly developing area. First, we unify task formulations and distinguish single-call tool use from long-horizon orchestration. Then, we organize the literature around six core dimensions: inference-time planning and execution, training and trajectory construction, safety and control, efficiency under resource constraints, capability completeness in open environments, and benchmark design and evaluation. We further summarize representative applications in software engineering, enterprise workflows, graphical user interfaces, and mobile systems. Finally, we discuss major challenges and outline future directions for building reliable, scalable, and verifiable multi-tool agents.

Principled Learning-to-Communicate with Quasi-Classical Information Structures

Learning-to-communicate (LTC) in partially observable environments has received increasing attention in deep multi-agent reinforcement learning, where the control and communication strategies are jointly learned. Meanwhile, the impact of communication on decision-making has been extensively studied in control theory. In this paper, we seek to formalize and better understand LTC by bridging these two lines of work, through the lens of information structures (ISs). To this end, we formalize LTC in decentralized partially observable Markov decision processes (Dec-POMDPs) under the common-information-based framework from decentralized stochastic control, and classify LTC problems based on the ISs before (additional) information sharing. We first show that non-classical LTCs are computationally intractable in general, and thus focus on quasi-classical (QC) LTCs. We then propose a series of conditions for QC LTCs, under which LTCs preserve the QC IS after information sharing, whereas violating which can cause computational hardness in general. Further, we develop provable planning and learning algorithms for QC LTCs, and establish quasi-polynomial time and sample complexities for several QC LTC examples that satisfy the above conditions. Along the way, we also establish results on the relationship between (strictly) QC IS and the condition of having strategy-independent common-information-based beliefs (SI-CIBs), as well as on solving Dec-POMDPs without computationally intractable oracles but beyond those with SI-CIBs, which may be of independent interest.

Singpath-VL Technical Report

We present Singpath-VL, a vision-language large model, to fill the vacancy of AI assistant in cervical cytology. Recent advances in multi-modal large language models (MLLMs) have significantly propelled the field of computational pathology. However, their application in cytopathology, particularly cervical cytology, remains underexplored, primarily due to the scarcity of large-scale, high-quality annotated datasets. To bridge this gap, we first develop a novel three-stage pipeline to synthesize a million-scale image-description dataset. The pipeline leverages multiple general-purpose MLLMs as weak annotators, refines their outputs through consensus fusion and expert knowledge injection, and produces high-fidelity descriptions of cell morphology. Using this dataset, we then fine-tune the Qwen3-VL-4B model via a multi-stage strategy to create a specialized cytopathology MLLM. The resulting model, named Singpath-VL, demonstrates superior performance in fine-grained morphological perception and cell-level diagnostic classification. To advance the field, we will open-source a portion of the synthetic dataset and benchmark.

Step 3.5 Flash: Open Frontier-Level Intelligence with 11B Active Parameters

We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction (MTP-3) to reduce the latency and cost of multi-round agentic interactions. To reach frontier-level intelligence, we design a scalable reinforcement learning framework that combines verifiable signals with preference feedback, while remaining stable under large-scale off-policy training, enabling consistent self-improvement across mathematics, code, and tool use. Step 3.5 Flash demonstrates strong performance across agent, coding, and math tasks, achieving 85.4% on IMO-AnswerBench, 86.4% on LiveCodeBench-v6 (2024.08-2025.05), 88.2% on tau2-Bench, 69.0% on BrowseComp (with context management), and 51.0% on Terminal-Bench 2.0, comparable to frontier models such as GPT-5.2 xHigh and Gemini 3.0 Pro. By redefining the efficiency frontier, Step 3.5 Flash provides a high-density foundation for deploying sophisticated agents in real-world industrial environments.

Wetland mapping from sparse annotations with satellite image time series and temporal-aware segment anything model

Accurate wetland mapping is essential for ecosystem monitoring, yet dense pixel-level annotation is prohibitively expensive and practical applications usually rely on sparse point labels, under which existing deep learning models perform poorly, while strong seasonal and inter-annual wetland dynamics further render single-date imagery inadequate and lead to significant mapping errors; although foundation models such as SAM show promising generalization from point prompts, they are inherently designed for static images and fail to model temporal information, resulting in fragmented masks in heterogeneous wetlands. To overcome these limitations, we propose WetSAM, a SAM-based framework that integrates satellite image time series for wetland mapping from sparse point supervision through a dual-branch design, where a temporally prompted branch extends SAM with hierarchical adapters and dynamic temporal aggregation to disentangle wetland characteristics from phenological variability, and a spatial branch employs a temporally constrained region-growing strategy to generate reliable dense pseudo-labels, while a bidirectional consistency regularization jointly optimizes both branches. Extensive experiments across eight global regions of approximately 5,000 km2 each demonstrate that WetSAM substantially outperforms state-of-the-art methods, achieving an average F1-score of 85.58%, and delivering accurate and structurally consistent wetland segmentation with minimal labeling effort, highlighting its strong generalization capability and potential for scalable, low-cost, high-resolution wetland mapping.

Step-DeepResearch Technical Report

As LLMs shift toward autonomous agents, Deep Research has emerged as a pivotal metric. However, existing academic benchmarks like BrowseComp often fail to meet real-world demands for open-ended research, which requires robust skills in intent recognition, long-horizon decision-making, and cross-source verification. To address this, we introduce Step-DeepResearch, a cost-effective, end-to-end agent. We propose a Data Synthesis Strategy Based on Atomic Capabilities to reinforce planning and report writing, combined with a progressive training path from agentic mid-training to SFT and RL. Enhanced by a Checklist-style Judger, this approach significantly improves robustness. Furthermore, to bridge the evaluation gap in the Chinese domain, we establish ADR-Bench for realistic deep research scenarios. Experimental results show that Step-DeepResearch (32B) scores 61.4% on Scale AI Research Rubrics. On ADR-Bench, it significantly outperforms comparable models and rivals SOTA closed-source models like OpenAI and Gemini DeepResearch. These findings prove that refined training enables medium-sized models to achieve expert-level capabilities at industry-leading cost-efficiency.