Mind Meets Space: Rethinking Agentic Spatial Intelligence from a Neuroscience-inspired Perspective

Recent advances in agentic AI have led to systems capable of autonomous task execution and language-based reasoning, yet their spatial reasoning abilities remain limited and underexplored, largely constrained to symbolic and sequential processing. In contrast, human spatial intelligence, rooted in integrated multisensory perception, spatial memory, and cognitive maps, enables flexible, context-aware decision-making in unstructured environments. Therefore, bridging this gap is critical for advancing Agentic Spatial Intelligence toward better interaction with the physical 3D world. To this end, we first start from scrutinizing the spatial neural models as studied in computational neuroscience, and accordingly introduce a novel computational framework grounded in neuroscience principles. This framework maps core biological functions to six essential computation modules: bio-inspired multimodal sensing, multi-sensory integration, egocentric-allocentric conversion, an artificial cognitive map, spatial memory, and spatial reasoning. Together, these modules form a perspective landscape for agentic spatial reasoning capability across both virtual and physical environments. On top, we conduct a framework-guided analysis of recent methods, evaluating their relevance to each module and identifying critical gaps that hinder the development of more neuroscience-grounded spatial reasoning modules. We further examine emerging benchmarks and datasets and explore potential application domains ranging from virtual to embodied systems, such as robotics. Finally, we outline potential research directions, emphasizing the promising roadmap that can generalize spatial reasoning across dynamic or unstructured environments. We hope this work will benefit the research community with a neuroscience-grounded perspective and a structured pathway. Our project page can be found at Github.

SAC-MIL: Spatial-Aware Correlated Multiple Instance Learning for Histopathology Whole Slide Image Classification

We propose Spatial-Aware Correlated Multiple Instance Learning (SAC-MIL) for performing WSI classification. SAC-MIL consists of a positional encoding module to encode position information and a SAC block to perform full instance correlations. The positional encoding module utilizes the instance coordinates within the slide to encode the spatial relationships instead of the instance index in the input WSI sequence. The positional encoding module can also handle the length extrapolation issue where the training and testing sequences have different lengths. The SAC block is an MLP-based method that performs full instance correlation in linear time complexity with respect to the sequence length. Due to the simple structure of MLP, it is easy to deploy since it does not require custom CUDA kernels, compared to Transformer-based methods for WSI classification. SAC-MIL has achieved state-of-the-art performance on the CAMELYON-16, TCGA-LUNG, and TCGA-BRAC datasets. The code will be released upon acceptance.

Coherent Compensation-Based Sensing for Long-Range Targets in Integrated Sensing and Communication System

Integrated sensing and communication (ISAC) is a promising candidate technology for 6G due to its improvement in spectral efficiency and energy efficiency. Orthogonal frequency division multiplexing (OFDM) signal is a mainstream candidate ISAC waveform. However, there are inter-symbol interference (ISI) and inter-carrier interference (ICI) when the round-trip delay exceeds the cyclic prefix (CP) duration for OFDM signals, which limits the maximum sensing range of ISAC system. When detecting a long-range target, the wide beam inevitably covers the close-range target, of which the echo's power is much larger than that of the long-range target. In order to tackle the above problem, a multiple signal classification (MUSIC) and least squares (LS)-based spatial signal separation method is proposed to separate the echo signals reflected from different targets. Moreover, a coherent compensation-based sensing signal processing method at the receiver is proposed to enhance the signal to interference plus noise power ratio (SINR) of the OFDM block for generating the range-Doppler map (RDM) with higher SINR. Simulation results reveal that the proposed method greatly enhances the SINR of RDM by 10 dB for a target at 500 m compared with two-dimensional fast Fourier transform (2D-FFT) method. Besides, the detection probability is also significantly improved compared to the benchmarking method.

A Curriculum Learning Approach to Reinforcement Learning: Leveraging RAG for Multimodal Question Answering

This paper describes the solutions of the Dianping-Trust-Safety team for the META CRAG-MM challenge. The challenge requires building a comprehensive retrieval-augmented generation system capable for multi-modal multi-turn question answering. The competition consists of three tasks: (1) answering questions using structured data retrieved from an image-based mock knowledge graph, (2) synthesizing information from both knowledge graphs and web search results, and (3) handling multi-turn conversations that require context understanding and information aggregation from multiple sources. For Task 1, our solution is based on the vision large language model, enhanced by supervised fine-tuning with knowledge distilled from GPT-4.1. We further applied curriculum learning strategies to guide reinforcement learning, resulting in improved answer accuracy and reduced hallucination. For Task 2 and Task 3, we additionally leveraged web search APIs to incorporate external knowledge, enabling the system to better handle complex queries and multi-turn conversations. Our approach achieved 1st place in Task 1 with a significant lead of 52.38\%, and 3rd place in Task 3, demonstrating the effectiveness of the integration of curriculum learning with reinforcement learning in our training pipeline.

PhysPatch: A Physically Realizable and Transferable Adversarial Patch Attack for Multimodal Large Language Models-based Autonomous Driving Systems

Multimodal Large Language Models (MLLMs) are becoming integral to autonomous driving (AD) systems due to their strong vision-language reasoning capabilities. However, MLLMs are vulnerable to adversarial attacks, particularly adversarial patch attacks, which can pose serious threats in real-world scenarios. Existing patch-based attack methods are primarily designed for object detection models and perform poorly when transferred to MLLM-based systems due to the latter's complex architectures and reasoning abilities. To address these limitations, we propose PhysPatch, a physically realizable and transferable adversarial patch framework tailored for MLLM-based AD systems. PhysPatch jointly optimizes patch location, shape, and content to enhance attack effectiveness and real-world applicability. It introduces a semantic-based mask initialization strategy for realistic placement, an SVD-based local alignment loss with patch-guided crop-resize to improve transferability, and a potential field-based mask refinement method. Extensive experiments across open-source, commercial, and reasoning-capable MLLMs demonstrate that PhysPatch significantly outperforms prior methods in steering MLLM-based AD systems toward target-aligned perception and planning outputs. Moreover, PhysPatch consistently places adversarial patches in physically feasible regions of AD scenes, ensuring strong real-world applicability and deployability.

Leader360V: The Large-scale, Real-world 360 Video Dataset for Multi-task Learning in Diverse Environment

360 video captures the complete surrounding scenes with the ultra-large field of view of 360X180. This makes 360 scene understanding tasks, eg, segmentation and tracking, crucial for appications, such as autonomous driving, robotics. With the recent emergence of foundation models, the community is, however, impeded by the lack of large-scale, labelled real-world datasets. This is caused by the inherent spherical properties, eg, severe distortion in polar regions, and content discontinuities, rendering the annotation costly yet complex. This paper introduces Leader360V, the first large-scale, labeled real-world 360 video datasets for instance segmentation and tracking. Our datasets enjoy high scene diversity, ranging from indoor and urban settings to natural and dynamic outdoor scenes. To automate annotation, we design an automatic labeling pipeline, which subtly coordinates pre-trained 2D segmentors and large language models to facilitate the labeling. The pipeline operates in three novel stages. Specifically, in the Initial Annotation Phase, we introduce a Semantic- and Distortion-aware Refinement module, which combines object mask proposals from multiple 2D segmentors with LLM-verified semantic labels. These are then converted into mask prompts to guide SAM2 in generating distortion-aware masks for subsequent frames. In the Auto-Refine Annotation Phase, missing or incomplete regions are corrected either by applying the SDR again or resolving the discontinuities near the horizontal borders. The Manual Revision Phase finally incorporates LLMs and human annotators to further refine and validate the annotations. Extensive user studies and evaluations demonstrate the effectiveness of our labeling pipeline. Meanwhile, experiments confirm that Leader360V significantly enhances model performance for 360 video segmentation and tracking, paving the way for more scalable 360 scene understanding.

Neural Brain: A Neuroscience-inspired Framework for Embodied Agents

The rapid evolution of artificial intelligence (AI) has shifted from static, data-driven models to dynamic systems capable of perceiving and interacting with real-world environments. Despite advancements in pattern recognition and symbolic reasoning, current AI systems, such as large language models, remain disembodied, unable to physically engage with the world. This limitation has driven the rise of embodied AI, where autonomous agents, such as humanoid robots, must navigate and manipulate unstructured environments with human-like adaptability. At the core of this challenge lies the concept of Neural Brain, a central intelligence system designed to drive embodied agents with human-like adaptability. A Neural Brain must seamlessly integrate multimodal sensing and perception with cognitive capabilities. Achieving this also requires an adaptive memory system and energy-efficient hardware-software co-design, enabling real-time action in dynamic environments. This paper introduces a unified framework for the Neural Brain of embodied agents, addressing two fundamental challenges: (1) defining the core components of Neural Brain and (2) bridging the gap between static AI models and the dynamic adaptability required for real-world deployment. To this end, we propose a biologically inspired architecture that integrates multimodal active sensing, perception-cognition-action function, neuroplasticity-based memory storage and updating, and neuromorphic hardware/software optimization. Furthermore, we also review the latest research on embodied agents across these four aspects and analyze the gap between current AI systems and human intelligence. By synthesizing insights from neuroscience, we outline a roadmap towards the development of generalizable, autonomous agents capable of human-level intelligence in real-world scenarios.

Nature's Insight: A Novel Framework and Comprehensive Analysis of Agentic Reasoning Through the Lens of Neuroscience

Autonomous AI is no longer a hard-to-reach concept, it enables the agents to move beyond executing tasks to independently addressing complex problems, adapting to change while handling the uncertainty of the environment. However, what makes the agents truly autonomous? It is agentic reasoning, that is crucial for foundation models to develop symbolic logic, statistical correlations, or large-scale pattern recognition to process information, draw inferences, and make decisions. However, it remains unclear why and how existing agentic reasoning approaches work, in comparison to biological reasoning, which instead is deeply rooted in neural mechanisms involving hierarchical cognition, multimodal integration, and dynamic interactions. In this work, we propose a novel neuroscience-inspired framework for agentic reasoning. Grounded in three neuroscience-based definitions and supported by mathematical and biological foundations, we propose a unified framework modeling reasoning from perception to action, encompassing four core types, perceptual, dimensional, logical, and interactive, inspired by distinct functional roles observed in the human brain. We apply this framework to systematically classify and analyze existing AI reasoning methods, evaluating their theoretical foundations, computational designs, and practical limitations. We also explore its implications for building more generalizable, cognitively aligned agents in physical and virtual environments. Finally, building on our framework, we outline future directions and propose new neural-inspired reasoning methods, analogous to chain-of-thought prompting. By bridging cognitive neuroscience and AI, this work offers a theoretical foundation and practical roadmap for advancing agentic reasoning in intelligent systems. The associated project can be found at: https://github.com/BioRAILab/Awesome-Neuroscience-Agent-Reasoning .

TimeTracker: Event-based Continuous Point Tracking for Video Frame Interpolation with Non-linear Motion

Video frame interpolation (VFI) that leverages the bio-inspired event cameras as guidance has recently shown better performance and memory efficiency than the frame-based methods, thanks to the event cameras' advantages, such as high temporal resolution. A hurdle for event-based VFI is how to effectively deal with non-linear motion, caused by the dynamic changes in motion direction and speed within the scene. Existing methods either use events to estimate sparse optical flow or fuse events with image features to estimate dense optical flow. Unfortunately, motion errors often degrade the VFI quality as the continuous motion cues from events do not align with the dense spatial information of images in the temporal dimension. In this paper, we find that object motion is continuous in space, tracking local regions over continuous time enables more accurate identification of spatiotemporal feature correlations. In light of this, we propose a novel continuous point tracking-based VFI framework, named TimeTracker. Specifically, we first design a Scene-Aware Region Segmentation (SARS) module to divide the scene into similar patches. Then, a Continuous Trajectory guided Motion Estimation (CTME) module is proposed to track the continuous motion trajectory of each patch through events. Finally, intermediate frames at any given time are generated through global motion optimization and frame refinement. Moreover, we collect a real-world dataset that features fast non-linear motion. Extensive experiments show that our method outperforms prior arts in both motion estimation and frame interpolation quality.

Fast-Slow Co-advancing Optimizer: Toward Harmonious Adversarial Training of GAN

Up to now, the training processes of typical Generative Adversarial Networks (GANs) are still particularly sensitive to data properties and hyperparameters, which may lead to severe oscillations, difficulties in convergence, or even failures to converge, especially when the overall variances of the training sets are large. These phenomena are often attributed to the training characteristics of such networks. Aiming at the problem, this paper develops a new intelligent optimizer, Fast-Slow Co-advancing Optimizer (FSCO), which employs reinforcement learning in the training process of GANs to make training easier. Specifically, this paper allows the training step size to be controlled by an agent to improve training stability, and makes the training process more intelligent with variable learning rates, making GANs less sensitive to step size. Experiments have been conducted on three benchmark datasets to verify the effectiveness of the developed FSCO.