Variational and Explanatory Neural Networks for Encoding Cancer Profiles and Predicting Drug Responses

Human cancers present a significant public health challenge and require the discovery of novel drugs through translational research. Transcriptomics profiling data that describes molecular activities in tumors and cancer cell lines are widely utilized for predicting anti-cancer drug responses. However, existing AI models face challenges due to noise in transcriptomics data and lack of biological interpretability. To overcome these limitations, we introduce VETE (Variational and Explanatory Transcriptomics Encoder), a novel neural network framework that incorporates a variational component to mitigate noise effects and integrates traceable gene ontology into the neural network architecture for encoding cancer transcriptomics data. Key innovations include a local interpretability-guided method for identifying ontology paths, a visualization tool to elucidate biological mechanisms of drug responses, and the application of centralized large scale hyperparameter optimization. VETE demonstrated robust accuracy in cancer cell line classification and drug response prediction. Additionally, it provided traceable biological explanations for both tasks and offers insights into the mechanisms underlying its predictions. VETE bridges the gap between AI-driven predictions and biologically meaningful insights in cancer research, which represents a promising advancement in the field.

InstructPipe: Building Visual Programming Pipelines with Human Instructions

Visual programming provides beginner-level programmers with a coding-free experience to build their customized pipelines. Existing systems require users to build a pipeline entirely from scratch, implying that novice users need to set up and link appropriate nodes all by themselves, starting from a blank workspace. We present InstructPipe, an AI assistant that enables users to start prototyping machine learning (ML) pipelines with text instructions. We designed two LLM modules and a code interpreter to execute our solution. LLM modules generate pseudocode of a target pipeline, and the interpreter renders a pipeline in the node-graph editor for further human-AI collaboration. Technical evaluations reveal that InstructPipe reduces user interactions by 81.1% compared to traditional methods. Our user study (N=16) showed that InstructPipe empowers novice users to streamline their workflow in creating desired ML pipelines, reduce their learning curve, and spark innovative ideas with open-ended commands.

Category Feature Transformer for Semantic Segmentation

Aggregation of multi-stage features has been revealed to play a significant role in semantic segmentation. Unlike previous methods employing point-wise summation or concatenation for feature aggregation, this study proposes the Category Feature Transformer (CFT) that explores the flow of category embedding and transformation among multi-stage features through the prevalent multi-head attention mechanism. CFT learns unified feature embeddings for individual semantic categories from high-level features during each aggregation process and dynamically broadcasts them to high-resolution features. Integrating the proposed CFT into a typical feature pyramid structure exhibits superior performance over a broad range of backbone networks. We conduct extensive experiments on popular semantic segmentation benchmarks. Specifically, the proposed CFT obtains a compelling 55.1% mIoU with greatly reduced model parameters and computations on the challenging ADE20K dataset.

Single Image Deraining via Feature-based Deep Convolutional Neural Network

It is challenging to remove rain-steaks from a single rainy image because the rain steaks are spatially varying in the rainy image. Although the CNN based methods have reported promising performance recently, there are still some defects, such as data dependency and insufficient interpretation. A single image deraining algorithm based on the combination of data-driven and model-based approaches is proposed. Firstly, an improved weighted guided image filter (iWGIF) is used to extract high-frequency information and learn the rain steaks to avoid interference from other information through the input image. Then, transfering the input image and rain steaks from the image domain to the feature domain adaptively to learn useful features for high-quality image deraining. Finally, networks with attention mechanisms is used to restore high-quality images from the latent features. Experiments show that the proposed algorithm significantly outperforms state-of-the-art methods in terms of both qualitative and quantitative measures.

Recovering Sign Bits of DCT Coefficients in Digital Images as an Optimization Problem

Recovering unknown, missing, damaged, distorted or lost information in DCT coefficients is a common task in multiple applications of digital image processing, including image compression, selective image encryption, and image communications. This paper investigates recovery of a special type of information in DCT coefficients of digital images: sign bits. This problem can be modelled as a mixed integer linear programming (MILP) problem, which is NP-hard in general. To efficiently solve the problem, we propose two approximation methods: 1) a relaxation-based method that convert the MILP problem to a linear programming (LP) problem; 2) a divide-and-conquer method which splits the target image into sufficiently small regions, each of which can be more efficiently solved as an MILP problem, and then conducts a global optimization phase as a smaller MILP problem or an LP problem to maximize smoothness across different regions. To the best of our knowledge, we are the first who considered how to use global optimization to recover sign bits of DCT coefficients. We considered how the proposed methods can be applied to JPEG-encoded images and conducted extensive experiments to validate the performances of our proposed methods. The experimental results showed that the proposed methods worked well, especially when the number of unknown sign bits per DCT block is not too large. Compared with other existing methods, which are all based on simple error-concealment strategies, our proposed methods outperformed them with a substantial margin, both according to objective quality metrics (PSNR and SSIM) and also our subjective evaluation. Our work has a number of profound implications, e.g., more sign bits can be discarded to develop more efficient image compression methods, and image encryption methods based on sign bit encryption can be less secure than we previously understood.

Reversed Image Signal Processing and RAW Reconstruction. AIM 2022 Challenge Report

Cameras capture sensor RAW images and transform them into pleasant RGB images, suitable for the human eyes, using their integrated Image Signal Processor (ISP). Numerous low-level vision tasks operate in the RAW domain (e.g. image denoising, white balance) due to its linear relationship with the scene irradiance, wide-range of information at 12bits, and sensor designs. Despite this, RAW image datasets are scarce and more expensive to collect than the already large and public RGB datasets. This paper introduces the AIM 2022 Challenge on Reversed Image Signal Processing and RAW Reconstruction. We aim to recover raw sensor images from the corresponding RGBs without metadata and, by doing this, "reverse" the ISP transformation. The proposed methods and benchmark establish the state-of-the-art for this low-level vision inverse problem, and generating realistic raw sensor readings can potentially benefit other tasks such as denoising and super-resolution.

MIPI 2022 Challenge on RGBW Sensor Fusion: Dataset and Report

Developing and integrating advanced image sensors with novel algorithms in camera systems are prevalent with the increasing demand for computational photography and imaging on mobile platforms. However, the lack of high-quality data for research and the rare opportunity for in-depth exchange of views from industry and academia constrain the development of mobile intelligent photography and imaging (MIPI). To bridge the gap, we introduce the first MIPI challenge, including five tracks focusing on novel image sensors and imaging algorithms. In this paper, RGBW Joint Fusion and Denoise, one of the five tracks, working on the fusion of binning-mode RGBW to Bayer, is introduced. The participants were provided with a new dataset including 70 (training) and 15 (validation) scenes of high-quality RGBW and Bayer pairs. In addition, for each scene, RGBW of different noise levels was provided at 24dB and 42dB. All the data were captured using an RGBW sensor in both outdoor and indoor conditions. The final results are evaluated using objective metrics, including PSNR, SSIM}, LPIPS, and KLD. A detailed description of all models developed in this challenge is provided in this paper. More details of this challenge and the link to the dataset can be found at https://github.com/mipi-challenge/MIPI2022.

MIPI 2022 Challenge on RGBW Sensor Re-mosaic: Dataset and Report

Developing and integrating advanced image sensors with novel algorithms in camera systems are prevalent with the increasing demand for computational photography and imaging on mobile platforms. However, the lack of high-quality data for research and the rare opportunity for in-depth exchange of views from industry and academia constrain the development of mobile intelligent photography and imaging (MIPI). To bridge the gap, we introduce the first MIPI challenge including five tracks focusing on novel image sensors and imaging algorithms. In this paper, RGBW Joint Remosaic and Denoise, one of the five tracks, working on the interpolation of RGBW CFA to Bayer at full resolution, is introduced. The participants were provided with a new dataset including 70 (training) and 15 (validation) scenes of high-quality RGBW and Bayer pairs. In addition, for each scene, RGBW of different noise levels was provided at 0dB, 24dB, and 42dB. All the data were captured using an RGBW sensor in both outdoor and indoor conditions. The final results are evaluated using objective metrics including PSNR, SSIM, LPIPS, and KLD. A detailed description of all models developed in this challenge is provided in this paper. More details of this challenge and the link to the dataset can be found at https://github.com/mipi-challenge/MIPI2022.

MIPI 2022 Challenge on Quad-Bayer Re-mosaic: Dataset and Report

Developing and integrating advanced image sensors with novel algorithms in camera systems are prevalent with the increasing demand for computational photography and imaging on mobile platforms. However, the lack of high-quality data for research and the rare opportunity for in-depth exchange of views from industry and academia constrain the development of mobile intelligent photography and imaging (MIPI). To bridge the gap, we introduce the first MIPI challenge, including five tracks focusing on novel image sensors and imaging algorithms. In this paper, Quad Joint Remosaic and Denoise, one of the five tracks, working on the interpolation of Quad CFA to Bayer at full resolution, is introduced. The participants were provided a new dataset, including 70 (training) and 15 (validation) scenes of high-quality Quad and Bayer pairs. In addition, for each scene, Quad of different noise levels was provided at 0dB, 24dB, and 42dB. All the data were captured using a Quad sensor in both outdoor and indoor conditions. The final results are evaluated using objective metrics, including PSNR, SSIM, LPIPS, and KLD. A detailed description of all models developed in this challenge is provided in this paper. More details of this challenge and the link to the dataset can be found at https://github.com/mipi-challenge/MIPI2022.

MIPI 2022 Challenge on RGB+ToF Depth Completion: Dataset and Report

Developing and integrating advanced image sensors with novel algorithms in camera systems is prevalent with the increasing demand for computational photography and imaging on mobile platforms. However, the lack of high-quality data for research and the rare opportunity for in-depth exchange of views from industry and academia constrain the development of mobile intelligent photography and imaging (MIPI). To bridge the gap, we introduce the first MIPI challenge including five tracks focusing on novel image sensors and imaging algorithms. In this paper, RGB+ToF Depth Completion, one of the five tracks, working on the fusion of RGB sensor and ToF sensor (with spot illumination) is introduced. The participants were provided with a new dataset called TetrasRGBD, which contains 18k pairs of high-quality synthetic RGB+Depth training data and 2.3k pairs of testing data from mixed sources. All the data are collected in an indoor scenario. We require that the running time of all methods should be real-time on desktop GPUs. The final results are evaluated using objective metrics and Mean Opinion Score (MOS) subjectively. A detailed description of all models developed in this challenge is provided in this paper. More details of this challenge and the link to the dataset can be found at https://github.com/mipi-challenge/MIPI2022.