Holter-to-Sleep: AI-Enabled Repurposing of Single-Lead ECG for Sleep Phenotyping

Sleep disturbances are tightly linked to cardiovascular risk, yet polysomnography (PSG)-the clinical reference standard-remains resource-intensive and poorly suited for multi-night, home-based, and large-scale screening. Single-lead electrocardiography (ECG), already ubiquitous in Holter and patch-based devices, enables comfortable long-term acquisition and encodes sleep-relevant physiology through autonomic modulation and cardiorespiratory coupling. Here, we present a proof-of-concept Holter-to-Sleep framework that, using single-lead ECG as the sole input, jointly supports overnight sleep phenotyping and Holter-grade cardiac phenotyping within the same recording, and further provides an explicit analytic pathway for scalable cardio-sleep association studies. The framework is developed and validated on a pooled multi-center PSG sample of 10,439 studies spanning four public cohorts, with independent external evaluation to assess cross-cohort generalizability, and additional real-world feasibility assessment using overnight patch-ECG recordings via objective-subjective consistency analysis. This integrated design enables robust extraction of clinically meaningful overnight sleep phenotypes under heterogeneous populations and acquisition conditions, and facilitates systematic linkage between ECG-derived sleep metrics and arrhythmia-related Holter phenotypes. Collectively, the Holter-to-Sleep paradigm offers a practical foundation for low-burden, home-deployable, and scalable cardio-sleep monitoring and research beyond traditional PSG-centric workflows.

GlyphBanana: Advancing Precise Text Rendering Through Agentic Workflows

Despite recent advances in generative models driving significant progress in text rendering, accurately generating complex text and mathematical formulas remains a formidable challenge. This difficulty primarily stems from the limited instruction-following capabilities of current models when encountering out-of-distribution prompts. To address this, we introduce GlyphBanana, alongside a corresponding benchmark specifically designed for rendering complex characters and formulas. GlyphBanana employs an agentic workflow that integrates auxiliary tools to inject glyph templates into both the latent space and attention maps, facilitating the iterative refinement of generated images. Notably, our training-free approach can be seamlessly applied to various Text-to-Image (T2I) models, achieving superior precision compared to existing baselines. Extensive experiments demonstrate the effectiveness of our proposed workflow. Associated code is publicly available at https://github.com/yuriYanZeXuan/GlyphBanana.

OmniGAIA: Towards Native Omni-Modal AI Agents

Human intelligence naturally intertwines omni-modal perception -- spanning vision, audio, and language -- with complex reasoning and tool usage to interact with the world. However, current multi-modal LLMs are primarily confined to bi-modal interactions (e.g., vision-language), lacking the unified cognitive capabilities required for general AI assistants. To bridge this gap, we introduce OmniGAIA, a comprehensive benchmark designed to evaluate omni-modal agents on tasks necessitating deep reasoning and multi-turn tool execution across video, audio, and image modalities. Constructed via a novel omni-modal event graph approach, OmniGAIA synthesizes complex, multi-hop queries derived from real-world data that require cross-modal reasoning and external tool integration. Furthermore, we propose OmniAtlas, a native omni-modal foundation agent under tool-integrated reasoning paradigm with active omni-modal perception. Trained on trajectories synthesized via a hindsight-guided tree exploration strategy and OmniDPO for fine-grained error correction, OmniAtlas effectively enhances the tool-use capabilities of existing open-source models. This work marks a step towards next-generation native omni-modal AI assistants for real-world scenarios.

ECG-R1: Protocol-Guided and Modality-Agnostic MLLM for Reliable ECG Interpretation

Electrocardiography (ECG) serves as an indispensable diagnostic tool in clinical practice, yet existing multimodal large language models (MLLMs) remain unreliable for ECG interpretation, often producing plausible but clinically incorrect analyses. To address this, we propose ECG-R1, the first reasoning MLLM designed for reliable ECG interpretation via three innovations. First, we construct the interpretation corpus using \textit{Protocol-Guided Instruction Data Generation}, grounding interpretation in measurable ECG features and monograph-defined quantitative thresholds and diagnostic logic. Second, we present a modality-decoupled architecture with \textit{Interleaved Modality Dropout} to improve robustness and cross-modal consistency when either the ECG signal or ECG image is missing. Third, we present \textit{Reinforcement Learning with ECG Diagnostic Evidence Rewards} to strengthen evidence-grounded ECG interpretation. Additionally, we systematically evaluate the ECG interpretation capabilities of proprietary, open-source, and medical MLLMs, and provide the first quantitative evidence that severe hallucinations are widespread, suggesting that the public should not directly trust these outputs without independent verification. Code and data are publicly available at \href{https://github.com/PKUDigitalHealth/ECG-R1}{here}, and an online platform can be accessed at \href{http://ai.heartvoice.com.cn/ECG-R1/}{here}.

ECGFlowCMR: Pretraining with ECG-Generated Cine CMR Improves Cardiac Disease Classification and Phenotype Prediction

Cardiac Magnetic Resonance (CMR) imaging provides a comprehensive assessment of cardiac structure and function but remains constrained by high acquisition costs and reliance on expert annotations, limiting the availability of large-scale labeled datasets. In contrast, electrocardiograms (ECGs) are inexpensive, widely accessible, and offer a promising modality for conditioning the generative synthesis of cine CMR. To this end, we propose ECGFlowCMR, a novel ECG-to-CMR generative framework that integrates a Phase-Aware Masked Autoencoder (PA-MAE) and an Anatomy-Motion Disentangled Flow (AMDF) to address two fundamental challenges: (1) the cross-modal temporal mismatch between multi-beat ECG recordings and single-cycle CMR sequences, and (2) the anatomical observability gap due to the limited structural information inherent in ECGs. Extensive experiments on the UK Biobank and a proprietary clinical dataset demonstrate that ECGFlowCMR can generate realistic cine CMR sequences from ECG inputs, enabling scalable pretraining and improving performance on downstream cardiac disease classification and phenotype prediction tasks.

Agent2World: Learning to Generate Symbolic World Models via Adaptive Multi-Agent Feedback

Symbolic world models (e.g., PDDL domains or executable simulators) are central to model-based planning, but training LLMs to generate such world models is limited by the lack of large-scale verifiable supervision. Current approaches rely primarily on static validation methods that fail to catch behavior-level errors arising from interactive execution. In this paper, we propose Agent2World, a tool-augmented multi-agent framework that achieves strong inference-time world-model generation and also serves as a data engine for supervised fine-tuning, by grounding generation in multi-agent feedback. Agent2World follows a three-stage pipeline: (i) A Deep Researcher agent performs knowledge synthesis by web searching to address specification gaps; (ii) A Model Developer agent implements executable world models; And (iii) a specialized Testing Team conducts adaptive unit testing and simulation-based validation. Agent2World demonstrates superior inference-time performance across three benchmarks spanning both Planning Domain Definition Language (PDDL) and executable code representations, achieving consistent state-of-the-art results. Beyond inference, Testing Team serves as an interactive environment for the Model Developer, providing behavior-aware adaptive feedback that yields multi-turn training trajectories. The model fine-tuned on these trajectories substantially improves world-model generation, yielding an average relative gain of 30.95% over the same model before training. Project page: https://agent2world.github.io.

Fints: Efficient Inference-Time Personalization for LLMs with Fine-Grained Instance-Tailored Steering

The rapid evolution of large language models (LLMs) has intensified the demand for effective personalization techniques that can adapt model behavior to individual user preferences. Despite the non-parametric methods utilizing the in-context learning ability of LLMs, recent parametric adaptation methods, including personalized parameter-efficient fine-tuning and reward modeling emerge. However, these methods face limitations in handling dynamic user patterns and high data sparsity scenarios, due to low adaptability and data efficiency. To address these challenges, we propose a fine-grained and instance-tailored steering framework that dynamically generates sample-level interference vectors from user data and injects them into the model's forward pass for personalized adaptation. Our approach introduces two key technical innovations: a fine-grained steering component that captures nuanced signals by hooking activations from attention and MLP layers, and an input-aware aggregation module that synthesizes these signals into contextually relevant enhancements. The method demonstrates high flexibility and data efficiency, excelling in fast-changing distribution and high data sparsity scenarios. In addition, the proposed method is orthogonal to existing methods and operates as a plug-in component compatible with different personalization techniques. Extensive experiments across diverse scenarios--including short-to-long text generation, and web function calling--validate the effectiveness and compatibility of our approach. Results show that our method significantly enhances personalization performance in fast-shifting environments while maintaining robustness across varying interaction modes and context lengths. Implementation is available at https://github.com/KounianhuaDu/Fints.

DeepAgent: A General Reasoning Agent with Scalable Toolsets

Large reasoning models have demonstrated strong problem-solving abilities, yet real-world tasks often require external tools and long-horizon interactions. Existing agent frameworks typically follow predefined workflows, which limit autonomous and global task completion. In this paper, we introduce DeepAgent, an end-to-end deep reasoning agent that performs autonomous thinking, tool discovery, and action execution within a single, coherent reasoning process. To address the challenges of long-horizon interactions, particularly the context length explosion from multiple tool calls and the accumulation of interaction history, we introduce an autonomous memory folding mechanism that compresses past interactions into structured episodic, working, and tool memories, reducing error accumulation while preserving critical information. To teach general-purpose tool use efficiently and stably, we develop an end-to-end reinforcement learning strategy, namely ToolPO, that leverages LLM-simulated APIs and applies tool-call advantage attribution to assign fine-grained credit to the tool invocation tokens. Extensive experiments on eight benchmarks, including general tool-use tasks (ToolBench, API-Bank, TMDB, Spotify, ToolHop) and downstream applications (ALFWorld, WebShop, GAIA, HLE), demonstrate that DeepAgent consistently outperforms baselines across both labeled-tool and open-set tool retrieval scenarios. This work takes a step toward more general and capable agents for real-world applications. The code and demo are available at https://github.com/RUC-NLPIR/DeepAgent.

A Metric for MLLM Alignment in Large-scale Recommendation

Multimodal recommendation has emerged as a critical technique in modern recommender systems, leveraging content representations from advanced multimodal large language models (MLLMs). To ensure these representations are well-adapted, alignment with the recommender system is essential. However, evaluating the alignment of MLLMs for recommendation presents significant challenges due to three key issues: (1) static benchmarks are inaccurate because of the dynamism in real-world applications, (2) evaluations with online system, while accurate, are prohibitively expensive at scale, and (3) conventional metrics fail to provide actionable insights when learned representations underperform. To address these challenges, we propose the Leakage Impact Score (LIS), a novel metric for multimodal recommendation. Rather than directly assessing MLLMs, LIS efficiently measures the upper bound of preference data. We also share practical insights on deploying MLLMs with LIS in real-world scenarios. Online A/B tests on both Content Feed and Display Ads of Xiaohongshu's Explore Feed production demonstrate the effectiveness of our proposed method, showing significant improvements in user spent time and advertiser value.

Large Language Models are Demonstration Pre-Selectors for Themselves

In-context learning (ICL) with large language models (LLMs) delivers strong few-shot performance by choosing few-shot demonstrations from the entire training data. However, existing ICL methods, which rely on similarity or diversity scores to choose demonstrations, incur high computational costs due to repeatedly retrieval from large-scale datasets for each query. To this end, we propose FEEDER (FEw yet Essential Demonstration prE-selectoR), a novel pre-selection framework that identifies a representative subset of demonstrations containing the most representative examples in the training data, tailored to specific LLMs. To construct this subset, we introduce the "sufficiency" and "necessity" metrics in the pre-selection stage and design a tree-based algorithm to identify representative examples efficiently. Once pre-selected, this representative subset can effectively replace the full training data, improving efficiency while maintaining comparable performance in ICL. Additionally, our pre-selected subset also benefits fine-tuning LLMs, where we introduce a bi-level optimization method that enhances training efficiency without sacrificing performance. Experiments with LLMs ranging from 300M to 8B parameters show that FEEDER can reduce training data size by over 20% while maintaining performance and seamlessly integrating with various downstream demonstration selection strategies in ICL.