Interactive Gadolinium-Free MRI Synthesis: A Transformer with Localization Prompt Learning

Contrast-enhanced magnetic resonance imaging (CE-MRI) is crucial for tumor detection and diagnosis, but the use of gadolinium-based contrast agents (GBCAs) in clinical settings raises safety concerns due to potential health risks. To circumvent these issues while preserving diagnostic accuracy, we propose a novel Transformer with Localization Prompts (TLP) framework for synthesizing CE-MRI from non-contrast MR images. Our architecture introduces three key innovations: a hierarchical backbone that uses efficient Transformer to process multi-scale features; a multi-stage fusion system consisting of Local and Global Fusion modules that hierarchically integrate complementary information via spatial attention operations and cross-attention mechanisms, respectively; and a Fuzzy Prompt Generation (FPG) module that enhances the TLP model's generalization by emulating radiologists' manual annotation through stochastic feature perturbation. The framework uniquely enables interactive clinical integration by allowing radiologists to input diagnostic prompts during inference, synergizing artificial intelligence with medical expertise. This research establishes a new paradigm for contrast-free MRI synthesis while addressing critical clinical needs for safer diagnostic procedures. Codes are available at https://github.com/ChanghuiSu/TLP.

Finding Local Diffusion Schrödinger Bridge using Kolmogorov-Arnold Network

In image generation, Schr\"odinger Bridge (SB)-based methods theoretically enhance the efficiency and quality compared to the diffusion models by finding the least costly path between two distributions. However, they are computationally expensive and time-consuming when applied to complex image data. The reason is that they focus on fitting globally optimal paths in high-dimensional spaces, directly generating images as next step on the path using complex networks through self-supervised training, which typically results in a gap with the global optimum. Meanwhile, most diffusion models are in the same path subspace generated by weights $f_A(t)$ and $f_B(t)$, as they follow the paradigm ($x_t = f_A(t)x_{Img} + f_B(t)\epsilon$). To address the limitations of SB-based methods, this paper proposes for the first time to find local Diffusion Schr\"odinger Bridges (LDSB) in the diffusion path subspace, which strengthens the connection between the SB problem and diffusion models. Specifically, our method optimizes the diffusion paths using Kolmogorov-Arnold Network (KAN), which has the advantage of resistance to forgetting and continuous output. The experiment shows that our LDSB significantly improves the quality and efficiency of image generation using the same pre-trained denoising network and the KAN for optimising is only less than 0.1MB. The FID metric is reduced by \textbf{more than 15\%}, especially with a reduction of 48.50\% when NFE of DDIM is $5$ for the CelebA dataset. Code is available at https://github.com/Qiu-XY/LDSB.

StructSR: Refuse Spurious Details in Real-World Image Super-Resolution

Diffusion-based models have shown great promise in real-world image super-resolution (Real-ISR), but often generate content with structural errors and spurious texture details due to the empirical priors and illusions of these models. To address this issue, we introduce StructSR, a simple, effective, and plug-and-play method that enhances structural fidelity and suppresses spurious details for diffusion-based Real-ISR. StructSR operates without the need for additional fine-tuning, external model priors, or high-level semantic knowledge. At its core is the Structure-Aware Screening (SAS) mechanism, which identifies the image with the highest structural similarity to the low-resolution (LR) input in the early inference stage, allowing us to leverage it as a historical structure knowledge to suppress the generation of spurious details. By intervening in the diffusion inference process, StructSR seamlessly integrates with existing diffusion-based Real-ISR models. Our experimental results demonstrate that StructSR significantly improves the fidelity of structure and texture, improving the PSNR and SSIM metrics by an average of 5.27% and 9.36% on a synthetic dataset (DIV2K-Val) and 4.13% and 8.64% on two real-world datasets (RealSR and DRealSR) when integrated with four state-of-the-art diffusion-based Real-ISR methods.

K-space Diffusion Model Based MR Reconstruction Method for Simultaneous Multislice Imaging

Simultaneous Multi-Slice(SMS) is a magnetic resonance imaging (MRI) technique which excites several slices concurrently using multiband radiofrequency pulses to reduce scanning time. However, due to its variable data structure and difficulty in acquisition, it is challenging to integrate SMS data as training data into deep learning frameworks.This study proposed a novel k-space diffusion model of SMS reconstruction that does not utilize SMS data for training. Instead, it incorporates Slice GRAPPA during the sampling process to reconstruct SMS data from different acquisition modes.Our results demonstrated that this method outperforms traditional SMS reconstruction methods and can achieve higher acceleration factors without in-plane aliasing.

Learnable Prompting SAM-induced Knowledge Distillation for Semi-supervised Medical Image Segmentation

The limited availability of labeled data has driven advancements in semi-supervised learning for medical image segmentation. Modern large-scale models tailored for general segmentation, such as the Segment Anything Model (SAM), have revealed robust generalization capabilities. However, applying these models directly to medical image segmentation still exposes performance degradation. In this paper, we propose a learnable prompting SAM-induced Knowledge distillation framework (KnowSAM) for semi-supervised medical image segmentation. Firstly, we propose a Multi-view Co-training (MC) strategy that employs two distinct sub-networks to employ a co-teaching paradigm, resulting in more robust outcomes. Secondly, we present a Learnable Prompt Strategy (LPS) to dynamically produce dense prompts and integrate an adapter to fine-tune SAM specifically for medical image segmentation tasks. Moreover, we propose SAM-induced Knowledge Distillation (SKD) to transfer useful knowledge from SAM to two sub-networks, enabling them to learn from SAM's predictions and alleviate the effects of incorrect pseudo-labels during training. Notably, the predictions generated by our subnets are used to produce mask prompts for SAM, facilitating effective inter-module information exchange. Extensive experimental results on various medical segmentation tasks demonstrate that our model outperforms the state-of-the-art semi-supervised segmentation approaches. Crucially, our SAM distillation framework can be seamlessly integrated into other semi-supervised segmentation methods to enhance performance. The code will be released upon acceptance of this manuscript at: https://github.com/taozh2017/KnowSAM

Reconstructing Quantitative Cerebral Perfusion Images Directly From Measured Sinogram Data Acquired Using C-arm Cone-Beam CT

To shorten the door-to-puncture time for better treating patients with acute ischemic stroke, it is highly desired to obtain quantitative cerebral perfusion images using C-arm cone-beam computed tomography (CBCT) equipped in the interventional suite. However, limited by the slow gantry rotation speed, the temporal resolution and temporal sampling density of typical C-arm CBCT are much poorer than those of multi-detector-row CT in the diagnostic imaging suite. The current quantitative perfusion imaging includes two cascaded steps: time-resolved image reconstruction and perfusion parametric estimation. For time-resolved image reconstruction, the technical challenge imposed by poor temporal resolution and poor sampling density causes inaccurate quantification of the temporal variation of cerebral artery and tissue attenuation values. For perfusion parametric estimation, it remains a technical challenge to appropriately design the handcrafted regularization for better solving the associated deconvolution problem. These two challenges together prevent obtaining quantitatively accurate perfusion images using C-arm CBCT. The purpose of this work is to simultaneously address these two challenges by combining the two cascaded steps into a single joint optimization problem and reconstructing quantitative perfusion images directly from the measured sinogram data. In the developed direct cerebral perfusion parametric image reconstruction technique, TRAINER in short, the quantitative perfusion images have been represented as a subject-specific conditional generative model trained under the constraint of the time-resolved CT forward model, perfusion convolutional model, and the subject's own measured sinogram data. Results shown in this paper demonstrated that using TRAINER, quantitative cerebral perfusion images can be accurately obtained using C-arm CBCT in the interventional suite.

Guided MRI Reconstruction via Schrödinger Bridge

Magnetic Resonance Imaging (MRI) is a multi-contrast imaging technique in which different contrast images share similar structural information. However, conventional diffusion models struggle to effectively leverage this structural similarity. Recently, the Schr\"odinger Bridge (SB), a nonlinear extension of the diffusion model, has been proposed to establish diffusion paths between any distributions, allowing the incorporation of guided priors. This study proposes an SB-based, multi-contrast image-guided reconstruction framework that establishes a diffusion bridge between the guiding and target image distributions. By using the guiding image along with data consistency during sampling, the target image is reconstructed more accurately. To better address structural differences between images, we introduce an inversion strategy from the field of image editing, termed $\mathbf{I}^2$SB-inversion. Experiments on a paried T1 and T2-FLAIR datasets demonstrate that $\mathbf{I}^2$SB-inversion achieve a high acceleration up to 14.4 and outperforms existing methods in terms of both reconstruction accuracy and stability.

Sub-DM:Subspace Diffusion Model with Orthogonal Decomposition for MRI Reconstruction

Diffusion model-based approaches recently achieved re-markable success in MRI reconstruction, but integration into clinical routine remains challenging due to its time-consuming convergence. This phenomenon is partic-ularly notable when directly apply conventional diffusion process to k-space data without considering the inherent properties of k-space sampling, limiting k-space learning efficiency and image reconstruction quality. To tackle these challenges, we introduce subspace diffusion model with orthogonal decomposition, a method (referred to as Sub-DM) that restrict the diffusion process via projections onto subspace as the k-space data distribution evolves toward noise. Particularly, the subspace diffusion model circumvents the inference challenges posed by the com-plex and high-dimensional characteristics of k-space data, so the highly compact subspace ensures that diffusion process requires only a few simple iterations to produce accurate prior information. Furthermore, the orthogonal decomposition strategy based on wavelet transform hin-ders the information loss during the migration of the vanilla diffusion process to the subspace. Considering the strate-gy is approximately reversible, such that the entire pro-cess can be reversed. As a result, it allows the diffusion processes in different spaces to refine models through a mutual feedback mechanism, enabling the learning of ac-curate prior even when dealing with complex k-space data. Comprehensive experiments on different datasets clearly demonstrate that the superiority of Sub-DM against state of-the-art methods in terms of reconstruction speed and quality.

Zero-shot Dynamic MRI Reconstruction with Global-to-local Diffusion Model

Diffusion models have recently demonstrated considerable advancement in the generation and reconstruction of magnetic resonance imaging (MRI) data. These models exhibit great potential in handling unsampled data and reducing noise, highlighting their promise as generative models. However, their application in dynamic MRI remains relatively underexplored. This is primarily due to the substantial amount of fully-sampled data typically required for training, which is difficult to obtain in dynamic MRI due to its spatio-temporal complexity and high acquisition costs. To address this challenge, we propose a dynamic MRI reconstruction method based on a time-interleaved acquisition scheme, termed the Glob-al-to-local Diffusion Model. Specifically, fully encoded full-resolution reference data are constructed by merging under-sampled k-space data from adjacent time frames, generating two distinct bulk training datasets for global and local models. The global-to-local diffusion framework alternately optimizes global information and local image details, enabling zero-shot reconstruction. Extensive experiments demonstrate that the proposed method performs well in terms of noise reduction and detail preservation, achieving reconstruction quality comparable to that of supervised approaches.

Theoretical Investigations and Practical Enhancements on Tail Task Risk Minimization in Meta Learning

Meta learning is a promising paradigm in the era of large models and task distributional robustness has become an indispensable consideration in real-world scenarios. Recent advances have examined the effectiveness of tail task risk minimization in fast adaptation robustness improvement \citep{wang2023simple}. This work contributes to more theoretical investigations and practical enhancements in the field. Specifically, we reduce the distributionally robust strategy to a max-min optimization problem, constitute the Stackelberg equilibrium as the solution concept, and estimate the convergence rate. In the presence of tail risk, we further derive the generalization bound, establish connections with estimated quantiles, and practically improve the studied strategy. Accordingly, extensive evaluations demonstrate the significance of our proposal and its scalability to multimodal large models in boosting robustness.