Vibe Medicine: Redefining Biomedical Research Through Human-AI Co-Work

With the emergence of large language models (LLMs) and AI agent frameworks, the human-AI co-work paradigm known as Vibe Coding is changing how people code, making it more accessible and productive. In scientific research, where workflows are more complex and the burden of specialized labor limits independent researchers and those in low-resource areas, the potential impact is even greater, particularly in biomedicine, which involves heterogeneous data modalities and multi-step analytical pipelines. In this paper, we introduce Vibe Medicine, a co-work paradigm in which clinicians and researchers direct skill-augmented AI agents through natural language to execute complex, multi-step biomedical workflows, while retaining the role of research director who specifies objectives, reviews intermediate results, and makes domain-informed decisions. The enabling infrastructure consists of three layers: capable LLMs, agent frameworks such as OpenClaw and Hermes Agent, and the OpenClaw medical skills collection, which includes more than 1,000 curated skills from multiple open-source repositories. We analyze the architecture and skill categories of this collection across ten biomedical domains, and present case studies covering rare disease diagnosis, drug repurposing, and clinical trial design that demonstrate end-to-end workflows in practice. We also identify the principal risks, such as hallucination, data privacy, and over-reliance, and outline directions toward more reliable, trustworthy, and clinically integrated agent-assisted research that advances research and technological equity and reduces health care resource disparities.

JoyAI-RA 0.1: A Foundation Model for Robotic Autonomy

Robotic autonomy in open-world environments is fundamentally limited by insufficient data diversity and poor cross-embodiment generalization. Existing robotic datasets are often limited in scale and task coverage, while relatively large differences across robot embodiments impede effective behavior knowledge transfer. To address these challenges, we propose JoyAI-RA, a vision-language-action (VLA) embodied foundation model tailored for generalizable robotic manipulation. JoyAI-RA presents a multi-source multi-level pretraining framework that integrates web data, large-scale egocentric human manipulation videos, simulation-generated trajectories, and real-robot data. Through training on heterogeneous multi-source data with explicit action-space unification, JoyAI-RA effectively bridges embodiment gaps, particularly between human manipulation and robotic control, thereby enhancing cross-embodiment behavior learning. JoyAI-RA outperforms state-of-the-art methods in both simulation and real-world benchmarks, especially on diverse tasks with generalization demands.

Dual-Anchoring: Addressing State Drift in Vision-Language Navigation

Vision-Language Navigation(VLN) requires an agent to navigate through 3D environments by following natural language instructions. While recent Video Large Language Models(Video-LLMs) have largely advanced VLN, they remain highly susceptible to State Drift in long scenarios. In these cases, the agent's internal state drifts away from the true task execution state, leading to aimless wandering and failure to execute essential maneuvers in the instruction. We attribute this failure to two distinct cognitive deficits: Progress Drift, where the agent fails to distinguish completed sub-goals from remaining ones, and Memory Drift, where the agent's history representations degrade, making it lose track of visited landmarks. In this paper, we propose a Dual-Anchoring Framework that explicitly anchors the instruction progress and history representations. First, to address progress drift, we introduce Instruction Progress Anchoring, which supervises the agent to generate structured text tokens that delineate completed versus remaining sub-goals. Second, to mitigate memory drift, we propose Memory Landmark Anchoring, which utilizes a Landmark-Centric World Model to retrospectively predict object-centric embeddings extracted by the Segment Anything Model, compelling the agent to explicitly verify past observations and preserve distinct representations of visited landmarks. Facilitating this framework, we curate two extensive datasets: 3.6 million samples with explicit progress descriptions, and 937k grounded landmark data for retrospective verification. Extensive experiments in both simulation and real-world environments demonstrate the superiority of our method, achieving a 15.2% improvement in Success Rate and a remarkable 24.7% gain on long-horizon trajectories. To facilitate further research, we will release our code, data generation pipelines, and the collected datasets.

Think before Go: Hierarchical Reasoning for Image-goal Navigation

Image-goal navigation steers an agent to a target location specified by an image in unseen environments. Existing methods primarily handle this task by learning an end-to-end navigation policy, which compares the similarities of target and observation images and directly predicts the actions. However, when the target is distant or lies in another room, such methods fail to extract informative visual cues, leading the agent to wander around. Motivated by the human cognitive principle that deliberate, high-level reasoning guides fast, reactive execution in complex tasks, we propose Hierarchical Reasoning Navigation (HRNav), a framework that decomposes image-goal navigation into high-level planning and low-level execution. In high-level planning, a vision-language model is trained on a self-collected dataset to generate a short-horizon plan, such as whether the agent should walk through the door or down the hallway. This downgrades the difficulty of the long-horizon task, making it more amenable to the execution part. In low-level execution, an online reinforcement learning policy is utilized to decide actions conditioned on the short-horizon plan. We also devise a novel Wandering Suppression Penalty (WSP) to further reduce the wandering problem. Together, these components form a hierarchical framework for Image-Goal Navigation. Extensive experiments in both simulation and real-world environments demonstrate the superiority of our method.

One-shot learning for the complex dynamical behaviors of weakly nonlinear forced oscillators

Extrapolative prediction of complex nonlinear dynamics remains a central challenge in engineering. This study proposes a one-shot learning method to identify global frequency-response curves from a single excitation time history by learning governing equations. We introduce MEv-SINDy (Multi-frequency Evolutionary Sparse Identification of Nonlinear Dynamics) to infer the governing equations of non-autonomous and multi-frequency systems. The methodology leverages the Generalized Harmonic Balance (GHB) method to decompose complex forced responses into a set of slow-varying evolution equations. We validated the capabilities of MEv-SINDy on two critical Micro-Electro-Mechanical Systems (MEMS). These applications include a nonlinear beam resonator and a MEMS micromirror. Our results show that the model trained on a single point accurately predicts softening/hardening effects and jump phenomena across a wide range of excitation levels. This approach significantly reduces the data acquisition burden for the characterization and design of nonlinear microsystems.

MARS-Dragonfly: Agile and Robust Flight Control of Modular Aerial Robot Systems

Modular Aerial Robot Systems (MARS) comprise multiple drone units with reconfigurable connected formations, providing high adaptability to diverse mission scenarios, fault conditions, and payload capacities. However, existing control algorithms for MARS rely on simplified quasi-static models and rule-based allocation, which generate discontinuous and unbounded motor commands. This leads to attitude error accumulation as the number of drone units scales, ultimately causing severe oscillations during docking, separation, and waypoint tracking. To address these limitations, we first design a compact mechanical system that enables passive docking, detection-free passive locking, and magnetic-assisted separation using a single micro servo. Second, we introduce a force-torque-equivalent and polytope-constraint virtual quadrotor that explicitly models feasible wrench sets. Together, these abstractions capture the full MARS dynamics and enable existing quadrotor controllers to be applied across different configurations. We further optimize the yaw angle that maximizes control authority to enhance agility. Third, building on this abstraction, we design a two-stage predictive-allocation pipeline: a constrained predictive tracker computes virtual inputs while respecting force/torque bounds, and a dynamic allocator maps these inputs to individual modules with balanced objectives to produce smooth, trackable motor commands. Simulations across over 10 configurations and real-world experiments demonstrate stable docking, locking, and separation, as well as effective control performance. To our knowledge, this is the first real-world demonstration of MARS achieving agile flight and transport with 40 deg peak pitch while maintaining an average position error of 0.0896 m. The video is available at: https://youtu.be/yqjccrIpz5o

DyGeoVLN: Infusing Dynamic Geometry Foundation Model into Vision-Language Navigation

Vision-language Navigation (VLN) requires an agent to understand visual observations and language instructions to navigate in unseen environments. Most existing approaches rely on static scene assumptions and struggle to generalize in dynamic, real-world scenarios. To address this challenge, we propose DyGeoVLN, a dynamic geometry-aware VLN framework. Our method infuses a dynamic geometry foundation model into the VLN framework through cross-branch feature fusion to enable explicit 3D spatial representation and visual-semantic reasoning. To efficiently compress historical token information in long-horizon, dynamic navigation, we further introduce a novel pose-free and adaptive-resolution token-pruning strategy. This strategy can remove spatio-temporal redundant tokens to reduce inference cost. Extensive experiments demonstrate that our approach achieves state-of-the-art performance on multiple benchmarks and exhibits strong robustness in real-world environments.

One-Step Sampler for Boltzmann Distributions via Drifting

We present a drifting-based framework for amortized sampling of Boltzmann distributions defined by energy functions. The method trains a one-step neural generator by projecting samples along a Gaussian-smoothed score field from the current model distribution toward the target Boltzmann distribution. For targets specified only up to an unknown normalization constant, we derive a practical target-side drift from a smoothed energy and use two estimators: a local importance-sampling mean-shift estimator and a second-order curvature-corrected approximation. Combined with a mini-batch Gaussian mean-shift estimate of the sampler-side smoothed score, this yields a simple stop-gradient objective for stable one-step training. On a four-mode Gaussian-mixture Boltzmann target, our sampler achieves mean error $0.0754$, covariance error $0.0425$, and RBF MMD $0.0020$. Additional double-well and banana targets show that the same formulation also handles nonconvex and curved low-energy geometries. Overall, the results support drifting as an effective way to amortize iterative sampling from Boltzmann distributions into a single forward pass at test time.

Not All Directions Matter: Toward Structured and Task-Aware Low-Rank Adaptation

Low-Rank Adaptation (LoRA) has become a cornerstone of parameter-efficient fine-tuning (PEFT). Yet, its efficacy is hampered by two fundamental limitations: semantic drift, by treating all update directions with equal importance, and structural incoherence, from adapting layers independently, resulting in suboptimal, uncoordinated updates. To remedy these, we propose StructLoRA, a framework that addresses both limitations through a principled, dual-component design: (1) an Information Bottleneck-guided filter that prunes task-irrelevant directions to mitigate semantic drift, and (2) a lightweight, training-only graph-based coordinator that enforces inter-layer consistency to resolve structural incoherence. Extensive experiments across large language model , vision language model, and vision model (including LLaMA, LLaVA, and ViT) demonstrate that StructLoRA consistently establishes a new state-of-the-art, outperforming not only vanilla LoRA but also advanced dynamic rank allocation and sparsity-based methods. Notably, the benefits are particularly pronounced in challenging low-rank and low-data regimes. Crucially, since our proposed modules operate only during training, StructLoRA enhances performance with zero additional inference cost, advancing the focus of PEFT -- from mere parameter compression to a more holistic optimization of information quality and structural integrity.

Neural Functional Alignment Space: Brain-Referenced Representation of Artificial Neural Networks

We propose the Neural Functional Alignment Space (NFAS), a brain-referenced representational framework for characterizing artificial neural networks on equal functional grounds. NFAS departs from conventional alignment approaches that rely on layer-wise features or task-specific activations by modeling the intrinsic dynamical evolution of stimulus representations across network depth. Specifically, we model layer-wise embeddings as a depth-wise dynamical trajectory and apply Dynamic Mode Decomposition (DMD) to extract the stable mode. This representation is then projected into a biologically anchored coordinate system defined by distributed neural responses. We also introduce the Signal-to-Noise Consistency Index (SNCI) to quantify cross-model consistency at the modality level. Across 45 pretrained models spanning vision, audio, and language, NFAS reveals structured organization within this brain-referenced space, including modality-specific clustering and cross-modal convergence in integrative cortical systems. Our findings suggest that representation dynamics provide a principled basis for