VenusFactory: A Unified Platform for Protein Engineering Data Retrieval and Language Model Fine-Tuning

Natural language processing (NLP) has significantly influenced scientific domains beyond human language, including protein engineering, where pre-trained protein language models (PLMs) have demonstrated remarkable success. However, interdisciplinary adoption remains limited due to challenges in data collection, task benchmarking, and application. This work presents VenusFactory, a versatile engine that integrates biological data retrieval, standardized task benchmarking, and modular fine-tuning of PLMs. VenusFactory supports both computer science and biology communities with choices of both a command-line execution and a Gradio-based no-code interface, integrating $40+$ protein-related datasets and $40+$ popular PLMs. All implementations are open-sourced on https://github.com/tyang816/VenusFactory.

Robust Audio-Visual Segmentation via Audio-Guided Visual Convergent Alignment

Accurately localizing audible objects based on audio-visual cues is the core objective of audio-visual segmentation. Most previous methods emphasize spatial or temporal multi-modal modeling, yet overlook challenges from ambiguous audio-visual correspondences such as nearby visually similar but acoustically different objects and frequent shifts in objects' sounding status. Consequently, they may struggle to reliably correlate audio and visual cues, leading to over- or under-segmentation. To address these limitations, we propose a novel framework with two primary components: an audio-guided modality alignment (AMA) module and an uncertainty estimation (UE) module. Instead of indiscriminately correlating audio-visual cues through a global attention mechanism, AMA performs audio-visual interactions within multiple groups and consolidates group features into compact representations based on their responsiveness to audio cues, effectively directing the model's attention to audio-relevant areas. Leveraging contrastive learning, AMA further distinguishes sounding regions from silent areas by treating features with strong audio responses as positive samples and weaker responses as negatives. Additionally, UE integrates spatial and temporal information to identify high-uncertainty regions caused by frequent changes in sound state, reducing prediction errors by lowering confidence in these areas. Experimental results demonstrate that our approach achieves superior accuracy compared to existing state-of-the-art methods, particularly in challenging scenarios where traditional approaches struggle to maintain reliable segmentation.

Dynamic Derivation and Elimination: Audio Visual Segmentation with Enhanced Audio Semantics

Sound-guided object segmentation has drawn considerable attention for its potential to enhance multimodal perception. Previous methods primarily focus on developing advanced architectures to facilitate effective audio-visual interactions, without fully addressing the inherent challenges posed by audio natures, \emph{\ie}, (1) feature confusion due to the overlapping nature of audio signals, and (2) audio-visual matching difficulty from the varied sounds produced by the same object. To address these challenges, we propose Dynamic Derivation and Elimination (DDESeg): a novel audio-visual segmentation framework. Specifically, to mitigate feature confusion, DDESeg reconstructs the semantic content of the mixed audio signal by enriching the distinct semantic information of each individual source, deriving representations that preserve the unique characteristics of each sound. To reduce the matching difficulty, we introduce a discriminative feature learning module, which enhances the semantic distinctiveness of generated audio representations. Considering that not all derived audio representations directly correspond to visual features (e.g., off-screen sounds), we propose a dynamic elimination module to filter out non-matching elements. This module facilitates targeted interaction between sounding regions and relevant audio semantics. By scoring the interacted features, we identify and filter out irrelevant audio information, ensuring accurate audio-visual alignment. Comprehensive experiments demonstrate that our framework achieves superior performance in AVS datasets.

7ABAW-Compound Expression Recognition via Curriculum Learning

With the advent of deep learning, expression recognition has made significant advancements. However, due to the limited availability of annotated compound expression datasets and the subtle variations of compound expressions, Compound Emotion Recognition (CE) still holds considerable potential for exploration. To advance this task, the 7th Affective Behavior Analysis in-the-wild (ABAW) competition introduces the Compound Expression Challenge based on C-EXPR-DB, a limited dataset without labels. In this paper, we present a curriculum learning-based framework that initially trains the model on single-expression tasks and subsequently incorporates multi-expression data. This design ensures that our model first masters the fundamental features of basic expressions before being exposed to the complexities of compound emotions. Specifically, our designs can be summarized as follows: 1) Single-Expression Pre-training: The model is first trained on datasets containing single expressions to learn the foundational facial features associated with basic emotions. 2) Dynamic Compound Expression Generation: Given the scarcity of annotated compound expression datasets, we employ CutMix and Mixup techniques on the original single-expression images to create hybrid images exhibiting characteristics of multiple basic emotions. 3) Incremental Multi-Expression Integration: After performing well on single-expression tasks, the model is progressively exposed to multi-expression data, allowing the model to adapt to the complexity and variability of compound expressions. The official results indicate that our method achieves the \textbf{best} performance in this competition track with an F-score of 0.6063. Our code is released at https://github.com/YenanLiu/ABAW7th.

Generative Video Bi-flow

We propose a novel generative video model by robustly learning temporal change as a neural Ordinary Differential Equation (ODE) flow with a bilinear objective of combining two aspects: The first is to map from the past into future video frames directly. Previous work has mapped the noise to new frames, a more computationally expensive process. Unfortunately, starting from the previous frame, instead of noise, is more prone to drifting errors. Hence, second, we additionally learn how to remove the accumulated errors as the joint objective by adding noise during training. We demonstrate unconditional video generation in a streaming manner for various video datasets, all at competitive quality compared to a baseline conditional diffusion but with higher speed, i.e., fewer ODE solver steps.

Fast Adversarial Training against Sparse Attacks Requires Loss Smoothing

This paper studies fast adversarial training against sparse adversarial perturbations bounded by $l_0$ norm. We demonstrate the challenges of employing $1$-step attacks on $l_0$ bounded perturbations for fast adversarial training, including degraded performance and the occurrence of catastrophic overfitting (CO). We highlight that CO in $l_0$ adversarial training is caused by sub-optimal perturbation locations of $1$-step attack. Theoretical and empirical analyses reveal that the loss landscape of $l_0$ adversarial training is more craggy compared to its $l_\infty$, $l_2$ and $l_1$ counterparts. Moreover, we corroborate that the craggy loss landscape can aggravate CO. To address these issues, we propose Fast-LS-$l_0$ that incorporates soft labels and the trade-off loss function to smooth the adversarial loss landscape. Extensive experiments demonstrate our method can overcome the challenge of catastrophic overfitting, achieve state-of-the-art performance, and narrow down the performance gap between $1$-step and multi-step adversarial training against sparse attacks.

Not All Frame Features Are Equal: Video-to-4D Generation via Decoupling Dynamic-Static Features

Recently, the generation of dynamic 3D objects from a video has shown impressive results. Existing methods directly optimize Gaussians using whole information in frames. However, when dynamic regions are interwoven with static regions within frames, particularly if the static regions account for a large proportion, existing methods often overlook information in dynamic regions and are prone to overfitting on static regions. This leads to producing results with blurry textures. We consider that decoupling dynamic-static features to enhance dynamic representations can alleviate this issue. Thus, we propose a dynamic-static feature decoupling module (DSFD). Along temporal axes, it regards the portions of current frame features that possess significant differences relative to reference frame features as dynamic features. Conversely, the remaining parts are the static features. Then, we acquire decoupled features driven by dynamic features and current frame features. Moreover, to further enhance the dynamic representation of decoupled features from different viewpoints and ensure accurate motion prediction, we design a temporal-spatial similarity fusion module (TSSF). Along spatial axes, it adaptively selects a similar information of dynamic regions. Hinging on the above, we construct a novel approach, DS4D. Experimental results verify our method achieves state-of-the-art (SOTA) results in video-to-4D. In addition, the experiments on a real-world scenario dataset demonstrate its effectiveness on the 4D scene. Our code will be publicly available.

A Reversible Solver for Diffusion SDEs

Diffusion models have quickly become the state-of-the-art for generation tasks across many different data modalities. An important ability of diffusion models is the ability to encode samples from the data distribution back into the sampling prior distribution. This is useful for performing alterations to real data samples along with guided generation via the continuous adjoint equations. We propose an algebraically reversible solver for diffusion SDEs that can exactly invert real data samples into the prior distribution.

Greed is Good: Guided Generation from a Greedy Perspective

Training-free guided generation is a widely used and powerful technique that allows the end user to exert further control over the generative process of diffusion models. In this work, we explore the guided generation from the perspective of optimizing the solution trajectory of a neural differential equation in a greedy manner. We present such a strategy as a unifying view on training-free guidance by showing that the greedy strategy is a first-order discretization of end-to-end optimization techniques. We show that a greedy guidance strategy makes good decisions and compare it to a guidance strategy using the ideal gradients found via the continuous adjoint equations. We then show how other popular training-free guidance strategies can be viewed in a unified manner from this perspective.

Text-Driven Tumor Synthesis

Tumor synthesis can generate examples that AI often misses or over-detects, improving AI performance by training on these challenging cases. However, existing synthesis methods, which are typically unconditional -- generating images from random variables -- or conditioned only by tumor shapes, lack controllability over specific tumor characteristics such as texture, heterogeneity, boundaries, and pathology type. As a result, the generated tumors may be overly similar or duplicates of existing training data, failing to effectively address AI's weaknesses. We propose a new text-driven tumor synthesis approach, termed TextoMorph, that provides textual control over tumor characteristics. This is particularly beneficial for examples that confuse the AI the most, such as early tumor detection (increasing Sensitivity by +8.5%), tumor segmentation for precise radiotherapy (increasing DSC by +6.3%), and classification between benign and malignant tumors (improving Sensitivity by +8.2%). By incorporating text mined from radiology reports into the synthesis process, we increase the variability and controllability of the synthetic tumors to target AI's failure cases more precisely. Moreover, TextoMorph uses contrastive learning across different texts and CT scans, significantly reducing dependence on scarce image-report pairs (only 141 pairs used in this study) by leveraging a large corpus of 34,035 radiology reports. Finally, we have developed rigorous tests to evaluate synthetic tumors, including Text-Driven Visual Turing Test and Radiomics Pattern Analysis, showing that our synthetic tumors is realistic and diverse in texture, heterogeneity, boundaries, and pathology.