On Improved Conditioning Mechanisms and Pre-training Strategies for Diffusion Models

Large-scale training of latent diffusion models (LDMs) has enabled unprecedented quality in image generation. However, the key components of the best performing LDM training recipes are oftentimes not available to the research community, preventing apple-to-apple comparisons and hindering the validation of progress in the field. In this work, we perform an in-depth study of LDM training recipes focusing on the performance of models and their training efficiency. To ensure apple-to-apple comparisons, we re-implement five previously published models with their corresponding recipes. Through our study, we explore the effects of (i)~the mechanisms used to condition the generative model on semantic information (e.g., text prompt) and control metadata (e.g., crop size, random flip flag, etc.) on the model performance, and (ii)~the transfer of the representations learned on smaller and lower-resolution datasets to larger ones on the training efficiency and model performance. We then propose a novel conditioning mechanism that disentangles semantic and control metadata conditionings and sets a new state-of-the-art in class-conditional generation on the ImageNet-1k dataset -- with FID improvements of 7% on 256 and 8% on 512 resolutions -- as well as text-to-image generation on the CC12M dataset -- with FID improvements of 8% on 256 and 23% on 512 resolution.

Exact Byte-Level Probabilities from Tokenized Language Models for FIM-Tasks and Model Ensembles

Tokenization is associated with many poorly understood shortcomings in language models (LMs), yet remains an important component for long sequence scaling purposes. This work studies how tokenization impacts model performance by analyzing and comparing the stochastic behavior of tokenized models with their byte-level, or token-free, counterparts. We discover that, even when the two models are statistically equivalent, their predictive distributions over the next byte can be substantially different, a phenomenon we term as "tokenization bias''. To fully characterize this phenomenon, we introduce the Byte-Token Representation Lemma, a framework that establishes a mapping between the learned token distribution and its equivalent byte-level distribution. From this result, we develop a next-byte sampling algorithm that eliminates tokenization bias without requiring further training or optimization. In other words, this enables zero-shot conversion of tokenized LMs into statistically equivalent token-free ones. We demonstrate its broad applicability with two use cases: fill-in-the-middle (FIM) tasks and model ensembles. In FIM tasks where input prompts may terminate mid-token, leading to out-of-distribution tokenization, our method mitigates performance degradation and achieves an approximately 18% improvement in FIM coding benchmarks, consistently outperforming the standard token healing fix. For model ensembles where each model employs a distinct vocabulary, our approach enables seamless integration, resulting in improved performance (up to 3.7%) over individual models across various standard baselines in reasoning, knowledge, and coding.

Understanding and Mitigating Tokenization Bias in Language Models

State-of-the-art language models are autoregressive and operate on subword units known as tokens. Specifically, one must encode the conditioning string into a list of tokens before passing to the language models for next-token prediction. We show that, for encoding schemes such as maximum prefix matching, tokenization induces a sampling bias that cannot be mitigated with more training or data. To counter this universal problem, we propose a novel algorithm to obtain unbiased estimates from a model that was trained on tokenized data. Our method does not require finetuning the model, and its complexity, defined as the number of model runs, scales linearly with the sequence length. As a consequence, we show that one can simulate token-free behavior from a tokenized language model. We empirically verify the correctness of our method through a Markov-chain setup, where it accurately recovers the transition probabilities, as opposed to the conventional method of directly prompting tokens into the language model.

Consistency-diversity-realism Pareto fronts of conditional image generative models

Building world models that accurately and comprehensively represent the real world is the utmost aspiration for conditional image generative models as it would enable their use as world simulators. For these models to be successful world models, they should not only excel at image quality and prompt-image consistency but also ensure high representation diversity. However, current research in generative models mostly focuses on creative applications that are predominantly concerned with human preferences of image quality and aesthetics. We note that generative models have inference time mechanisms - or knobs - that allow the control of generation consistency, quality, and diversity. In this paper, we use state-of-the-art text-to-image and image-and-text-to-image models and their knobs to draw consistency-diversity-realism Pareto fronts that provide a holistic view on consistency-diversity-realism multi-objective. Our experiments suggest that realism and consistency can both be improved simultaneously; however there exists a clear tradeoff between realism/consistency and diversity. By looking at Pareto optimal points, we note that earlier models are better at representation diversity and worse in consistency/realism, and more recent models excel in consistency/realism while decreasing significantly the representation diversity. By computing Pareto fronts on a geodiverse dataset, we find that the first version of latent diffusion models tends to perform better than more recent models in all axes of evaluation, and there exist pronounced consistency-diversity-realism disparities between geographical regions. Overall, our analysis clearly shows that there is no best model and the choice of model should be determined by the downstream application. With this analysis, we invite the research community to consider Pareto fronts as an analytical tool to measure progress towards world models.

Advancing human-centric AI for robust X-ray analysis through holistic self-supervised learning

AI Foundation models are gaining traction in various applications, including medical fields like radiology. However, medical foundation models are often tested on limited tasks, leaving their generalisability and biases unexplored. We present RayDINO, a large visual encoder trained by self-supervision on 873k chest X-rays. We compare RayDINO to previous state-of-the-art models across nine radiology tasks, from classification and dense segmentation to text generation, and provide an in depth analysis of population, age and sex biases of our model. Our findings suggest that self-supervision allows patient-centric AI proving useful in clinical workflows and interpreting X-rays holistically. With RayDINO and small task-specific adapters, we reach state-of-the-art results and improve generalization to unseen populations while mitigating bias, illustrating the true promise of foundation models: versatility and robustness.

Residual Quantization with Implicit Neural Codebooks

Vector quantization is a fundamental operation for data compression and vector search. To obtain high accuracy, multi-codebook methods increase the rate by representing each vector using codewords across multiple codebooks. Residual quantization (RQ) is one such method, which increases accuracy by iteratively quantizing the error of the previous step. The error distribution is dependent on previously selected codewords. This dependency is, however, not accounted for in conventional RQ as it uses a generic codebook per quantization step. In this paper, we propose QINCo, a neural RQ variant which predicts specialized codebooks per vector using a neural network that is conditioned on the approximation of the vector from previous steps. Experiments show that QINCo outperforms state-of-the-art methods by a large margin on several datasets and code sizes. For example, QINCo achieves better nearest-neighbor search accuracy using 12 bytes codes than other methods using 16 bytes on the BigANN and Deep1B dataset.

Latent Discretization for Continuous-time Sequence Compression

Neural compression offers a domain-agnostic approach to creating codecs for lossy or lossless compression via deep generative models. For sequence compression, however, most deep sequence models have costs that scale with the sequence length rather than the sequence complexity. In this work, we instead treat data sequences as observations from an underlying continuous-time process and learn how to efficiently discretize while retaining information about the full sequence. As a consequence of decoupling sequential information from its temporal discretization, our approach allows for greater compression rates and smaller computational complexity. Moreover, the continuous-time approach naturally allows us to decode at different time intervals. We empirically verify our approach on multiple domains involving compression of video and motion capture sequences, showing that our approaches can automatically achieve reductions in bit rates by learning how to discretize.

On learning adaptive acquisition policies for undersampled multi-coil MRI reconstruction

Most current approaches to undersampled multi-coil MRI reconstruction focus on learning the reconstruction model for a fixed, equidistant acquisition trajectory. In this paper, we study the problem of joint learning of the reconstruction model together with acquisition policies. To this end, we extend the End-to-End Variational Network with learnable acquisition policies that can adapt to different data points. We validate our model on a coil-compressed version of the large scale undersampled multi-coil fastMRI dataset using two undersampling factors: $4\times$ and $8\times$. Our experiments show on-par performance with the learnable non-adaptive and handcrafted equidistant strategies at $4\times$, and an observed improvement of more than $2\%$ in SSIM at $8\times$ acceleration, suggesting that potentially-adaptive $k$-space acquisition trajectories can improve reconstructed image quality for larger acceleration factors. However, and perhaps surprisingly, our best performing policies learn to be explicitly non-adaptive.

COVID-19 Prognosis via Self-Supervised Representation Learning and Multi-Image Prediction

The rapid spread of COVID-19 cases in recent months has strained hospital resources, making rapid and accurate triage of patients presenting to emergency departments a necessity. Machine learning techniques using clinical data such as chest X-rays have been used to predict which patients are most at risk of deterioration. We consider the task of predicting two types of patient deterioration based on chest X-rays: adverse event deterioration (i.e., transfer to the intensive care unit, intubation, or mortality) and increased oxygen requirements beyond 6 L per day. Due to the relative scarcity of COVID-19 patient data, existing solutions leverage supervised pretraining on related non-COVID images, but this is limited by the differences between the pretraining data and the target COVID-19 patient data. In this paper, we use self-supervised learning based on the momentum contrast (MoCo) method in the pretraining phase to learn more general image representations to use for downstream tasks. We present three results. The first is deterioration prediction from a single image, where our model achieves an area under receiver operating characteristic curve (AUC) of 0.742 for predicting an adverse event within 96 hours (compared to 0.703 with supervised pretraining) and an AUC of 0.765 for predicting oxygen requirements greater than 6 L a day at 24 hours (compared to 0.749 with supervised pretraining). We then propose a new transformer-based architecture that can process sequences of multiple images for prediction and show that this model can achieve an improved AUC of 0.786 for predicting an adverse event at 96 hours and an AUC of 0.848 for predicting mortalities at 96 hours. A small pilot clinical study suggested that the prediction accuracy of our model is comparable to that of experienced radiologists analyzing the same information.