MIO: A Foundation Model on Multimodal Tokens

In this paper, we introduce MIO, a novel foundation model built on multimodal tokens, capable of understanding and generating speech, text, images, and videos in an end-to-end, autoregressive manner. While the emergence of large language models (LLMs) and multimodal large language models (MM-LLMs) propels advancements in artificial general intelligence through their versatile capabilities, they still lack true any-to-any understanding and generation. Recently, the release of GPT-4o has showcased the remarkable potential of any-to-any LLMs for complex real-world tasks, enabling omnidirectional input and output across images, speech, and text. However, it is closed-source and does not support the generation of multimodal interleaved sequences. To address this gap, we present MIO, which is trained on a mixture of discrete tokens across four modalities using causal multimodal modeling. MIO undergoes a four-stage training process: (1) alignment pre-training, (2) interleaved pre-training, (3) speech-enhanced pre-training, and (4) comprehensive supervised fine-tuning on diverse textual, visual, and speech tasks. Our experimental results indicate that MIO exhibits competitive, and in some cases superior, performance compared to previous dual-modal baselines, any-to-any model baselines, and even modality-specific baselines. Moreover, MIO demonstrates advanced capabilities inherent to its any-to-any feature, such as interleaved video-text generation, chain-of-visual-thought reasoning, visual guideline generation, instructional image editing, etc.

Large Language Models for Disease Diagnosis: A Scoping Review

Automatic disease diagnosis has become increasingly valuable in clinical practice. The advent of large language models (LLMs) has catalyzed a paradigm shift in artificial intelligence, with growing evidence supporting the efficacy of LLMs in diagnostic tasks. Despite the growing attention in this field, many critical research questions remain under-explored. For instance, what diseases and LLM techniques have been investigated for diagnostic tasks? How can suitable LLM techniques and evaluation methods be selected for clinical decision-making? To answer these questions, we performed a comprehensive analysis of LLM-based methods for disease diagnosis. This scoping review examined the types of diseases, associated organ systems, relevant clinical data, LLM techniques, and evaluation methods reported in existing studies. Furthermore, we offered guidelines for data preprocessing and the selection of appropriate LLM techniques and evaluation strategies for diagnostic tasks. We also assessed the limitations of current research and delineated the challenges and future directions in this research field. In summary, our review outlined a blueprint for LLM-based disease diagnosis, helping to streamline and guide future research endeavors.

Interpretable Differential Diagnosis with Dual-Inference Large Language Models

Methodological advancements to automate the generation of differential diagnosis (DDx) to predict a list of potential diseases as differentials given patients' symptom descriptions are critical to clinical reasoning and applications such as decision support. However, providing reasoning or interpretation for these differential diagnoses is more meaningful. Fortunately, large language models (LLMs) possess powerful language processing abilities and have been proven effective in various related tasks. Motivated by this potential, we investigate the use of LLMs for interpretable DDx. First, we develop a new DDx dataset with expert-derived interpretation on 570 public clinical notes. Second, we propose a novel framework, named Dual-Inf, that enables LLMs to conduct bidirectional inference for interpretation. Both human and automated evaluation demonstrate the effectiveness of Dual-Inf in predicting differentials and diagnosis explanations. Specifically, the performance improvement of Dual-Inf over the baseline methods exceeds 32% w.r.t. BERTScore in DDx interpretation. Furthermore, experiments verify that Dual-Inf (1) makes fewer errors in interpretation, (2) has great generalizability, (3) is promising for rare disease diagnosis and explanation.

Towards a Client-Centered Assessment of LLM Therapists by Client Simulation

Although there is a growing belief that LLMs can be used as therapists, exploring LLMs' capabilities and inefficacy, particularly from the client's perspective, is limited. This work focuses on a client-centered assessment of LLM therapists with the involvement of simulated clients, a standard approach in clinical medical education. However, there are two challenges when applying the approach to assess LLM therapists at scale. Ethically, asking humans to frequently mimic clients and exposing them to potentially harmful LLM outputs can be risky and unsafe. Technically, it can be difficult to consistently compare the performances of different LLM therapists interacting with the same client. To this end, we adopt LLMs to simulate clients and propose ClientCAST, a client-centered approach to assessing LLM therapists by client simulation. Specifically, the simulated client is utilized to interact with LLM therapists and complete questionnaires related to the interaction. Based on the questionnaire results, we assess LLM therapists from three client-centered aspects: session outcome, therapeutic alliance, and self-reported feelings. We conduct experiments to examine the reliability of ClientCAST and use it to evaluate LLMs therapists implemented by Claude-3, GPT-3.5, LLaMA3-70B, and Mixtral 8*7B. Codes are released at https://github.com/wangjs9/ClientCAST.

Instruct Once, Chat Consistently in Multiple Rounds: An Efficient Tuning Framework for Dialogue

Tuning pretrained language models for dialogue generation has been a prevalent paradigm for building capable dialogue agents. Yet, traditional tuning narrowly views dialogue generation as resembling other language generation tasks, ignoring the role disparities between two speakers and the multi-round interactive process that dialogues ought to be. Such a manner leads to unsatisfactory chat consistency of the built agent. In this work, we emphasize the interactive, communicative nature of dialogue and argue that it is more feasible to model the speaker roles of agent and user separately, enabling the agent to adhere to its role consistently. We propose an efficient Multi-round Interactive Dialogue Tuning (Midi-Tuning) framework. It models the agent and user individually with two adapters built upon large language models, where they utilize utterances round by round in alternating order and are tuned via a round-level memory caching mechanism. Extensive experiments demonstrate that, our framework performs superior to traditional fine-tuning and harbors the tremendous potential for improving dialogue consistency.

Mitigating Unhelpfulness in Emotional Support Conversations with Multifaceted AI Feedback

An emotional support conversation system aims to alleviate users' emotional distress and assist them in addressing their challenges. To generate supportive responses, it is critical to consider multiple factors such as empathy, support strategies, and response coherence, as established in prior methods. Nonetheless, previous models occasionally generate unhelpful responses, which intend to provide support but display counterproductive effects. According to psychology and communication theories, poor performance in just one contributing factor might cause a response to be unhelpful. From the model training perspective, since these models have not been exposed to unhelpful responses during their training phase, they are unable to distinguish if the tokens they generate might result in unhelpful responses during inference. To address this issue, we introduce a novel model-agnostic framework named mitigating unhelpfulness with multifaceted AI feedback for emotional support (Muffin). Specifically, Muffin employs a multifaceted AI feedback module to assess the helpfulness of responses generated by a specific model with consideration of multiple factors. Using contrastive learning, it then reduces the likelihood of the model generating unhelpful responses compared to the helpful ones. Experimental results demonstrate that Muffin effectively mitigates the generation of unhelpful responses while slightly increasing response fluency and relevance.

How Far Are We from Believable AI Agents? A Framework for Evaluating the Believability of Human Behavior Simulation

Human behavior simulation of AI agents necessitates the agents to possess a quality of believability, which is crucial as it facilitates users in establishing trust toward the agents and streamlines the fulfillment of the agents' goal. While recent advancements in Large Language Model (LLM) based agents have improved human behavior simulation, challenges inherent to LLMs (e.g., long context modeling) can undermine their believability. Consequently, evaluating AI agent believability becomes imperative. Unfortunately, prior research often neglects the negative impacts of LLM deficiencies. To address these gaps, we introduce two metrics for assessing LLM-based agent believability: consistency, and robustness, together with a benchmark, SimulateBench, with which, we evaluate the consistency and robustness of agents implemented with popular LLMs. We find that agents (i) struggle to accurately depict character information when presented with lengthy profile inputs; (ii) exhibit vulnerability to profile perturbations; and (iii) are significantly affected by certain key factors that impact their overall believability. Code and SimulateBench are public at https://github.com/GAIR-NLP/GPTMan.

Self-Detoxifying Language Models via Toxification Reversal

Language model detoxification aims to minimize the risk of generating offensive or harmful content in pretrained language models (PLMs) for safer deployment. Existing methods can be roughly categorized as finetuning-based and decoding-based. However, the former is often resource-intensive, while the latter relies on additional components and potentially compromises the generation fluency. In this paper, we propose a more lightweight approach that enables the PLM itself to achieve "self-detoxification". Our method is built upon the observation that prepending a negative steering prompt can effectively induce PLMs to generate toxic content. At the same time, we are inspired by the recent research in the interpretability field, which formulates the evolving contextualized representations within the PLM as an information stream facilitated by the attention layers. Drawing on this idea, we devise a method to identify the toxification direction from the normal generation process to the one prompted with the negative prefix, and then steer the generation to the reversed direction by manipulating the information movement within the attention layers. Experimental results show that our approach, without any fine-tuning or extra components, can achieve comparable performance with state-of-the-art methods.

Aligning Language Models with Human Preferences via a Bayesian Approach

In the quest to advance human-centric natural language generation (NLG) systems, ensuring alignment between NLG models and human preferences is crucial. For this alignment, current popular methods leverage a reinforcement learning (RL) approach with a reward model trained on feedback from humans. However, inherent disagreements due to the subjective nature of human preferences pose a significant challenge for training the reward model, resulting in a deterioration of the NLG performance. To tackle this issue, previous approaches typically rely on majority voting or averaging to consolidate multiple inconsistent preferences into a merged one. Although straightforward to understand and execute, such methods suffer from an inability to capture the nuanced degrees of disaggregation among humans and may only represent a specialized subset of individuals, thereby lacking the ability to quantitatively disclose the universality of human preferences. To address this challenge, this paper proposes a novel approach, which employs a Bayesian framework to account for the distribution of disagreements among human preferences as training a preference model, and names it as d-PM. Besides, considering the RL strategy's inefficient and complex training process over the training efficiency, we further propose utilizing the contrastive learning strategy to train the NLG model with the preference scores derived from the d-PM model. Extensive experiments on two human-centric NLG tasks, i.e., emotional support conversation and integrity "Rule-of-Thumb" generation, show that our method consistently exceeds previous SOTA models in both automatic and human evaluations.

CARE: Causality Reasoning for Empathetic Responses by Conditional Graph Generation

Recent approaches to empathetic response generation incorporate emotion causalities to enhance comprehension of both the user's feelings and experiences. However, these approaches suffer from two critical issues. First, they only consider causalities between the user's emotion and the user's experiences, and ignore those between the user's experiences. Second, they neglect interdependence among causalities and reason them independently. To solve the above problems, we expect to reason all plausible causalities interdependently and simultaneously, given the user's emotion, dialogue history, and future dialogue content. Then, we infuse these causalities into response generation for empathetic responses. Specifically, we design a new model, i.e., the Conditional Variational Graph Auto-Encoder (CVGAE), for the causality reasoning, and adopt a multi-source attention mechanism in the decoder for the causality infusion. We name the whole framework as CARE, abbreviated for CAusality Reasoning for Empathetic conversation. Experimental results indicate that our method achieves state-of-the-art performance.