A CT-guided Control Framework of a Robotic Flexible Endoscope for the Diagnosis of the Maxillary Sinusitis

Flexible endoscopes are commonly adopted in narrow and confined anatomical cavities due to their higher reachability and dexterity. However, prolonged and unintuitive manipulation of these endoscopes leads to an increased workload on surgeons and risks of collision. To address these challenges, this paper proposes a CT-guided control framework for the diagnosis of maxillary sinusitis by using a robotic flexible endoscope. In the CT-guided control framework, a feasible path to the target position in the maxillary sinus cavity for the robotic flexible endoscope is designed. Besides, an optimal control scheme is proposed to autonomously control the robotic flexible endoscope to follow the feasible path. This greatly improves the efficiency and reduces the workload for surgeons. Several experiments were conducted based on a widely utilized sinus phantom, and the results showed that the robotic flexible endoscope can accurately and autonomously follow the feasible path and reach the target position in the maxillary sinus cavity. The results also verified the feasibility of the CT-guided control framework, which contributes an effective approach to early diagnosis of sinusitis in the future.

Infusing clinical knowledge into tokenisers for language models

This study introduces a novel knowledge enhanced tokenisation mechanism, K-Tokeniser, for clinical text processing. Technically, at initialisation stage, K-Tokeniser populates global representations of tokens based on semantic types of domain concepts (such as drugs or diseases) from either a domain ontology like Unified Medical Language System or the training data of the task related corpus. At training or inference stage, sentence level localised context will be utilised for choosing the optimal global token representation to realise the semantic-based tokenisation. To avoid pretraining using the new tokeniser, an embedding initialisation approach is proposed to generate representations for new tokens. Using three transformer-based language models, a comprehensive set of experiments are conducted on four real-world datasets for evaluating K-Tokeniser in a wide range of clinical text analytics tasks including clinical concept and relation extraction, automated clinical coding, clinical phenotype identification, and clinical research article classification. Overall, our models demonstrate consistent improvements over their counterparts in all tasks. In particular, substantial improvements are observed in the automated clinical coding task with 13\% increase on Micro $F_1$ score. Furthermore, K-Tokeniser also shows significant capacities in facilitating quicker converge of language models. Specifically, using K-Tokeniser, the language models would only require 50\% of the training data to achieve the best performance of the baseline tokeniser using all training data in the concept extraction task and less than 20\% of the data for the automated coding task. It is worth mentioning that all these improvements require no pre-training process, making the approach generalisable.

Explainable Bayesian Recurrent Neural Smoother to Capture Global State Evolutionary Correlations

Through integrating the evolutionary correlations across global states in the bidirectional recursion, an explainable Bayesian recurrent neural smoother (EBRNS) is proposed for offline data-assisted fixed-interval state smoothing. At first, the proposed model, containing global states in the evolutionary interval, is transformed into an equivalent model with bidirectional memory. This transformation incorporates crucial global state information with support for bi-directional recursive computation. For the transformed model, the joint state-memory-trend Bayesian filtering and smoothing frameworks are derived by introducing the bidirectional memory iteration mechanism and offline data into Bayesian estimation theory. The derived frameworks are implemented using the Gaussian approximation to ensure analytical properties and computational efficiency. Finally, the neural network modules within EBRNS and its two-stage training scheme are designed. Unlike most existing approaches that artificially combine deep learning and model-based estimation, the bidirectional recursion and internal gated structures of EBRNS are naturally derived from Bayesian estimation theory, explainably integrating prior model knowledge, online measurement, and offline data. Experiments on representative real-world datasets demonstrate that the high smoothing accuracy of EBRNS is accompanied by data efficiency and a lightweight parameter scale.

Deterministic Computing Power Networking: Architecture, Technologies and Prospects

With the development of new Internet services such as computation-intensive and delay-sensitive tasks, the traditional "Best Effort" network transmission mode has been greatly challenged. The network system is urgently required to provide end-to-end transmission determinacy and computing determinacy for new applications to ensure the safe and efficient operation of services. Based on the research of the convergence of computing and networking, a new network paradigm named deterministic computing power networking (Det-CPN) is proposed. In this article, we firstly introduce the research advance of computing power networking. And then the motivations and scenarios of Det-CPN are analyzed. Following that, we present the system architecture, technological capabilities, workflow as well as key technologies for Det-CPN. Finally, the challenges and future trends of Det-CPN are analyzed and discussed.

TIA: A Teaching Intonation Assessment Dataset in Real Teaching Situations

Intonation is one of the important factors affecting the teaching language arts, so it is an urgent problem to be addressed by evaluating the teachers' intonation through artificial intelligence technology. However, the lack of an intonation assessment dataset has hindered the development of the field. To this end, this paper constructs a Teaching Intonation Assessment (TIA) dataset for the first time in real teaching situations. This dataset covers 9 disciplines, 396 teachers, total of 11,444 utterance samples with a length of 15 seconds. In order to test the validity of the dataset, this paper proposes a teaching intonation assessment model (TIAM) based on low-level and deep-level features of speech. The experimental results show that TIAM based on the dataset constructed in this paper is basically consistent with the results of manual evaluation, and the results are better than the baseline models, which proves the effectiveness of the evaluation model.

Ontology-Based and Weakly Supervised Rare Disease Phenotyping from Clinical Notes

Computational text phenotyping is the practice of identifying patients with certain disorders and traits from clinical notes. Rare diseases are challenging to be identified due to few cases available for machine learning and the need for data annotation from domain experts. We propose a method using ontologies and weak supervision, with recent pre-trained contextual representations from Bi-directional Transformers (e.g. BERT). The ontology-based framework includes two steps: (i) Text-to-UMLS, extracting phenotypes by contextually linking mentions to concepts in Unified Medical Language System (UMLS), with a Named Entity Recognition and Linking (NER+L) tool, SemEHR, and weak supervision with customised rules and contextual mention representation; (ii) UMLS-to-ORDO, matching UMLS concepts to rare diseases in Orphanet Rare Disease Ontology (ORDO). The weakly supervised approach is proposed to learn a phenotype confirmation model to improve Text-to-UMLS linking, without annotated data from domain experts. We evaluated the approach on three clinical datasets of discharge summaries and radiology reports from two institutions in the US and the UK. Our best weakly supervised method achieved 81.4% precision and 91.4% recall on extracting rare disease UMLS phenotypes from MIMIC-III discharge summaries. The overall pipeline processing clinical notes can surface rare disease cases, mostly uncaptured in structured data (manually assigned ICD codes). Results on radiology reports from MIMIC-III and NHS Tayside were consistent with the discharge summaries. We discuss the usefulness of the weak supervision approach and propose directions for future studies.

Rare Disease Identification from Clinical Notes with Ontologies and Weak Supervision

The identification of rare diseases from clinical notes with Natural Language Processing (NLP) is challenging due to the few cases available for machine learning and the need of data annotation from clinical experts. We propose a method using ontologies and weak supervision. The approach includes two steps: (i) Text-to-UMLS, linking text mentions to concepts in Unified Medical Language System (UMLS), with a named entity linking tool (e.g. SemEHR) and weak supervision based on customised rules and Bidirectional Encoder Representations from Transformers (BERT) based contextual representations, and (ii) UMLS-to-ORDO, matching UMLS concepts to rare diseases in Orphanet Rare Disease Ontology (ORDO). Using MIMIC-III discharge summaries as a case study, we show that the Text-to-UMLS process can be greatly improved with weak supervision, without any annotated data from domain experts. Our analysis shows that the overall pipeline processing discharge summaries can surface rare disease cases, which are mostly uncaptured in manual ICD codes of the hospital admissions.