MALADE: Orchestration of LLM-powered Agents with Retrieval Augmented Generation for Pharmacovigilance

In the era of Large Language Models (LLMs), given their remarkable text understanding and generation abilities, there is an unprecedented opportunity to develop new, LLM-based methods for trustworthy medical knowledge synthesis, extraction and summarization. This paper focuses on the problem of Pharmacovigilance (PhV), where the significance and challenges lie in identifying Adverse Drug Events (ADEs) from diverse text sources, such as medical literature, clinical notes, and drug labels. Unfortunately, this task is hindered by factors including variations in the terminologies of drugs and outcomes, and ADE descriptions often being buried in large amounts of narrative text. We present MALADE, the first effective collaborative multi-agent system powered by LLM with Retrieval Augmented Generation for ADE extraction from drug label data. This technique involves augmenting a query to an LLM with relevant information extracted from text resources, and instructing the LLM to compose a response consistent with the augmented data. MALADE is a general LLM-agnostic architecture, and its unique capabilities are: (1) leveraging a variety of external sources, such as medical literature, drug labels, and FDA tools (e.g., OpenFDA drug information API), (2) extracting drug-outcome association in a structured format along with the strength of the association, and (3) providing explanations for established associations. Instantiated with GPT-4 Turbo or GPT-4o, and FDA drug label data, MALADE demonstrates its efficacy with an Area Under ROC Curve of 0.90 against the OMOP Ground Truth table of ADEs. Our implementation leverages the Langroid multi-agent LLM framework and can be found at https://github.com/jihyechoi77/malade.

PRP: Propagating Universal Perturbations to Attack Large Language Model Guard-Rails

Large language models (LLMs) are typically aligned to be harmless to humans. Unfortunately, recent work has shown that such models are susceptible to automated jailbreak attacks that induce them to generate harmful content. More recent LLMs often incorporate an additional layer of defense, a Guard Model, which is a second LLM that is designed to check and moderate the output response of the primary LLM. Our key contribution is to show a novel attack strategy, PRP, that is successful against several open-source (e.g., Llama 2) and closed-source (e.g., GPT 3.5) implementations of Guard Models. PRP leverages a two step prefix-based attack that operates by (a) constructing a universal adversarial prefix for the Guard Model, and (b) propagating this prefix to the response. We find that this procedure is effective across multiple threat models, including ones in which the adversary has no access to the Guard Model at all. Our work suggests that further advances are required on defenses and Guard Models before they can be considered effective.

Why Train More? Effective and Efficient Membership Inference via Memorization

Membership Inference Attacks (MIAs) aim to identify specific data samples within the private training dataset of machine learning models, leading to serious privacy violations and other sophisticated threats. Many practical black-box MIAs require query access to the data distribution (the same distribution where the private data is drawn) to train shadow models. By doing so, the adversary obtains models trained "with" or "without" samples drawn from the distribution, and analyzes the characteristics of the samples under consideration. The adversary is often required to train more than hundreds of shadow models to extract the signals needed for MIAs; this becomes the computational overhead of MIAs. In this paper, we propose that by strategically choosing the samples, MI adversaries can maximize their attack success while minimizing the number of shadow models. First, our motivational experiments suggest memorization as the key property explaining disparate sample vulnerability to MIAs. We formalize this through a theoretical bound that connects MI advantage with memorization. Second, we show sample complexity bounds that connect the number of shadow models needed for MIAs with memorization. Lastly, we confirm our theoretical arguments with comprehensive experiments; by utilizing samples with high memorization scores, the adversary can (a) significantly improve its efficacy regardless of the MIA used, and (b) reduce the number of shadow models by nearly two orders of magnitude compared to state-of-the-art approaches.

Identifying and Mitigating the Security Risks of Generative AI

Every major technical invention resurfaces the dual-use dilemma -- the new technology has the potential to be used for good as well as for harm. Generative AI (GenAI) techniques, such as large language models (LLMs) and diffusion models, have shown remarkable capabilities (e.g., in-context learning, code-completion, and text-to-image generation and editing). However, GenAI can be used just as well by attackers to generate new attacks and increase the velocity and efficacy of existing attacks. This paper reports the findings of a workshop held at Google (co-organized by Stanford University and the University of Wisconsin-Madison) on the dual-use dilemma posed by GenAI. This paper is not meant to be comprehensive, but is rather an attempt to synthesize some of the interesting findings from the workshop. We discuss short-term and long-term goals for the community on this topic. We hope this paper provides both a launching point for a discussion on this important topic as well as interesting problems that the research community can work to address.

Rethink Diversity in Deep Learning Testing

Deep neural networks (DNNs) have demonstrated extraordinary capabilities and are an integral part of modern software systems. However, they also suffer from various vulnerabilities such as adversarial attacks and unfairness. Testing deep learning (DL) systems is therefore an important task, to detect and mitigate those vulnerabilities. Motivated by the success of traditional software testing, which often employs diversity heuristics, various diversity measures on DNNs have been proposed to help efficiently expose the buggy behavior of DNNs. In this work, we argue that many DNN testing tasks should be treated as directed testing problems rather than general-purpose testing tasks, because these tasks are specific and well-defined. Hence, the diversity-based approach is less effective. Following our argument based on the semantics of DNNs and the testing goal, we derive $6$ metrics that can be used for DNN testing and carefully analyze their application scopes. We empirically show their efficacy in exposing bugs in DNNs compared to recent diversity-based metrics. Moreover, we also notice discrepancies between the practices of the software engineering (SE) community and the DL community. We point out some of these gaps, and hopefully, this can lead to bridging the SE practice and DL findings.

Stratified Adversarial Robustness with Rejection

Recently, there is an emerging interest in adversarially training a classifier with a rejection option (also known as a selective classifier) for boosting adversarial robustness. While rejection can incur a cost in many applications, existing studies typically associate zero cost with rejecting perturbed inputs, which can result in the rejection of numerous slightly-perturbed inputs that could be correctly classified. In this work, we study adversarially-robust classification with rejection in the stratified rejection setting, where the rejection cost is modeled by rejection loss functions monotonically non-increasing in the perturbation magnitude. We theoretically analyze the stratified rejection setting and propose a novel defense method -- Adversarial Training with Consistent Prediction-based Rejection (CPR) -- for building a robust selective classifier. Experiments on image datasets demonstrate that the proposed method significantly outperforms existing methods under strong adaptive attacks. For instance, on CIFAR-10, CPR reduces the total robust loss (for different rejection losses) by at least 7.3% under both seen and unseen attacks.

Concept-Based Explanations for Tabular Data

The interpretability of machine learning models has been an essential area of research for the safe deployment of machine learning systems. One particular approach is to attribute model decisions to high-level concepts that humans can understand. However, such concept-based explainability for Deep Neural Networks (DNNs) has been studied mostly on image domain. In this paper, we extend TCAV, the concept attribution approach, to tabular learning, by providing an idea on how to define concepts over tabular data. On a synthetic dataset with ground-truth concept explanations and a real-world dataset, we show the validity of our method in generating interpretability results that match the human-level intuitions. On top of this, we propose a notion of fairness based on TCAV that quantifies what layer of DNN has learned representations that lead to biased predictions of the model. Also, we empirically demonstrate the relation of TCAV-based fairness to a group fairness notion, Demographic Parity.

Concept-based Explanations for Out-Of-Distribution Detectors

Out-of-distribution (OOD) detection plays a crucial role in ensuring the safe deployment of deep neural network (DNN) classifiers. While a myriad of methods have focused on improving the performance of OOD detectors, a critical gap remains in interpreting their decisions. We help bridge this gap by providing explanations for OOD detectors based on learned high-level concepts. We first propose two new metrics for assessing the effectiveness of a particular set of concepts for explaining OOD detectors: 1) detection completeness, which quantifies the sufficiency of concepts for explaining an OOD-detector's decisions, and 2) concept separability, which captures the distributional separation between in-distribution and OOD data in the concept space. Based on these metrics, we propose a framework for learning a set of concepts that satisfy the desired properties of detection completeness and concept separability and demonstrate the framework's effectiveness in providing concept-based explanations for diverse OOD techniques. We also show how to identify prominent concepts that contribute to the detection results via a modified Shapley value-based importance score.

Stochastic Doubly Robust Gradient

When training a machine learning model with observational data, it is often encountered that some values are systemically missing. Learning from the incomplete data in which the missingness depends on some covariates may lead to biased estimation of parameters and even harm the fairness of decision outcome. This paper proposes how to adjust the causal effect of covariates on the missingness when training models using stochastic gradient descent (SGD). Inspired by the design of doubly robust estimator and its theoretical property of double robustness, we introduce stochastic doubly robust gradient (SDRG) consisting of two models: weight-corrected gradients for inverse propensity score weighting and per-covariate control variates for regression adjustment. Also, we identify the connection between double robustness and variance reduction in SGD by demonstrating the SDRG algorithm with a unifying framework for variance reduced SGD. The performance of our approach is empirically tested by showing the convergence in training image classifiers with several examples of missing data.