Mortality Prediction of Pulmonary Embolism Patients with Deep Learning and XGBoost

Pulmonary Embolism (PE) is a serious cardiovascular condition that remains a leading cause of mortality and critical illness, underscoring the need for enhanced diagnostic strategies. Conventional clinical methods have limited success in predicting 30-day in-hospital mortality of PE patients. In this study, we present a new algorithm, called PEP-Net, for 30-day mortality prediction of PE patients based on the initial imaging data (CT) that opportunistically integrates a 3D Residual Network (3DResNet) with Extreme Gradient Boosting (XGBoost) algorithm with patient level binary labels without annotations of the emboli and its extent. Our proposed system offers a comprehensive prediction strategy by handling class imbalance problems, reducing overfitting via regularization, and reducing the prediction variance for more stable predictions. PEP-Net was tested in a cohort of 193 volumetric CT scans diagnosed with Acute PE, and it demonstrated a superior performance by significantly outperforming baseline models (76-78\%) with an accuracy of 94.5\% (+/-0.3) and 94.0\% (+/-0.7) when the input image is either lung region (Lung-ROI) or heart region (Cardiac-ROI). Our results advance PE prognostics by using only initial imaging data, setting a new benchmark in the field. While purely deep learning models have become the go-to for many medical classification (diagnostic) tasks, combined ResNet and XGBoost models herein outperform sole deep learning models due to a potential reason for having lack of enough data.

Evidential Federated Learning for Skin Lesion Image Classification

We introduce FedEvPrompt, a federated learning approach that integrates principles of evidential deep learning, prompt tuning, and knowledge distillation for distributed skin lesion classification. FedEvPrompt leverages two sets of prompts: b-prompts (for low-level basic visual knowledge) and t-prompts (for task-specific knowledge) prepended to frozen pre-trained Vision Transformer (ViT) models trained in an evidential learning framework to maximize class evidences. Crucially, knowledge sharing across federation clients is achieved only through knowledge distillation on attention maps generated by the local ViT models, ensuring enhanced privacy preservation compared to traditional parameter or synthetic image sharing methodologies. FedEvPrompt is optimized within a round-based learning paradigm, where each round involves training local models followed by attention maps sharing with all federation clients. Experimental validation conducted in a real distributed setting, on the ISIC2019 dataset, demonstrates the superior performance of FedEvPrompt against baseline federated learning algorithms and knowledge distillation methods, without sharing model parameters. In conclusion, FedEvPrompt offers a promising approach for federated learning, effectively addressing challenges such as data heterogeneity, imbalance, privacy preservation, and knowledge sharing.

IPMN Risk Assessment under Federated Learning Paradigm

Accurate classification of Intraductal Papillary Mucinous Neoplasms (IPMN) is essential for identifying high-risk cases that require timely intervention. In this study, we develop a federated learning framework for multi-center IPMN classification utilizing a comprehensive pancreas MRI dataset. This dataset includes 653 T1-weighted and 656 T2-weighted MRI images, accompanied by corresponding IPMN risk scores from 7 leading medical institutions, making it the largest and most diverse dataset for IPMN classification to date. We assess the performance of DenseNet-121 in both centralized and federated settings for training on distributed data. Our results demonstrate that the federated learning approach achieves high classification accuracy comparable to centralized learning while ensuring data privacy across institutions. This work marks a significant advancement in collaborative IPMN classification, facilitating secure and high-accuracy model training across multiple centers.

A New Logic For Pediatric Brain Tumor Segmentation

In this paper, we present a novel approach for segmenting pediatric brain tumors using a deep learning architecture, inspired by expert radiologists' segmentation strategies. Our model delineates four distinct tumor labels and is benchmarked on a held-out PED BraTS 2024 test set (i.e., pediatric brain tumor datasets introduced by BraTS). Furthermore, we evaluate our model's performance against the state-of-the-art (SOTA) model using a new external dataset of 30 patients from CBTN (Children's Brain Tumor Network), labeled in accordance with the PED BraTS 2024 guidelines. We compare segmentation outcomes with the winning algorithm from the PED BraTS 2023 challenge as the SOTA model. Our proposed algorithm achieved an average Dice score of 0.642 and an HD95 of 73.0 mm on the CBTN test data, outperforming the SOTA model, which achieved a Dice score of 0.626 and an HD95 of 84.0 mm. Our results indicate that the proposed model is a step towards providing more accurate segmentation for pediatric brain tumors, which is essential for evaluating therapy response and monitoring patient progress.

Adaptive Aggregation Weights for Federated Segmentation of Pancreas MRI

Federated learning (FL) enables collaborative model training across institutions without sharing sensitive data, making it an attractive solution for medical imaging tasks. However, traditional FL methods, such as Federated Averaging (FedAvg), face difficulties in generalizing across domains due to variations in imaging protocols and patient demographics across institutions. This challenge is particularly evident in pancreas MRI segmentation, where anatomical variability and imaging artifacts significantly impact performance. In this paper, we conduct a comprehensive evaluation of FL algorithms for pancreas MRI segmentation and introduce a novel approach that incorporates adaptive aggregation weights. By dynamically adjusting the contribution of each client during model aggregation, our method accounts for domain-specific differences and improves generalization across heterogeneous datasets. Experimental results demonstrate that our approach enhances segmentation accuracy and reduces the impact of domain shift compared to conventional FL methods while maintaining privacy-preserving capabilities. Significant performance improvements are observed across multiple hospitals (centers).

Order-aware Interactive Segmentation

Interactive segmentation aims to accurately segment target objects with minimal user interactions. However, current methods often fail to accurately separate target objects from the background, due to a limited understanding of order, the relative depth between objects in a scene. To address this issue, we propose OIS: order-aware interactive segmentation, where we explicitly encode the relative depth between objects into order maps. We introduce a novel order-aware attention, where the order maps seamlessly guide the user interactions (in the form of clicks) to attend to the image features. We further present an object-aware attention module to incorporate a strong object-level understanding to better differentiate objects with similar order. Our approach allows both dense and sparse integration of user clicks, enhancing both accuracy and efficiency as compared to prior works. Experimental results demonstrate that OIS achieves state-of-the-art performance, improving mIoU after one click by 7.61 on the HQSeg44K dataset and 1.32 on the DAVIS dataset as compared to the previous state-of-the-art SegNext, while also doubling inference speed compared to current leading methods. The project page is https://ukaukaaaa.github.io/projects/OIS/index.html

Frequency-Based Federated Domain Generalization for Polyp Segmentation

Federated Learning (FL) offers a powerful strategy for training machine learning models across decentralized datasets while maintaining data privacy, yet domain shifts among clients can degrade performance, particularly in medical imaging tasks like polyp segmentation. This paper introduces a novel Frequency-Based Domain Generalization (FDG) framework, utilizing soft- and hard-thresholding in the Fourier domain to address these challenges. By applying soft- and hard-thresholding to Fourier coefficients, our method generates new images with reduced background noise and enhances the model's ability to generalize across diverse medical imaging domains. Extensive experiments demonstrate substantial improvements in segmentation accuracy and domain robustness over baseline methods. This innovation integrates frequency domain techniques into FL, presenting a resilient approach to overcoming domain variability in decentralized medical image analysis.

Classification of Endoscopy and Video Capsule Images using CNN-Transformer Model

Gastrointestinal cancer is a leading cause of cancer-related incidence and death, making it crucial to develop novel computer-aided diagnosis systems for early detection and enhanced treatment. Traditional approaches rely on the expertise of gastroenterologists to identify diseases; however, this process is subjective, and interpretation can vary even among expert clinicians. Considering recent advancements in classifying gastrointestinal anomalies and landmarks in endoscopic and video capsule endoscopy images, this study proposes a hybrid model that combines the advantages of Transformers and Convolutional Neural Networks (CNNs) to enhance classification performance. Our model utilizes DenseNet201 as a CNN branch to extract local features and integrates a Swin Transformer branch for global feature understanding, combining both to perform the classification task. For the GastroVision dataset, our proposed model demonstrates excellent performance with Precision, Recall, F1 score, Accuracy, and Matthews Correlation Coefficient (MCC) of 0.8320, 0.8386, 0.8324, 0.8386, and 0.8191, respectively, showcasing its robustness against class imbalance and surpassing other CNNs as well as the Swin Transformer model. Similarly, for the Kvasir-Capsule, a large video capsule endoscopy dataset, our model outperforms all others, achieving overall Precision, Recall, F1 score, Accuracy, and MCC of 0.7007, 0.7239, 0.6900, 0.7239, and 0.3871. Moreover, we generated saliency maps to explain our model's focus areas, demonstrating its reliable decision-making process. The results underscore the potential of our hybrid CNN-Transformer model in aiding the early and accurate detection of gastrointestinal (GI) anomalies.

A Novel Momentum-Based Deep Learning Techniques for Medical Image Classification and Segmentation

Accurately segmenting different organs from medical images is a critical prerequisite for computer-assisted diagnosis and intervention planning. This study proposes a deep learning-based approach for segmenting various organs from CT and MRI scans and classifying diseases. Our study introduces a novel technique integrating momentum within residual blocks for enhanced training dynamics in medical image analysis. We applied our method in two distinct tasks: segmenting liver, lung, & colon data and classifying abdominal pelvic CT and MRI scans. The proposed approach has shown promising results, outperforming state-of-the-art methods on publicly available benchmarking datasets. For instance, in the lung segmentation dataset, our approach yielded significant enhancements over the TransNetR model, including a 5.72% increase in dice score, a 5.04% improvement in mean Intersection over Union (mIoU), an 8.02% improvement in recall, and a 4.42% improvement in precision. Hence, incorporating momentum led to state-of-the-art performance in both segmentation and classification tasks, representing a significant advancement in the field of medical imaging.

Towards Synergistic Deep Learning Models for Volumetric Cirrhotic Liver Segmentation in MRIs

Liver cirrhosis, a leading cause of global mortality, requires precise segmentation of ROIs for effective disease monitoring and treatment planning. Existing segmentation models often fail to capture complex feature interactions and generalize across diverse datasets. To address these limitations, we propose a novel synergistic theory that leverages complementary latent spaces for enhanced feature interaction modeling. Our proposed architecture, nnSynergyNet3D integrates continuous and discrete latent spaces for 3D volumes and features auto-configured training. This approach captures both fine-grained and coarse features, enabling effective modeling of intricate feature interactions. We empirically validated nnSynergyNet3D on a private dataset of 628 high-resolution T1 abdominal MRI scans from 339 patients. Our model outperformed the baseline nnUNet3D by approximately 2%. Additionally, zero-shot testing on healthy liver CT scans from the public LiTS dataset demonstrated superior cross-modal generalization capabilities. These results highlight the potential of synergistic latent space models to improve segmentation accuracy and robustness, thereby enhancing clinical workflows by ensuring consistency across CT and MRI modalities.