Uncertainty-Guided Coarse-to-Fine Tumor Segmentation with Anatomy-Aware Post-Processing

Reliable tumor segmentation in thoracic computed tomography (CT) remains challenging due to boundary ambiguity, class imbalance, and anatomical variability. We propose an uncertainty-guided, coarse-to-fine segmentation framework that combines full-volume tumor localization with refined region-of-interest (ROI) segmentation, enhanced by anatomically aware post-processing. The first-stage model generates a coarse prediction, followed by anatomically informed filtering based on lung overlap, proximity to lung surfaces, and component size. The resulting ROIs are segmented by a second-stage model trained with uncertainty-aware loss functions to improve accuracy and boundary calibration in ambiguous regions. Experiments on private and public datasets demonstrate improvements in Dice and Hausdorff scores, with fewer false positives and enhanced spatial interpretability. These results highlight the value of combining uncertainty modeling and anatomical priors in cascaded segmentation pipelines for robust and clinically meaningful tumor delineation. On the Orlando dataset, our framework improved Swin UNETR Dice from 0.4690 to 0.6447. Reduction in spurious components was strongly correlated with segmentation gains, underscoring the value of anatomically informed post-processing.

VideoAds for Fast-Paced Video Understanding: Where Opensource Foundation Models Beat GPT-4o & Gemini-1.5 Pro

Advertisement videos serve as a rich and valuable source of purpose-driven information, encompassing high-quality visual, textual, and contextual cues designed to engage viewers. They are often more complex than general videos of similar duration due to their structured narratives and rapid scene transitions, posing significant challenges to multi-modal large language models (MLLMs). In this work, we introduce VideoAds, the first dataset tailored for benchmarking the performance of MLLMs on advertisement videos. VideoAds comprises well-curated advertisement videos with complex temporal structures, accompanied by \textbf{manually} annotated diverse questions across three core tasks: visual finding, video summary, and visual reasoning. We propose a quantitative measure to compare VideoAds against existing benchmarks in terms of video complexity. Through extensive experiments, we find that Qwen2.5-VL-72B, an opensource MLLM, achieves 73.35\% accuracy on VideoAds, outperforming GPT-4o (66.82\%) and Gemini-1.5 Pro (69.66\%); the two proprietary models especially fall behind the opensource model in video summarization and reasoning, but perform the best in visual finding. Notably, human experts easily achieve a remarkable accuracy of 94.27\%. These results underscore the necessity of advancing MLLMs' temporal modeling capabilities and highlight VideoAds as a potentially pivotal benchmark for future research in understanding video that requires high FPS sampling. The dataset and evaluation code will be publicly available at https://videoadsbenchmark.netlify.app.

Eyes Tell the Truth: GazeVal Highlights Shortcomings of Generative AI in Medical Imaging

The demand for high-quality synthetic data for model training and augmentation has never been greater in medical imaging. However, current evaluations predominantly rely on computational metrics that fail to align with human expert recognition. This leads to synthetic images that may appear realistic numerically but lack clinical authenticity, posing significant challenges in ensuring the reliability and effectiveness of AI-driven medical tools. To address this gap, we introduce GazeVal, a practical framework that synergizes expert eye-tracking data with direct radiological evaluations to assess the quality of synthetic medical images. GazeVal leverages gaze patterns of radiologists as they provide a deeper understanding of how experts perceive and interact with synthetic data in different tasks (i.e., diagnostic or Turing tests). Experiments with sixteen radiologists revealed that 96.6% of the generated images (by the most recent state-of-the-art AI algorithm) were identified as fake, demonstrating the limitations of generative AI in producing clinically accurate images.

A Reverse Mamba Attention Network for Pathological Liver Segmentation

We present RMA-Mamba, a novel architecture that advances the capabilities of vision state space models through a specialized reverse mamba attention module (RMA). The key innovation lies in RMA-Mamba's ability to capture long-range dependencies while maintaining precise local feature representation through its hierarchical processing pipeline. By integrating Vision Mamba (VMamba)'s efficient sequence modeling with RMA's targeted feature refinement, our architecture achieves superior feature learning across multiple scales. This dual-mechanism approach enables robust handling of complex morphological patterns while maintaining computational efficiency. We demonstrate RMA-Mamba's effectiveness in the challenging domain of pathological liver segmentation (from both CT and MRI), where traditional segmentation approaches often fail due to tissue variations. When evaluated on a newly introduced cirrhotic liver dataset (CirrMRI600+) of T2-weighted MRI scans, RMA-Mamba achieves the state-of-the-art performance with a Dice coefficient of 92.08%, mean IoU of 87.36%, and recall of 92.96%. The architecture's generalizability is further validated on the cancerous liver segmentation from CT scans (LiTS: Liver Tumor Segmentation dataset), yielding a Dice score of 92.9% and mIoU of 88.99%. The source code of the proposed RMA-Mamba is available at https://github.com/JunZengz/RMAMamba.

Liver Cirrhosis Stage Estimation from MRI with Deep Learning

We present an end-to-end deep learning framework for automated liver cirrhosis stage estimation from multi-sequence MRI. Cirrhosis is the severe scarring (fibrosis) of the liver and a common endpoint of various chronic liver diseases. Early diagnosis is vital to prevent complications such as decompensation and cancer, which significantly decreases life expectancy. However, diagnosing cirrhosis in its early stages is challenging, and patients often present with life-threatening complications. Our approach integrates multi-scale feature learning with sequence-specific attention mechanisms to capture subtle tissue variations across cirrhosis progression stages. Using CirrMRI600+, a large-scale publicly available dataset of 628 high-resolution MRI scans from 339 patients, we demonstrate state-of-the-art performance in three-stage cirrhosis classification. Our best model achieves 72.8% accuracy on T1W and 63.8% on T2W sequences, significantly outperforming traditional radiomics-based approaches. Through extensive ablation studies, we show that our architecture effectively learns stage-specific imaging biomarkers. We establish new benchmarks for automated cirrhosis staging and provide insights for developing clinically applicable deep learning systems. The source code will be available at https://github.com/JunZengz/CirrhosisStage.

Is Long Range Sequential Modeling Necessary For Colorectal Tumor Segmentation?

Segmentation of colorectal cancer (CRC) tumors in 3D medical imaging is both complex and clinically critical, providing vital support for effective radiation therapy planning and survival outcome assessment. Recently, 3D volumetric segmentation architectures incorporating long-range sequence modeling mechanisms, such as Transformers and Mamba, have gained attention for their capacity to achieve high accuracy in 3D medical image segmentation. In this work, we evaluate the effectiveness of these global token modeling techniques by pitting them against our proposed MambaOutUNet within the context of our newly introduced colorectal tumor segmentation dataset (CTS-204). Our findings suggest that robust local token interactions can outperform long-range modeling techniques in cases where the region of interest is small and anatomically complex, proposing a potential shift in 3D tumor segmentation research.

Diverse Image Generation with Diffusion Models and Cross Class Label Learning for Polyp Classification

Pathologic diagnosis is a critical phase in deciding the optimal treatment procedure for dealing with colorectal cancer (CRC). Colonic polyps, precursors to CRC, can pathologically be classified into two major types: adenomatous and hyperplastic. For precise classification and early diagnosis of such polyps, the medical procedure of colonoscopy has been widely adopted paired with various imaging techniques, including narrow band imaging and white light imaging. However, the existing classification techniques mainly rely on a single imaging modality and show limited performance due to data scarcity. Recently, generative artificial intelligence has been gaining prominence in overcoming such issues. Additionally, various generation-controlling mechanisms using text prompts and images have been introduced to obtain visually appealing and desired outcomes. However, such mechanisms require class labels to make the model respond efficiently to the provided control input. In the colonoscopy domain, such controlling mechanisms are rarely explored; specifically, the text prompt is a completely uninvestigated area. Moreover, the unavailability of expensive class-wise labels for diverse sets of images limits such explorations. Therefore, we develop a novel model, PathoPolyp-Diff, that generates text-controlled synthetic images with diverse characteristics in terms of pathology, imaging modalities, and quality. We introduce cross-class label learning to make the model learn features from other classes, reducing the burdensome task of data annotation. The experimental results report an improvement of up to 7.91% in balanced accuracy using a publicly available dataset. Moreover, cross-class label learning achieves a statistically significant improvement of up to 18.33% in balanced accuracy during video-level analysis. The code is available at https://github.com/Vanshali/PathoPolyp-Diff.

Uncertainty-Guided Cross Attention Ensemble Mean Teacher for Semi-supervised Medical Image Segmentation

This work proposes a novel framework, Uncertainty-Guided Cross Attention Ensemble Mean Teacher (UG-CEMT), for achieving state-of-the-art performance in semi-supervised medical image segmentation. UG-CEMT leverages the strengths of co-training and knowledge distillation by combining a Cross-attention Ensemble Mean Teacher framework (CEMT) inspired by Vision Transformers (ViT) with uncertainty-guided consistency regularization and Sharpness-Aware Minimization emphasizing uncertainty. UG-CEMT improves semi-supervised performance while maintaining a consistent network architecture and task setting by fostering high disparity between sub-networks. Experiments demonstrate significant advantages over existing methods like Mean Teacher and Cross-pseudo Supervision in terms of disparity, domain generalization, and medical image segmentation performance. UG-CEMT achieves state-of-the-art results on multi-center prostate MRI and cardiac MRI datasets, where object segmentation is particularly challenging. Our results show that using only 10\% labeled data, UG-CEMT approaches the performance of fully supervised methods, demonstrating its effectiveness in exploiting unlabeled data for robust medical image segmentation. The code is publicly available at \url{https://github.com/Meghnak13/UG-CEMT}

Mortality Prediction of Pulmonary Embolism Patients with Deep Learning and XGBoost

Pulmonary Embolism (PE) is a serious cardiovascular condition that remains a leading cause of mortality and critical illness, underscoring the need for enhanced diagnostic strategies. Conventional clinical methods have limited success in predicting 30-day in-hospital mortality of PE patients. In this study, we present a new algorithm, called PEP-Net, for 30-day mortality prediction of PE patients based on the initial imaging data (CT) that opportunistically integrates a 3D Residual Network (3DResNet) with Extreme Gradient Boosting (XGBoost) algorithm with patient level binary labels without annotations of the emboli and its extent. Our proposed system offers a comprehensive prediction strategy by handling class imbalance problems, reducing overfitting via regularization, and reducing the prediction variance for more stable predictions. PEP-Net was tested in a cohort of 193 volumetric CT scans diagnosed with Acute PE, and it demonstrated a superior performance by significantly outperforming baseline models (76-78\%) with an accuracy of 94.5\% (+/-0.3) and 94.0\% (+/-0.7) when the input image is either lung region (Lung-ROI) or heart region (Cardiac-ROI). Our results advance PE prognostics by using only initial imaging data, setting a new benchmark in the field. While purely deep learning models have become the go-to for many medical classification (diagnostic) tasks, combined ResNet and XGBoost models herein outperform sole deep learning models due to a potential reason for having lack of enough data.

Evidential Federated Learning for Skin Lesion Image Classification

We introduce FedEvPrompt, a federated learning approach that integrates principles of evidential deep learning, prompt tuning, and knowledge distillation for distributed skin lesion classification. FedEvPrompt leverages two sets of prompts: b-prompts (for low-level basic visual knowledge) and t-prompts (for task-specific knowledge) prepended to frozen pre-trained Vision Transformer (ViT) models trained in an evidential learning framework to maximize class evidences. Crucially, knowledge sharing across federation clients is achieved only through knowledge distillation on attention maps generated by the local ViT models, ensuring enhanced privacy preservation compared to traditional parameter or synthetic image sharing methodologies. FedEvPrompt is optimized within a round-based learning paradigm, where each round involves training local models followed by attention maps sharing with all federation clients. Experimental validation conducted in a real distributed setting, on the ISIC2019 dataset, demonstrates the superior performance of FedEvPrompt against baseline federated learning algorithms and knowledge distillation methods, without sharing model parameters. In conclusion, FedEvPrompt offers a promising approach for federated learning, effectively addressing challenges such as data heterogeneity, imbalance, privacy preservation, and knowledge sharing.