MaskGCT: Zero-Shot Text-to-Speech with Masked Generative Codec Transformer

Nowadays, large-scale text-to-speech (TTS) systems are primarily divided into two types: autoregressive and non-autoregressive. The autoregressive systems have certain deficiencies in robustness and cannot control speech duration. In contrast, non-autoregressive systems require explicit prediction of phone-level duration, which may compromise their naturalness. We introduce the Masked Generative Codec Transformer (MaskGCT), a fully non-autoregressive model for TTS that does not require precise alignment information between text and speech. MaskGCT is a two-stage model: in the first stage, the model uses text to predict semantic tokens extracted from a speech self-supervised learning (SSL) model, and in the second stage, the model predicts acoustic tokens conditioned on these semantic tokens. MaskGCT follows the \textit{mask-and-predict} learning paradigm. During training, MaskGCT learns to predict masked semantic or acoustic tokens based on given conditions and prompts. During inference, the model generates tokens of a specified length in a parallel manner. We scale MaskGCT to a large-scale multilingual dataset with 100K hours of in-the-wild speech. Our experiments demonstrate that MaskGCT achieves superior or competitive performance compared to state-of-the-art zero-shot TTS systems in terms of quality, similarity, and intelligibility while offering higher generation efficiency than diffusion-based or autoregressive TTS models. Audio samples are available at https://maskgct.github.io.

Token-Mol 1.0: Tokenized drug design with large language model

Significant interests have recently risen in leveraging sequence-based large language models (LLMs) for drug design. However, most current applications of LLMs in drug discovery lack the ability to comprehend three-dimensional (3D) structures, thereby limiting their effectiveness in tasks that explicitly involve molecular conformations. In this study, we introduced Token-Mol, a token-only 3D drug design model. This model encodes all molecular information, including 2D and 3D structures, as well as molecular property data, into tokens, which transforms classification and regression tasks in drug discovery into probabilistic prediction problems, thereby enabling learning through a unified paradigm. Token-Mol is built on the transformer decoder architecture and trained using random causal masking techniques. Additionally, we proposed the Gaussian cross-entropy (GCE) loss function to overcome the challenges in regression tasks, significantly enhancing the capacity of LLMs to learn continuous numerical values. Through a combination of fine-tuning and reinforcement learning (RL), Token-Mol achieves performance comparable to or surpassing existing task-specific methods across various downstream tasks, including pocket-based molecular generation, conformation generation, and molecular property prediction. Compared to existing molecular pre-trained models, Token-Mol exhibits superior proficiency in handling a wider range of downstream tasks essential for drug design. Notably, our approach improves regression task accuracy by approximately 30% compared to similar token-only methods. Token-Mol overcomes the precision limitations of token-only models and has the potential to integrate seamlessly with general models such as ChatGPT, paving the way for the development of a universal artificial intelligence drug design model that facilitates rapid and high-quality drug design by experts.

Emilia: An Extensive, Multilingual, and Diverse Speech Dataset for Large-Scale Speech Generation

Recently, speech generation models have made significant progress by using large-scale training data. However, the research community struggle to produce highly spontaneous and human-like speech due to the lack of large-scale, diverse, and spontaneous speech data. This paper presents \textit{Emilia}, the first multilingual speech generation dataset from in-the-wild speech data, and Emilia-Pipe, the first open-source preprocessing pipeline designed to transform in-the-wild speech data into high-quality training data with annotations for speech generation. Emilia starts with over 101k hours of speech in six languages and features diverse speech with varied speaking styles. To facilitate the scale-up of Emilia, the open-source pipeline Emilia-Pipe can process one hour of raw speech data ready for model training in a few mins, which enables the research community to collaborate on large-scale speech generation research. Experimental results validate the effectiveness of Emilia. Demos are available at: https://emilia-dataset.github.io/Emilia-Demo-Page/.