DAMM-Diffusion: Learning Divergence-Aware Multi-Modal Diffusion Model for Nanoparticles Distribution Prediction

The prediction of nanoparticles (NPs) distribution is crucial for the diagnosis and treatment of tumors. Recent studies indicate that the heterogeneity of tumor microenvironment (TME) highly affects the distribution of NPs across tumors. Hence, it has become a research hotspot to generate the NPs distribution by the aid of multi-modal TME components. However, the distribution divergence among multi-modal TME components may cause side effects i.e., the best uni-modal model may outperform the joint generative model. To address the above issues, we propose a \textbf{D}ivergence-\textbf{A}ware \textbf{M}ulti-\textbf{M}odal \textbf{Diffusion} model (i.e., \textbf{DAMM-Diffusion}) to adaptively generate the prediction results from uni-modal and multi-modal branches in a unified network. In detail, the uni-modal branch is composed of the U-Net architecture while the multi-modal branch extends it by introducing two novel fusion modules i.e., Multi-Modal Fusion Module (MMFM) and Uncertainty-Aware Fusion Module (UAFM). Specifically, the MMFM is proposed to fuse features from multiple modalities, while the UAFM module is introduced to learn the uncertainty map for cross-attention computation. Following the individual prediction results from each branch, the Divergence-Aware Multi-Modal Predictor (DAMMP) module is proposed to assess the consistency of multi-modal data with the uncertainty map, which determines whether the final prediction results come from multi-modal or uni-modal predictions. We predict the NPs distribution given the TME components of tumor vessels and cell nuclei, and the experimental results show that DAMM-Diffusion can generate the distribution of NPs with higher accuracy than the comparing methods. Additional results on the multi-modal brain image synthesis task further validate the effectiveness of the proposed method.

Robust Multimodal Survival Prediction with the Latent Differentiation Conditional Variational AutoEncoder

The integrative analysis of histopathological images and genomic data has received increasing attention for survival prediction of human cancers. However, the existing studies always hold the assumption that full modalities are available. As a matter of fact, the cost for collecting genomic data is high, which sometimes makes genomic data unavailable in testing samples. A common way of tackling such incompleteness is to generate the genomic representations from the pathology images. Nevertheless, such strategy still faces the following two challenges: (1) The gigapixel whole slide images (WSIs) are huge and thus hard for representation. (2) It is difficult to generate the genomic embeddings with diverse function categories in a unified generative framework. To address the above challenges, we propose a Conditional Latent Differentiation Variational AutoEncoder (LD-CVAE) for robust multimodal survival prediction, even with missing genomic data. Specifically, a Variational Information Bottleneck Transformer (VIB-Trans) module is proposed to learn compressed pathological representations from the gigapixel WSIs. To generate different functional genomic features, we develop a novel Latent Differentiation Variational AutoEncoder (LD-VAE) to learn the common and specific posteriors for the genomic embeddings with diverse functions. Finally, we use the product-of-experts technique to integrate the genomic common posterior and image posterior for the joint latent distribution estimation in LD-CVAE. We test the effectiveness of our method on five different cancer datasets, and the experimental results demonstrate its superiority in both complete and missing modality scenarios.

MomentSeeker: A Comprehensive Benchmark and A Strong Baseline For Moment Retrieval Within Long Videos

Retrieval augmented generation (RAG) holds great promise in addressing challenges associated with long video understanding. These methods retrieve useful moments from long videos for their presented tasks, thereby enabling multimodal large language models (MLLMs) to generate high-quality answers in a cost-effective way. In this work, we present MomentSeeker, a comprehensive benchmark to evaluate retrieval models' performance in handling general long-video moment retrieval (LVMR) tasks. MomentSeeker offers three key advantages. First, it incorporates long videos of over 500 seconds on average, making it the first benchmark specialized for long-video moment retrieval. Second, it covers a wide range of task categories (including Moment Search, Caption Alignment, Image-conditioned Moment Search, and Video-conditioned Moment Search) and diverse application scenarios (e.g., sports, movies, cartoons, and ego), making it a comprehensive tool for assessing retrieval models' general LVMR performance. Additionally, the evaluation tasks are carefully curated through human annotation, ensuring the reliability of assessment. We further fine-tune an MLLM-based LVMR retriever on synthetic data, which demonstrates strong performance on our benchmark. We perform extensive experiments with various popular multimodal retrievers based on our benchmark, whose results highlight the challenges of LVMR and limitations for existing methods. Our created resources will be shared with community to advance future research in this field.

Any Information Is Just Worth One Single Screenshot: Unifying Search With Visualized Information Retrieval

With the popularity of multimodal techniques, it receives growing interests to acquire useful information in visual forms. In this work, we formally define an emerging IR paradigm called \textit{Visualized Information Retrieval}, or \textbf{Vis-IR}, where multimodal information, such as texts, images, tables and charts, is jointly represented by a unified visual format called \textbf{Screenshots}, for various retrieval applications. We further make three key contributions for Vis-IR. First, we create \textbf{VIRA} (Vis-IR Aggregation), a large-scale dataset comprising a vast collection of screenshots from diverse sources, carefully curated into captioned and question-answer formats. Second, we develop \textbf{UniSE} (Universal Screenshot Embeddings), a family of retrieval models that enable screenshots to query or be queried across arbitrary data modalities. Finally, we construct \textbf{MVRB} (Massive Visualized IR Benchmark), a comprehensive benchmark covering a variety of task forms and application scenarios. Through extensive evaluations on MVRB, we highlight the deficiency from existing multimodal retrievers and the substantial improvements made by UniSE. Our work will be shared with the community, laying a solid foundation for this emerging field.

MegaPairs: Massive Data Synthesis For Universal Multimodal Retrieval

Despite the rapidly growing demand for multimodal retrieval, progress in this field remains severely constrained by a lack of training data. In this paper, we introduce MegaPairs, a novel data synthesis method that leverages vision language models (VLMs) and open-domain images, together with a massive synthetic dataset generated from this method. Our empirical analysis shows that MegaPairs generates high-quality data, enabling the multimodal retriever to significantly outperform the baseline model trained on 70$\times$ more data from existing datasets. Moreover, since MegaPairs solely relies on general image corpora and open-source VLMs, it can be easily scaled up, enabling continuous improvements in retrieval performance. In this stage, we produced more than 26 million training instances and trained several models of varying sizes using this data. These new models achieve state-of-the-art zero-shot performance across 4 popular composed image retrieval (CIR) benchmarks and the highest overall performance on the 36 datasets provided by MMEB. They also demonstrate notable performance improvements with additional downstream fine-tuning. Our produced dataset, well-trained models, and data synthesis pipeline will be made publicly available to facilitate the future development of this field.

All You Need in Knowledge Distillation Is a Tailored Coordinate System

Knowledge Distillation (KD) is essential in transferring dark knowledge from a large teacher to a small student network, such that the student can be much more efficient than the teacher but with comparable accuracy. Existing KD methods, however, rely on a large teacher trained specifically for the target task, which is both very inflexible and inefficient. In this paper, we argue that a SSL-pretrained model can effectively act as the teacher and its dark knowledge can be captured by the coordinate system or linear subspace where the features lie in. We then need only one forward pass of the teacher, and then tailor the coordinate system (TCS) for the student network. Our TCS method is teacher-free and applies to diverse architectures, works well for KD and practical few-shot learning, and allows cross-architecture distillation with large capacity gap. Experiments show that TCS achieves significantly higher accuracy than state-of-the-art KD methods, while only requiring roughly half of their training time and GPU memory costs.

Quantization without Tears

Deep neural networks, while achieving remarkable success across diverse tasks, demand significant resources, including computation, GPU memory, bandwidth, storage, and energy. Network quantization, as a standard compression and acceleration technique, reduces storage costs and enables potential inference acceleration by discretizing network weights and activations into a finite set of integer values. However, current quantization methods are often complex and sensitive, requiring extensive task-specific hyperparameters, where even a single misconfiguration can impair model performance, limiting generality across different models and tasks. In this paper, we propose Quantization without Tears (QwT), a method that simultaneously achieves quantization speed, accuracy, simplicity, and generality. The key insight of QwT is to incorporate a lightweight additional structure into the quantized network to mitigate information loss during quantization. This structure consists solely of a small set of linear layers, keeping the method simple and efficient. More importantly, it provides a closed-form solution, allowing us to improve accuracy effortlessly under 2 minutes. Extensive experiments across various vision, language, and multimodal tasks demonstrate that QwT is both highly effective and versatile. In fact, our approach offers a robust solution for network quantization that combines simplicity, accuracy, and adaptability, which provides new insights for the design of novel quantization paradigms.

DiffRoad: Realistic and Diverse Road Scenario Generation for Autonomous Vehicle Testing

Generating realistic and diverse road scenarios is essential for autonomous vehicle testing and validation. Nevertheless, owing to the complexity and variability of real-world road environments, creating authentic and varied scenarios for intelligent driving testing is challenging. In this paper, we propose DiffRoad, a novel diffusion model designed to produce controllable and high-fidelity 3D road scenarios. DiffRoad leverages the generative capabilities of diffusion models to synthesize road layouts from white noise through an inverse denoising process, preserving real-world spatial features. To enhance the quality of generated scenarios, we design the Road-UNet architecture, optimizing the balance between backbone and skip connections for high-realism scenario generation. Furthermore, we introduce a road scenario evaluation module that screens adequate and reasonable scenarios for intelligent driving testing using two critical metrics: road continuity and road reasonableness. Experimental results on multiple real-world datasets demonstrate DiffRoad's ability to generate realistic and smooth road structures while maintaining the original distribution. Additionally, the generated scenarios can be fully automated into the OpenDRIVE format, facilitating generalized autonomous vehicle simulation testing. DiffRoad provides a rich and diverse scenario library for large-scale autonomous vehicle testing and offers valuable insights for future infrastructure designs that are better suited for autonomous vehicles.

Video-XL: Extra-Long Vision Language Model for Hour-Scale Video Understanding

Although current Multi-modal Large Language Models (MLLMs) demonstrate promising results in video understanding, processing extremely long videos remains an ongoing challenge. Typically, MLLMs struggle with handling thousands of tokens that exceed the maximum context length of LLMs, and they experience reduced visual clarity due to token aggregation. Another challenge is the high computational cost stemming from the large number of video tokens. To tackle these issues, we propose Video-XL, an extra-long vision language model designed for efficient hour-scale video understanding. Specifically, we argue that LLMs can be adapted as effective visual condensers and introduce Visual Context Latent Summarization, which condenses visual contexts into highly compact forms. Extensive experiments demonstrate that our model achieves promising results on popular long video understanding benchmarks, despite being trained on limited image data. Moreover, Video-XL strikes a promising balance between efficiency and effectiveness, processing 1024 frames on a single 80GB GPU while achieving nearly 100\% accuracy in the Needle-in-a-Haystack evaluation. We envision Video-XL becoming a valuable tool for long video applications such as video summarization, surveillance anomaly detection, and Ad placement identification.

OmniGen: Unified Image Generation

In this work, we introduce OmniGen, a new diffusion model for unified image generation. Unlike popular diffusion models (e.g., Stable Diffusion), OmniGen no longer requires additional modules such as ControlNet or IP-Adapter to process diverse control conditions. OmniGenis characterized by the following features: 1) Unification: OmniGen not only demonstrates text-to-image generation capabilities but also inherently supports other downstream tasks, such as image editing, subject-driven generation, and visual-conditional generation. Additionally, OmniGen can handle classical computer vision tasks by transforming them into image generation tasks, such as edge detection and human pose recognition. 2) Simplicity: The architecture of OmniGen is highly simplified, eliminating the need for additional text encoders. Moreover, it is more user-friendly compared to existing diffusion models, enabling complex tasks to be accomplished through instructions without the need for extra preprocessing steps (e.g., human pose estimation), thereby significantly simplifying the workflow of image generation. 3) Knowledge Transfer: Through learning in a unified format, OmniGen effectively transfers knowledge across different tasks, manages unseen tasks and domains, and exhibits novel capabilities. We also explore the model's reasoning capabilities and potential applications of chain-of-thought mechanism. This work represents the first attempt at a general-purpose image generation model, and there remain several unresolved issues. We will open-source the related resources at https://github.com/VectorSpaceLab/OmniGen to foster advancements in this field.