A Review of Image Processing Methods in Prostate Ultrasound

Prostate cancer (PCa) poses a significant threat to men's health, with early diagnosis being crucial for improving prognosis and reducing mortality rates. Transrectal ultrasound (TRUS) plays a vital role in the diagnosis and image-guided intervention of PCa.To facilitate physicians with more accurate and efficient computer-assisted diagnosis and interventions, many image processing algorithms in TRUS have been proposed and achieved state-of-the-art performance in several tasks, including prostate gland segmentation, prostate image registration, PCa classification and detection, and interventional needle detection.The rapid development of these algorithms over the past two decades necessitates a comprehensive summary. In consequence, this survey provides a systematic analysis of this field, outlining the evolution of image processing methods in the context of TRUS image analysis and meanwhile highlighting their relevant contributions. Furthermore, this survey discusses current challenges and suggests future research directions to possibly advance this field further.

Towards Multi-modality Fusion and Prototype-based Feature Refinement for Clinically Significant Prostate Cancer Classification in Transrectal Ultrasound

Prostate cancer is a highly prevalent cancer and ranks as the second leading cause of cancer-related deaths in men globally. Recently, the utilization of multi-modality transrectal ultrasound (TRUS) has gained significant traction as a valuable technique for guiding prostate biopsies. In this study, we propose a novel learning framework for clinically significant prostate cancer (csPCa) classification using multi-modality TRUS. The proposed framework employs two separate 3D ResNet-50 to extract distinctive features from B-mode and shear wave elastography (SWE). Additionally, an attention module is incorporated to effectively refine B-mode features and aggregate the extracted features from both modalities. Furthermore, we utilize few shot segmentation task to enhance the capacity of classification encoder. Due to the limited availability of csPCa masks, a prototype correction module is employed to extract representative prototypes of csPCa. The performance of the framework is assessed on a large-scale dataset consisting of 512 TRUS videos with biopsy-proved prostate cancer. The results demonstrate the strong capability in accurately identifying csPCa, achieving an area under the curve (AUC) of 0.86. Moreover, the framework generates visual class activation mapping (CAM), which can serve as valuable assistance for localizing csPCa. These CAM images may offer valuable guidance during TRUS-guided targeted biopsies, enhancing the efficacy of the biopsy procedure.The code is available at https://github.com/2313595986/SmileCode.

Efficient Multi-View Fusion and Flexible Adaptation to View Missing in Cardiovascular System Signals

The progression of deep learning and the widespread adoption of sensors have facilitated automatic multi-view fusion (MVF) about the cardiovascular system (CVS) signals. However, prevalent MVF model architecture often amalgamates CVS signals from the same temporal step but different views into a unified representation, disregarding the asynchronous nature of cardiovascular events and the inherent heterogeneity across views, leading to catastrophic view confusion. Efficient training strategies specifically tailored for MVF models to attain comprehensive representations need simultaneous consideration. Crucially, real-world data frequently arrives with incomplete views, an aspect rarely noticed by researchers. Thus, the View-Centric Transformer (VCT) and Multitask Masked Autoencoder (M2AE) are specifically designed to emphasize the centrality of each view and harness unlabeled data to achieve superior fused representations. Additionally, we systematically define the missing-view problem for the first time and introduce prompt techniques to aid pretrained MVF models in flexibly adapting to various missing-view scenarios. Rigorous experiments involving atrial fibrillation detection, blood pressure estimation, and sleep staging-typical health monitoring tasks-demonstrate the remarkable advantage of our method in MVF compared to prevailing methodologies. Notably, the prompt technique requires finetuning less than 3% of the entire model's data, substantially fortifying the model's resilience to view missing while circumventing the need for complete retraining. The results demonstrate the effectiveness of our approaches, highlighting their potential for practical applications in cardiovascular health monitoring. Codes and models are released at URL.

Multi-modality transrectal ultrasound video classification for identification of clinically significant prostate cancer

Prostate cancer is the most common noncutaneous cancer in the world. Recently, multi-modality transrectal ultrasound (TRUS) has increasingly become an effective tool for the guidance of prostate biopsies. With the aim of effectively identifying prostate cancer, we propose a framework for the classification of clinically significant prostate cancer (csPCa) from multi-modality TRUS videos. The framework utilizes two 3D ResNet-50 models to extract features from B-mode images and shear wave elastography images, respectively. An adaptive spatial fusion module is introduced to aggregate two modalities' features. An orthogonal regularized loss is further used to mitigate feature redundancy. The proposed framework is evaluated on an in-house dataset containing 512 TRUS videos, and achieves favorable performance in identifying csPCa with an area under curve (AUC) of 0.84. Furthermore, the visualized class activation mapping (CAM) images generated from the proposed framework may provide valuable guidance for the localization of csPCa, thus facilitating the TRUS-guided targeted biopsy. Our code is publicly available at https://github.com/2313595986/ProstateTRUS.

A Prototype-Based Neural Network for Image Anomaly Detection and Localization

Image anomaly detection and localization perform not only image-level anomaly classification but also locate pixel-level anomaly regions. Recently, it has received much research attention due to its wide application in various fields. This paper proposes ProtoAD, a prototype-based neural network for image anomaly detection and localization. First, the patch features of normal images are extracted by a deep network pre-trained on nature images. Then, the prototypes of the normal patch features are learned by non-parametric clustering. Finally, we construct an image anomaly localization network (ProtoAD) by appending the feature extraction network with $L2$ feature normalization, a $1\times1$ convolutional layer, a channel max-pooling, and a subtraction operation. We use the prototypes as the kernels of the $1\times1$ convolutional layer; therefore, our neural network does not need a training phase and can conduct anomaly detection and localization in an end-to-end manner. Extensive experiments on two challenging industrial anomaly detection datasets, MVTec AD and BTAD, demonstrate that ProtoAD achieves competitive performance compared to the state-of-the-art methods with a higher inference speed. The source code is available at: https://github.com/98chao/ProtoAD.

A Unified and Efficient Coordinating Framework for Autonomous DBMS Tuning

Recently using machine learning (ML) based techniques to optimize modern database management systems has attracted intensive interest from both industry and academia. With an objective to tune a specific component of a DBMS (e.g., index selection, knobs tuning), the ML-based tuning agents have shown to be able to find better configurations than experienced database administrators. However, one critical yet challenging question remains unexplored -- how to make those ML-based tuning agents work collaboratively. Existing methods do not consider the dependencies among the multiple agents, and the model used by each agent only studies the effect of changing the configurations in a single component. To tune different components for DBMS, a coordinating mechanism is needed to make the multiple agents cognizant of each other. Also, we need to decide how to allocate the limited tuning budget among the agents to maximize the performance. Such a decision is difficult to make since the distribution of the reward for each agent is unknown and non-stationary. In this paper, we study the above question and present a unified coordinating framework to efficiently utilize existing ML-based agents. First, we propose a message propagation protocol that specifies the collaboration behaviors for agents and encapsulates the global tuning messages in each agent's model. Second, we combine Thompson Sampling, a well-studied reinforcement learning algorithm with a memory buffer so that our framework can allocate budget judiciously in a non-stationary environment. Our framework defines the interfaces adapted to a broad class of ML-based tuning agents, yet simple enough for integration with existing implementations and future extensions. We show that it can effectively utilize different ML-based agents and find better configurations with 1.4~14.1X speedups on the workload execution time compared with baselines.

End-To-End Audiovisual Feature Fusion for Active Speaker Detection

Active speaker detection plays a vital role in human-machine interaction. Recently, a few end-to-end audiovisual frameworks emerged. However, these models' inference time was not explored and are not applicable for real-time applications due to their complexity and large input size. In addition, they explored a similar feature extraction strategy that employs the ConvNet on audio and visual inputs. This work presents a novel two-stream end-to-end framework fusing features extracted from images via VGG-M with raw Mel Frequency Cepstrum Coefficients features extracted from the audio waveform. The network has two BiGRU layers attached to each stream to handle each stream's temporal dynamic before fusion. After fusion, one BiGRU layer is attached to model the joint temporal dynamics. The experiment result on the AVA-ActiveSpeaker dataset indicates that our new feature extraction strategy shows more robustness to noisy signals and better inference time than models that employed ConvNet on both modalities. The proposed model predicts within 44.41 ms, which is fast enough for real-time applications. Our best-performing model attained 88.929% accuracy, nearly the same detection result as state-of-the-art -work.

Feature Aggregation and Refinement Network for 2D AnatomicalLandmark Detection

Localization of anatomical landmarks is essential for clinical diagnosis, treatment planning, and research. In this paper, we propose a novel deep network, named feature aggregation and refinement network (FARNet), for the automatic detection of anatomical landmarks. To alleviate the problem of limited training data in the medical domain, our network adopts a deep network pre-trained on natural images as the backbone network and several popular networks have been compared. Our FARNet also includes a multi-scale feature aggregation module for multi-scale feature fusion and a feature refinement module for high-resolution heatmap regression. Coarse-to-fine supervisions are applied to the two modules to facilitate the end-to-end training. We further propose a novel loss function named Exponential Weighted Center loss for accurate heatmap regression, which focuses on the losses from the pixels near landmarks and suppresses the ones from far away. Our network has been evaluated on three publicly available anatomical landmark detection datasets, including cephalometric radiographs, hand radiographs, and spine radiographs, and achieves state-of-art performances on all three datasets. Code is available at: \url{https://github.com/JuvenileInWind/FARNet}

Pixel Contrastive-Consistent Semi-Supervised Semantic Segmentation

We present a novel semi-supervised semantic segmentation method which jointly achieves two desiderata of segmentation model regularities: the label-space consistency property between image augmentations and the feature-space contrastive property among different pixels. We leverage the pixel-level L2 loss and the pixel contrastive loss for the two purposes respectively. To address the computational efficiency issue and the false negative noise issue involved in the pixel contrastive loss, we further introduce and investigate several negative sampling techniques. Extensive experiments demonstrate the state-of-the-art performance of our method (PC2Seg) with the DeepLab-v3+ architecture, in several challenging semi-supervised settings derived from the VOC, Cityscapes, and COCO datasets.

Full-Resolution Encoder-Decoder Networks with Multi-Scale Feature Fusion for Human Pose Estimation

To achieve more accurate 2D human pose estimation, we extend the successful encoder-decoder network, simple baseline network (SBN), in three ways. To reduce the quantization errors caused by the large output stride size, two more decoder modules are appended to the end of the simple baseline network to get full output resolution. Then, the global context blocks (GCBs) are added to the encoder and decoder modules to enhance them with global context features. Furthermore, we propose a novel spatial-attention-based multi-scale feature collection and distribution module (SA-MFCD) to fuse and distribute multi-scale features to boost the pose estimation. Experimental results on the MS COCO dataset indicate that our network can remarkably improve the accuracy of human pose estimation over SBN, our network using ResNet34 as the backbone network can even achieve the same accuracy as SBN with ResNet152, and our networks can achieve superior results with big backbone networks.