$\texttt{PatentAgent}$: Intelligent Agent for Automated Pharmaceutical Patent Analysis

Pharmaceutical patents play a vital role in biochemical industries, especially in drug discovery, providing researchers with unique early access to data, experimental results, and research insights. With the advancement of machine learning, patent analysis has evolved from manual labor to tasks assisted by automatic tools. However, there still lacks an unified agent that assists every aspect of patent analysis, from patent reading to core chemical identification. Leveraging the capabilities of Large Language Models (LLMs) to understand requests and follow instructions, we introduce the $\textbf{first}$ intelligent agent in this domain, $\texttt{PatentAgent}$, poised to advance and potentially revolutionize the landscape of pharmaceutical research. $\texttt{PatentAgent}$ comprises three key end-to-end modules -- $\textit{PA-QA}$, $\textit{PA-Img2Mol}$, and $\textit{PA-CoreId}$ -- that respectively perform (1) patent question-answering, (2) image-to-molecular-structure conversion, and (3) core chemical structure identification, addressing the essential needs of scientists and practitioners in pharmaceutical patent analysis. Each module of $\texttt{PatentAgent}$ demonstrates significant effectiveness with the updated algorithm and the synergistic design of $\texttt{PatentAgent}$ framework. $\textit{PA-Img2Mol}$ outperforms existing methods across CLEF, JPO, UOB, and USPTO patent benchmarks with an accuracy gain between 2.46% and 8.37% while $\textit{PA-CoreId}$ realizes accuracy improvement ranging from 7.15% to 7.62% on PatentNetML benchmark. Our code and dataset will be publicly available.

Emotional Dimension Control in Language Model-Based Text-to-Speech: Spanning a Broad Spectrum of Human Emotions

Current emotional text-to-speech (TTS) systems face challenges in mimicking a broad spectrum of human emotions due to the inherent complexity of emotions and limitations in emotional speech datasets and models. This paper proposes a TTS framework that facilitates control over pleasure, arousal, and dominance, and can synthesize a diversity of emotional styles without requiring any emotional speech data during TTS training. We train an emotional attribute predictor using only categorical labels from speech data, aligning with psychological research and incorporating anchored dimensionality reduction on self-supervised learning (SSL) features. The TTS framework converts text inputs into phonetic tokens via an autoregressive language model and uses pseudo-emotional dimensions to guide the parallel prediction of fine-grained acoustic details. Experiments conducted on the LibriTTS dataset demonstrate that our framework can synthesize speech with enhanced naturalness and a variety of emotional styles by effectively controlling emotional dimensions, even without the inclusion of any emotional speech during TTS training.

Dynamic Prompting of Frozen Text-to-Image Diffusion Models for Panoptic Narrative Grounding

Panoptic narrative grounding (PNG), whose core target is fine-grained image-text alignment, requires a panoptic segmentation of referred objects given a narrative caption. Previous discriminative methods achieve only weak or coarse-grained alignment by panoptic segmentation pretraining or CLIP model adaptation. Given the recent progress of text-to-image Diffusion models, several works have shown their capability to achieve fine-grained image-text alignment through cross-attention maps and improved general segmentation performance. However, the direct use of phrase features as static prompts to apply frozen Diffusion models to the PNG task still suffers from a large task gap and insufficient vision-language interaction, yielding inferior performance. Therefore, we propose an Extractive-Injective Phrase Adapter (EIPA) bypass within the Diffusion UNet to dynamically update phrase prompts with image features and inject the multimodal cues back, which leverages the fine-grained image-text alignment capability of Diffusion models more sufficiently. In addition, we also design a Multi-Level Mutual Aggregation (MLMA) module to reciprocally fuse multi-level image and phrase features for segmentation refinement. Extensive experiments on the PNG benchmark show that our method achieves new state-of-the-art performance.

Towards Audio Codec-based Speech Separation

Recent improvements in neural audio codec (NAC) models have generated interest in adopting pre-trained codecs for a variety of speech processing applications to take advantage of the efficiencies gained from high compression, but these have yet been applied to the speech separation (SS) task. SS can benefit from high compression because the compute required for traditional SS models makes them impractical for many edge computing use cases. However, SS is a waveform-masking task where compression tends to introduce distortions that severely impact performance. Here we propose a novel task of Audio Codec-based SS, where SS is performed within the embedding space of a NAC, and propose a new model, Codecformer, to address this task. At inference, Codecformer achieves a 52x reduction in MAC while producing separation performance comparable to a cloud deployment of Sepformer. This method charts a new direction for performing efficient SS in practical scenarios.

Phonetic Enhanced Language Modeling for Text-to-Speech Synthesis

Recent language model-based text-to-speech (TTS) frameworks demonstrate scalability and in-context learning capabilities. However, they suffer from robustness issues due to the accumulation of errors in speech unit predictions during autoregressive language modeling. In this paper, we propose a phonetic enhanced language modeling method to improve the performance of TTS models. We leverage self-supervised representations that are phonetically rich as the training target for the autoregressive language model. Subsequently, a non-autoregressive model is employed to predict discrete acoustic codecs that contain fine-grained acoustic details. The TTS model focuses solely on linguistic modeling during autoregressive training, thereby reducing the error propagation that occurs in non-autoregressive training. Both objective and subjective evaluations validate the effectiveness of our proposed method.

MossFormer2: Combining Transformer and RNN-Free Recurrent Network for Enhanced Time-Domain Monaural Speech Separation

Our previously proposed MossFormer has achieved promising performance in monaural speech separation. However, it predominantly adopts a self-attention-based MossFormer module, which tends to emphasize longer-range, coarser-scale dependencies, with a deficiency in effectively modelling finer-scale recurrent patterns. In this paper, we introduce a novel hybrid model that provides the capabilities to model both long-range, coarse-scale dependencies and fine-scale recurrent patterns by integrating a recurrent module into the MossFormer framework. Instead of applying the recurrent neural networks (RNNs) that use traditional recurrent connections, we present a recurrent module based on a feedforward sequential memory network (FSMN), which is considered "RNN-free" recurrent network due to the ability to capture recurrent patterns without using recurrent connections. Our recurrent module mainly comprises an enhanced dilated FSMN block by using gated convolutional units (GCU) and dense connections. In addition, a bottleneck layer and an output layer are also added for controlling information flow. The recurrent module relies on linear projections and convolutions for seamless, parallel processing of the entire sequence. The integrated MossFormer2 hybrid model demonstrates remarkable enhancements over MossFormer and surpasses other state-of-the-art methods in WSJ0-2/3mix, Libri2Mix, and WHAM!/WHAMR! benchmarks.

Robust Identity Perceptual Watermark Against Deepfake Face Swapping

Notwithstanding offering convenience and entertainment to society, Deepfake face swapping has caused critical privacy issues with the rapid development of deep generative models. Due to imperceptible artifacts in high-quality synthetic images, passive detection models against face swapping in recent years usually suffer performance damping regarding the generalizability issue. Therefore, several studies have been attempted to proactively protect the original images against malicious manipulations by inserting invisible signals in advance. However, the existing proactive defense approaches demonstrate unsatisfactory results with respect to visual quality, detection accuracy, and source tracing ability. In this study, we propose the first robust identity perceptual watermarking framework that concurrently performs detection and source tracing against Deepfake face swapping proactively. We assign identity semantics regarding the image contents to the watermarks and devise an unpredictable and unreversible chaotic encryption system to ensure watermark confidentiality. The watermarks are encoded and recovered by jointly training an encoder-decoder framework along with adversarial image manipulations. Extensive experiments demonstrate state-of-the-art performance against Deepfake face swapping under both cross-dataset and cross-manipulation settings.

SPGM: Prioritizing Local Features for enhanced speech separation performance

Dual-path is a popular architecture for speech separation models (e.g. Sepformer) which splits long sequences into overlapping chunks for its intra- and inter-blocks that separately model intra-chunk local features and inter-chunk global relationships. However, it has been found that inter-blocks, which comprise half a dual-path model's parameters, contribute minimally to performance. Thus, we propose the Single-Path Global Modulation (SPGM) block to replace inter-blocks. SPGM is named after its structure consisting of a parameter-free global pooling module followed by a modulation module comprising only 2% of the model's total parameters. The SPGM block allows all transformer layers in the model to be dedicated to local feature modelling, making the overall model single-path. SPGM achieves 22.1 dB SI-SDRi on WSJ0-2Mix and 20.4 dB SI-SDRi on Libri2Mix, exceeding the performance of Sepformer by 0.5 dB and 0.3 dB respectively and matches the performance of recent SOTA models with up to 8 times fewer parameters.

Are Soft Prompts Good Zero-shot Learners for Speech Recognition?

Large self-supervised pre-trained speech models require computationally expensive fine-tuning for downstream tasks. Soft prompt tuning offers a simple parameter-efficient alternative by utilizing minimal soft prompt guidance, enhancing portability while also maintaining competitive performance. However, not many people understand how and why this is so. In this study, we aim to deepen our understanding of this emerging method by investigating the role of soft prompts in automatic speech recognition (ASR). Our findings highlight their role as zero-shot learners in improving ASR performance but also make them vulnerable to malicious modifications. Soft prompts aid generalization but are not obligatory for inference. We also identify two primary roles of soft prompts: content refinement and noise information enhancement, which enhances robustness against background noise. Additionally, we propose an effective modification on noise prompts to show that they are capable of zero-shot learning on adapting to out-of-distribution noise environments.

Analysis of Speech Separation Performance Degradation on Emotional Speech Mixtures

Despite recent strides made in Speech Separation, most models are trained on datasets with neutral emotions. Emotional speech has been known to degrade performance of models in a variety of speech tasks, which reduces the effectiveness of these models when deployed in real-world scenarios. In this paper we perform analysis to differentiate the performance degradation arising from the emotions in speech from the impact of out-of-domain inference. This is measured using a carefully designed test dataset, Emo2Mix, consisting of balanced data across all emotional combinations. We show that even models with strong out-of-domain performance such as Sepformer can still suffer significant degradation of up to 5.1 dB SI-SDRi on mixtures with strong emotions. This demonstrates the importance of accounting for emotions in real-world speech separation applications.