How Good is my Histopathology Vision-Language Foundation Model? A Holistic Benchmark

Recently, histopathology vision-language foundation models (VLMs) have gained popularity due to their enhanced performance and generalizability across different downstream tasks. However, most existing histopathology benchmarks are either unimodal or limited in terms of diversity of clinical tasks, organs, and acquisition instruments, as well as their partial availability to the public due to patient data privacy. As a consequence, there is a lack of comprehensive evaluation of existing histopathology VLMs on a unified benchmark setting that better reflects a wide range of clinical scenarios. To address this gap, we introduce HistoVL, a fully open-source comprehensive benchmark comprising images acquired using up to 11 various acquisition tools that are paired with specifically crafted captions by incorporating class names and diverse pathology descriptions. Our Histo-VL includes 26 organs, 31 cancer types, and a wide variety of tissue obtained from 14 heterogeneous patient cohorts, totaling more than 5 million patches obtained from over 41K WSIs viewed under various magnification levels. We systematically evaluate existing histopathology VLMs on Histo-VL to simulate diverse tasks performed by experts in real-world clinical scenarios. Our analysis reveals interesting findings, including large sensitivity of most existing histopathology VLMs to textual changes with a drop in balanced accuracy of up to 25% in tasks such as Metastasis detection, low robustness to adversarial attacks, as well as improper calibration of models evident through high ECE values and low model prediction confidence, all of which can affect their clinical implementation.

Hierarchical Self-Supervised Adversarial Training for Robust Vision Models in Histopathology

Adversarial attacks pose significant challenges for vision models in critical fields like healthcare, where reliability is essential. Although adversarial training has been well studied in natural images, its application to biomedical and microscopy data remains limited. Existing self-supervised adversarial training methods overlook the hierarchical structure of histopathology images, where patient-slide-patch relationships provide valuable discriminative signals. To address this, we propose Hierarchical Self-Supervised Adversarial Training (HSAT), which exploits these properties to craft adversarial examples using multi-level contrastive learning and integrate it into adversarial training for enhanced robustness. We evaluate HSAT on multiclass histopathology dataset OpenSRH and the results show that HSAT outperforms existing methods from both biomedical and natural image domains. HSAT enhances robustness, achieving an average gain of 54.31% in the white-box setting and reducing performance drops to 3-4% in the black-box setting, compared to 25-30% for the baseline. These results set a new benchmark for adversarial training in this domain, paving the way for more robust models. Our Code for training and evaluation is available at https://github.com/HashmatShadab/HSAT.

Robust-LLaVA: On the Effectiveness of Large-Scale Robust Image Encoders for Multi-modal Large Language Models

Multi-modal Large Language Models (MLLMs) excel in vision-language tasks but remain vulnerable to visual adversarial perturbations that can induce hallucinations, manipulate responses, or bypass safety mechanisms. Existing methods seek to mitigate these risks by applying constrained adversarial fine-tuning to CLIP vision encoders on ImageNet-scale data, ensuring their generalization ability is preserved. However, this limited adversarial training restricts robustness and broader generalization. In this work, we explore an alternative approach of leveraging existing vision classification models that have been adversarially pre-trained on large-scale data. Our analysis reveals two principal contributions: (1) the extensive scale and diversity of adversarial pre-training enables these models to demonstrate superior robustness against diverse adversarial threats, ranging from imperceptible perturbations to advanced jailbreaking attempts, without requiring additional adversarial training, and (2) end-to-end MLLM integration with these robust models facilitates enhanced adaptation of language components to robust visual features, outperforming existing plug-and-play methodologies on complex reasoning tasks. Through systematic evaluation across visual question-answering, image captioning, and jail-break attacks, we demonstrate that MLLMs trained with these robust models achieve superior adversarial robustness while maintaining favorable clean performance. Our framework achieves 2x and 1.5x average robustness gains in captioning and VQA tasks, respectively, and delivers over 10% improvement against jailbreak attacks. Code and pretrained models will be available at https://github.com/HashmatShadab/Robust-LLaVA.

Test-Time Optimization for Domain Adaptive Open Vocabulary Segmentation

We present Seg-TTO, a novel framework for zero-shot, open-vocabulary semantic segmentation (OVSS), designed to excel in specialized domain tasks. While current open vocabulary approaches show impressive performance on standard segmentation benchmarks under zero-shot settings, they fall short of supervised counterparts on highly domain-specific datasets. We focus on segmentation-specific test-time optimization to address this gap. Segmentation requires an understanding of multiple concepts within a single image while retaining the locality and spatial structure of representations. We propose a novel self-supervised objective adhering to these requirements and use it to align the model parameters with input images at test time. In the textual modality, we learn multiple embeddings for each category to capture diverse concepts within an image, while in the visual modality, we calculate pixel-level losses followed by embedding aggregation operations specific to preserving spatial structure. Our resulting framework termed Seg-TTO is a plug-in-play module. We integrate Seg-TTO with three state-of-the-art OVSS approaches and evaluate across 22 challenging OVSS tasks covering a range of specialized domains. Our Seg-TTO demonstrates clear performance improvements across these establishing new state-of-the-art. Code: https://github.com/UlinduP/SegTTO.

Video-Panda: Parameter-efficient Alignment for Encoder-free Video-Language Models

We present an efficient encoder-free approach for video-language understanding that achieves competitive performance while significantly reducing computational overhead. Current video-language models typically rely on heavyweight image encoders (300M-1.1B parameters) or video encoders (1B-1.4B parameters), creating a substantial computational burden when processing multi-frame videos. Our method introduces a novel Spatio-Temporal Alignment Block (STAB) that directly processes video inputs without requiring pre-trained encoders while using only 45M parameters for visual processing - at least a 6.5$\times$ reduction compared to traditional approaches. The STAB architecture combines Local Spatio-Temporal Encoding for fine-grained feature extraction, efficient spatial downsampling through learned attention and separate mechanisms for modeling frame-level and video-level relationships. Our model achieves comparable or superior performance to encoder-based approaches for open-ended video question answering on standard benchmarks. The fine-grained video question-answering evaluation demonstrates our model's effectiveness, outperforming the encoder-based approaches Video-ChatGPT and Video-LLaVA in key aspects like correctness and temporal understanding. Extensive ablation studies validate our architectural choices and demonstrate the effectiveness of our spatio-temporal modeling approach while achieving 3-4$\times$ faster processing speeds than previous methods. Code is available at \url{https://github.com/jh-yi/Video-Panda}.

UniMed-CLIP: Towards a Unified Image-Text Pretraining Paradigm for Diverse Medical Imaging Modalities

Vision-Language Models (VLMs) trained via contrastive learning have achieved notable success in natural image tasks. However, their application in the medical domain remains limited due to the scarcity of openly accessible, large-scale medical image-text datasets. Existing medical VLMs either train on closed-source proprietary or relatively small open-source datasets that do not generalize well. Similarly, most models remain specific to a single or limited number of medical imaging domains, again restricting their applicability to other modalities. To address this gap, we introduce UniMed, a large-scale, open-source multi-modal medical dataset comprising over 5.3 million image-text pairs across six diverse imaging modalities: X-ray, CT, MRI, Ultrasound, Pathology, and Fundus. UniMed is developed using a data-collection framework that leverages Large Language Models (LLMs) to transform modality-specific classification datasets into image-text formats while incorporating existing image-text data from the medical domain, facilitating scalable VLM pretraining. Using UniMed, we trained UniMed-CLIP, a unified VLM for six modalities that significantly outperforms existing generalist VLMs and matches modality-specific medical VLMs, achieving notable gains in zero-shot evaluations. For instance, UniMed-CLIP improves over BiomedCLIP (trained on proprietary data) by an absolute gain of +12.61, averaged over 21 datasets, while using 3x less training data. To facilitate future research, we release UniMed dataset, training codes, and models at https://github.com/mbzuai-oryx/UniMed-CLIP.

AgriCLIP: Adapting CLIP for Agriculture and Livestock via Domain-Specialized Cross-Model Alignment

Capitalizing on vast amount of image-text data, large-scale vision-language pre-training has demonstrated remarkable zero-shot capabilities and has been utilized in several applications. However, models trained on general everyday web-crawled data often exhibit sub-optimal performance for specialized domains, likely due to domain shift. Recent works have tackled this problem for some domains (e.g., healthcare) by constructing domain-specialized image-text data. However, constructing a dedicated large-scale image-text dataset for sustainable area of agriculture and livestock is still open to research. Further, this domain desires fine-grained feature learning due to the subtle nature of the downstream tasks (e.g, nutrient deficiency detection, livestock breed classification). To address this we present AgriCLIP, a vision-language foundational model dedicated to the domain of agriculture and livestock. First, we propose a large-scale dataset, named ALive, that leverages customized prompt generation strategy to overcome the scarcity of expert annotations. Our ALive dataset covers crops, livestock, and fishery, with around 600,000 image-text pairs. Second, we propose a training pipeline that integrates both contrastive and self-supervised learning to learn both global semantic and local fine-grained domain-specialized features. Experiments on diverse set of 20 downstream tasks demonstrate the effectiveness of AgriCLIP framework, achieving an absolute gain of 7.8\% in terms of average zero-shot classification accuracy, over the standard CLIP adaptation via domain-specialized ALive dataset. Our ALive dataset and code can be accessible at \href{https://github.com/umair1221/AgriCLIP/tree/main}{Github}.

Y-CA-Net: A Convolutional Attention Based Network for Volumetric Medical Image Segmentation

Recent attention-based volumetric segmentation (VS) methods have achieved remarkable performance in the medical domain which focuses on modeling long-range dependencies. However, for voxel-wise prediction tasks, discriminative local features are key components for the performance of the VS models which is missing in attention-based VS methods. Aiming at resolving this issue, we deliberately incorporate the convolutional encoder branch with transformer backbone to extract local and global features in a parallel manner and aggregate them in Cross Feature Mixer Module (CFMM) for better prediction of segmentation mask. Consequently, we observe that the derived model, Y-CT-Net, achieves competitive performance on multiple medical segmentation tasks. For example, on multi-organ segmentation, Y-CT-Net achieves an 82.4% dice score, surpassing well-tuned VS Transformer/CNN-like baselines UNETR/ResNet-3D by 2.9%/1.4%. With the success of Y-CT-Net, we extend this concept with hybrid attention models, that derived Y-CH-Net model, which brings a 3% improvement in terms of HD95 score for same segmentation task. The effectiveness of both models Y-CT-Net and Y-CH-Net verifies our hypothesis and motivates us to initiate the concept of Y-CA-Net, a versatile generic architecture based upon any two encoders and a decoder backbones, to fully exploit the complementary strengths of both convolution and attention mechanisms. Based on experimental results, we argue Y-CA-Net is a key player in achieving superior results for volumetric segmentation.

CDChat: A Large Multimodal Model for Remote Sensing Change Description

Large multimodal models (LMMs) have shown encouraging performance in the natural image domain using visual instruction tuning. However, these LMMs struggle to describe the content of remote sensing images for tasks such as image or region grounding, classification, etc. Recently, GeoChat make an effort to describe the contents of the RS images. Although, GeoChat achieves promising performance for various RS tasks, it struggles to describe the changes between bi-temporal RS images which is a key RS task. This necessitates the development of an LMM that can describe the changes between the bi-temporal RS images. However, there is insufficiency of datasets that can be utilized to tune LMMs. In order to achieve this, we introduce a change description instruction dataset that can be utilized to finetune an LMM and provide better change descriptions for RS images. Furthermore, we show that the LLaVA-1.5 model, with slight modifications, can be finetuned on the change description instruction dataset and achieve favorably better performance.

Distillation-free Scaling of Large SSMs for Images and Videos

State-space models (SSMs), exemplified by S4, have introduced a novel context modeling method by integrating state-space techniques into deep learning. However, they struggle with global context modeling due to their data-independent matrices. The Mamba model addressed this with data-dependent variants via the S6 selective-scan algorithm, enhancing context modeling, especially for long sequences. However, Mamba-based architectures are difficult to scale with respect to the number of parameters, which is a major limitation for vision applications. This paper addresses the scalability issue of large SSMs for image classification and action recognition without requiring additional techniques like knowledge distillation. We analyze the distinct characteristics of Mamba-based and Attention-based models, proposing a Mamba-Attention interleaved architecture that enhances scalability, robustness, and performance. We demonstrate that the stable and efficient interleaved architecture resolves the scalability issue of Mamba-based architectures for images and videos and increases robustness to common artifacts like JPEG compression. Our thorough evaluation on the ImageNet-1K, Kinetics-400 and Something-Something-v2 benchmarks demonstrates that our approach improves the accuracy of state-of-the-art Mamba-based architectures by up to $+1.7$.